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Patent code US9403846

Compile Data Set for Download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))		BDBM239006
PNG
(US9403846, 20)
Show SMILES C[C@@H]1C[C@H]1[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:11|
Show InChI InChI=1S/C17H20F2N2OS/c1-9-4-12(9)15-5-10-7-23-16(20)21-17(10,8-22-15)13-3-2-11(18)6-14(13)19/h2-3,6,9-10,12,15H,4-5,7-8H2,1H3,(H2,20,21)/t9-,10+,12-,15-,17+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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antibodypedia
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PC sid
UniChem
US Patent
n/an/a 116n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239005
PNG
(US9403846, 19)
Show SMILES CC1(C)CCC(O1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14|
Show InChI InChI=1S/C19H24F2N2O2S/c1-18(2)6-5-15(25-18)16-7-11-9-26-17(22)23-19(11,10-24-16)13-4-3-12(20)8-14(13)21/h3-4,8,11,15-16H,5-7,9-10H2,1-2H3,(H2,22,23)/t11-,15?,16+,19-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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antibodypedia
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PC sid
UniChem
US Patent
n/an/a 184n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238993
PNG
(US9403846, 8)
Show SMILES NC1=N[C@]2(CO[C@@H](CC3CC3)C[C@H]2CS1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H20F2N2OS/c18-12-3-4-14(15(19)7-12)17-9-22-13(5-10-1-2-10)6-11(17)8-23-16(20)21-17/h3-4,7,10-11,13H,1-2,5-6,8-9H2,(H2,20,21)/t11-,13-,17-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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PC sid
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US Patent
n/an/a 235n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238984
PNG
(US9403846, 2)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C16H18F2N2OS/c17-11-3-4-12(13(18)6-11)16-8-21-14(9-1-2-9)5-10(16)7-22-15(19)20-16/h3-4,6,9-10,14H,1-2,5,7-8H2,(H2,19,20)/t10-,14+,16-/m0/s1
PDB
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n/an/a 281n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239007
PNG
(US9403846, 21)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)[C@@H]1CCCO1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H20F2N2O2S/c18-11-3-4-12(13(19)7-11)17-9-23-15(14-2-1-5-22-14)6-10(17)8-24-16(20)21-17/h3-4,7,10,14-15H,1-2,5-6,8-9H2,(H2,20,21)/t10-,14-,15+,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC sid
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n/an/a 302n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238986
PNG
(US9403846, 3)
Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)C1CC1)c1ccc(F)cc1F |c:4|
Show InChI InChI=1S/C17H20F2N2OS/c1-9-13-7-15(10-2-3-10)22-8-17(13,21-16(20)23-9)12-5-4-11(18)6-14(12)19/h4-6,9-10,13,15H,2-3,7-8H2,1H3,(H2,20,21)/t9-,13+,15-,17-/m1/s1
PDB
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n/an/a 337n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238989
PNG
(US9403846, 6)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2[C@@H](CF)S1)C1CC1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H19F3N2OS/c18-7-15-12-6-14(9-1-2-9)23-8-17(12,22-16(21)24-15)11-4-3-10(19)5-13(11)20/h3-5,9,12,14-15H,1-2,6-8H2,(H2,21,22)/t12-,14+,15+,17+/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 346n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238998
PNG
(US9403846, 12)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1c(F)cccc1F |t:1|
Show InChI InChI=1S/C16H18F2N2OS/c17-11-2-1-3-12(18)14(11)16-8-21-13(9-4-5-9)6-10(16)7-22-15(19)20-16/h1-3,9-10,13H,4-8H2,(H2,19,20)/t10-,13+,16-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 395n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238999
PNG
(US9403846, 13)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccccc1F |t:1|
Show InChI InChI=1S/C16H19FN2OS/c17-13-4-2-1-3-12(13)16-9-20-14(10-5-6-10)7-11(16)8-21-15(18)19-16/h1-4,10-11,14H,5-9H2,(H2,18,19)/t11-,14+,16-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 422n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238983
PNG
(US9403846, 1)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CCCO1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H20F2N2O2S/c18-11-3-4-12(13(19)7-11)17-9-23-15(14-2-1-5-22-14)6-10(17)8-24-16(20)21-17/h3-4,7,10,14-15H,1-2,5-6,8-9H2,(H2,20,21)/t10-,14?,15+,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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PC sid
UniChem
US Patent
n/an/a 447n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238991
PNG
(US9403846, 7)
Show SMILES CC1(CC1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:11|
Show InChI InChI=1S/C17H20F2N2OS/c1-16(4-5-16)14-6-10-8-23-15(20)21-17(10,9-22-14)12-3-2-11(18)7-13(12)19/h2-3,7,10,14H,4-6,8-9H2,1H3,(H2,20,21)/t10-,14+,17-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 484n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238996
PNG
(US9403846, 10)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccc(F)cc1 |t:1|
Show InChI InChI=1S/C16H19FN2OS/c17-13-5-3-11(4-6-13)16-9-20-14(10-1-2-10)7-12(16)8-21-15(18)19-16/h3-6,10,12,14H,1-2,7-9H2,(H2,18,19)/t12-,14+,16+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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n/an/a 572n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239001
PNG
(US9403846, 15)
Show SMILES Cc1ccc(c(F)c1)[C@]12CO[C@H](C[C@H]1CSC(N)=N2)C1CC1 |c:19|
Show InChI InChI=1S/C17H21FN2OS/c1-10-2-5-13(14(18)6-10)17-9-21-15(11-3-4-11)7-12(17)8-22-16(19)20-17/h2,5-6,11-12,15H,3-4,7-9H2,1H3,(H2,19,20)/t12-,15+,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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PC sid
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n/an/a 715n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239002
PNG
(US9403846, 16)
Show SMILES Cc1ccc(cc1F)[C@]12CO[C@H](C[C@H]1CSC(N)=N2)C1CC1 |c:19|
Show InChI InChI=1S/C17H21FN2OS/c1-10-2-5-12(6-14(10)18)17-9-21-15(11-3-4-11)7-13(17)8-22-16(19)20-17/h2,5-6,11,13,15H,3-4,7-9H2,1H3,(H2,19,20)/t13-,15+,17+/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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n/an/a 897n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238995
PNG
(US9403846, 9)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1c(F)cc(F)cc1F |t:1|
Show InChI InChI=1S/C16H17F3N2OS/c17-10-4-11(18)14(12(19)5-10)16-7-22-13(8-1-2-8)3-9(16)6-23-15(20)21-16/h4-5,8-9,13H,1-3,6-7H2,(H2,20,21)/t9-,13+,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC sid
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US Patent
n/an/a 1.05E+3n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239000
PNG
(US9403846, 14)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccccc1 |t:1|
Show InChI InChI=1S/C16H20N2OS/c17-15-18-16(12-4-2-1-3-5-12)10-19-14(11-6-7-11)8-13(16)9-20-15/h1-5,11,13-14H,6-10H2,(H2,17,18)/t13-,14+,16+/m0/s1
PDB
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UniProtKB/SwissProt

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n/an/a 1.28E+3n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 2 [21-466]


(Homo sapiens (Human))		BDBM238983
PNG
(US9403846, 1)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CCCO1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H20F2N2O2S/c18-11-3-4-12(13(19)7-11)17-9-23-15(14-2-1-5-22-14)6-10(17)8-24-16(20)21-17/h3-4,7,10,14-15H,1-2,5-6,8-9H2,(H2,20,21)/t10-,14?,15+,17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a 1.29E+3n/an/an/an/a4.537



Pfizer Inc.

US Patent


Assay Description
A synthetic substrate that can be cleaved by BACE2 having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Green at the Cy...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238987
PNG
(US9403846, 4)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CCO1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C16H18F2N2O2S/c17-10-1-2-11(12(18)6-10)16-8-22-14(13-3-4-21-13)5-9(16)7-23-15(19)20-16/h1-2,6,9,13-14H,3-5,7-8H2,(H2,19,20)/t9-,13?,14+,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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n/an/a 1.31E+3n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238988
PNG
(US9403846, 5)
Show SMILES COC[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)C1CC1)c1ccc(F)cc1F |c:6|
Show InChI InChI=1S/C18H22F2N2O2S/c1-23-8-16-13-7-15(10-2-3-10)24-9-18(13,22-17(21)25-16)12-5-4-11(19)6-14(12)20/h4-6,10,13,15-16H,2-3,7-9H2,1H3,(H2,21,22)/t13-,15+,16+,18+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.41E+3n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238997
PNG
(US9403846, 11)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1cc(F)ccc1F |t:1|
Show InChI InChI=1S/C16H18F2N2OS/c17-11-3-4-13(18)12(6-11)16-8-21-14(9-1-2-9)5-10(16)7-22-15(19)20-16/h3-4,6,9-10,14H,1-2,5,7-8H2,(H2,19,20)/t10-,14+,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.42E+3n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 2 [21-466]


(Homo sapiens (Human))		BDBM238984
PNG
(US9403846, 2)
Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C16H18F2N2OS/c17-11-3-4-12(13(18)6-11)16-8-21-14(9-1-2-9)5-10(16)7-22-15(19)20-16/h3-4,6,9-10,14H,1-2,5,7-8H2,(H2,19,20)/t10-,14+,16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.26E+3n/an/an/an/a4.537



Pfizer Inc.

US Patent


Assay Description
A synthetic substrate that can be cleaved by BACE2 having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Green at the Cy...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 2 [21-466]


(Homo sapiens (Human))		BDBM238986
PNG
(US9403846, 3)
Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)C1CC1)c1ccc(F)cc1F |c:4|
Show InChI InChI=1S/C17H20F2N2OS/c1-9-13-7-15(10-2-3-10)22-8-17(13,21-16(20)23-9)12-5-4-11(18)6-14(12)19/h4-6,9-10,13,15H,2-3,7-8H2,1H3,(H2,20,21)/t9-,13+,15-,17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.49E+3n/an/an/an/a4.537



Pfizer Inc.

US Patent


Assay Description
A synthetic substrate that can be cleaved by BACE2 having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Green at the Cy...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239004
PNG
(US9403846, 18)
Show SMILES NC1=N[C@@]2(CO[C@@H](C[C@@H]2CS1)C1CC1)c1ccc(F)cc1 |t:1|
Show InChI InChI=1S/C16H19FN2OS/c17-13-5-3-11(4-6-13)16-9-20-14(10-1-2-10)7-12(16)8-21-15(18)19-16/h3-6,10,12,14H,1-2,7-9H2,(H2,18,19)/t12-,14+,16+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.56E+4n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM239003
PNG
(US9403846, 17)
Show SMILES NC1=N[C@@]2(CO[C@@H](C[C@@H]2CS1)C1CC1)c1ccccc1F |t:1|
Show InChI InChI=1S/C16H19FN2OS/c17-13-4-2-1-3-12(13)16-9-20-14(10-5-6-10)7-11(16)8-21-15(18)19-16/h1-4,10-11,14H,5-9H2,(H2,18,19)/t11-,14+,16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.57E+4n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238985
PNG
(US9403846, C23)
Show SMILES NC1=N[C@@]2(CO[C@@H](C[C@@H]2CS1)C1CC1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C16H18F2N2OS/c17-11-3-4-12(13(18)6-11)16-8-21-14(9-1-2-9)5-10(16)7-22-15(19)20-16/h3-4,6,9-10,14H,1-2,5,7-8H2,(H2,19,20)/t10-,14+,16-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238990
PNG
(US9403846, C48)
Show SMILES NC1=N[C@@]2(CO[C@@H](C[C@@H]2[C@H](CF)S1)C1CC1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H19F3N2OS/c18-7-15-12-6-14(9-1-2-9)23-8-17(12,22-16(21)24-15)11-4-3-10(19)5-13(11)20/h3-5,9,12,14-15H,1-2,6-8H2,(H2,21,22)/t12-,14+,15+,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238992
PNG
(US9403846, C61)
Show SMILES CC1(CC1)[C@@H]1C[C@@H]2CSC(N)=N[C@@]2(CO1)c1ccc(F)cc1F |c:11|
Show InChI InChI=1S/C17H20F2N2OS/c1-16(4-5-16)14-6-10-8-23-15(20)21-17(10,9-22-14)12-3-2-11(18)7-13(12)19/h2-3,7,10,14H,4-6,8-9H2,1H3,(H2,20,21)/t10-,14+,17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70E+7n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))		BDBM238994
PNG
(US9403846, C74)
Show SMILES NC1=N[C@@]2(CO[C@H](CC3CC3)C[C@@H]2CS1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C17H20F2N2OS/c18-12-3-4-14(15(19)7-12)17-9-22-13(5-10-1-2-10)6-11(17)8-23-16(20)21-17/h3-4,7,10-11,13H,1-2,5-6,8-9H2,(H2,20,21)/t11-,13-,17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>8.60E+7n/an/an/an/a4.5n/a



Pfizer Inc.

US Patent


Assay Description
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...

US Patent US9403846 (2016)


BindingDB Entry DOI: 10.7270/Q2JW8CTW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%