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| | QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Valerie Tokars and Andrew Mesecar, University of Illinois at Chicago (UIC) Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1-R03-MH084162-01A1 Grant Proposal PI: Valerie Tokars and Andrew Mesecar, UIC External Assay ID: 3CLPRO_INH_QFRET_1536_3XIC50 Name: QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro). Description: Coronaviruses are enveloped, large plus-strand RNA viruses that cause the common cold and other disorders such as lower respiratory tract infections and diarrhea (1). In 2003, the novel SARS coronavirus (SARS-CoV) was identified (2, 3) as the etiological agent of the global epidemic of severe acute respiratory syndrome (SARS), an atypical pneumonia that led to progre |
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