Patent

Data

Compounds

HGNC
(for human-derived proteins)

Patent Title

Organization

Deposition

Downloads

43

HGNC:6833 6834 29079

(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors

Oryzon Genomics, S.A.

05/11/20

2D 3D TSV

64

6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds

Pfizer Inc

05/11/20

2D 3D TSV

34

Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof

Enanta Pharmaceuticals Inc

05/11/20

2D 3D TSV

27

HGNC:1079 1057 1133 6193 11719 7972 3942

Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof

Dana-Farber Cancer Institute Inc

05/11/20

2D 3D TSV

8

Combination Alzheimer therapy using anti-N3pGlu Abeta antibodies + a BACE inhibitor

Eli Lilly and Company

05/11/20

2D 3D TSV

142

HGNC:19310 8987

Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors

Incyte Corporation

05/11/20

2D 3D TSV

13

HGNC:7110 7111

Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers

eFFECTOR Therapeutics Inc

05/11/20

2D 3D TSV

111

P2X7 Modulators

Janssen Pharmaceutica NV

05/11/20

2D 3D TSV

387

Piperidin-4-yl azetidine derivatives as JAK1 inhibitors

Incyte Holdings Corporation

05/11/20

2D 3D TSV

24

HGNC:1232 12680 14661

Prolyl hydroxylase inhibitors and methods of use

Akebia Therapeutics, Inc.

05/11/20

2D 3D TSV

21

Pyrazines as modulators of GPR6

Takeda Pharmaceutical Company Limited

05/11/20

2D 3D TSV

143

Pyrazole compounds and methods of making and using same

ABIDE THERAPEUTICS, INC.

05/11/20

2D 3D TSV

150

HGNC:7160 195 7173 7163 7175 7176 7155 7166 7159

Pyridone derivative, pharmaceutical containing the same and methods of use thereof

Kaken Pharmaceutical Co., Ltd

05/11/20

2D 3D TSV

61

Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors

Boehringer Ingelheim International GmbH

05/11/20

2D 3D TSV

69

Substituted pyrrolidines as mGluR5 antagonists

Hua Medicine (Shanghai) Ltd.

05/11/20

2D 3D TSV

135

Substituted pyrrolizine compounds and uses thereof

Gilead Sciences Inc

05/11/20

2D 3D TSV

217

TYK2 inhibitors and uses thereof

Nimbus Lakshmi, Inc.

05/11/20

2D 3D TSV

22

Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors

Bristol-Myers Squibb Company

05/11/20

2D 3D TSV

118

Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas

Celgene Corporation

05/11/20

2D 3D TSV

14

Triazine carboxamides as sodium channel blockers

Purdue Pharma LP

05/11/20

2D 3D TSV

3

Urea derivatives and uses thereof

Kala Pharmaceuticals, Inc.

05/11/20

2D 3D TSV

21

Compounds and methods for inhibiting Cif virulence factor

Dartmouth College

05/10/20

2D 3D TSV

24

Imidazol- or 1,2,4-triazol-derivatives and their use

UNIVERSITE DE LILLE 2 DROIT ET SANTE

05/10/20

2D 3D TSV

196

HGNC:5992 8537

Indole derivatives and their use in neurodegenerative diseases

Merck Patent GmbH

05/10/20

2D 3D TSV

61

HGNC:220 221

Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure

UNIVERSITETET I OSLO

05/10/20

2D 3D TSV

46

N-benzoate group substituted benzopyrroline-2-one derivative and use thereof

Beijing Hanmi Pharmaceutical Co., Ltd.

05/10/20

2D 3D TSV

13

HGNC:2637 3537

Preparation and use of 7a-heterocycle substituted-6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists

TBA

05/10/20

2D 3D TSV

6

HGNC:6190 6192 6193

Pyrazolylaminobenzimidazole derivatives as JAK inhibitors

Eli Lilly and Company

05/10/20

2D 3D TSV

638

Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors

Array BioPharma Inc

05/10/20

2D 3D TSV

227

Quinazoline and quinoline compounds and uses thereof

Millennium Pharmaceuticals Inc

05/10/20

2D 3D TSV

19

Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof

Beijing Tide Pharmaceutical Co., Ltd

05/10/20

2D 3D TSV

365

HGNC:3169 3167 3165 14299 3170

Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders

The Scripps Research Institute

05/10/20

2D 3D TSV

13

Substituted piperidinyl tetrahydroquinolines

Bayer Pharma Aktiengesellschaft

05/10/20

2D 3D TSV

114

Triazoles as NR2B receptor inhibitors

JANSSEN PHARMACEUTICALS, INC.

05/10/20

2D 3D TSV

11

HGNC:8154 8156

10-substituted morphinan hydantoins

Purdue Pharma LP

05/07/20

2D 3D TSV

32

HGNC:11491 11283 4616 6874

1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors

Respivert Ltd

05/05/20

2D 3D TSV

10

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

Georgetown University

05/05/20

2D 3D TSV

138

Compositions useful for treating disorders related to kit

BLUEPRINT MEDICINES CORPORATION

05/05/20

2D 3D TSV

129

Cyclopropylamines as LSD1 inhibitors

Incyte Corporation

05/05/20

2D 3D TSV

16

H3 antagonists containing phenoxypiperidine core structure

Richter Gedeon Nyrt.

05/05/20

2D 3D TSV

149

Heteroarylamide inhibitors of TBK1

Takeda Pharmaceutical Company Limited

05/05/20

2D 3D TSV

8

Heterocyclic modulators of lipid synthesis for use against cancer and viral infections

3-V Biosciences, Inc.

05/05/20

2D 3D TSV

54

Substituted [1,2,4]triazolo[1,5-a]pyrazines as phosphodiesterase inhibitors

Sunovion Pharmaceuticals Inc

05/05/20

2D 3D TSV

33

Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors

Principia Biopharma Inc

05/05/20

2D 3D TSV

43

Trk-inhibiting compound

Ono Pharmaceutical Co., Ltd

05/05/20

2D 3D TSV

13

HGNC:8154 8156

7-beta-alkyl analogs of orvinols

Purdue Pharma LP

04/30/20

2D 3D TSV

47

HGNC:11526 11527 11528

N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists

Ogeda SA

04/30/20

2D 3D TSV

24

HGNC:4849 4848

5,5-bicyclic oxazole orexin receptor antagonists

Merck Sharp & Dohme Corp

04/25/20

2D 3D TSV

8

Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes

Jenrin Discovery Inc

04/25/20

2D 3D TSV

33

Inhibitors of lysine gingipain

CORTEXYME, INC.

04/25/20

2D 3D TSV

31

Pharmaceutical composition comprising pyridone derivatives

SK Biopharmaceuticals Co. Ltd

04/25/20

2D 3D TSV

41

Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof

FUJIFILM Corporation

04/25/20

2D 3D TSV

5

Primary amines and derivitves thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto

Arena Pharmaceuticals Inc

04/25/20

2D 3D TSV

239

HGNC:1079 6193 6171 3236

Substituted 2,4-diaminopyrimidines as kinase inhibitors

Celgene CAR LLC

04/25/20

2D 3D TSV

29

3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors

Janssen Pharmaceutica NV

04/18/20

2D 3D TSV

124

GDF-8 inhibitors

Rigel Pharmaceuticals, Inc

04/18/20

2D 3D TSV

73

IRE-1α inhibitors

FOSUN ORINOVE PHARMATECH, INC.

04/18/20

2D 3D TSV

146

HGNC:7027 12446

Pyrrolotriazine compounds as tam inhibitors

Incyte Corporation

04/18/20

2D 3D TSV

296

HGNC:5301 11050 5295 5294

Serotonin receptor modulators

Janssen Pharmaceutica NV

04/18/20

2D 3D TSV

74

HGNC:391 10436

Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors

Merck Patent GmbH

04/18/20

2D 3D TSV

116

Triazoles as NR2B receptor inhibitors

JANSSEN PHARMACEUTICALS, INC.

04/18/20

2D 3D TSV

10

HGNC:11708 6059

Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization

NewLink Genetics Corporation

04/18/20

2D 3D TSV

73

Trifluoromethylpropanamide derivatives

Hoffman-La Roche Inc

04/18/20

2D 3D TSV

17

β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators

Samumed, LLC

04/15/20

2D 3D TSV

23

1-sulfonyl piperidine derivatives as modulators of prokineticin receptors

Takeda Pharmaceutical Company Limited

04/15/20

2D 3D TSV

40

1H-pyrrol-3-amines

Bayer Pharma Aktiengesellschaft

04/15/20

2D 3D TSV

18

Apoptosis signal-regulating kinase inhibitors

Gilead Sciences Inc

04/15/20

2D 3D TSV

80

Aromatic heterocyclic compound

Mitsubishi Tanabe Pharma Corporation

04/15/20

2D 3D TSV

170

Compounds and compositions for inhibiting the activity of SHP2

Novartis AG

04/15/20

2D 3D TSV

3

Fucosidase inhibitors

HORIZON ORPHAN LLC

04/15/20

2D 3D TSV

10

Heterocyclic compounds and methods for their use

Novartis AG

04/15/20

2D 3D TSV

267

Heterocyclic compounds as immunomodulators

Incyte Corporation

04/15/20

2D 3D TSV

163

Heterocyclic compounds as inhibitors of Vanin-1 enzyme

Pfizer Inc

04/15/20

2D 3D TSV

3

Inhibitors of PTP4A3 for the treatment of cancer

University of Virginia Patent Foundation

04/15/20

2D 3D TSV

15

Inhibitors of cyclin-dependent kinase 7 (CDK7)

Syros Pharmaceuticals, Inc.

04/15/20

2D 3D TSV

18

Methods of use of cyclopamine analogs

Infinity Pharmaceuticals Inc

04/15/20

2D 3D TSV

74

Muscarinic M1 receptor positive allosteric modulators

Suven Life Sciences Limited

04/15/20

2D 3D TSV

167

Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors

Boehringer Ingelheim International GmbH

04/15/20

2D 3D TSV

43

HGNC:4849 4848

Piperidine oxadiazole and thiadiazole orexin receptor antagonists

Merck Sharp & Dohme Corp

04/15/20

2D 3D TSV

18

Preparation and use of kinase inhibitor

CHANGZHOU LONGTHERA PHARMACEUTICALS INC.

04/15/20

2D 3D TSV

14

Proton pump inhibitors

Takeda Pharmaceutical Company Limited

04/15/20

2D 3D TSV

121

HGNC:2160 2159

Pyridine derivatives

Hoffmann-La Roche Inc

04/15/20

2D 3D TSV

34

Pyridinyl and fused pyridinyl triazolone derivatives

Takeda Pharmaceutical Company Limited

04/15/20

2D 3D TSV

22

Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs

Bayer Pharma Aktiengesellschaft

04/15/20

2D 3D TSV

673

Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof

Epizyme Inc

04/15/20

2D 3D TSV

16

HGNC:6190 6192

Therapeutic compounds and compositions, and methods of use thereof

Genentech Inc

04/15/20

2D 3D TSV

238

Therapeutic compounds and uses thereof

Genentech Inc

04/15/20

2D 3D TSV

310

Therapeutic inhibitory compounds

LIFESCI PHARMACEUTICALS, INC.

04/15/20

2D 3D TSV

28

HGNC:8979 8978 8980 8977

Thienopyranones as kinase and epigenetic inhibitors

Signal Rx Pharmaceuticals Inc

04/15/20

2D 3D TSV

60

Tricyclic heterocyclic compounds useful as inhibitors of TNF

Bristol-Myers Squibb Company

04/15/20

2D 3D TSV

31

HGNC:4849 4848

2-pyridyloxy-3-ester-4-ether orexin receptor antagonists

Merck Sharp & Dohme Corp

04/10/20

2D 3D TSV

36

Aromatic heterocyclic derivatives and pharmaceutical applications thereof

Sunshine Lake Pharma Co., Ltd

04/10/20

2D 3D TSV

2

HGNC:3023 5286

Arylpiperazine derivatives and methods of utilizing same

Reviva Pharmaceuticals Inc

04/10/20

2D 3D TSV

10

Benzimidazole derivatives and use thereof

Purdue Pharma LP

04/10/20

2D 3D TSV

3

Benzomorphan analogs and use thereof

Purdue Pharma LP

04/10/20

2D 3D TSV

11

Compounds for the inhibition of cyclophilins and uses thereof

Merck Patent GmbH

04/10/20

2D 3D TSV

4

HGNC:933 4617

Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer''s disease

FONDAZIONE ISTITUTO ITAIANO DI TECNOLOGIA

04/10/20

2D 3D TSV

44

HGNC:6371 3529

Factor XIa inhibitors

Merck Sharp & Dohme Corp

04/10/20

2D 3D TSV

63

HGNC:1079 1133 11719 12434

Heteroaromatic compounds as BTK inhibitors

Boehringer Ingelheim International GmbH

04/10/20

2D 3D TSV

80

HGNC:8978 8975 8977 8976

Pyrimidinones as PI3K inhibitors

Incyte Holdings Corporation

04/10/20

2D 3D TSV

50

3-(4-(benzyloxy)phenyl)hex-4-ynoic acid derivative, method of preparing same and pharmaceutical composition for preventing and treating metabolic disease including same as effective ingredient

HYUNDAI PHARM CO., LTD

04/06/20

2D 3D TSV

122

Compounds useful as CCR9 modulators

Norgine B.V.

04/06/20

2D 3D TSV

53

Factor IXa inhibitors

Merck Sharp & Dohme Corp

04/06/20

2D 3D TSV

166

Inhibitors of IRAK4 activity

Merck Sharp & Dohme Corp

04/06/20

2D 3D TSV

190

Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof

Sanford-Burnham Medical Research Institute

04/06/20

2D 3D TSV

6

HGNC:11526 11527 11528

N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders

Ogeda SA

04/06/20

2D 3D TSV

8

P2X4 receptor antagonist

Nippon Chemiphar Co., Ltd

04/06/20

2D 3D TSV

10

HGNC:6251 2625

Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists

Rugen Holdings (Cayman) Limited

04/06/20

2D 3D TSV

9

Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them

Wisconsin Alumni Research Foundation

04/06/20

2D 3D TSV

130

HGNC:3023 3024

Urea and amide derivatives of aminoalkylpiperazines and use thereof

Southern Research Institute

04/06/20

2D 3D TSV

1

HGNC:8153 8154 8156

Morphinan derivative

University of Tsukuba

03/30/20

2D 3D TSV

117

N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof

Northeastern University

03/30/20

2D 3D TSV

220

N-arylmethyl sulfonamide negative modulators of NR2A

Luc Therapeutics, Inc.

03/30/20

2D 3D TSV

26

Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use

Genentech Inc

03/30/20

2D 3D TSV

40

Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

Taiho Pharmaceutical Co., Ltd

03/30/20

2D 3D TSV

45

Pyrrolopyrimidine compounds used as TLR7 agonist

Chia Tai Tianqing Pharmaceutical Group Co., Ltd

03/30/20

2D 3D TSV

13

Radiolabeled compounds

Takeda Pharmaceutical Company Limited

03/30/20

2D 3D TSV

18

HGNC:2637 20581 2603 2622 2623

Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase

University of Washington Through its Center for Commercialization

03/30/20

2D 3D TSV

43

Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators

LABORATORIOS DEL DR. ESTEVE S.A.

03/30/20

2D 3D TSV

15

HGNC:1373 1383 1371 1368

Sulfonamide compounds for inhibition of metastatic tumor growth

Welichem Biotech Inc.

03/30/20

2D 3D TSV

12

HGNC:3521 9642

Use of small molecule inhibitors targeting EYA tyrosine phosphatase

Children''s Hospital Medical Center

03/30/20

2D 3D TSV

25

Compositions and methods of modulating 15-PGDH activity

University of Kentucky Research Foundation

03/26/20

2D 3D TSV

63

Heteroaromatic derivatives and their use as pharmaceuticals

Mutabilis

03/26/20

2D 3D TSV

61

HGNC:4852 4854 4853

Histone deacetylase inhibitors

BioMarin Pharmaceutical Inc

03/26/20

2D 3D TSV

31

Imidazole derivative having JNK inhibitory activity and use thereof

SAMJIN PHARMACEUTICAL CO., LTD.

03/26/20

2D 3D TSV

365

Inhibitors of ERK and methods of use

Kura Oncology Inc

03/26/20

2D 3D TSV

15

HGNC:11491 11283 4616

Kinase inhibitors

Topivert Pharma Limited

03/26/20

2D 3D TSV

33

Phosphonate compounds for treatment of complement mediated disorders

Achillion Pharmaceuticals Inc

03/26/20

2D 3D TSV

33

HGNC:6932 6929 6931

Piperazine derivative

Astellas Pharma Inc

03/26/20

2D 3D TSV

180

Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors

Bristol-Myers Squibb Company

03/26/20

2D 3D TSV

62

Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

Guangzhou Innocare Pharma Tech Co., Ltd.

03/26/20

2D 3D TSV

139

Therapeutic inhibitory compounds

LIFESCI PHARMACEUTICALS, INC.

03/26/20

2D 3D TSV

54

1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2

Novartis AG

03/25/20

2D 3D TSV

14

CGRP receptor antagonists

Heptares Therapeutics Limited

03/25/20

2D 3D TSV

306

Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ]

Phenex Pharmaceuticals AG

03/25/20

2D 3D TSV

153

Compounds and methods for kinase modulation, and indications therefor

Plexxikon Inc.

03/25/20

2D 3D TSV

61

Cyclopropylamines as LSD1 inhibitors

Incyte Corporation

03/25/20

2D 3D TSV

41

Imidazole derivatives as formyl peptide receptor modulators

Allergan Inc

03/25/20

2D 3D TSV

118

Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors

Zhejiang DTRM Biopharma Co. Ltd

03/25/20

2D 3D TSV

53

Tetrahydropyridopyrimidine compound or salt thereof

Taiho Pharmaceutical Co., Ltd

03/25/20

2D 3D TSV

87

Therapeutic compounds and uses thereof

Genentech Inc

03/25/20

2D 3D TSV

53

Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation

UNIVERSITAT BERN

03/25/20

2D 3D TSV

43

Trk-inhibiting compound

Ono Pharmaceutical Co., Ltd

03/25/20

2D 3D TSV

18

Tyrosine kinase inhibitor and uses thereof

Xuanzhu Pharma Co., Ltd

03/25/20

2D 3D TSV

40

Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy

Sanford Burnham Prebys Medical Discovery Institute

03/25/20

2D 3D TSV

88

1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins

Incyte Corporation

03/23/20

2D 3D TSV

103

5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum

University of Washington Through its Center for Commercialization

03/23/20

2D 3D TSV

59

6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives

Hoffman-La Roche Inc

03/23/20

2D 3D TSV

139

Benzimidazol-2-amines as mIDH1 inhibitors

Bayer Pharma Aktiengesellschaft

03/23/20

2D 3D TSV

184

Bromodomain inhibitors

AbbVie Inc

03/23/20

2D 3D TSV

44

CDK inhibitors

GI Therapeutics, Inc.

03/23/20

2D 3D TSV

4

Compounds for the treatment of cancer and inflammatory diseases

TBA

03/23/20

2D 3D TSV

423

HGNC:6190 6192

Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors

Merck Sharp & Dohme Corp

03/23/20

2D 3D TSV

75

HGNC:6190 6192

N-(2-cyano heterocyclyl) pyrazolo pyridones as janus kinase inhibitors

Merck Sharp & Dohme Corp

03/23/20

2D 3D TSV

21

HGNC:4852 14064

Selective histone deactylase 6 inhibitors

H. Lee Moffitt Cancer Center and Research Institute Inc

03/23/20

2D 3D TSV

61

Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

BEIJING INNOCARE PHARMA TECH CO., LTD.

03/18/20

2D 3D TSV

147

8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives

IDORSIA PHARMACEUTICALS Ltd

03/16/20

2D 3D TSV

116

Aminopyridazinone compounds as protein kinase inhibitors

Jiangsu Hengrui Medicine Co., Ltd.

03/16/20

2D 3D TSV

346

Benzimidazol-2-amines as MIDH1 inhibitors

Bayer Pharma Aktiengesellschaft

03/16/20

2D 3D TSV

219

HGNC:6371 3529

Dihydropyridone P1 as factor XIa inhibitors

Bristol-Myers Squibb Company

03/16/20

2D 3D TSV

13

Heterocyclic vinyl autotaxin inhibitor compounds

PharmAkea Inc

03/16/20

2D 3D TSV

154

HGNC:6251 550

Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors

Proximagen Limited

03/16/20

2D 3D TSV

305

Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments

Bayer Pharma Aktiengesellschaft

03/16/20

2D 3D TSV

25

Inhibitors of beta-secretase

Vitae Pharmaceuticals Inc

03/16/20

2D 3D TSV

236

HGNC:4617 3091

Isoquinolin-3-yl carboxamides and preparation and use thereof

Samumed, LLC

03/16/20

2D 3D TSV

35

HGNC:7872 7873

Mammalian and bacterial nitric oxide synthase inhibitors

Northwestern University

03/16/20

2D 3D TSV

28

Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors

iTeos Therapeutics

03/16/20

2D 3D TSV

3

HGNC:7175 7176

Selective matrix metalloproteinase inhibitors

University of Notre Dame du Lac

03/16/20

2D 3D TSV

63

Styryl quinazoline derivatives as pharmaceutically active agents

Vichem Chemie Kutató

03/16/20

2D 3D TSV

23

Tertiary amines for use in the treatment of cardiac disorders

UNIVERSITETET I OSLO

03/16/20

2D 3D TSV

43

HGNC:6833 6834 29079

(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors

Oryzon Genomics, S.A.

03/12/20

2D 3D TSV

109

Bicyclic azaheterocyclobenzylamines as PI3K inhibitors

Incyte Holdings Corporation

03/12/20

2D 3D TSV

5

HGNC:2160 2159

Cannabinoid receptor modulators

Arena Pharmaceuticals Inc

03/12/20

2D 3D TSV

8

Factor XIa inhibitors

Merck Sharp & Dohme Corp

03/12/20

2D 3D TSV

138

Heterocyclic compounds as LSD1 inhibitors

Incyte Corporation

03/12/20

2D 3D TSV

205

Imidazotriazines and imidazopyrimidines as kinase inhibitors

Incyte Corporation

03/12/20

2D 3D TSV

167

HGNC:6251 11050 2637 2625 11048 11049

Inhibiting neurotransmitter reuptake

Mayo Foundation for Medical Education and Research

03/12/20

2D 3D TSV

17

Inhibitors of IRAK4 activity

Merck Sharp & Dohme Corp

03/12/20

2D 3D TSV

103

Oxazole compound and pharmaceutical composition

Otsuka Pharmaceutical Co., Ltd

03/12/20

2D 3D TSV

61

HGNC:17432 1936

Substituted amino triazoles useful as human chitinase inhibitors

OncoArendi Therapeutics SA

03/12/20

2D 3D TSV

57

1, 3, 4-thiadiazole compounds and their use in treating cancer

AstraZeneca AB

03/10/20

2D 3D TSV

11

HGNC:4586 6251 2625

3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists

Rugen Holdings (Cayman) Limited

03/10/20

2D 3D TSV

150

4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity

VIROSTATICS SRL

03/10/20

2D 3D TSV

21

HGNC:11283 12841 9617 8803 4840 6735 3697 4037 1057 76 6342 3955 3942 9967 6524

Compounds

UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

03/10/20

2D 3D TSV

2

Compounds as rearranged during transfection (RET) inhibitors

GlaxoSmithKline Intellectual Property Development Limited

03/10/20

2D 3D TSV

27

Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators

Suven Life Sciences Limited

03/10/20

2D 3D TSV

398

Heteroaryl substituted aminopyridine compounds

Bristol-Myers Squibb Company

03/10/20

2D 3D TSV

273

HGNC:27269 6059

Inhibitors of the kynurenine pathway

CURADEV PHARMA, PVT. LTD.

03/10/20

2D 3D TSV

47

Oxazoline and isoxazoline derivatives as CRAC modulators

LUPIN LIMITED

03/10/20

2D 3D TSV

3

HGNC:11037 11036

Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof

Tianjin Institute of Pharmaceutical Research

03/10/20

2D 3D TSV

80

Positive allosteric modulators of human melanocortin-4 receptor

Vanderbilt University

03/10/20

2D 3D TSV

129

HGNC:3689 3688

Quinolone derivatives as fibroblast growth factor receptor inhibitors

Principia Biopharma Inc

03/10/20

2D 3D TSV

15

HGNC:6190 6192 6193 12440

Small molecule inhibitors of the JAK family of kinases

Janssen Pharmaceutica NV

03/10/20

2D 3D TSV

135

HGNC:9542 9545

Substituted boronic acids and boronate esters as immunoproteasome inhibitors

Merck Patent GmbH

03/10/20

2D 3D TSV

36

HGNC:11772 11773

TGF beta receptor antagonists

Bristol-Myers Squibb Company

03/10/20

2D 3D TSV

33

1,3,4-thiadiazole compounds and their use in treating cancer

AstraZeneca AB

03/02/20

2D 3D TSV

81

HGNC:4849 4848

6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists

Merck Sharp & Dohme Corp

03/02/20

2D 3D TSV

34

C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof

Merck Patent GmbH

03/02/20

2D 3D TSV

116

Cyclopropanecarboxylic acid GPR120 modulators

Bristol-Myers Squibb Company

03/02/20

2D 3D TSV

668

Heterocyclic inhibitors of glutaminase

Calithera Biosciences Inc

03/02/20

2D 3D TSV

34

HGNC:9475 3528 3535

Hydrazine compound as blood coagulation factor Xa inhibitor

North China Pharmaceutical Company., Ltd.

03/02/20

2D 3D TSV

22

HGNC:6307 7029

Naphthyridine compounds, medical combinations and use thereof

NANJING NATINEFY PHARMATECH CO., LTD.

03/02/20

2D 3D TSV

25

HGNC:6190 6192 11393 11390 3765

Substituted heteroaryl compounds and methods of use

CALITOR SCIENCES, LLC

03/02/20

2D 3D TSV

9

Therapeutic pyrazolyl thienopyridines

FBM THERAPEUTICS, LLC

03/02/20

2D 3D TSV

13

HGNC:8978 8975 8977 8976

Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors

Karus Therapeutics Limited

03/02/20

2D 3D TSV

260

Compounds

Takeda Pharmaceutical Company Limited

02/29/20

2D 3D TSV

66

Pyridazinone compounds and their use as DAAO inhibitors

Takeda Pharmaceutical Company Limited

02/29/20

2D 3D TSV

70

3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof

Samumed, LLC

02/27/20

2D 3D TSV

66

3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof

Samumed, LLC

02/27/20

2D 3D TSV

43

5-hydroxytryptamine receptor 7 activity modulators and their method of use

TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

02/27/20

2D 3D TSV

3

Amino pyrimidine SSAO inhibitors

Eli Lilly and Company

02/27/20

2D 3D TSV

698

Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

Achillion Pharmaceuticals Inc

02/27/20

2D 3D TSV

22

Bicyclic heterocyclic compounds as PDE2 inhibitors

Merck Sharp & Dohme Corp

02/27/20

2D 3D TSV

129

CXCR7 antagonists

ChemoCentryx, Inc.

02/27/20

2D 3D TSV

37

Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors

AstraZeneca AB

02/27/20

2D 3D TSV

14

HGNC:6026 6027

Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies

Galderma Research & Development

02/27/20

2D 3D TSV

30

Compounds for treatment of fibrosis diseases

CUREGENIX, INC.

02/27/20

2D 3D TSV

64

Heterocyclic derivatives as modulators of kinase activity

Merck Patent GmbH

02/27/20

2D 3D TSV

4

HGNC:4840 1133

Imidazolyl kinase inhibitors and uses thereof

Dana-Farber Cancer Institute Inc

02/27/20

2D 3D TSV

39

Inhibitors of human 12/15-lipoxygenase

THE CHILDREN'S HOSPITAL CORPORATION

02/27/20

2D 3D TSV

304

HGNC:4617 3091

Isoquinolin-3-yl carboxamides and preparation and use thereof

Samumed, LLC

02/27/20

2D 3D TSV

35

Morphan and morphinan analogues, and methods of use

ALKERMES PHARMA IRELAND LIMITED

02/27/20

2D 3D TSV

197

Pyrimidinone amide compounds as PDE2 inhibitors

Merck Sharp & Dohme Corp

02/27/20

2D 3D TSV

126

Substituted indazole compounds as RORgammaT inhibitors and uses thereof

Merck Sharp & Dohme Corp

02/27/20

2D 3D TSV

261

Substituted piperidine compound and use thereof

Takeda Pharmaceutical Company Limited

02/27/20

2D 3D TSV

51

Substituted pyrimidines containing acidic groups as TLR7 modulators

APROS THERAPEUTICS, INC.

02/27/20

2D 3D TSV

303

TGF-β inhibitors

Rigel Pharmaceuticals, Inc

02/27/20

2D 3D TSV

125

2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof

Samumed, LLC

02/24/20

2D 3D TSV

14

HGNC:6171 12434

Benzimidazole derivatives as RLK and ITK inhibitors

Principia Biopharma Inc

02/24/20

2D 3D TSV

166

Compounds, compositions, and methods

Denali Therapeutics Inc.

02/24/20

2D 3D TSV

2

FXR (NR1H4) modulating compounds

Gilead Sciences Inc

02/24/20

2D 3D TSV

98

Heterocyclic inhibitors of PTPN11

The University of Texas System

02/24/20

2D 3D TSV

69

HGNC:1133 2433

Heterocyclic kinase inhibitors

AbbVie Inc

02/24/20

2D 3D TSV

101

Inhibitors of IRAK4 activity

Merck Sharp & Dohme Corp

02/24/20

2D 3D TSV

39

Purine derivatives for the treatment of viral infections

Janssen Sciences Ireland UC

02/24/20

2D 3D TSV

5

HGNC:1780 1771

Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof

The Council of Scientific & Industrial Research

02/24/20

2D 3D TSV

7

Syk inhibitors

Gilead Sciences Inc

02/24/20

2D 3D TSV

112

Use of pyrazolopyrimidine derivatives for the treatment of PI3K-delta related disorders

Incyte Corporation

02/24/20

2D 3D TSV

15

Combination therapy with glutaminase inhibitors

Calithera Biosciences Inc

02/21/20

2D 3D TSV

36

Identification of stabilizers of multimeric proteins

The Board of Trustees of the Leland Stanford Junior University

02/21/20

2D 3D TSV

26

Phthalazinone compounds and methods for the treatment of cystic fibrosis

Flatley Discovery Lab LLC

02/21/20

2D 3D TSV

16

Pyrazolopyridone compounds and uses thereof

Incyte Corporation

02/21/20

2D 3D TSV

213

Pyridazine derivatives as RORc modulators

Genentech Inc

02/21/20

2D 3D TSV

40

Pyridopyrimidinones and methods of use thereof

Genentech Inc

02/21/20

2D 3D TSV

183

Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

FORMA TM2, INC.

02/21/20

2D 3D TSV

2

HGNC:1133 3236

Salt of fused pyrimidine compound and crystal thereof

Taiho Pharmaceutical Co., Ltd

02/21/20

2D 3D TSV

172

Serine/threonine kinase inhibitors

Genentech Inc

02/21/20

2D 3D TSV

219

Therapeutic compounds and uses thereof

Genentech Inc

02/21/20

2D 3D TSV

11

HGNC:11177 11178

Tricyclic analogues, preparation method and uses thereof

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

02/21/20

2D 3D TSV

26

Compounds that are S1P modulating agents and/or ATX modulating agents

BIOGEN MA INC.

02/20/20

2D 3D TSV

163

HGNC:22978 9886 17071 18039 13610

Histone demethylase inhibitors

CELGENE QUANTSCEL RESEARCH, INC.

02/20/20

2D 3D TSV

475

Inhibitors of glucocorticoid receptor translocation

Sanford Burnham Prebys Medical Discovery Institute

02/20/20

2D 3D TSV

5

HGNC:3763 6307 11390 3767 7029 9967 3765

Metabolites of N-{4-([6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Exelixis Inc

02/20/20

2D 3D TSV

180

NHE3-binding compounds and methods for inhibiting phosphate transport

ARDELYX, INC.

02/20/20

2D 3D TSV

83

NRF2 regulators

GlaxoSmithKline Intellectual Propert Development Limited

02/20/20

2D 3D TSV

14

Piperidinone carboxamide azaindane CGRP receptor antagonists

Merck Sharp & Dohme Corp

02/20/20

2D 3D TSV

8

HGNC:3690 3691 3689 3688

Pteridines as FGFR inhibitors

Astex Therapeutics Ltd

02/20/20

2D 3D TSV

21

Pyrazines as modulators of GPR6

Takeda Pharmaceutical Company Limited

02/20/20

2D 3D TSV

389

Substituted 6,5-fused bicyclic heteroaryl compounds

Epizyme Inc

02/20/20

2D 3D TSV

173

HGNC:3023 3024

Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators

Indivior UK Limited

02/20/20

2D 3D TSV

15

Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof

Piramal Enterprises Limited

02/20/20

2D 3D TSV

39

HGNC:4588 4587 4586

Subunit selective NMDA receptor potentiators for the treatment of neurological conditions

Emory University

02/20/20

2D 3D TSV

804

Tricyclic sulfones as RORγ modulators

Bristol-Myers Squibb Company

02/20/20

2D 3D TSV

15

2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

02/16/20

2D 3D TSV

130

Aldosterone synthase inhibitors

Boehringer Ingelheim International GmbH

02/16/20

2D 3D TSV

23

HGNC:15631 15632

Benzazepine sulfonamide compounds

Hoffmann-La Roche Inc

02/16/20

2D 3D TSV

52

HGNC:19310 8987

Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors

Incyte Corporation

02/16/20

2D 3D TSV

37

HGNC:3690 3691 3689 3688

Bicyclic heterocycles as FGFR4 inhibitors

Incyte Corporation

02/16/20

2D 3D TSV

3

Compounds I

Proximagen Limited

02/16/20

2D 3D TSV

168

HGNC:13575 1103 2348 1104

Imidazopyrrolidine derivatives and their use in the treatment of disease

Novartis AG

02/16/20

2D 3D TSV

169

HGNC:11491 11283 4616

Urea derivatives useful as kinase inhibitors

Respivert Limited

02/16/20

2D 3D TSV

451

HGNC:7160 195 7155 7166 7159 221

5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis

Galapagos NV

02/10/20

2D 3D TSV

13

Bipyrazole derivatives as JAK inhibitors

Incyte Corporation

02/10/20

2D 3D TSV

33

Inhibition of MCL-1 and/or BFL-1/A1

Dana-Farber Cancer Institute Inc

02/10/20

2D 3D TSV

53

Inhibitors of IRAK4 activity

Merck Sharp & Dohme Corp

02/10/20

2D 3D TSV

34

Inhibitors of bruton's tyrosine kinase

Centaurus BioPharma Co., Ltd

02/10/20

2D 3D TSV

401

HGNC:10251 10252

Phthalazinones and isoquinolinones as rock inhibitors

Bristol-Myers Squibb Company

02/10/20

2D 3D TSV

53

Tetracyclic autotaxin inhibitors

PharmAkea Inc

02/10/20

2D 3D TSV

11

2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists

Gilead Sciences Inc

02/07/20

2D 3D TSV

22

2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof

Merck Patent GmbH

02/07/20

2D 3D TSV

27

HGNC:6613 3763 11724 6735 4037 3386 5960 6859 9829 3689 6873 7027 3767 2730 7029 3688 2731 6192 8031 12841 9617 8803 4840 3430 6307 1079 1057 1133 3395 77 1097 76 3393 3955 3236 2444 1974 6524

3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof

St. Chuan University

02/07/20

2D 3D TSV

71

HGNC:3827 3826

6-membered cyclic amines or lactames substituted with urea and phenyl

GRÜNENTHAL GMBH

02/07/20

2D 3D TSV

26

HGNC:11986 11989

Bacterial topoisomerase I inhibitors with antibacterial activity

THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES

02/07/20

2D 3D TSV

109

Bicyclic azaheterocyclobenzylamines as PI3K inhibitors

Incyte Corporation; Incyte Holdings Corporation

02/07/20

2D 3D TSV

64

Bile acid analogs as FXR/TGR5 agonists and methods of use thereof

Enanta Pharmaceuticals Inc

02/07/20

2D 3D TSV

13

Branched 3-phenylpropionic acid derivatives and their use

Bayer Intellectual Property GmbH

02/07/20

2D 3D TSV

134

HGNC:1133 3236

Bruton's tyrosine kinase inhibitors

Pfizer Inc

02/07/20

2D 3D TSV

168

Carbazole derivatives

Bristol-Myers Squibb Company

02/07/20

2D 3D TSV

118

HGNC:12805 17989

Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof

Sunshine Lake Pharma Co., Ltd

02/07/20

2D 3D TSV

26

Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof

GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

02/07/20

2D 3D TSV

18

EZH2 inhibitors

Mirati Therapeutics Inc

02/07/20

2D 3D TSV

29

HGNC:1133 3765

Inhibitor of FLT3 kinase and use thereof

HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES

02/07/20

2D 3D TSV

4

Psychotropic agents and uses thereof

LB PHARMACEUTICALS INC.

02/07/20

2D 3D TSV

932

HGNC:15513 20982

Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer

Epizyme Inc

02/07/20

2D 3D TSV

187

Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases

Bayer Intellectual Property GmbH

02/07/20

2D 3D TSV

258

HGNC:11584 14552

Tank-binding kinase inhibitor compounds

Gilead Sciences Inc

02/07/20

2D 3D TSV

144

Therapeutic inhibitory compounds

LIFESCI PHARMACEUTICALS, INC.

02/07/20

2D 3D TSV

106

HGNC:19310 8987

Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors

Incyte Corporation

02/07/20

2D 3D TSV

70

Thioacetate compounds, compositions and methods of use

Ardea Biosciences, Inc.

02/07/20

2D 3D TSV

343

ULK1 inhibitors and methods using same

SALK INSTITUTE FOR BIOLOGICAL STUDIES

02/07/20

2D 3D TSV

155

Compounds and their use as BACE inhibitors

AstraZeneca AB

02/04/20

2D 3D TSV

109

HGNC:6833 6834 29079

Cyclopropanamine compound and use thereof

Takeda Pharmaceutical Company Limited

02/04/20

2D 3D TSV

168

HGNC:19310 8987

Heterocyclic compounds useful as pim kinase inhibitors

Incyte Corporation

02/04/20

2D 3D TSV

218

Indole carboxamide compounds

Bristol-Myers Squibb Company

02/04/20

2D 3D TSV

30

Methyl oxazole orexin receptor antagonists

Merck Sharp & Dohme Corp

02/04/20

2D 3D TSV

104

Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof

Pfizer Inc

02/04/20

2D 3D TSV

35

HGNC:6251 11050 11048 11049

N-(hetero)aryl-substituted heteroyclic derivatives useful for the treatment of diseases or conditions related to the central nervous system

CHRONOS THERAPEUTICS LIMITED

02/04/20

2D 3D TSV

79

Pyrazolo[3,4-d]pyrimidine compound or salt thereof

Taiho Pharmaceutical Co., Ltd

02/04/20

2D 3D TSV

2

Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors

GlaxoSmithKline Intellectual Property Development Limited

02/04/20

2D 3D TSV

14

Substituted oxopyridine derivatives and use thereof as factor XIa/plasma

Bayer Pharma Aktiengesellschaft

02/04/20

2D 3D TSV

111

HGNC:13575 1103

Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors

Incyte Corporation

02/04/20

2D 3D TSV

78

HGNC:11491 11390 4617 3765

Heteroaryl Syk inhibitors

Boehringer Ingelheim International GmbH

01/30/20

2D 3D TSV

30

Naphthylamide compound, preparation method and use thereof

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

01/30/20

2D 3D TSV

156

Pyrazolo[1,5-a]pyridine derivatives and methods of their use

IGNYTA, INC.

01/30/20

2D 3D TSV

113

TrKA kinase inhibitors, compositions and methods thereof

Merck Sharp & Dohme Corp

01/30/20

2D 3D TSV

404

Tricyclic pyrido-carboxamide derivatives as rock inhibitors

Bristol-Myers Squibb Company

01/30/20

2D 3D TSV

11

HGNC:4849 4848

Use of benzimidazole-proline derivatives

IDORSIA PHARMACEUTICALS Ltd

01/30/20

2D 3D TSV

45

Apoptosis signal-regulating kinase inhibitors

Gilead Sciences Inc

01/27/20

2D 3D TSV

65

Aryl ethers and uses thereof

PELOTON THERAPEUTICS, INC.

01/27/20

2D 3D TSV

132

HGNC:7110 7111

Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof

Agency for Science, Technology and Research

01/27/20

2D 3D TSV

48

HGNC:4852 4854 4853

Histone deacetylase inhibitors

BioMarin Pharmaceutical Inc

01/27/20

2D 3D TSV

154

HGNC:22978 9886 17071 18039 13610

Histone demethylase inhibitors

Celgene Quanticel Research Inc

01/27/20

2D 3D TSV

198

HGNC:11393 11390 11397 3765

Kinase inhibitors and method of treating cancer

University Health Network

01/27/20

2D 3D TSV

8

HGNC:1133 4195 7972

Methods to treat lymphoplasmacytic lymphoma

Dana-Farber Cancer Institute Inc

01/27/20

2D 3D TSV

84

HGNC:6251 11050 11048 11049

Spirocyclic derivatives

CHRONOS THERAPEUTICS LIMITED

01/27/20

2D 3D TSV

88

HGNC:6190 6192

Tricyclic fused thiophene derivatives as JAK inhibitors

Incyte Corporation

01/27/20

2D 3D TSV

32

HGNC:3432 3430 3236

1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions

SABILA BIOSCIENCES LLC

01/21/20

2D 3D TSV

135

4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors

Janssen Pharmaceutica NV

01/21/20

2D 3D TSV

41

Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof

Enanta Pharmaceuticals Inc

01/21/20

2D 3D TSV

65

Aryl ethers and uses thereof

PELOTON THERAPEUTICS, INC.

01/21/20

2D 3D TSV

5

HGNC:5960 11584 14552 1974

Assays for screening for or identifying an agent or molecule that can block or inhibit AVB3 integrin from forming a complex with KRAS

The Regents of the University of California

01/21/20

2D 3D TSV

101

Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1

Novartis AG

01/21/20

2D 3D TSV

330

HGNC:10593 10585 10596

Benzenesulfonamide compounds and their use as therapeutic agents

Xenon Pharmaceuticals Inc

01/21/20

2D 3D TSV

235

Biaryl kinase inhibitors

Bristol-Myers Squibb Company

01/21/20

2D 3D TSV

186

HGNC:3690 3691 3689 3688

Bicyclic heterocycles as FGFR4 inhibitors

Incyte Corporation

01/21/20

2D 3D TSV

88

Chemokine receptor modulators and uses thereof

FLX BIO, INC.

01/21/20

2D 3D TSV

243

Compounds, compositions and methods

Denali Therapeutics Inc.

01/21/20

2D 3D TSV

9

HGNC:7856 263 264

Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors

Palobiofarma, S.L.

01/21/20

2D 3D TSV

18

HGNC:6190 6192 6193 8031 8032 8033 427

Diaryl macrocycles as modulators of protein kinases

TP Therapeutics, Inc.

01/21/20

2D 3D TSV

57

Fused tricyclic compounds as Raf kinase inhibitors

BeiGene, Ltd

01/21/20

2D 3D TSV

106

HGNC:29012 13606 17071 18039 20672 13610

Histone demethylase inhibitors

Celgene Quanticel Research Inc

01/21/20

2D 3D TSV

509

IRAK4 inhibiting agents

BIOGEN MA INC.

01/21/20

2D 3D TSV

53

Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof

Boehringer Ingelheim International GmbH

01/21/20

2D 3D TSV

28

Indazole and azaindazole Btk inhibitors

Merck Sharp & Dohme Corp

01/21/20

2D 3D TSV

51

Inhibiting G protein coupled receptor 6 kinase polypeptides

Mayo Foundation for Medical Education and Research

01/21/20

2D 3D TSV

31

Inhibitors of lysine specific demethylase-1

Celgene Quanticel Research Inc

01/21/20

2D 3D TSV

46

Macrocyclic compounds as TRK kinase inhibitors

Array BioPharma Inc

01/21/20

2D 3D TSV

227

N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators

Novartis AG

01/21/20

2D 3D TSV

31

N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors

Array BioPharma Inc

01/21/20

2D 3D TSV

13

Polysubstituted pyridine compound, preparation method, use and pharmaceutical composition

PEKING UNIVERSITY FOUNDER GROUP CO., LTD.

01/21/20

2D 3D TSV

85

Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

FORMA TM2, INC.

01/21/20

2D 3D TSV

4

HGNC:8154 8156

Pyridone-sulfone morphinan analogs as opioid receptor ligands

Purdue Pharma LP

01/21/20

2D 3D TSV

7

HGNC:6307 3690 3691 3689 3688

Quinoxaline derivatives useful as FGFR kinase modulators

Astex Therapeutics Ltd

01/21/20

2D 3D TSV

57

Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors

Boehringer Ingelheim International GmbH

01/21/20

2D 3D TSV

168

Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)

EXONHIT THERAPEUTICS, SA

01/21/20

2D 3D TSV

365

HGNC:4849 4848

Substituted prolines/piperidines as orexin receptor antagonists

EOLAS THERAPEUTICS, INC.

01/21/20

2D 3D TSV

232

HGNC:6190 6192 6193 8031 12440

Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors

Array BioPharm Inc.

01/21/20

2D 3D TSV

609

HGNC:6192 11584 14552

Tank-binding kinase inhibitor compounds

Gilead Sciences Inc

01/21/20

2D 3D TSV

46

TrkA kinase inhibitors, compositions and methods thereof

Merck Sharp & Dohme Corp

01/21/20

2D 3D TSV

32

HGNC:4840 11491 11283 4617 4616 6874

1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors

Respivert Limited

12/30/19

2D 3D TSV

620

HGNC:8605 270

2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG

Cancer Research Technology Limited

12/30/19

2D 3D TSV

16

3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds

Parion Sciences Inc

12/30/19

2D 3D TSV

22

4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators

Heptares Therapeutics Limited

12/30/19

2D 3D TSV

132

HGNC:6735 4037 1133 11283 6524

4-imidazopyridazin-1-yl-benzamides as BTK inhibitors

Merck Sharp & Dohme B.V.

12/30/19

2D 3D TSV

43

5-hydroxytryptamine receptor 7 activity modulators and their method of use

TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

12/30/19

2D 3D TSV

22

Benzoazepine derivatives

ViiV HEALTHCARE UK LIMITED

12/30/19

2D 3D TSV

48

Benzothiazole and benzothiophene compounds

Universite de Montreal

12/30/19

2D 3D TSV

1057

Biaryl amide compounds as kinase inhibitors

Novartis AG

12/30/19

2D 3D TSV

49

HGNC:934 933

C5-C6-fused tricyclic iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use

TBA

12/30/19

2D 3D TSV

190

Dopamine D3 receptor antagonists

Indivior UK Limited

12/30/19

2D 3D TSV

53

HGNC:4849 4848

Heteroaryl orexin receptor antagonists

Merck Sharp & Dohme Corp

12/30/19

2D 3D TSV

12

Liver X receptor (LXR) modulators

RALEXAR THERAPEUTICS, INC.

12/30/19

2D 3D TSV

357

Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C

Boehringer Ingelheim International GmbH

12/30/19

2D 3D TSV

141

N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B

CADENT THERAPEUTICS, INC.

12/30/19

2D 3D TSV

75

Positive allosteric modulators of the muscarinic acetylcholine receptor M4

Vanderbilt University

12/30/19

2D 3D TSV

25

RIPK2 inhibitors and method of treating cancer with same

University Health Network

12/30/19

2D 3D TSV

86

Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors

Dart NeuroScience (Cayman) Ltd

12/30/19

2D 3D TSV

243

HGNC:10593 10597

Sulfonamide compounds as voltage-gated sodium channel modulators

LUPIN LIMITED

12/30/19

2D 3D TSV

58

Therapeutic compounds and uses thereof

Genetech, Inc

12/30/19

2D 3D TSV

169

Triaza-spirodecanones as DDR1 inhibitors

Hoffman-La Roche Inc

12/30/19

2D 3D TSV

240

Triazole compounds as T-type calcium channel blockers

IDORSIA PHARMACEUTICALS Ltd

12/30/19

2D 3D TSV

76

Triterpenoids with HIV maturation inhibitory activity

VIIV HEALTHCARE UK (NO. 4) LIMITED

12/30/19

2D 3D TSV

248

HGNC:934 2529 933

Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use

Amgen Inc

12/30/19

2D 3D TSV

287

3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones

Bayer Pharma Aktiengesellschaft

12/27/19

2D 3D TSV

57

9-membered fused ring derivative

Shionogi & Co., Ltd

12/27/19

2D 3D TSV

8

HGNC:6833 6834 29079

Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use

Oryzon Genomics, S.A.

12/27/19

2D 3D TSV

45

Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments

University of California

12/27/19

2D 3D TSV

221

HGNC:1771 1773

CDK2/4/6 inhibitors

Pfizer Inc

12/27/19

2D 3D TSV

650

Compounds and methods for kinase modulation, and indications therefor

Plexxikon Inc.

12/27/19

2D 3D TSV

159

Compounds and their use as BACE inhibitors

AstraZeneca AB

12/27/19

2D 3D TSV

49

Compounds for use as GPR120 agonists

Piramal Enterprises Limited

12/27/19

2D 3D TSV

130

Compounds useful for treating disorders related to RET

BLUEPRINT MEDICINES CORPORATION

12/27/19

2D 3D TSV

13

Cystathionine-gamma-lyase (CSE) inhibitors

SOVA PHARMACEUTICALS, INC.

12/27/19

2D 3D TSV

6

Enantiomers of the 1′,6′-isomer of neplanocin A

Auburn University

12/27/19

2D 3D TSV

8

Estrogen receptor modulators and uses thereof

Genentech Inc

12/27/19

2D 3D TSV

47

Fused bicyclic compounds for the treatment of disease

AKARNA THERAPEUTICS, LTD.

12/27/19

2D 3D TSV

76

Fused pyrimidine compound or salt thereof

Taiho Pharmaceutical Co., Ltd

12/27/19

2D 3D TSV

6

Ghrelin 0-acyl transferase inhibitors

Eli Lilly and Company

12/27/19

2D 3D TSV

46

Glucosylceramide synthase inhibitors for the treatment of diseases

BioMarin Pharmaceutical Inc

12/27/19

2D 3D TSV

99

Heteroaryl compounds for kinase inhibition

ARIAD Pharmaceuticals Inc

12/27/19

2D 3D TSV

337

Heterocyclic modulators of lipid synthesis and combinations thereof

3-V Biosciences, Inc.

12/27/19

2D 3D TSV

21

Histone demethylase inhibitors

Celgene Quanticel Research Inc

12/27/19

2D 3D TSV

157

IDO inhibitors

NewLink Genetics Corporation

12/27/19

2D 3D TSV

145

Inhibiting agents for bruton's tyrosine kinase

BIOGEN MA INC.

12/27/19

2D 3D TSV

11

Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety

Universitetet | Oslo

12/27/19

2D 3D TSV

109

Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Vanderbilt University

12/27/19

2D 3D TSV

158

LSD1 inhibitors

Mirati Therapeutics Inc

12/27/19

2D 3D TSV

369

Metallo-β-lactamase inhibitors

Merck Sharp & Dohme Corp

12/27/19

2D 3D TSV

39

Methods for treating depressive symptoms

ALKERMES PHARMA IRELAND LIMITED

12/27/19

2D 3D TSV

104

Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use therof

Pfizer Inc

12/27/19

2D 3D TSV

129

Phosphatidylinositol 3-kinase inhibitors

Gilead Sciences Inc

12/27/19

2D 3D TSV

16

HGNC:4849 4848

Pyrazole orexin receptor antagonists

Merck Sharp & Dohme Corp

12/27/19

2D 3D TSV

24

HGNC:4852 14064

Selective histone deactylase 6 inhibitors

H. Lee Moffitt Cancer Center and Research Institute Inc

12/27/19

2D 3D TSV

75

Small molecule NF-κB inhibitors

ImmuneTarget, Inc.

12/27/19

2D 3D TSV

642

Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators

Janssen Pharmaceutica NV

12/27/19

2D 3D TSV

136

HGNC:10593 10597

Substituted benzenesulfonamides as sodium channel blockers

Daewoong Pharmaceutical Co., Ltd.

12/27/19

2D 3D TSV

75

HGNC:391 10436

Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors

Merck Patent GmbH

12/27/19

2D 3D TSV

244

Substituted spirocyclic inhibitors of autotaxin

X-Rx, Inc.

12/27/19

2D 3D TSV

4

T-type calcium channel modulator and uses thereof

UTI LIMITED PARTNERSHIP

12/27/19

2D 3D TSV

25

TRPV1 vanilloid receptor antagonists with a bicyclic portion

TBA

12/27/19

2D 3D TSV

26

Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors

Bristol-Myers Squibb Company

12/27/19

2D 3D TSV

28

Tricyclic heterocycles as bet protein inhibitors

Incyte Corporation

12/27/19

2D 3D TSV

292

Compounds useful as immunomodulators

Bristol-Myers Squibb Company

12/19/19

2D 3D TSV

307

Methods of treatment using pyridinonyl PDK1 inhibitors

Sunesis Pharmaceuticals Inc

12/19/19

2D 3D TSV

43

P2X4 receptor antagonist

Nippon Chemiphar Co., Ltd

12/19/19

2D 3D TSV

774

HGNC:6190 6192

Triazolopyridine compounds, compositions and methods of use thereof

Genentech Inc

12/19/19

2D 3D TSV

47

Heterocycles as modulators of kinase activity

Merck Patent GmbH

12/12/19

2D 3D TSV

72

HGNC:6307 8804 9437

Pyridyl benzothiophenes as kinase inhibitors

Allergan Inc

12/12/19

2D 3D TSV

92

C-linked heterocycloaklyl substituted pyrimidines and their uses

Genentech Inc

12/10/19

2D 3D TSV

51

HGNC:934 933

Diazine-fused amidines as BACE inhibitors, compositions, and their use

Merck Sharp & Dohme Corp

12/10/19

2D 3D TSV

19

Heteroaromatic compounds and their use as dopamine D1 ligands

Pfizer Inc

12/10/19

2D 3D TSV

214

Inhibitors of protein kinases

Portola Pharmaceuticals Inc

12/10/19

2D 3D TSV

185

Serine/threonine kinase inhibitors

Genentech Inc

12/10/19

2D 3D TSV

110

Thiazolopyrrolidine inhibitors of ROR- γ

Vitae Pharmaceuticals Inc

12/10/19

2D 3D TSV

7

HGNC:6190 6192 6193 76 12440

Hydrophobically tagged janus kinase inhibitors and uses thereof

Dana-Farber Cancer Institute Inc

12/03/19

2D 3D TSV

393

Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation

Bristol-Myers Squibb Company

12/03/19

2D 3D TSV

7

Indolyl-containing RORγt inhibitors

ORCA PHARMACEUTICALS LIMITED

12/03/19

2D 3D TSV

20

HGNC:8154 8156

Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Purdue Pharma LP

12/03/19

2D 3D TSV

58

Potent and selective inhibitors of monoamine transporters; method of making; and use thereof

THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

12/03/19

2D 3D TSV

13

HGNC:8978 8984 8975 3942 8974 8977 8976

Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors

Novartis AG

12/03/19

2D 3D TSV

13

Tetrahydrocarboline derivative

Ono Pharmaceutical Co., Ltd

12/03/19

2D 3D TSV

83

TrkA kinase inhibitors, compositions and methods thereof

Merck Sharp & Dohme Corp

12/03/19

2D 3D TSV

106

2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase

Cancer Therapeutics CRC Pty Ltd

11/21/19

2D 3D TSV

340

Aminoquinazoline and pyridopyrimidine derivatives

Genentech Inc

11/21/19

2D 3D TSV

38

Carboxylic acid compound, method for preparation thereof, and use thereof

InventisBio Shanghai Ltd.

11/21/19

2D 3D TSV

39

Heteroaromatic compounds and their use as dopamine D1 ligands

Pfizer Inc

11/21/19

2D 3D TSV

124

Inhibitor compounds of phosphodiesterase type 10A

AbbVie Deutschland GmbH & Co. KG

11/21/19

2D 3D TSV

68

Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2)

Sanofi

11/21/19

2D 3D TSV

42

Substituted pyrazolo[1,5-a]pyridines as PDE-10 inhibitors

Sunovion Pharmaceuticals Inc

11/21/19

2D 3D TSV

57

Substituted tropane derivatives

Toa Eiyo Ltd

11/21/19

2D 3D TSV

11

Treatment of respiratory disorders using ROR-gamma inhibitors

GLENMARK PHARMACEUTICALS S.A.

11/21/19

2D 3D TSV

5

1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties

The Regents of the University of Michigan

11/14/19

2D 3D TSV

122

Autotaxin inhibitor compounds

PharmAkea Inc

11/14/19

2D 3D TSV

375

Compounds useful as immunomodulators

Bristol-Myers Squibb Company

11/14/19

2D 3D TSV

151

Cycloalkane derivatives

Daiichi Sankyo Company, Limited

11/14/19

2D 3D TSV

21

Inhibitors of the renal outer medullary potassium channel

Merck Sharp & Dohme Corp

11/14/19

2D 3D TSV

485

Intermediates for preparing triazole agonists of the APJ receptor

Amgen Inc

11/14/19

2D 3D TSV

62

Isoindoline inhibitors of ROR-gamma

Vitae Pharmaceuticals Inc

11/14/19

2D 3D TSV

10

HGNC:2592 2591

Pyrazolopyridyl compounds as aldosterone synthase inhibitors

Merck Sharp & Dohme Corp

11/14/19

2D 3D TSV

27

SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors

Indiana University Research and Technology Corporation

11/14/19

2D 3D TSV

47

Substituted 2-azabicycles and their use as orexin receptor modulators

TBA

11/14/19

2D 3D TSV

43

HGNC:6192 1133

Substituted tetrahydrocarbazole and carbazole carboxamide compounds

Bristol-Myers Squibb Company

11/14/19

2D 3D TSV

207

Therapeutically active compositions and their methods of use

Agios Pharmaceuticals Inc

11/14/19

2D 3D TSV

13

Tricyclic heterocycles as BET protein inhibitors

Incyte Corporation

11/14/19

2D 3D TSV

10

HGNC:7027 12446

Heterocyclic compounds and uses thereof

Incyte Corporation

10/31/19

2D 3D TSV

121

Morpholin-pyridine derivatives

Hoffmann-La Roche Inc

10/31/19

2D 3D TSV

18

HGNC:11526 11527 11528

N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders

OGED SA

10/31/19

2D 3D TSV

32

HGNC:8978 8975 8977

Substituted quinazolin-4-one derivatives

Novartis AG

10/31/19

2D 3D TSV

41

BTK inhibitors

Merck Sharp & Dohme Corp

10/28/19

2D 3D TSV

125

HGNC:6371 6357

Benzylamine derivatives

Kalvista Pharmceuticals Limited

10/28/19

2D 3D TSV

12

Indazoles and use thereof

Purdue Pharma LP

10/28/19

2D 3D TSV

14

Piperidinone carboxamide azaindane CGRP receptor antagonists

Merck Sharp & Dohme Corp

10/28/19

2D 3D TSV

129

HGNC:6190 6192 6193 12440

Pyridazine compounds as JAK inhibitors

Portola Pharmaceuticals Inc

10/28/19

2D 3D TSV

109

HGNC:6193 6171

Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors

ARRIEN PHARMACEUTICALS LLC

10/28/19

2D 3D TSV

209

Substituted quinolines as PDE-10 inhibitors

Sunovion Pharmaceuticals Inc

10/28/19

2D 3D TSV

13

Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors

vTv Therapeutics LLC

10/28/19

2D 3D TSV

29

Tricyclic heterocycles as bet protein inhibitors

Incyte Corporation

10/28/19

2D 3D TSV

19

HGNC:4586 6251 2625

3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists

Rugen Holdings (Cayman) Limited

10/27/19

2D 3D TSV

64

Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Vanderbilt University

10/27/19

2D 3D TSV

159

HGNC:6251 3467

Chemical compounds

AstraZeneca AB

10/27/19

2D 3D TSV

248

Inhibiting the transient receptor potential A1 ion channel

Hydra Biosciences Inc

10/27/19

2D 3D TSV

492

Metallo-beta-lactamase inhibitors

Merck Sharp & Dohme Corp

10/27/19

2D 3D TSV

22

HGNC:6943 990

N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors

The Regents of the University of Michigan

10/27/19

2D 3D TSV

147

HGNC:8978 8980 8977

Phosphatidylinositol 3-kinase inhibitors

Gilead Sciences Inc

10/27/19

2D 3D TSV

82

Purine inhibitors of human phosphatidylinositol 3-kinase delta

Merck Sharp & Dohme Corp

10/27/19

2D 3D TSV

44

Pyridine compounds

Daiichi Sankyo Company, Limited

10/27/19

2D 3D TSV

25

Pyridinecarboxamides as CXCR2 modulators

Syntrix Biosystems, Inc.

10/27/19

2D 3D TSV

42

Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1

Vanderbilt University

10/27/19

2D 3D TSV

64

Oxazole orexin receptor antagonists

Merck Sharp & Dohme Corp

10/24/19

2D 3D TSV

92

Alkyne compounds for treatment of complement mediated disorders

Achillion Pharmaceuticals Inc

10/22/19

2D 3D TSV

10

Benzimidazole derivatives and use thereof

Purdue Pharma LP

10/22/19

2D 3D TSV

224

Biphenyl derivatives and methods for preparing same

DONG-A ST CO., LTD

10/22/19

2D 3D TSV

93

HGNC:9886 17071 18039

Histone demethylase inhibitors

Celgene Quanticel Research Inc

10/22/19

2D 3D TSV

166

Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2

Merck Sharpe & Dohme Corp.

10/22/19

2D 3D TSV

69

HGNC:8978 8972 8975 8977

Kinase inhibitors and methods of use

Intellikine LLC

10/22/19

2D 3D TSV

47

Substituted pyrazino[2,2-a]isoquinoline derivatives

Hoffmann-La Roche Inc

10/22/19

2D 3D TSV

88

Substituted pyrazolopyrimidines and method of use

AbbVie Deutschland GmbH & Co. KG

10/22/19

2D 3D TSV

56

HGNC:6833 6834 29079

(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors

Oryzon Genomics, S.A.

10/20/19

2D 3D TSV

19

2-heteroaryl carboxamides

Bayer Intellectual Property GmbH

10/20/19

2D 3D TSV

14

5-(N-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication

ViiV HEALTHCARE UK (NO. 5) LIMITED

10/20/19

2D 3D TSV

11

Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof

TBA

10/20/19

2D 3D TSV

18

Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders

Bayer Pharma Aktiengesellschaft

10/20/19

2D 3D TSV

18

HGNC:10593 10597

Amino-substituted heterocyclic derivatives as sodium channel inhibitors

Almirall, S.A.

10/20/19

2D 3D TSV

76

Amlexanox analogs

The Regents of the University of Michigan

10/20/19

2D 3D TSV

85

HGNC:19310 8987

Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors

Incyte Corporation

10/20/19

2D 3D TSV

774

Bicyclic heteroaryl amine compounds

Bristol-Myers Squibb Company

10/20/19

2D 3D TSV

37

HGNC:3690 3691 3689 3688

Bicyclic heterocycles as FGFR4 inhibitors

Incyte Corporation

10/20/19

2D 3D TSV

174

Btk inhibitors

Merck Sharp & Dohme Corp

10/20/19

2D 3D TSV

137

Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators

Reset Therapeutics, Inc.

10/20/19

2D 3D TSV

97

Compositions and methods for treating ocular diseases

Aerpio Therapeutics Inc

10/20/19

2D 3D TSV

9

Compounds and methods for inhibiting production of trimethylamine

The Procter & Gamble Company

10/20/19

2D 3D TSV

9

Compounds, compositions and methods useful for cholesterol mobilization

Cerenis Therapeutics Holding SA

10/20/19

2D 3D TSV

94

Dihydropyridinone MGAT2 inhibitors

Bristol-Myers Squibb Company

10/20/19

2D 3D TSV

227

HGNC:3529 6357

Factor XIA inhibitors

Merck Sharp & Dohme Corp

10/20/19

2D 3D TSV