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Patent code US8716287

Compile Data Set for Download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120931
PNG
(US8716287, 64)
Show SMILES COc1cc(CCNCc2ccc(cc2)N2CCNCC2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C26H29ClN8O2/c1-37-24-12-19(6-7-30-15-18-2-4-21(5-3-18)35-10-8-29-9-11-35)22(27)13-23(24)33-26(36)34-25-17-31-20(14-28)16-32-25/h2-5,12-13,16-17,29-30H,6-11,15H2,1H3,(H2,32,33,34,36)
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n/an/a 0.0300n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120919
PNG
(US8716287, 52)
Show SMILES COc1cc(CCN[C@@H](C)c2ccc(cc2)N2CCNCC2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N |r|
Show InChI InChI=1S/C27H31ClN8O2/c1-18(19-3-5-22(6-4-19)36-11-9-30-10-12-36)31-8-7-20-13-25(38-2)24(14-23(20)28)34-27(37)35-26-17-32-21(15-29)16-33-26/h3-6,13-14,16-18,30-31H,7-12H2,1-2H3,(H2,33,34,35,37)/t18-/m0/s1
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n/an/a 0.130n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120921
PNG
(US8716287, 54)
Show SMILES COc1cc(CCNCc2ccc3OCOc3c2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C23H21ClN6O4/c1-32-20-7-15(4-5-26-10-14-2-3-19-21(6-14)34-13-33-19)17(24)8-18(20)29-23(31)30-22-12-27-16(9-25)11-28-22/h2-3,6-8,11-12,26H,4-5,10,13H2,1H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120916
PNG
(US8716287, 49)
Show SMILES COc1ccc(CNCCc2cc(OC)c(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C23H23ClN6O3/c1-32-18-5-3-15(4-6-18)12-26-8-7-16-9-21(33-2)20(10-19(16)24)29-23(31)30-22-14-27-17(11-25)13-28-22/h3-6,9-10,13-14,26H,7-8,12H2,1-2H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120913
PNG
(US8716287, 46)
Show SMILES CC(C)Oc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C24H24ClFN6O2/c1-15(2)34-22-9-17(7-8-28-12-16-3-5-18(26)6-4-16)20(25)10-21(22)31-24(33)32-23-14-29-19(11-27)13-30-23/h3-6,9-10,13-15,28H,7-8,12H2,1-2H3,(H2,30,31,32,33)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120917
PNG
(US8716287, 50)
Show SMILES COc1cc(CCNCc2ccc(cc2)N2CCN(C)CC2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C27H31ClN8O2/c1-35-9-11-36(12-10-35)22-5-3-19(4-6-22)16-30-8-7-20-13-25(38-2)24(14-23(20)28)33-27(37)34-26-18-31-21(15-29)17-32-26/h3-6,13-14,17-18,30H,7-12,16H2,1-2H3,(H2,32,33,34,37)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120909
PNG
(US8716287, 42)
Show SMILES COc1cc(CCNCc2ccc(F)cc2)c(Br)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20BrFN6O2/c1-32-20-8-15(6-7-26-11-14-2-4-16(24)5-3-14)18(23)9-19(20)29-22(31)30-21-13-27-17(10-25)12-28-21/h2-5,8-9,12-13,26H,6-7,11H2,1H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120915
PNG
(US8716287, 48)
Show SMILES COc1cccc(CNCCc2cc(OC)c(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1
Show InChI InChI=1S/C23H23ClN6O3/c1-32-18-5-3-4-15(8-18)12-26-7-6-16-9-21(33-2)20(10-19(16)24)29-23(31)30-22-14-27-17(11-25)13-28-22/h3-5,8-10,13-14,26H,6-7,12H2,1-2H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120922
PNG
(US8716287, 55)
Show SMILES COc1ccccc1CNCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C23H23ClN6O3/c1-32-20-6-4-3-5-16(20)12-26-8-7-15-9-21(33-2)19(10-18(15)24)29-23(31)30-22-14-27-17(11-25)13-28-22/h3-6,9-10,13-14,26H,7-8,12H2,1-2H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120920
PNG
(US8716287, 53)
Show SMILES COc1ccc(cc1)[C@H](C)NCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl |r|
Show InChI InChI=1S/C24H25ClN6O3/c1-15(16-4-6-19(33-2)7-5-16)27-9-8-17-10-22(34-3)21(11-20(17)25)30-24(32)31-23-14-28-18(12-26)13-29-23/h4-7,10-11,13-15,27H,8-9H2,1-3H3,(H2,29,30,31,32)/t15-/m0/s1
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120932
PNG
(US8716287, 65)
Show SMILES COc1cccc(c1)[C@H](C)NCCc1cc(OC)c(NC(=O)Nc2cnc(cn2)C#N)cc1Cl |r|
Show InChI InChI=1S/C24H25ClN6O3/c1-15(16-5-4-6-19(9-16)33-2)27-8-7-17-10-22(34-3)21(11-20(17)25)30-24(32)31-23-14-28-18(12-26)13-29-23/h4-6,9-11,13-15,27H,7-8H2,1-3H3,(H2,29,30,31,32)/t15-/m0/s1
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120912
PNG
(US8716287, 45)
Show SMILES CCOc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C23H22ClFN6O2/c1-2-33-21-9-16(7-8-27-12-15-3-5-17(25)6-4-15)19(24)10-20(21)30-23(32)31-22-14-28-18(11-26)13-29-22/h3-6,9-10,13-14,27H,2,7-8,12H2,1H3,(H2,29,30,31,32)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120886
PNG
(US8716287, 19)
Show SMILES COc1cc(CCNCc2cccc(F)c2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20ClFN6O2/c1-32-20-8-15(5-6-26-11-14-3-2-4-16(24)7-14)18(23)9-19(20)29-22(31)30-21-13-27-17(10-25)12-28-21/h2-4,7-9,12-13,26H,5-6,11H2,1H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120902
PNG
(US8716287, 35)
Show SMILES CN1CCN(CC1)c1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C26H29ClN8O/c1-34-10-12-35(13-11-34)23-6-2-19(3-7-23)16-29-9-8-20-4-5-21(14-24(20)27)32-26(36)33-25-18-30-22(15-28)17-31-25/h2-7,14,17-18,29H,8-13,16H2,1H3,(H2,31,32,33,36)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120904
PNG
(US8716287, 37)
Show SMILES COc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20ClFN6O2/c1-32-20-8-15(6-7-26-11-14-2-4-16(24)5-3-14)18(23)9-19(20)29-22(31)30-21-13-27-17(10-25)12-28-21/h2-5,8-9,12-13,26H,6-7,11H2,1H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120927
PNG
(US8716287, 60)
Show SMILES COc1ccc(CNCc2ccc(NC(=O)Nc3cnc(cn3)C#N)c(OC)c2)cc1
Show InChI InChI=1S/C22H22N6O3/c1-30-18-6-3-15(4-7-18)11-24-12-16-5-8-19(20(9-16)31-2)27-22(29)28-21-14-25-17(10-23)13-26-21/h3-9,13-14,24H,11-12H2,1-2H3,(H2,26,27,28,29)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120876
PNG
(US8716287, 9)
Show SMILES Fc1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1
Show InChI InChI=1S/C21H18ClFN6O/c22-19-9-17(28-21(30)29-20-13-26-18(10-24)12-27-20)5-4-15(19)6-7-25-11-14-2-1-3-16(23)8-14/h1-5,8-9,12-13,25H,6-7,11H2,(H2,27,28,29,30)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120898
PNG
(US8716287, 31)
Show SMILES COc1cc(CCNCCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C23H23FN6O2/c1-32-21-12-17(9-11-26-10-8-16-2-5-18(24)6-3-16)4-7-20(21)29-23(31)30-22-15-27-19(13-25)14-28-22/h2-7,12,14-15,26H,8-11H2,1H3,(H2,28,29,30,31)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120923
PNG
(US8716287, 56)
Show SMILES COc1cc(CNCc2ccccc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H19ClN6O2/c1-30-19-7-15(11-24-10-14-5-3-2-4-6-14)17(22)8-18(19)27-21(29)28-20-13-25-16(9-23)12-26-20/h2-8,12-13,24H,10-11H2,1H3,(H2,26,27,28,29)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120887
PNG
(US8716287, 20)
Show SMILES COc1cc(CCNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H21FN6O2/c1-31-20-10-15(8-9-25-12-16-2-5-17(23)6-3-16)4-7-19(20)28-22(30)29-21-14-26-18(11-24)13-27-21/h2-7,10,13-14,25H,8-9,12H2,1H3,(H2,27,28,29,30)
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n/an/a 2.80n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120900
PNG
(US8716287, 33)
Show SMILES COc1cc(OCCNCc2ccc(F)cc2F)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20F2N6O3/c1-32-20-9-17(33-7-6-26-11-14-2-3-15(23)8-18(14)24)4-5-19(20)29-22(31)30-21-13-27-16(10-25)12-28-21/h2-5,8-9,12-13,26H,6-7,11H2,1H3,(H2,28,29,30,31)
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n/an/a 3n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120910
PNG
(US8716287, 43)
Show SMILES COc1cc(CCN[C@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N |r|
Show InChI InChI=1S/C23H23FN6O2/c1-15(17-4-6-18(24)7-5-17)26-10-9-16-3-8-20(21(11-16)32-2)29-23(31)30-22-14-27-19(12-25)13-28-22/h3-8,11,13-15,26H,9-10H2,1-2H3,(H2,28,29,30,31)/t15-/m1/s1
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n/an/a 3.30n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120918
PNG
(US8716287, 51)
Show SMILES COc1cc(CCNCc2ccc(cc2)N2CCN(C)CC2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C27H32N8O2/c1-34-11-13-35(14-12-34)23-6-3-21(4-7-23)17-29-10-9-20-5-8-24(25(15-20)37-2)32-27(36)33-26-19-30-22(16-28)18-31-26/h3-8,15,18-19,29H,9-14,17H2,1-2H3,(H2,31,32,33,36)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120882
PNG
(US8716287, 15)
Show SMILES COc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C22H21ClN6O2/c1-31-19-6-2-15(3-7-19)12-25-9-8-16-4-5-17(10-20(16)23)28-22(30)29-21-14-26-18(11-24)13-27-21/h2-7,10,13-14,25H,8-9,12H2,1H3,(H2,27,28,29,30)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120888
PNG
(US8716287, 21)
Show SMILES COc1cc(OCCNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H21FN6O3/c1-31-20-10-18(32-9-8-25-12-15-2-4-16(23)5-3-15)6-7-19(20)28-22(30)29-21-14-26-17(11-24)13-27-21/h2-7,10,13-14,25H,8-9,12H2,1H3,(H2,27,28,29,30)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120911
PNG
(US8716287, 44)
Show SMILES COc1cc(CCN[C@@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N |r|
Show InChI InChI=1S/C23H23FN6O2/c1-15(17-4-6-18(24)7-5-17)26-10-9-16-3-8-20(21(11-16)32-2)29-23(31)30-22-14-27-19(12-25)13-28-22/h3-8,11,13-15,26H,9-10H2,1-2H3,(H2,28,29,30,31)/t15-/m0/s1
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n/an/a 5.10n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120897
PNG
(US8716287, 30)
Show SMILES COc1cc(CCNCc2ccc(F)cc2F)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20F2N6O2/c1-32-20-8-14(6-7-26-11-15-3-4-16(23)9-18(15)24)2-5-19(20)29-22(31)30-21-13-27-17(10-25)12-28-21/h2-5,8-9,12-13,26H,6-7,11H2,1H3,(H2,28,29,30,31)
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n/an/a 6.40n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120928
PNG
(US8716287, 61)
Show SMILES COc1cccc(CNCc2ccc(NC(=O)Nc3cnc(cn3)C#N)c(OC)c2)c1
Show InChI InChI=1S/C22H22N6O3/c1-30-18-5-3-4-15(8-18)11-24-12-16-6-7-19(20(9-16)31-2)27-22(29)28-21-14-25-17(10-23)13-26-21/h3-9,13-14,24H,11-12H2,1-2H3,(H2,26,27,28,29)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120929
PNG
(US8716287, 62)
Show SMILES COc1ccccc1CNCc1ccc(NC(=O)Nc2cnc(cn2)C#N)c(OC)c1
Show InChI InChI=1S/C22H22N6O3/c1-30-19-6-4-3-5-16(19)12-24-11-15-7-8-18(20(9-15)31-2)27-22(29)28-21-14-25-17(10-23)13-26-21/h3-9,13-14,24H,11-12H2,1-2H3,(H2,26,27,28,29)
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Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120907
PNG
(US8716287, 40)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1F
Show InChI InChI=1S/C21H17ClF2N6O/c22-17-8-15(29-21(31)30-20-12-27-16(9-25)11-28-20)3-2-14(17)5-6-26-10-13-1-4-18(23)19(24)7-13/h1-4,7-8,11-12,26H,5-6,10H2,(H2,28,29,30,31)
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n/an/a 7.90n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120914
PNG
(US8716287, 47)
Show SMILES COc1cc(OCCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C22H20ClFN6O3/c1-32-20-9-19(33-7-6-26-11-14-2-4-15(24)5-3-14)17(23)8-18(20)29-22(31)30-21-13-27-16(10-25)12-28-21/h2-5,8-9,12-13,26H,6-7,11H2,1H3,(H2,28,29,30,31)
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n/an/a 8.40n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120924
PNG
(US8716287, 57)
Show SMILES COc1cc(CNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H19FN6O2/c1-30-19-8-15(11-24-10-14-2-5-16(22)6-3-14)4-7-18(19)27-21(29)28-20-13-25-17(9-23)12-26-20/h2-8,12-13,24H,10-11H2,1H3,(H2,26,27,28,29)
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n/an/a 8.90n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120905
PNG
(US8716287, 38)
Show SMILES CN1CCN(CC1)c1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1
Show InChI InChI=1S/C26H29ClN8O/c1-34-9-11-35(12-10-34)23-4-2-3-19(13-23)16-29-8-7-20-5-6-21(14-24(20)27)32-26(36)33-25-18-30-22(15-28)17-31-25/h2-6,13-14,17-18,29H,7-12,16H2,1H3,(H2,31,32,33,36)
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n/an/a 9.10n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120930
PNG
(US8716287, 63)
Show SMILES COc1cc(CNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H18ClFN6O2/c1-31-19-6-14(10-25-9-13-2-4-15(23)5-3-13)17(22)7-18(19)28-21(30)29-20-12-26-16(8-24)11-27-20/h2-7,11-12,25H,9-10H2,1H3,(H2,27,28,29,30)
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n/an/a 9.80n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120903
PNG
(US8716287, 36)
Show SMILES Cc1cc(NC(=O)Nc2cnc(cn2)C#N)ccc1CCNCc1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6O/c1-15-10-19(28-22(30)29-21-14-26-20(11-24)13-27-21)7-4-17(15)8-9-25-12-16-2-5-18(23)6-3-16/h2-7,10,13-14,25H,8-9,12H2,1H3,(H2,27,28,29,30)
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n/an/a 10n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120890
PNG
(US8716287, 23)
Show SMILES Fc1ccccc1CNCCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C21H18ClFN6O/c22-18-9-16(28-21(30)29-20-13-26-17(10-24)12-27-20)6-5-14(18)7-8-25-11-15-3-1-2-4-19(15)23/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 11n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120875
PNG
(US8716287, 8)
Show SMILES Clc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C21H18Cl2N6O/c22-16-4-1-14(2-5-16)11-25-8-7-15-3-6-17(9-19(15)23)28-21(30)29-20-13-26-18(10-24)12-27-20/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 11n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120879
PNG
(US8716287, 12)
Show SMILES COc1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1
Show InChI InChI=1S/C22H21ClN6O2/c1-31-19-4-2-3-15(9-19)12-25-8-7-16-5-6-17(10-20(16)23)28-22(30)29-21-14-26-18(11-24)13-27-21/h2-6,9-10,13-14,25H,7-8,12H2,1H3,(H2,27,28,29,30)
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n/an/a 11n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120906
PNG
(US8716287, 39)
Show SMILES Clc1cc(NC(=O)Nc2cnc(cn2)C#N)ccc1CCNCc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C25H26ClN7O2/c26-23-13-20(31-25(34)32-24-17-29-21(14-27)16-30-24)5-4-19(23)6-7-28-15-18-2-1-3-22(12-18)33-8-10-35-11-9-33/h1-5,12-13,16-17,28H,6-11,15H2,(H2,30,31,32,34)
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n/an/a 12n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120883
PNG
(US8716287, 16)
Show SMILES COc1ccccc1CNCCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C22H21ClN6O2/c1-31-20-5-3-2-4-16(20)12-25-9-8-15-6-7-17(10-19(15)23)28-22(30)29-21-14-26-18(11-24)13-27-21/h2-7,10,13-14,25H,8-9,12H2,1H3,(H2,27,28,29,30)
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n/an/a 13n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120891
PNG
(US8716287, 24)
Show SMILES C[C@@H](NCCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H20ClFN6O/c1-14(15-2-5-17(24)6-3-15)26-9-8-16-4-7-18(10-20(16)23)29-22(31)30-21-13-27-19(11-25)12-28-21/h2-7,10,12-14,26H,8-9H2,1H3,(H2,28,29,30,31)/t14-/m1/s1
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n/an/a 13n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120926
PNG
(US8716287, 59)
Show SMILES COc1cc(CNCc2ccccc2F)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H19FN6O2/c1-30-19-8-14(10-24-11-15-4-2-3-5-17(15)22)6-7-18(19)27-21(29)28-20-13-25-16(9-23)12-26-20/h2-8,12-13,24H,10-11H2,1H3,(H2,26,27,28,29)
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n/an/a 13n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120871
PNG
(US8716287, 4)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C21H18ClFN6O/c22-19-9-17(28-21(30)29-20-13-26-18(10-24)12-27-20)6-3-15(19)7-8-25-11-14-1-4-16(23)5-2-14/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 15n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120874
PNG
(US8716287, 7)
Show SMILES Fc1ccc(CCNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C22H20ClFN6O/c23-20-11-18(29-22(31)30-21-14-27-19(12-25)13-28-21)6-3-16(20)8-10-26-9-7-15-1-4-17(24)5-2-15/h1-6,11,13-14,26H,7-10H2,(H2,28,29,30,31)
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n/an/a 16n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120892
PNG
(US8716287, 25)
Show SMILES Clc1cc(NC(=O)Nc2cnc(cn2)C#N)ccc1CCNCc1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C25H26ClN7O2/c26-23-13-20(31-25(34)32-24-17-29-21(14-27)16-30-24)4-3-19(23)7-8-28-15-18-1-5-22(6-2-18)33-9-11-35-12-10-33/h1-6,13,16-17,28H,7-12,15H2,(H2,30,31,32,34)
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n/an/a 18n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120908
PNG
(US8716287, 41)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Br)cc1
Show InChI InChI=1S/C21H18BrFN6O/c22-19-9-17(28-21(30)29-20-13-26-18(10-24)12-27-20)6-3-15(19)7-8-25-11-14-1-4-16(23)5-2-14/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 19n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120925
PNG
(US8716287, 58)
Show SMILES COc1cc(CNCc2cccc(F)c2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H19FN6O2/c1-30-19-8-15(11-24-10-14-3-2-4-16(22)7-14)5-6-18(19)27-21(29)28-20-13-25-17(9-23)12-26-20/h2-8,12-13,24H,10-11H2,1H3,(H2,26,27,28,29)
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n/an/a 21n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120885
PNG
(US8716287, 18)
Show SMILES C[C@H](NCCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H20ClFN6O/c1-14(15-2-5-17(24)6-3-15)26-9-8-16-4-7-18(10-20(16)23)29-22(31)30-21-13-27-19(11-25)12-28-21/h2-7,10,12-14,26H,8-9H2,1H3,(H2,28,29,30,31)/t14-/m0/s1
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n/an/a 21n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120893
PNG
(US8716287, 26)
Show SMILES Fc1ccc(CNCCOc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C21H18ClFN6O2/c22-18-9-16(28-21(30)29-20-13-26-17(10-24)12-27-20)5-6-19(18)31-8-7-25-11-14-1-3-15(23)4-2-14/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 21n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120873
PNG
(US8716287, 6)
Show SMILES Fc1ccc(CNCCOc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c(F)c1
Show InChI InChI=1S/C21H17ClF2N6O2/c22-17-8-15(29-21(31)30-20-12-27-16(9-25)11-28-20)3-4-19(17)32-6-5-26-10-13-1-2-14(23)7-18(13)24/h1-4,7-8,11-12,26H,5-6,10H2,(H2,28,29,30,31)
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n/an/a 26n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120899
PNG
(US8716287, 32)
Show SMILES COc1cc(CCNCc2ccccc2)ccc1NC(=O)Nc1cnc(C)cn1
Show InChI InChI=1S/C22H25N5O2/c1-16-13-25-21(15-24-16)27-22(28)26-19-9-8-17(12-20(19)29-2)10-11-23-14-18-6-4-3-5-7-18/h3-9,12-13,15,23H,10-11,14H2,1-2H3,(H2,25,26,27,28)
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n/an/a 27n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120894
PNG
(US8716287, 27)
Show SMILES COc1cc(CCNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C)cn1
Show InChI InChI=1S/C22H24FN5O2/c1-15-12-26-21(14-25-15)28-22(29)27-19-8-5-16(11-20(19)30-2)9-10-24-13-17-3-6-18(23)7-4-17/h3-8,11-12,14,24H,9-10,13H2,1-2H3,(H2,26,27,28,29)
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n/an/a 33n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120880
PNG
(US8716287, 13)
Show SMILES Clc1cccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c1
Show InChI InChI=1S/C21H18Cl2N6O/c22-16-3-1-2-14(8-16)11-25-7-6-15-4-5-17(9-19(15)23)28-21(30)29-20-13-26-18(10-24)12-27-20/h1-5,8-9,12-13,25H,6-7,11H2,(H2,27,28,29,30)
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n/an/a 37n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120872
PNG
(US8716287, 5)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c(F)c1
Show InChI InChI=1S/C21H17ClF2N6O/c22-18-8-16(29-21(31)30-20-12-27-17(9-25)11-28-20)4-2-13(18)5-6-26-10-14-1-3-15(23)7-19(14)24/h1-4,7-8,11-12,26H,5-6,10H2,(H2,28,29,30,31)
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n/an/a 38n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120869
PNG
(US8716287, 2)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2)cc1
Show InChI InChI=1S/C21H19FN6O/c22-17-5-1-16(2-6-17)12-24-10-9-15-3-7-18(8-4-15)27-21(29)28-20-14-25-19(11-23)13-26-20/h1-8,13-14,24H,9-10,12H2,(H2,26,27,28,29)
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n/an/a 44n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120895
PNG
(US8716287, 28)
Show SMILES Fc1ccc(CCNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)c(F)c1
Show InChI InChI=1S/C22H19ClF2N6O/c23-19-10-17(30-22(32)31-21-13-28-18(11-26)12-29-21)4-2-14(19)5-7-27-8-6-15-1-3-16(24)9-20(15)25/h1-4,9-10,12-13,27H,5-8H2,(H2,29,30,31,32)
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n/an/a 47n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120877
PNG
(US8716287, 10)
Show SMILES Clc1ccccc1CNCCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C21H18Cl2N6O/c22-18-4-2-1-3-15(18)11-25-8-7-14-5-6-16(9-19(14)23)28-21(30)29-20-13-26-17(10-24)12-27-20/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 62n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120881
PNG
(US8716287, 14)
Show SMILES FC(F)(F)Oc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C22H18ClF3N6O2/c23-19-9-16(31-21(33)32-20-13-29-17(10-27)12-30-20)4-3-15(19)7-8-28-11-14-1-5-18(6-2-14)34-22(24,25)26/h1-6,9,12-13,28H,7-8,11H2,(H2,30,31,32,33)
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n/an/a 68n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120901
PNG
(US8716287, 34)
Show SMILES Fc1ccc(CNCCc2cccc(NC(=O)Nc3cnc(cn3)C#N)c2)cc1
Show InChI InChI=1S/C21H19FN6O/c22-17-6-4-16(5-7-17)12-24-9-8-15-2-1-3-18(10-15)27-21(29)28-20-14-25-19(11-23)13-26-20/h1-7,10,13-14,24H,8-9,12H2,(H2,26,27,28,29)
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n/an/a 69n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120884
PNG
(US8716287, 17)
Show SMILES FC(F)(F)c1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2Cl)cc1
Show InChI InChI=1S/C22H18ClF3N6O/c23-19-9-17(31-21(33)32-20-13-29-18(10-27)12-30-20)6-3-15(19)7-8-28-11-14-1-4-16(5-2-14)22(24,25)26/h1-6,9,12-13,28H,7-8,11H2,(H2,30,31,32,33)
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n/an/a 78n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120889
PNG
(US8716287, 22)
Show SMILES COc1cc(CNCc2ccccc2)ccc1NC(=O)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H20N6O2/c1-29-19-9-16(12-23-11-15-5-3-2-4-6-15)7-8-18(19)26-21(28)27-20-14-24-17(10-22)13-25-20/h2-9,13-14,23H,11-12H2,1H3,(H2,25,26,27,28)
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n/an/a 99n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120878
PNG
(US8716287, 11)
Show SMILES CN(CCc1ccc(NC(=O)Nc2cnc(cn2)C#N)cc1Cl)Cc1ccc(F)cc1
Show InChI InChI=1S/C22H20ClFN6O/c1-30(14-15-2-5-17(24)6-3-15)9-8-16-4-7-18(10-20(16)23)28-22(31)29-21-13-26-19(11-25)12-27-21/h2-7,10,12-13H,8-9,14H2,1H3,(H2,27,28,29,31)
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n/an/a 146n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120870
PNG
(US8716287, 3)
Show SMILES Fc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(cn3)C#N)cc2)c(F)c1
Show InChI InChI=1S/C21H18F2N6O/c22-16-4-3-15(19(23)9-16)11-25-8-7-14-1-5-17(6-2-14)28-21(30)29-20-13-26-18(10-24)12-27-20/h1-6,9,12-13,25H,7-8,11H2,(H2,27,28,29,30)
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n/an/a 179n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120868
PNG
(US8716287, 1)
Show SMILES O=C(Nc1ccc(CCNCc2ccccc2)cc1)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C21H20N6O/c22-12-19-14-25-20(15-24-19)27-21(28)26-18-8-6-16(7-9-18)10-11-23-13-17-4-2-1-3-5-17/h1-9,14-15,23H,10-11,13H2,(H2,25,26,27,28)
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n/an/a 200n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM120896
PNG
(US8716287, 29)
Show SMILES O=C(Nc1ccc(CNCc2ccccc2)cc1)Nc1cnc(cn1)C#N
Show InChI InChI=1S/C20H18N6O/c21-10-18-13-24-19(14-23-18)26-20(27)25-17-8-6-16(7-9-17)12-22-11-15-4-2-1-3-5-15/h1-9,13-14,22H,11-12H2,(H2,24,25,26,27)
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n/an/a 320n/an/an/an/a7.5n/a



Sentinel Oncology Limited

US Patent


Assay Description
The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...

US Patent US8716287 (2014)


BindingDB Entry DOI: 10.7270/Q2TD9W0C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%