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Assay Method Information |
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| | FXa Inhibition Assay |
| Description: | Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays were conducted in 0.1 M phosphate buffer containing 0.2 M NaCl and 0.5% PEG 8000 adjusted to pH 7.4. Final reagent concentrations are shown in parentheses. Apixaban (0 and 0.5-8.0 nM in 2-fold increments) and S2765 (31.25-1000 μM by 2-fold increments) were incubated for 10 min. Reactions at 25°C were initiated by adding FXa (75 pM). |
| Affinity data for this assay | |
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