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| | Ligand-Induced Uptake of [35S]-GTP-gamma-S |
| Description: | EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membranes. It is found that these modified 3-arylpropionic acids appeared to be more potent when evaluated in the functional assay than in the competitive binding assay, and their EC50 values served as a better guide for interpreting in vivo activity. All 3-arylpropionic acids and their modified analogs are found to be inactive against S1P2,4 receptors (IC50 > 10 uM). |
| Affinity data for this assay | |
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