| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM105240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| pH | 8±0 |
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| IC50 | 42±n/a nM |
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| Citation |  Guzi, TJ; Paruch, K; Dwyer, MP; Labroli, MA; Keertikar, KM Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors US Patent US8580782 Publication Date 11/12/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM105240 |
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| n/a |
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| Name | BDBM105240 |
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| Synonyms: | US8580782, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16BrN5 |
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| Mol. Mass. | 346.225 |
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| SMILES | CC(C)c1cc(NCc2ccncc2)n2ncc(Br)c2n1 |
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| Structure | 
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