BDBM120911 US8716287, 44

SMILES: COc1cc(CCN[C@@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N

InChI Key: InChIKey=QHAYBUJGFXDSLH-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM120911 (US8716287, 44) Show SMILES COc1cc(CCN[C@@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(cn1)C#N |r| Show InChI InChI=1S/C23H23FN6O2/c1-15(17-4-6-18(24)7-5-17)26-10-9-16-3-8-20(21(11-16)32-2)29-23(31)30-22-14-27-19(12-25)13-28-22/h3-8,11,13-15,26H,9-10H2,1-2H3,(H2,28,29,30,31)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.5	n/a
Sentinel Oncology Limited US Patent					Assay Description The compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set out below. Reaction Buffer: Base R...				US Patent US8716287 (2014) BindingDB Entry DOI: 10.7270/Q2TD9W0C
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