62 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Riken Csrs
Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Shizuoka
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Shizuoka
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyowa Hakko Kirin
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyoto University
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Nanjing University
Resistance by allostery: a novel perspective for eg5-targeted drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Beatson Institute For Cancer Research
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cairo University
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Beatson Institute For Cancer Research
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Csir-Central Drug Research Institute
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Strathclyde
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Beatson Institute For Cancer Research
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Serono
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Recent progress in biological activities of synthesized phenothiazines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Medical University of Silesia
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca
De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
China Pharmaceutical University
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
New Mexico State University
Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Indian Institute of Chemical Technology
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyoto University
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute For Cancer Research
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
China Pharmaceutical University
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute For Cancer Research
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyoto University
Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
China Pharmaceutical University
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Schering-Plough Research Institute
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Shizuoka
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cnrs-Commissariat à
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Shizuoka
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tanta University
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Karnatak University
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University College London
Synthesis and anticancer activity of new dihydropyrimidinone derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Mansoura University
Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kwazulu-Natal (Ukzn)
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alagappa University
Hetarylcoumarins: Synthesis and biological evaluation as potent a-glucosidase inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Kinnaird College For Women
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Wuhan University of Technology
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Monash University