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Assay Method Information

Assay Name:  SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 2
Description:  Data Source: Sanford-Burnham Center for Chemical Genomics Source Affiliation: Sanford-Burnham Medical Research Institute Network: NIH Molecular Libraries Production Centers Network (MLPCN) Grant Number: 1X01MH085708-01 Assay Provider: Dr. Lawrence Barak, Duke University Addictive behavior stems from abnormal signaling activities in the brain. Thus identification of compounds blocking this modified signaling activity may lead to treatments for addictive behavior. GPR35, a to-date uncharacterized orphan G-Protein Coupled Receptor, is thought to play a role in addiction and has homology to other known receptors of abuse. This high-content imaging assay is developed and performed to confirm activity of hits originally identified in a high-content screen for antagonists of the GPR35 receptor, "Image-Based HTS for Selective Antagonists of GPR35" (AID 2058) and to study the structure-activity relationship on analogs of the confirmed hits. Compounds are either acquired from commercial
Affinity data for this assay
 

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Last update November 1, 2007
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