Affinity Data by Patent

Patent code US8580782

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50223567 (3-bromo-5-(2-chlorophenyl)-N-(pyridin-3-ylmethyl)p...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105239 (US8580782, 7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105239 (US8580782, 7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105236 (US8580782, 4) Show SMILES Fc1ccccc1-c1cc(NCc2cccnc2)n2ncc(Br)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105234 (US8580782, 1) Show SMILES Brc1cnn2c(NCc3ccncc3)cc(nc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105237 (US8575203, I-4 \| US8580782, 5) Show SMILES Fc1ccccc1-c1cc(NCc2cccnc2)n2ncc(Cl)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105235 (US8580782, 3) Show SMILES Fc1ccccc1-c1cc(NCc2ccncc2)n2ncc(Br)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105238 (US8575203, I-5 \| US8580782, 6) Show SMILES Fc1ccccc1-c1cc(NCc2ccncc2)n2ncc(Cl)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105234 (US8580782, 1) Show SMILES Brc1cnn2c(NCc3ccncc3)cc(nc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105235 (US8580782, 3) Show SMILES Fc1ccccc1-c1cc(NCc2ccncc2)n2ncc(Br)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105240 (US8580782, 10) Show SMILES CC(C)c1cc(NCc2ccncc2)n2ncc(Br)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105238 (US8575203, I-5 \| US8580782, 6) Show SMILES Fc1ccccc1-c1cc(NCc2ccncc2)n2ncc(Cl)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105244 (US8580782, 18) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105241 (US8580782, 12) Show SMILES CC(C)(C)c1cc(NCc2ccncc2)n2ncc(Br)c2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105242 (US8580782, 16) Show SMILES N#Cc1cnn2c(NCc3ccncc3)cc(nc12)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	620	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM105243 (US8580782, 17) Show SMILES CN1CCN(CC1)c1cc(NCc2cccnc2)n2nccc2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	8.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).				US Patent US8580782 (2013) BindingDB Entry DOI: 10.7270/Q2VM49WG
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%