Affinity Data by Patent

Patent code US9216984

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
Incyte Corporation; Incyte Holdings Corporation US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%