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| | TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mamuka Kvaratskhelia, Ohio State University Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R01 AI081581 Grant Proposal PI: Mamuka Kvaratskhelia, Ohio State University External Assay ID: LEDGF-p75_INH_TRFRET_1536_3XIC50 DRUN Name: TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration. Description: HIV-1 integrase (IN) is an important therapeutic target in the fight against AIDS as its function is essential for viral replication. Multimeric IN catalyzes pair-wise integration of the linear viral DNA ends in a two-step reaction. The main novelty of the current approach is to discover new probes that stabilize functionally compromised IN multimers rather than interfere with IN multimerization (referred to as MINIs [multimeric IN inhibi |
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