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Patent code US10174035

Compile Data Set for Download or QSAR

Found 234 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320554
PNG
(US10174035, Compound 97 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C
Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320553
PNG
(US10174035, Compound 96 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H33FN8O3/c1-16-18(15-31(2)30-16)20-19(26)22(33-9-13-37-14-10-33)21-23(27-20)29-24(28-21)25(35)34-5-3-17(4-6-34)32-7-11-36-12-8-32/h15,17H,3-14H2,1-2H3,(H,27,28,29)
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n/an/a 3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320554
PNG
(US10174035, Compound 97 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C
Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320544
PNG
(US10174035, Compound 87 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2n(C)c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C26H35FN8O3/c1-17-19(16-31(2)30-17)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)32(3)25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h16,18H,4-15H2,1-3H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320544
PNG
(US10174035, Compound 87 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2n(C)c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C26H35FN8O3/c1-17-19(16-31(2)30-17)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)32(3)25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h16,18H,4-15H2,1-3H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320591
PNG
(US10174035, Compound 134 | [4-(Morpholin-4-yl)pipe...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H29F3N8O3/c25-24(26,27)20-16(14-28-32-20)17-13-18(34-7-11-38-12-8-34)19-21(29-17)31-22(30-19)23(36)35-3-1-15(2-4-35)33-5-9-37-10-6-33/h13-15H,1-12H2,(H,28,32)(H,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320551
PNG
(US10174035, Compound 94 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H34N8O3/c1-17-19(16-30(2)29-17)20-15-21(32-9-13-36-14-10-32)22-23(26-20)28-24(27-22)25(34)33-5-3-18(4-6-33)31-7-11-35-12-8-31/h15-16,18H,3-14H2,1-2H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320551
PNG
(US10174035, Compound 94 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H34N8O3/c1-17-19(16-30(2)29-17)20-15-21(32-9-13-36-14-10-32)22-23(26-20)28-24(27-22)25(34)33-5-3-18(4-6-33)31-7-11-35-12-8-31/h15-16,18H,3-14H2,1-2H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320580
PNG
(US10174035, Compound 123 | {6-Fluoro-7-(morpholin-...)
Show SMILES Fc1c(nc2[nH]c(nc2c1N1CCOCC1)C(=O)N1CCC(CC1)N1CCOCC1)-c1c[nH]nc1C(F)(F)F
Show InChI InChI=1S/C24H28F4N8O3/c25-16-17(15-13-29-33-20(15)24(26,27)28)30-21-18(19(16)35-7-11-39-12-8-35)31-22(32-21)23(37)36-3-1-14(2-4-36)34-5-9-38-10-6-34/h13-14H,1-12H2,(H,29,33)(H,30,31,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320541
PNG
(US10174035, Compound 84 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C24H32FN7O3/c1-14-16(13-30(4)29-14)18-17(25)20(31-9-11-35-12-10-31)19-21(26-18)28-22(27-19)23(33)32-7-5-15(6-8-32)24(2,3)34/h13,15,34H,5-12H2,1-4H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320576
PNG
(US10174035, Compound 119 | {3-[(2R,6S)-2,6-dimethy...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CN(C1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C24H32N8O3/c1-15-10-31(11-16(2)35-15)18-13-32(14-18)24(33)23-27-21-20(30-4-6-34-7-5-30)8-19(26-22(21)28-23)17-9-25-29(3)12-17/h8-9,12,15-16,18H,4-7,10-11,13-14H2,1-3H3,(H,26,27,28)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320555
PNG
(US10174035, Compound 98 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-4-2-17(3-5-33)31-6-10-35-11-7-31/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320570
PNG
(US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1
Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320570
PNG
(US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1
Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320555
PNG
(US10174035, Compound 98 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-4-2-17(3-5-33)31-6-10-35-11-7-31/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320537
PNG
(US10174035, Compound 81 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-6-4-31(5-7-33)17-2-10-35-11-3-17/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320529
PNG
(4-(1-{[6-(Morpholin-4-yl)-2-(1H-pyrazol-4-yl)-9H-p...)
Show SMILES O=C(N1CCC(CC1)N1CCOCC1=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C22H27N9O4/c32-16-13-35-10-7-31(16)15-1-3-30(4-2-15)22(33)20-25-17-19(27-20)26-18(14-11-23-24-12-14)28-21(17)29-5-8-34-9-6-29/h11-12,15H,1-10,13H2,(H,23,24)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320462
PNG
(US10174035, Compound 9 | [2-(1,3-Dimethyl-1H-pyraz...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-7-5-31(6-8-33)17-3-11-35-12-4-17/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320496
PNG
(US10174035, Compound 42 | [4-(Morpholin-4-yl)piper...)
Show SMILES O=C(N1CCC(CC1)N1CCOCC1)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C22H29N9O3/c32-22(31-3-1-16(2-4-31)29-5-9-33-10-6-29)20-25-17-19(27-20)26-18(15-13-23-24-14-15)28-21(17)30-7-11-34-12-8-30/h13-14,16H,1-12H2,(H,23,24)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320532
PNG
(4-(1-{[5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1=O
Show InChI InChI=1S/C24H30N8O4/c1-29-14-16(13-25-29)18-12-19(30-6-9-35-10-7-30)21-22(26-18)28-23(27-21)24(34)31-4-2-17(3-5-31)32-8-11-36-15-20(32)33/h12-14,17H,2-11,15H2,1H3,(H,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320586
PNG
(1-Methyl-4-(1-{[5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES CN1CCN(CC1=O)C1CN(C1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C23H29N9O3/c1-28-3-4-31(14-19(28)33)16-12-32(13-16)23(34)22-26-20-18(30-5-7-35-8-6-30)9-17(25-21(20)27-22)15-10-24-29(2)11-15/h9-11,16H,3-8,12-14H2,1-2H3,(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320577
PNG
(US10174035, Compound 120 | [5-(1-Methyl-1H-pyrazol...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CC(C1)N1CCOCC1
Show InChI InChI=1S/C22H28N8O3/c1-27-12-15(11-23-27)17-10-18(29-4-8-33-9-5-29)19-20(24-17)26-21(25-19)22(31)30-13-16(14-30)28-2-6-32-7-3-28/h10-12,16H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320587
PNG
(1-Methyl-4-(1-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(mo...)
Show SMILES CN1CCN(CC1=O)C1CN(C1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C22H28N10O3/c1-28-3-4-31(13-16(28)33)15-11-32(12-15)22(34)20-24-17-19(26-20)25-18(14-9-23-29(2)10-14)27-21(17)30-5-7-35-8-6-30/h9-10,15H,3-8,11-13H2,1-2H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320538
PNG
(2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320458
PNG
(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C25H35N9O3/c1-16-13-34(14-17(2)37-16)19-4-6-33(7-5-19)25(35)23-27-20-22(29-23)28-21(18-12-26-31(3)15-18)30-24(20)32-8-10-36-11-9-32/h12,15-17,19H,4-11,13-14H2,1-3H3,(H,27,28,29,30)/t16-,17+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320538
PNG
(2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320458
PNG
(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C25H35N9O3/c1-16-13-34(14-17(2)37-16)19-4-6-33(7-5-19)25(35)23-27-20-22(29-23)28-21(18-12-26-31(3)15-18)30-24(20)32-8-10-36-11-9-32/h12,15-17,19H,4-11,13-14H2,1-3H3,(H,27,28,29,30)/t16-,17+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320521
PNG
(9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1
Show InChI InChI=1S/C22H31N9O3/c1-28-15-16(14-24-28)18-26-19-17(20(27-18)31-8-12-34-13-9-31)25-21(29(19)2)22(32)23-4-3-5-30-6-10-33-11-7-30/h14-15H,3-13H2,1-2H3,(H,23,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320521
PNG
(9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1
Show InChI InChI=1S/C22H31N9O3/c1-28-15-16(14-24-28)18-26-19-17(20(27-18)31-8-12-34-13-9-31)25-21(29(19)2)22(32)23-4-3-5-30-6-10-33-11-7-30/h14-15H,3-13H2,1-2H3,(H,23,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3,(H,25,26)(H,27,28,29,30)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3,(H,25,26)(H,27,28,29,30)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320471
PNG
(US10174035, Compound 17 | {2-[1-Methyl-3-(trifluor...)
Show SMILES Cn1cc(c(n1)C(F)(F)F)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H30F3N9O3/c1-33-14-16(18(32-33)24(25,26)27)19-29-20-17(22(31-19)35-8-12-39-13-9-35)28-21(30-20)23(37)36-4-2-15(3-5-36)34-6-10-38-11-7-34/h14-15H,2-13H2,1H3,(H,28,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H28F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2,(H,27,32)(H,28,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H28F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2,(H,27,32)(H,28,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320512
PNG
(US10174035, Compound 58 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-29-15-16(14-24-29)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-4-2-17(3-5-32)30-6-10-34-11-7-30/h14-15,17H,2-13H2,1H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320512
PNG
(US10174035, Compound 58 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-29-15-16(14-24-29)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-4-2-17(3-5-32)30-6-10-34-11-7-30/h14-15,17H,2-13H2,1H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320490
PNG
(N-(Cyclohexylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H28N8O2/c1-28-13-15(12-23-28)17-25-18-16(20(27-17)29-7-9-31-10-8-29)24-19(26-18)21(30)22-11-14-5-3-2-4-6-14/h12-14H,2-11H2,1H3,(H,22,30)(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320569
PNG
(US10174035, Compound 112 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2n1C)-c1cn(C)nc1C
Show InChI InChI=1S/C28H39FN8O3/c1-17-14-37(15-18(2)40-17)20-6-8-36(9-7-20)28(38)27-31-24-25(35-10-12-39-13-11-35)22(29)23(30-26(24)34(27)5)21-16-33(4)32-19(21)3/h16-18,20H,6-15H2,1-5H3/t17-,18+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320572
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C22H30N8O3/c1-28-15-16(14-24-28)17-13-18(30-7-11-33-12-8-30)19-20(25-17)27-21(26-19)22(31)23-3-2-4-29-5-9-32-10-6-29/h13-15H,2-12H2,1H3,(H,23,31)(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320468
PNG
(US10174035, Compound 14 | [4-(2-Hydroxypropan-2-yl...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C22H30N8O3/c1-22(2,32)15-4-6-30(7-5-15)21(31)19-24-16-18(26-19)25-17(14-12-23-28(3)13-14)27-20(16)29-8-10-33-11-9-29/h12-13,15,32H,4-11H2,1-3H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320468
PNG
(US10174035, Compound 14 | [4-(2-Hydroxypropan-2-yl...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C22H30N8O3/c1-22(2,32)15-4-6-30(7-5-15)21(31)19-24-16-18(26-19)25-17(14-12-23-28(3)13-14)27-20(16)29-8-10-33-11-9-29/h12-13,15,32H,4-11H2,1-3H3,(H,24,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320518
PNG
(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Show SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 234 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%