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| | Biochemical Assay |
| Description: | Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of Novel Series of Tankyrase Inhibitors by a Hybridization Approach J. Med. Chem. 2017). IC50 calculations:XLfit (idbs) was used to determine the IC50-values in inhibition experiments. The following formula was chosen to fit the data points (Langmuir Binding Isotherm):fit=((A+(B*x))+4(C−B)*(1−exp((−1*D)*x)))/D)), res=(y−fit) |
| Affinity data for this assay | |
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