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| | Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation |
| Description: | NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, University of Illinois Urbana-Champaign MLSCN Grant: 1 X01MH78953-01 Assay Overview Menopause is associated with the onset of hot flashes, night sweats, mood changes, and urogenital atrophy, which many women find distressing enough to seek medical management for relief. Estrogens in the form of hormone therapy (HT) have been the standard treatment for menopausal symptoms for decades. Although HT is the most effective treatment for hot flashes, the Women's Health Initiative (WHI) trial found that the combination of estrogen and progestin increases a woman's risk for heart disease, stroke, breast cancer, venous thromboembolic events, and dementia and does not improve quality of life indices such as emotional and sexual functioning and vitality. The adverse effects of HT created a large unmet need for selective estrogen rece |
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