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Patent code US8586571

Compile Data Set for Download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106687
PNG
(US8586571, 50)
Show SMILES CC(C)(C)c1ccccc1OC1CCN(CC1)C(=O)c1ccccn1
Show InChI InChI=1S/C21H26N2O2/c1-21(2,3)17-8-4-5-10-19(17)25-16-11-14-23(15-12-16)20(24)18-9-6-7-13-22-18/h4-10,13,16H,11-12,14-15H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106685
PNG
(US8586571, 17)
Show SMILES CC(C)(C)c1ccccc1SC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)15-8-4-5-10-17(15)23-14-12-21(13-14)18(22)16-9-6-7-11-20-16/h4-11,14H,12-13H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106694
PNG
(US8586571, 207)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OCC1CN(C1)C(=O)C(O)=O
Show InChI InChI=1S/C16H20ClNO4/c1-16(2,3)12-6-11(17)4-5-13(12)22-9-10-7-18(8-10)14(19)15(20)21/h4-6,10H,7-9H2,1-3H3,(H,20,21)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106691
PNG
(US8586571, 164)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106688
PNG
(US8586571, 80)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-8-11(18)4-5-14(13)23-12-9-19(10-12)15(20)6-7-16(21)22/h4-5,8,12H,6-7,9-10H2,1-3H3,(H,21,22)
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106681
PNG
(US8586571, 6)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21FN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106690
PNG
(US8586571, 143)
Show SMILES CC(C)(C)c1cc(F)ccc1OCC1CN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-6-12(18)4-5-14(13)23-10-11-8-19(9-11)15(20)7-16(21)22/h4-6,11H,7-10H2,1-3H3,(H,21,22)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106684
PNG
(US8586571, 14)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)C1(CC1)C(O)=O
Show InChI InChI=1S/C18H23NO4/c1-17(2,3)13-6-4-5-7-14(13)23-12-10-19(11-12)15(20)18(8-9-18)16(21)22/h4-7,12H,8-11H2,1-3H3,(H,21,22)
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106695
PNG
(US8586571, 215)
Show SMILES CC(C)(C)c1cc(F)ccc1OCC1CCN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C18H24FNO4/c1-18(2,3)14-8-13(19)4-5-15(14)24-11-12-6-7-20(10-12)16(21)9-17(22)23/h4-5,8,12H,6-7,9-11H2,1-3H3,(H,22,23)
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106682
PNG
(US8586571, 36)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C16H21NO4/c1-16(2,3)12-6-4-5-7-13(12)21-11-9-17(10-11)14(18)8-15(19)20/h4-7,11H,8-10H2,1-3H3,(H,19,20)
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n/an/a 36n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106693
PNG
(US8586571, 197)
Show SMILES CC(C)(C)c1ccccc1OCC1CCN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C18H25NO4/c1-18(2,3)14-6-4-5-7-15(14)23-12-13-8-9-19(11-13)16(20)10-17(21)22/h4-7,13H,8-12H2,1-3H3,(H,21,22)
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n/an/a 40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106692
PNG
(US8586571, 189)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H22ClNO4/c1-17(2,3)13-8-11(18)4-5-14(13)23-12-9-19(10-12)15(20)6-7-16(21)22/h4-5,8,12H,6-7,9-10H2,1-3H3,(H,21,22)
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n/an/a 71n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106683
PNG
(US8586571, 12)
Show SMILES CC(C)(C)c1ccccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H23NO4/c1-17(2,3)13-6-4-5-7-14(13)22-12-10-18(11-12)15(19)8-9-16(20)21/h4-7,12H,8-11H2,1-3H3,(H,20,21)
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n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106686
PNG
(US8586571, 20)
Show SMILES CC(C)(C)c1ccccc1S(=O)(=O)C1CN(C1)C(=O)c1ccccc1
Show InChI InChI=1S/C20H23NO3S/c1-20(2,3)17-11-7-8-12-18(17)25(23,24)16-13-21(14-16)19(22)15-9-5-4-6-10-15/h4-12,16H,13-14H2,1-3H3
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n/an/a 290n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
Retinol-binding protein 4


(Homo sapiens (Human))		BDBM106689
PNG
(US8586571, 121)
Show SMILES CCCCCS(=O)(=O)NC(=O)C(=O)N1CCC(COc2ccccc2C(C)(C)C)CC1
Show InChI InChI=1S/C23H36N2O5S/c1-5-6-9-16-31(28,29)24-21(26)22(27)25-14-12-18(13-15-25)17-30-20-11-8-7-10-19(20)23(2,3)4/h7-8,10-11,18H,5-6,9,12-17H2,1-4H3,(H,24,26)
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n/an/a 790n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...

US Patent US8586571 (2013)


BindingDB Entry DOI: 10.7270/Q26W98QK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%