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| | Dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 3 (S1P3) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Hugh Rosen, TSRI Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 MH076533-01 Grant Proposal PI: Germana Sanna, TSRI External Assay ID: S1P3_ANT_BLA_384_IC50 Name: Dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 3 (S1P3) Description: Sphingosine 1-phosphate (S1P) influences heart rate [1, 2], coronary artery caliber, endothelial integrity, lung epithelial integrity [3] and lymphocyte recirculation [1, 4-6] through five related high affinity G-protein coupled receptors [7, 8] which are involved in diverse biology. For example, S1P1 activation is sufficient to control lymphocyte numbers, with no discernable role in sinus rhythm control, whereas S1P3 regulates sinus rhythm but not lymphocyte recirculation. |
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