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Patent code US9278968

Compile Data Set for Download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213241
PNG
(US9278968, 1)
Show SMILES CCc1nnc(o1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H23F2N5O4/c1-4-18-28-29-22(34-18)23(3,12-31)27-21(32)19-13(2)26-20-17(9-6-10-30(19)20)33-11-14-15(24)7-5-8-16(14)25/h5-10,31H,4,11-12H2,1-3H3,(H,27,32)
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US Patent
n/an/an/an/a 5.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213262
PNG
(US9278968, 21)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1nc(CO)cs1 |r|
Show InChI InChI=1S/C23H22F2N4O4S/c1-13-19(21(32)28-23(2,12-31)22-27-14(9-30)11-34-22)29-8-4-7-18(20(29)26-13)33-10-15-16(24)5-3-6-17(15)25/h3-8,11,30-31H,9-10,12H2,1-2H3,(H,28,32)/t23-/m0/s1
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US Patent
n/an/an/an/a 4.00E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213265
PNG
(US9278968, 24)
Show SMILES Cc1ncc(s1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H20F2N4O3S/c1-12-20(22(30)27-17(10-29)19-9-25-13(2)32-19)28-8-4-7-18(21(28)26-12)31-11-14-15(23)5-3-6-16(14)24/h3-9,17,29H,10-11H2,1-2H3,(H,27,30)/t17-/m0/s1
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US Patent
n/an/an/an/a 3.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213273
PNG
(US9278968, 32)
Show SMILES C[C@H](O)[C@H](O)c1ccccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-15-23(26(34)29-13-17-7-3-4-8-18(17)24(33)16(2)32)31-12-6-11-22(25(31)30-15)35-14-19-20(27)9-5-10-21(19)28/h3-12,16,24,32-33H,13-14H2,1-2H3,(H,29,34)/t16-,24-/m0/s1
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US Patent
n/an/an/an/a 8.20E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213281
PNG
(US9278968, 40)
Show SMILES Cc1csc(n1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O3S/c1-13-11-33-22(26-13)23(3,12-30)28-21(31)19-14(2)27-20-18(8-5-9-29(19)20)32-10-15-16(24)6-4-7-17(15)25/h4-9,11,30H,10,12H2,1-3H3,(H,28,31)
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n/an/an/an/a 3.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213294
PNG
(US9278968, 53)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1cccc(CO)c1
Show InChI InChI=1S/C26H25F2N3O5/c1-16-23(25(35)30-26(14-33,15-34)18-6-2-5-17(11-18)12-32)31-10-4-9-22(24(31)29-16)36-13-19-20(27)7-3-8-21(19)28/h2-11,32-34H,12-15H2,1H3,(H,30,35)
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US Patent
n/an/an/an/a 1.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213296
PNG
(US9278968, 55)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1cccc(F)c1
Show InChI InChI=1S/C25H22F3N3O4/c1-15-22(24(34)30-25(13-32,14-33)16-5-2-6-17(26)11-16)31-10-4-9-21(23(31)29-15)35-12-18-19(27)7-3-8-20(18)28/h2-11,32-33H,12-14H2,1H3,(H,30,34)
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US Patent
n/an/an/an/a 2.00E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213297
PNG
(US9278968, 56)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccc(C)cn1
Show InChI InChI=1S/C25H24F2N4O4/c1-15-8-9-21(28-11-15)25(13-32,14-33)30-24(34)22-16(2)29-23-20(7-4-10-31(22)23)35-12-17-18(26)5-3-6-19(17)27/h3-11,32-33H,12-14H2,1-2H3,(H,30,34)
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US Patent
n/an/an/an/a 8.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213313
PNG
(US9278968, 70)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccc(Cl)cn1
Show InChI InChI=1S/C24H21ClF2N4O4/c1-14-21(23(34)30-24(12-32,13-33)20-8-7-15(25)10-28-20)31-9-3-6-19(22(31)29-14)35-11-16-17(26)4-2-5-18(16)27/h2-10,32-33H,11-13H2,1H3,(H,30,34)
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US Patent
n/an/an/an/a 3.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213316
PNG
(US9278968, 73a)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(C)(CO)c1nnn(C)n1
Show InChI InChI=1S/C21H29N7O3/c1-14-17(19(30)23-21(2,13-29)20-24-26-27(3)25-20)28-11-7-10-16(18(28)22-14)31-12-15-8-5-4-6-9-15/h7,10-11,15,29H,4-6,8-9,12-13H2,1-3H3,(H,23,30)
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US Patent
n/an/an/an/a 6.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213332
PNG
(US9278968, 88)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(C)(CO)c1nnc(o1)C1CC1
Show InChI InChI=1S/C24H31N5O4/c1-15-19(21(31)26-24(2,14-30)23-28-27-22(33-23)17-10-11-17)29-12-6-9-18(20(29)25-15)32-13-16-7-4-3-5-8-16/h6,9,12,16-17,30H,3-5,7-8,10-11,13-14H2,1-2H3,(H,26,31)
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US Patent
n/an/an/an/a 5.30E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213335
PNG
(US9278968, 91)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H18F5N5O4/c1-11-16(18(34)29-21(2,10-33)19-30-31-20(36-19)22(25,26)27)32-8-4-7-15(17(32)28-11)35-9-12-13(23)5-3-6-14(12)24/h3-8,33H,9-10H2,1-2H3,(H,29,34)
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US Patent
n/an/an/an/a 1.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213343
PNG
(US9278968, 99)
Show SMILES CCc1nnc(o1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C23H31N5O5/c1-3-18-26-27-22(33-18)23(13-29,14-30)25-21(31)19-15(2)24-20-17(10-7-11-28(19)20)32-12-16-8-5-4-6-9-16/h7,10-11,16,29-30H,3-6,8-9,12-14H2,1-2H3,(H,25,31)
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US Patent
n/an/an/an/a 1.70E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213345
PNG
(US9278968, 101)
Show SMILES CCn1cc(cn1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C24H25F2N5O4/c1-3-30-11-16(10-27-30)24(13-32,14-33)29-23(34)21-15(2)28-22-20(8-5-9-31(21)22)35-12-17-18(25)6-4-7-19(17)26/h4-11,32-33H,3,12-14H2,1-2H3,(H,29,34)
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n/an/an/an/a 2.60E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213347
PNG
(US9278968, 103)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(CC2CC2)n1
Show InChI InChI=1S/C24H25F2N7O3/c1-14-20(22(35)28-24(2,13-34)23-29-31-33(30-23)11-15-8-9-15)32-10-4-7-19(21(32)27-14)36-12-16-17(25)5-3-6-18(16)26/h3-7,10,15,34H,8-9,11-13H2,1-2H3,(H,28,35)
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n/an/an/an/a 6.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213348
PNG
(US9278968, 104)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(C)(CO)c1nnn(CCO)n1
Show InChI InChI=1S/C22H31N7O4/c1-15-18(20(32)24-22(2,14-31)21-25-27-29(26-21)11-12-30)28-10-6-9-17(19(28)23-15)33-13-16-7-4-3-5-8-16/h6,9-10,16,30-31H,3-5,7-8,11-14H2,1-2H3,(H,24,32)
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n/an/an/an/a 7.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213353
PNG
(US9278968, 108a)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1nnn(C)n1 |r|
Show InChI InChI=1S/C21H21F2N7O3/c1-12-17(19(32)25-21(2,11-31)20-26-28-29(3)27-20)30-9-5-8-16(18(30)24-12)33-10-13-14(22)6-4-7-15(13)23/h4-9,31H,10-11H2,1-3H3,(H,25,32)/t21-/m0/s1
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US Patent
n/an/an/an/a 4.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213249
PNG
(US9278968, 8)
Show SMILES CCn1nnc(n1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C22H23F2N7O3/c1-4-31-28-21(27-29-31)22(3,12-32)26-20(33)18-13(2)25-19-17(9-6-10-30(18)19)34-11-14-15(23)7-5-8-16(14)24/h5-10,32H,4,11-12H2,1-3H3,(H,26,33)
PDB
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UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a 5.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213270
PNG
(US9278968, 29)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CO)c1nnnn1C |r|
Show InChI InChI=1S/C20H27N7O3/c1-13-17(20(29)22-15(11-28)18-23-24-25-26(18)2)27-10-6-9-16(19(27)21-13)30-12-14-7-4-3-5-8-14/h6,9-10,14-15,28H,3-5,7-8,11-12H2,1-2H3,(H,22,29)/t15-/m0/s1
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n/an/an/an/a 1.70E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213275
PNG
(US9278968, 34)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CO)c1nnn(C)n1 |r|
Show InChI InChI=1S/C20H27N7O3/c1-13-17(20(29)22-15(11-28)18-23-25-26(2)24-18)27-10-6-9-16(19(27)21-13)30-12-14-7-4-3-5-8-14/h6,9-10,14-15,28H,3-5,7-8,11-12H2,1-2H3,(H,22,29)/t15-/m0/s1
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n/an/an/an/a 1.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213280
PNG
(US9278968, 39)
Show SMILES Cc1noc(n1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C22H21F2N5O4/c1-12-18(20(31)27-22(3,11-30)21-26-13(2)28-33-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,27,31)
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n/an/an/an/a 4.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213286
PNG
(US9278968, 45)
Show SMILES CCc1nnc(o1)[C@H](CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12 |r|
Show InChI InChI=1S/C22H29N5O4/c1-3-18-25-26-22(31-18)16(12-28)24-21(29)19-14(2)23-20-17(10-7-11-27(19)20)30-13-15-8-5-4-6-9-15/h7,10-11,15-16,28H,3-6,8-9,12-13H2,1-2H3,(H,24,29)/t16-/m0/s1
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n/an/an/an/a 9.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213288
PNG
(US9278968, 47)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CO)c1nnc(o1)C1CC1 |r|
Show InChI InChI=1S/C23H29N5O4/c1-14-19(21(30)25-17(12-29)23-27-26-22(32-23)16-9-10-16)28-11-5-8-18(20(28)24-14)31-13-15-6-3-2-4-7-15/h5,8,11,15-17,29H,2-4,6-7,9-10,12-13H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/an/an/a 1.30E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213290
PNG
(US9278968, 49)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)c1cnn(C)c1
Show InChI InChI=1S/C22H21F2N5O3/c1-13-20(22(31)27-18(11-30)14-9-25-28(2)10-14)29-8-4-7-19(21(29)26-13)32-12-15-16(23)5-3-6-17(15)24/h3-10,18,30H,11-12H2,1-2H3,(H,27,31)
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n/an/an/an/a 2.50E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213308
PNG
(US9278968, 66)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(CO)(CO)c1nnn(C)n1
Show InChI InChI=1S/C21H29N7O4/c1-14-17(19(31)23-21(12-29,13-30)20-24-26-27(2)25-20)28-10-6-9-16(18(28)22-14)32-11-15-7-4-3-5-8-15/h6,9-10,15,29-30H,3-5,7-8,11-13H2,1-2H3,(H,23,31)
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n/an/an/an/a 1.60E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213309
PNG
(US9278968, 67)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@]1(C[C@H](O)[C@H](O)C1)c1ccccn1 |r|
Show InChI InChI=1S/C26H24F2N4O4/c1-15-23(25(35)31-26(12-19(33)20(34)13-26)22-9-2-3-10-29-22)32-11-5-8-21(24(32)30-15)36-14-16-17(27)6-4-7-18(16)28/h2-11,19-20,33-34H,12-14H2,1H3,(H,31,35)/t19-,20+,26-
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n/an/an/an/a 2.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213320
PNG
(US9278968, 76)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(n1)C1CC1
Show InChI InChI=1S/C23H23F2N7O3/c1-13-19(21(34)27-23(2,12-33)22-28-30-32(29-22)14-8-9-14)31-10-4-7-18(20(31)26-13)35-11-15-16(24)5-3-6-17(15)25/h3-7,10,14,33H,8-9,11-12H2,1-2H3,(H,27,34)
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n/an/an/an/a 5.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213349
PNG
(US9278968, 105)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(CC(C)(C)O)n1
Show InChI InChI=1S/C24H27F2N7O4/c1-14-19(21(35)28-24(4,13-34)22-29-31-33(30-22)12-23(2,3)36)32-10-6-9-18(20(32)27-14)37-11-15-16(25)7-5-8-17(15)26/h5-10,34,36H,11-13H2,1-4H3,(H,28,35)
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n/an/an/an/a 1.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213363
PNG
(US9278968, 117)
Show SMILES Cc1nnc(o1)[C@](C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H21F2N5O4/c1-12-18(20(31)26-22(3,11-30)21-28-27-13(2)33-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,26,31)/t22-/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213246
PNG
(US9278968, 6)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(n1)C(F)F
Show InChI InChI=1S/C21H19F4N7O3/c1-11-16(18(34)27-21(2,10-33)19-28-30-32(29-19)20(24)25)31-8-4-7-15(17(31)26-11)35-9-12-13(22)5-3-6-14(12)23/h3-8,20,33H,9-10H2,1-2H3,(H,27,34)
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n/an/an/an/a 1.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213255
PNG
(US9278968, 14)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1ncccn1
Show InChI InChI=1S/C23H21F2N5O3/c1-14-19(21(32)29-23(2,13-31)22-26-9-5-10-27-22)30-11-4-8-18(20(30)28-14)33-12-15-16(24)6-3-7-17(15)25/h3-11,31H,12-13H2,1-2H3,(H,29,32)
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n/an/an/an/a 4.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213259
PNG
(US9278968, 18)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ccccc1F |r|
Show InChI InChI=1S/C25H22F3N3O3/c1-15-22(24(33)30-25(2,14-32)17-7-3-4-8-20(17)28)31-12-6-11-21(23(31)29-15)34-13-16-18(26)9-5-10-19(16)27/h3-12,32H,13-14H2,1-2H3,(H,30,33)/t25-/m0/s1
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n/an/an/an/a 1.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213279
PNG
(US9278968, 38)
Show SMILES Cc1cnc(o1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O4/c1-13-10-26-22(33-13)23(3,12-30)28-21(31)19-14(2)27-20-18(8-5-9-29(19)20)32-11-15-16(24)6-4-7-17(15)25/h4-10,30H,11-12H2,1-3H3,(H,28,31)
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n/an/an/an/a 2.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213310
PNG
(US9278968, 68)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@]1(C[C@H](O)[C@H](O)C1)c1ccccn1 |r|
Show InChI InChI=1S/C26H32N4O4/c1-17-23(25(33)29-26(14-19(31)20(32)15-26)22-11-5-6-12-27-22)30-13-7-10-21(24(30)28-17)34-16-18-8-3-2-4-9-18/h5-7,10-13,18-20,31-32H,2-4,8-9,14-16H2,1H3,(H,29,33)/t19-,20+,26-
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n/an/an/an/a 1.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213322
PNG
(US9278968, 78)
Show SMILES Cc1ncc(s1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O4S/c1-13-20(22(32)28-23(11-30,12-31)19-9-26-14(2)34-19)29-8-4-7-18(21(29)27-13)33-10-15-16(24)5-3-6-17(15)25/h3-9,30-31H,10-12H2,1-2H3,(H,28,32)
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n/an/an/an/a 5.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213333
PNG
(US9278968, 89)
Show SMILES C[C@@H](O)[C@H](O)c1ncccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C25H24F2N4O4/c1-14-22(25(34)29-12-16-6-4-10-28-21(16)23(33)15(2)32)31-11-5-9-20(24(31)30-14)35-13-17-18(26)7-3-8-19(17)27/h3-11,15,23,32-33H,12-13H2,1-2H3,(H,29,34)/t15-,23+/m1/s1
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n/an/an/an/a 1.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213326
PNG
(US9278968, 82)
Show SMILES Cc1nc2c(OCc3cccc(F)c3F)cccn2c1C(=O)NC(C)(CO)c1nnn(C)n1
Show InChI InChI=1S/C21H21F2N7O3/c1-12-17(19(32)25-21(2,11-31)20-26-28-29(3)27-20)30-9-5-8-15(18(30)24-12)33-10-13-6-4-7-14(22)16(13)23/h4-9,31H,10-11H2,1-3H3,(H,25,32)
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n/an/an/an/a 2.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213245
PNG
(US9278968, 5)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NCc1ccccc1C(O)CO
Show InChI InChI=1S/C25H23F2N3O4/c1-15-23(25(33)28-12-16-6-2-3-7-17(16)21(32)13-31)30-11-5-10-22(24(30)29-15)34-14-18-19(26)8-4-9-20(18)27/h2-11,21,31-32H,12-14H2,1H3,(H,28,33)
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n/an/an/an/a 6.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213264
PNG
(US9278968, 23)
Show SMILES Cc1nc2c(OCc3ncccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ccccc1F |r|
Show InChI InChI=1S/C24H22F2N4O3/c1-15-21(23(32)29-24(2,14-31)16-7-3-4-8-17(16)25)30-12-6-10-20(22(30)28-15)33-13-19-18(26)9-5-11-27-19/h3-12,31H,13-14H2,1-2H3,(H,29,32)/t24-/m0/s1
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n/an/an/an/a 9.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213267
PNG
(US9278968, 26)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@H](CO)c1nnn(C)n1 |r|
Show InChI InChI=1S/C20H19F2N7O3/c1-11-17(20(31)24-15(9-30)18-25-27-28(2)26-18)29-8-4-7-16(19(29)23-11)32-10-12-13(21)5-3-6-14(12)22/h3-8,15,30H,9-10H2,1-2H3,(H,24,31)/t15-/m0/s1
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n/an/an/an/a 2.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213282
PNG
(US9278968, 41)
Show SMILES Cc1nc(no1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C22H21F2N5O4/c1-12-18(20(31)27-22(3,11-30)21-26-13(2)33-28-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,27,31)
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n/an/an/an/a 5.30E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213284
PNG
(US9278968, 43)
Show SMILES Cc1nnc(o1)[C@H](CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12 |r|
Show InChI InChI=1S/C21H27N5O4/c1-13-18(20(28)23-16(11-27)21-25-24-14(2)30-21)26-10-6-9-17(19(26)22-13)29-12-15-7-4-3-5-8-15/h6,9-10,15-16,27H,3-5,7-8,11-12H2,1-2H3,(H,23,28)/t16-/m0/s1
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n/an/an/an/a 1.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213298
PNG
(US9278968, 57)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccc(F)cn1
Show InChI InChI=1S/C24H21F3N4O4/c1-14-21(23(34)30-24(12-32,13-33)20-8-7-15(25)10-28-20)31-9-3-6-19(22(31)29-14)35-11-16-17(26)4-2-5-18(16)27/h2-10,32-33H,11-13H2,1H3,(H,30,34)
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n/an/an/an/a 3.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213328
PNG
(US9278968, 84)
Show SMILES Cc1nnc(o1)C(C)(CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C22H29N5O4/c1-14-18(20(29)24-22(3,13-28)21-26-25-15(2)31-21)27-11-7-10-17(19(27)23-14)30-12-16-8-5-4-6-9-16/h7,10-11,16,28H,4-6,8-9,12-13H2,1-3H3,(H,24,29)
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n/an/an/an/a 7.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213337
PNG
(US9278968, 93)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1cnn(C)c1C
Show InChI InChI=1S/C24H25F2N5O3/c1-14-21(23(33)29-24(3,13-32)17-11-27-30(4)15(17)2)31-10-6-9-20(22(31)28-14)34-12-16-18(25)7-5-8-19(16)26/h5-11,32H,12-13H2,1-4H3,(H,29,33)
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n/an/an/an/a 2.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213355
PNG
(US9278968, 109)
Show SMILES Cc1nn(C)cc1C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C24H25F2N5O4/c1-14-17(10-30(3)29-14)24(12-32,13-33)28-23(34)21-15(2)27-22-20(8-5-9-31(21)22)35-11-16-18(25)6-4-7-19(16)26/h4-10,32-33H,11-13H2,1-3H3,(H,28,34)
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n/an/an/an/a 2.30E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213357
PNG
(US9278968, 111)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)-c1nn[nH]n1 |r|
PDB
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n/an/an/an/a 560n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213360
PNG
(US9278968, 114)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1nnn(n1)C(F)F |r|
Show InChI InChI=1S/C21H19F4N7O3/c1-11-16(18(34)27-21(2,10-33)19-28-30-32(29-19)20(24)25)31-8-4-7-15(17(31)26-11)35-9-12-13(22)5-3-6-14(12)23/h3-8,20,33H,9-10H2,1-2H3,(H,27,34)/t21-/m0/s1
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n/an/an/an/a 730n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213314
PNG
(US9278968, 71)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1cnn(C)c1
Show InChI InChI=1S/C23H23F2N5O4/c1-14-20(22(33)28-23(12-31,13-32)15-9-26-29(2)10-15)30-8-4-7-19(21(30)27-14)34-11-16-17(24)5-3-6-18(16)25/h3-10,31-32H,11-13H2,1-2H3,(H,28,33)
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n/an/an/an/a 2.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213346
PNG
(US9278968, 102)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)-c1nnn(C)n1 |r|
Show InChI InChI=1S/C27H33N7O3/c1-18-23(34-14-8-13-22(25(34)28-18)37-16-19-9-5-4-6-10-19)26(36)29-27(2,17-35)21-12-7-11-20(15-21)24-30-32-33(3)31-24/h7-8,11-15,19,35H,4-6,9-10,16-17H2,1-3H3,(H,29,36)/t27-/m0/s1
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n/an/an/an/a 2.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213350
PNG
(US9278968, 106)
Show SMILES CC(O)Cn1nnc(n1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H25F2N7O4/c1-13(34)10-32-29-22(28-30-32)23(3,12-33)27-21(35)19-14(2)26-20-18(8-5-9-31(19)20)36-11-15-16(24)6-4-7-17(15)25/h4-9,13,33-34H,10-12H2,1-3H3,(H,27,35)
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n/an/an/an/a 9.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213242
PNG
(US9278968, 2)
Show SMILES Cc1ncc(s1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O3S/c1-13-20(22(31)28-23(3,12-30)19-10-26-14(2)33-19)29-9-5-8-18(21(29)27-13)32-11-15-16(24)6-4-7-17(15)25/h4-10,30H,11-12H2,1-3H3,(H,28,31)
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n/an/an/an/a 2.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213247
PNG
(US9278968, 7a)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(C)n1
Show InChI InChI=1S/C21H21F2N7O3/c1-12-17(19(32)25-21(2,11-31)20-26-28-29(3)27-20)30-9-5-8-16(18(30)24-12)33-10-13-14(22)6-4-7-15(13)23/h4-9,31H,10-11H2,1-3H3,(H,25,32)
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n/an/an/an/a 9.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213252
PNG
(US9278968, 11)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ccccn1 |r|
Show InChI InChI=1S/C24H22F2N4O3/c1-15-21(23(32)29-24(2,14-31)20-10-3-4-11-27-20)30-12-6-9-19(22(30)28-15)33-13-16-17(25)7-5-8-18(16)26/h3-12,31H,13-14H2,1-2H3,(H,29,32)/t24-/m0/s1
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n/an/an/an/a 1.30E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213254
PNG
(US9278968, 13)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)C(N)=O |r|
Show InChI InChI=1S/C26H32N4O4/c1-17-22(25(33)29-26(2,16-31)20-11-6-10-19(14-20)23(27)32)30-13-7-12-21(24(30)28-17)34-15-18-8-4-3-5-9-18/h6-7,10-14,18,31H,3-5,8-9,15-16H2,1-2H3,(H2,27,32)(H,29,33)/t26-/m0/s1
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n/an/an/an/a 840n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213257
PNG
(US9278968, 16)
Show SMILES Cc1cnc(s1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H20F2N4O3S/c1-12-9-25-22(32-12)17(10-29)27-21(30)19-13(2)26-20-18(7-4-8-28(19)20)31-11-14-15(23)5-3-6-16(14)24/h3-9,17,29H,10-11H2,1-2H3,(H,27,30)/t17-/m0/s1
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n/an/an/an/a 2.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213260
PNG
(US9278968, 19)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ncc(CO)s1 |r|
Show InChI InChI=1S/C23H22F2N4O4S/c1-13-19(21(32)28-23(2,12-31)22-26-9-14(10-30)34-22)29-8-4-7-18(20(29)27-13)33-11-15-16(24)5-3-6-17(15)25/h3-9,30-31H,10-12H2,1-2H3,(H,28,32)/t23-/m0/s1
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n/an/an/an/a 3.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213268
PNG
(US9278968, 27)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@]1(CC[C@@H](O)[C@H]1O)c1ccccc1 |r|
Show InChI InChI=1S/C27H25F2N3O4/c1-16-23(26(35)31-27(13-12-21(33)24(27)34)17-7-3-2-4-8-17)32-14-6-11-22(25(32)30-16)36-15-18-19(28)9-5-10-20(18)29/h2-11,14,21,24,33-34H,12-13,15H2,1H3,(H,31,35)/t21-,24-,27+/m1/s1
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n/an/an/an/a 1.20E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213277
PNG
(US9278968, 36)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1ccn(C)n1
Show InChI InChI=1S/C23H23F2N5O3/c1-14-20(22(32)27-23(2,13-31)19-9-11-29(3)28-19)30-10-5-8-18(21(30)26-14)33-12-15-16(24)6-4-7-17(15)25/h4-11,31H,12-13H2,1-3H3,(H,27,32)
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n/an/an/an/a 1.10E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213285
PNG
(US9278968, 44)
Show SMILES CCc1nnc(o1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H21F2N5O4/c1-3-18-27-28-22(33-18)16(10-30)26-21(31)19-12(2)25-20-17(8-5-9-29(19)20)32-11-13-14(23)6-4-7-15(13)24/h4-9,16,30H,3,10-11H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/an/an/a 1.60E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213291
PNG
(US9278968, 50)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1cnn(C)c1
Show InChI InChI=1S/C23H23F2N5O3/c1-14-20(22(32)28-23(2,13-31)15-10-26-29(3)11-15)30-9-5-8-19(21(30)27-14)33-12-16-17(24)6-4-7-18(16)25/h4-11,31H,12-13H2,1-3H3,(H,28,32)
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n/an/an/an/a 7.90E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213299
PNG
(US9278968, 58)
Show SMILES COc1ccc(cn1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C25H24F2N4O5/c1-15-22(24(34)30-25(13-32,14-33)16-8-9-21(35-2)28-11-16)31-10-4-7-20(23(31)29-15)36-12-17-18(26)5-3-6-19(17)27/h3-11,32-33H,12-14H2,1-2H3,(H,30,34)
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n/an/an/an/a 3.30E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213300
PNG
(US9278968, 59)
Show SMILES C[C@H](NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12)c1ccccc1[C@@H](O)CO |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-15(17-7-3-4-8-18(17)22(33)13-32)30-26(34)24-16(2)29-25-23(11-6-12-31(24)25)35-14-19-20(27)9-5-10-21(19)28/h3-12,15,22,32-33H,13-14H2,1-2H3,(H,30,34)/t15-,22-/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213318
PNG
(US9278968, 74)
Show SMILES COCCn1nnc(n1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H25F2N7O4/c1-14-19(21(34)27-23(2,13-33)22-28-30-32(29-22)10-11-35-3)31-9-5-8-18(20(31)26-14)36-12-15-16(24)6-4-7-17(15)25/h4-9,33H,10-13H2,1-3H3,(H,27,34)
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n/an/an/an/a 1.20E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213321
PNG
(US9278968, 77)
Show SMILES Cc1cnc(s1)[C@](C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C23H22F2N4O3S/c1-13-10-26-22(33-13)23(3,12-30)28-21(31)19-14(2)27-20-18(8-5-9-29(19)20)32-11-15-16(24)6-4-7-17(15)25/h4-10,30H,11-12H2,1-3H3,(H,28,31)/t23-/m0/s1
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n/an/an/an/a 1.30E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213331
PNG
(US9278968, 87)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnc(o1)C1CC1
Show InChI InChI=1S/C24H23F2N5O4/c1-13-19(21(33)28-24(2,12-32)23-30-29-22(35-23)14-8-9-14)31-10-4-7-18(20(31)27-13)34-11-15-16(25)5-3-6-17(15)26/h3-7,10,14,32H,8-9,11-12H2,1-2H3,(H,28,33)
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n/an/an/an/a 5.90E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213344
PNG
(US9278968, 100)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(CO)(CO)c1nnc(o1)C1CC1
Show InChI InChI=1S/C24H31N5O5/c1-15-19(21(32)26-24(13-30,14-31)23-28-27-22(34-23)17-9-10-17)29-11-5-8-18(20(29)25-15)33-12-16-6-3-2-4-7-16/h5,8,11,16-17,30-31H,2-4,6-7,9-10,12-14H2,1H3,(H,26,32)
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n/an/an/an/a 2.00E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213325
PNG
(US9278968, 81)
Show SMILES CCn1nnc(n1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C21H21F2N7O3/c1-3-30-27-19(26-28-30)16(10-31)25-21(32)18-12(2)24-20-17(8-5-9-29(18)20)33-11-13-14(22)6-4-7-15(13)23/h4-9,16,31H,3,10-11H2,1-2H3,(H,25,32)/t16-/m0/s1
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n/an/an/an/a 1.60E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213334
PNG
(US9278968, 90)
Show SMILES C[C@@H](O)[C@H](O)c1cnccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C25H24F2N4O4/c1-14-22(25(34)29-11-16-8-9-28-12-17(16)23(33)15(2)32)31-10-4-7-21(24(31)30-14)35-13-18-19(26)5-3-6-20(18)27/h3-10,12,15,23,32-33H,11,13H2,1-2H3,(H,29,34)/t15-,23+/m1/s1
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n/an/an/an/a 9.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213338
PNG
(US9278968, 94)
Show SMILES Cc1nn(C)cc1C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C24H25F2N5O3/c1-14-17(11-30(4)29-14)24(3,13-32)28-23(33)21-15(2)27-22-20(9-6-10-31(21)22)34-12-16-18(25)7-5-8-19(16)26/h5-11,32H,12-13H2,1-4H3,(H,28,33)
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n/an/an/an/a 1.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213244
PNG
(US9278968, 4)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1ccc(CO)cc1
Show InChI InChI=1S/C26H25F2N3O4/c1-16-23(25(34)30-26(2,15-33)18-10-8-17(13-32)9-11-18)31-12-4-7-22(24(31)29-16)35-14-19-20(27)5-3-6-21(19)28/h3-12,32-33H,13-15H2,1-2H3,(H,30,34)
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n/an/an/an/a 1.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213253
PNG
(US9278968, 12)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)C(N)=O |r|
Show InChI InChI=1S/C26H24F2N4O4/c1-15-22(25(35)31-26(2,14-33)17-7-3-6-16(12-17)23(29)34)32-11-5-10-21(24(32)30-15)36-13-18-19(27)8-4-9-20(18)28/h3-12,33H,13-14H2,1-2H3,(H2,29,34)(H,31,35)/t26-/m0/s1
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n/an/an/an/a 780n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213271
PNG
(US9278968, 30)
Show SMILES C[C@H](O)[C@@H](O)c1ccccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-15-23(26(34)29-13-17-7-3-4-8-18(17)24(33)16(2)32)31-12-6-11-22(25(31)30-15)35-14-19-20(27)9-5-10-21(19)28/h3-12,16,24,32-33H,13-14H2,1-2H3,(H,29,34)/t16-,24+/m0/s1
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n/an/an/an/a 5.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213272
PNG
(US9278968, 31)
Show SMILES C[C@@H](O)[C@H](O)c1ccccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-15-23(26(34)29-13-17-7-3-4-8-18(17)24(33)16(2)32)31-12-6-11-22(25(31)30-15)35-14-19-20(27)9-5-10-21(19)28/h3-12,16,24,32-33H,13-14H2,1-2H3,(H,29,34)/t16-,24+/m1/s1
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n/an/an/an/a 4.90E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213276
PNG
(US9278968, 35)
Show SMILES Cc1nnc(o1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C22H21F2N5O4/c1-12-18(20(31)26-22(3,11-30)21-28-27-13(2)33-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,26,31)
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n/an/an/an/a 6.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213278
PNG
(US9278968, 37)
Show SMILES Cc1nnc(s1)C(C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C22H21F2N5O3S/c1-12-18(20(31)26-22(3,11-30)21-28-27-13(2)33-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,26,31)
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n/an/an/an/a 7.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213287
PNG
(US9278968, 46)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@H](CO)c1nnc(o1)C1CC1 |r|
Show InChI InChI=1S/C23H21F2N5O4/c1-12-19(21(32)27-17(10-31)23-29-28-22(34-23)13-7-8-13)30-9-3-6-18(20(30)26-12)33-11-14-15(24)4-2-5-16(14)25/h2-6,9,13,17,31H,7-8,10-11H2,1H3,(H,27,32)/t17-/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213289
PNG
(US9278968, 48)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1cncnc1
Show InChI InChI=1S/C23H21F2N5O3/c1-14-20(22(32)29-23(2,12-31)15-9-26-13-27-10-15)30-8-4-7-19(21(30)28-14)33-11-16-17(24)5-3-6-18(16)25/h3-10,13,31H,11-12H2,1-2H3,(H,29,32)
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n/an/an/an/a 2.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213292
PNG
(US9278968, 51)
Show SMILES Cc1nc2c(OCc3ccccc3F)cccn2c1C(=O)NC(C)(CO)c1ccc(CO)cc1
Show InChI InChI=1S/C26H26FN3O4/c1-17-23(25(33)29-26(2,16-32)20-11-9-18(14-31)10-12-20)30-13-5-8-22(24(30)28-17)34-15-19-6-3-4-7-21(19)27/h3-13,31-32H,14-16H2,1-2H3,(H,29,33)
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n/an/an/an/a 1.20E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213293
PNG
(US9278968, 52)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1ccc(F)c(CO)c1
Show InChI InChI=1S/C26H24F3N3O4/c1-15-23(25(35)31-26(2,14-34)17-8-9-19(27)16(11-17)12-33)32-10-4-7-22(24(32)30-15)36-13-18-20(28)5-3-6-21(18)29/h3-11,33-34H,12-14H2,1-2H3,(H,31,35)
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n/an/an/an/a 2.20E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213303
PNG
(US9278968, 61)
Show SMILES Cc1nc2c(OCc3cccc(F)c3F)cccn2c1C(=O)NC(CO)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C25H22F3N3O4/c1-15-22(24(34)30-25(13-32,14-33)17-7-9-18(26)10-8-17)31-11-3-6-20(23(31)29-15)35-12-16-4-2-5-19(27)21(16)28/h2-11,32-33H,12-14H2,1H3,(H,30,34)
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n/an/an/an/a 6.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213306
PNG
(US9278968, 64)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1nnn(C)n1
Show InChI InChI=1S/C21H21F2N7O4/c1-12-17(19(33)25-21(10-31,11-32)20-26-28-29(2)27-20)30-8-4-7-16(18(30)24-12)34-9-13-14(22)5-3-6-15(13)23/h3-8,31-32H,9-11H2,1-2H3,(H,25,33)
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n/an/an/an/a 3.00E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213315
PNG
(US9278968, 72)
Show SMILES Cc1cnc(s1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O4S/c1-13-9-26-22(34-13)23(11-30,12-31)28-21(32)19-14(2)27-20-18(7-4-8-29(19)20)33-10-15-16(24)5-3-6-17(15)25/h3-9,30-31H,10-12H2,1-2H3,(H,28,32)
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n/an/an/an/a 2.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213327
PNG
(US9278968, 83)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@H](CO)c1nnn(n1)C(F)F |r|
Show InChI InChI=1S/C20H17F4N7O3/c1-10-16(19(33)26-14(8-32)17-27-29-31(28-17)20(23)24)30-7-3-6-15(18(30)25-10)34-9-11-12(21)4-2-5-13(11)22/h2-7,14,20,32H,8-9H2,1H3,(H,26,33)/t14-/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213339
PNG
(US9278968, 95)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccn(C)n1
Show InChI InChI=1S/C23H23F2N5O4/c1-14-20(22(33)27-23(12-31,13-32)19-8-10-29(2)28-19)30-9-4-7-18(21(30)26-14)34-11-15-16(24)5-3-6-17(15)25/h3-10,31-32H,11-13H2,1-2H3,(H,27,33)
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n/an/an/an/a 1.80E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213364
PNG
(US9278968, 118)
Show SMILES Cc1nnc(s1)[C@](C)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H21F2N5O3S/c1-12-18(20(31)26-22(3,11-30)21-28-27-13(2)33-21)29-9-5-8-17(19(29)25-12)32-10-14-15(23)6-4-7-16(14)24/h4-9,30H,10-11H2,1-3H3,(H,26,31)/t22-/m0/s1
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n/an/an/an/a 1.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213319
PNG
(US9278968, 75)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(CO)c1nnn(CCO)n1
Show InChI InChI=1S/C22H23F2N7O4/c1-13-18(20(34)26-22(2,12-33)21-27-29-31(28-21)9-10-32)30-8-4-7-17(19(30)25-13)35-11-14-15(23)5-3-6-16(14)24/h3-8,32-33H,9-12H2,1-2H3,(H,26,34)
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n/an/an/an/a 9.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213324
PNG
(US9278968, 80)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(C)c1cccc(c1)C(N)=O
Show InChI InChI=1S/C26H24F2N4O3/c1-15-22(25(34)31-26(2,3)17-8-4-7-16(13-17)23(29)33)32-12-6-11-21(24(32)30-15)35-14-18-19(27)9-5-10-20(18)28/h4-13H,14H2,1-3H3,(H2,29,33)(H,31,34)
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n/an/an/an/a 7.10E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213330
PNG
(US9278968, 86)
Show SMILES CCc1nnc(o1)C(C)(CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C23H31N5O4/c1-4-18-26-27-22(32-18)23(3,14-29)25-21(30)19-15(2)24-20-17(11-8-12-28(19)20)31-13-16-9-6-5-7-10-16/h8,11-12,16,29H,4-7,9-10,13-14H2,1-3H3,(H,25,30)
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n/an/an/an/a 5.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213342
PNG
(US9278968, 98)
Show SMILES Cc1nnc(o1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C22H29N5O5/c1-14-18(20(30)24-22(12-28,13-29)21-26-25-15(2)32-21)27-10-6-9-17(19(27)23-14)31-11-16-7-4-3-5-8-16/h6,9-10,16,28-29H,3-5,7-8,11-13H2,1-2H3,(H,24,30)
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n/an/an/an/a 2.40E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213256
PNG
(US9278968, 15)
Show SMILES Cc1nc2c(OCc3ccccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(CO)c1 |r|
Show InChI InChI=1S/C26H26FN3O4/c1-17-23(25(33)29-26(2,16-32)20-9-5-7-18(13-20)14-31)30-12-6-11-22(24(30)28-17)34-15-19-8-3-4-10-21(19)27/h3-13,31-32H,14-16H2,1-2H3,(H,29,33)/t26-/m0/s1
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n/an/an/an/a 2.80E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213295
PNG
(US9278968, 54)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccc(F)cc1
Show InChI InChI=1S/C25H22F3N3O4/c1-15-22(24(34)30-25(13-32,14-33)16-7-9-17(26)10-8-16)31-11-3-6-21(23(31)29-15)35-12-18-19(27)4-2-5-20(18)28/h2-11,32-33H,12-14H2,1H3,(H,30,34)
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n/an/an/an/a 2.70E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213311
PNG
(US9278968, 69)
Show SMILES Cc1cnc(s1)[C@@]1(C[C@H](O)[C@H](O)C1)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C25H24F2N4O4S/c1-13-11-28-24(36-13)25(9-18(32)19(33)10-25)30-23(34)21-14(2)29-22-20(7-4-8-31(21)22)35-12-15-16(26)5-3-6-17(15)27/h3-8,11,18-19,32-33H,9-10,12H2,1-2H3,(H,30,34)/t18-,19+,25-
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n/an/an/an/a 4.60E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213336
PNG
(US9278968, 92)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(C)(CO)c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C22H26F3N5O4/c1-13-16(18(32)27-21(2,12-31)19-28-29-20(34-19)22(23,24)25)30-10-6-9-15(17(30)26-13)33-11-14-7-4-3-5-8-14/h6,9-10,14,31H,3-5,7-8,11-12H2,1-2H3,(H,27,32)
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n/an/an/an/a 1.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213356
PNG
(US9278968, 110)
Show SMILES CC(C)n1nnc(n1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C22H23F2N7O3/c1-12(2)31-28-20(27-29-31)17(10-32)26-22(33)19-13(3)25-21-18(8-5-9-30(19)21)34-11-14-15(23)6-4-7-16(14)24/h4-9,12,17,32H,10-11H2,1-3H3,(H,26,33)/t17-/m0/s1
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n/an/an/an/a 1.20E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213243
PNG
(US9278968, 3)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)C(O)=O |r|
Show InChI InChI=1S/C26H31N3O5/c1-17-22(24(31)28-26(2,16-30)20-11-6-10-19(14-20)25(32)33)29-13-7-12-21(23(29)27-17)34-15-18-8-4-3-5-9-18/h6-7,10-14,18,30H,3-5,8-9,15-16H2,1-2H3,(H,28,31)(H,32,33)/t26-/m0/s1
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n/an/an/an/a 720n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213250
PNG
(US9278968, 9)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ccccc1 |r|
Show InChI InChI=1S/C25H23F2N3O3/c1-16-22(24(32)29-25(2,15-31)17-8-4-3-5-9-17)30-13-7-12-21(23(30)28-16)33-14-18-19(26)10-6-11-20(18)27/h3-13,31H,14-15H2,1-2H3,(H,29,32)/t25-/m0/s1
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n/an/an/an/a 720n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213269
PNG
(US9278968, 28)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@]1(CC[C@H](O)[C@H]1O)c1ccccc1 |r|
Show InChI InChI=1S/C27H25F2N3O4/c1-16-23(26(35)31-27(13-12-21(33)24(27)34)17-7-3-2-4-8-17)32-14-6-11-22(25(32)30-16)36-15-18-19(28)9-5-10-20(18)29/h2-11,14,21,24,33-34H,12-13,15H2,1H3,(H,31,35)/t21-,24+,27-/m0/s1
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n/an/an/an/a 1.30E+4n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213274
PNG
(US9278968, 33)
Show SMILES C[C@@H](O)[C@@H](O)c1ccccc1CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-15-23(26(34)29-13-17-7-3-4-8-18(17)24(33)16(2)32)31-12-6-11-22(25(31)30-15)35-14-19-20(27)9-5-10-21(19)28/h3-12,16,24,32-33H,13-14H2,1-2H3,(H,29,34)/t16-,24-/m1/s1
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n/an/an/an/a 7.40E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213283
PNG
(US9278968, 42)
Show SMILES Cc1nnc(o1)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12 |r|
Show InChI InChI=1S/C21H19F2N5O4/c1-11-18(20(30)25-16(9-29)21-27-26-12(2)32-21)28-8-4-7-17(19(28)24-11)31-10-13-14(22)5-3-6-15(13)23/h3-8,16,29H,9-10H2,1-2H3,(H,25,30)/t16-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213302
PNG
(US9278968, 60)
Show SMILES Cc1cnc(o1)C(CO)(CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C23H22F2N4O5/c1-13-9-26-22(34-13)23(11-30,12-31)28-21(32)19-14(2)27-20-18(7-4-8-29(19)20)33-10-15-16(24)5-3-6-17(15)25/h3-9,30-31H,10-12H2,1-2H3,(H,28,32)
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Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213304
PNG
(US9278968, 62)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1cc(C)ccn1
Show InChI InChI=1S/C25H24F2N4O4/c1-15-8-9-28-21(11-15)25(13-32,14-33)30-24(34)22-16(2)29-23-20(7-4-10-31(22)23)35-12-17-18(26)5-3-6-19(17)27/h3-11,32-33H,12-14H2,1-2H3,(H,30,34)
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n/an/an/an/a 6.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213329
PNG
(US9278968, 85)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@](C)(CO)c1cccc(c1)[N+]#[C-] |r|
Show InChI InChI=1S/C26H30N4O3/c1-18-23(25(32)29-26(2,17-31)20-11-7-12-21(15-20)27-3)30-14-8-13-22(24(30)28-18)33-16-19-9-5-4-6-10-19/h7-8,11-15,19,31H,4-6,9-10,16-17H2,1-2H3,(H,29,32)/t26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213340
PNG
(US9278968, 96)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1nnn(n1)C(F)F
Show InChI InChI=1S/C21H19F4N7O4/c1-11-16(18(35)27-21(9-33,10-34)19-28-30-32(29-19)20(24)25)31-7-3-6-15(17(31)26-11)36-8-12-13(22)4-2-5-14(12)23/h2-7,20,33-34H,8-10H2,1H3,(H,27,35)
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Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213341
PNG
(US9278968, 97)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(CO)(CO)c1nnn(n1)C(F)F
Show InChI InChI=1S/C21H27F2N7O4/c1-13-16(18(33)25-21(11-31,12-32)19-26-28-30(27-19)20(22)23)29-9-5-8-15(17(29)24-13)34-10-14-6-3-2-4-7-14/h5,8-9,14,20,31-32H,2-4,6-7,10-12H2,1H3,(H,25,33)
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n/an/an/an/a 3.50E+3n/an/an/a25



Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM213351
PNG
(US9278968, 107a)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@](C)(CO)c1ccc(CO)cc1 |r|
Show InChI InChI=1S/C26H25F2N3O4/c1-16-23(25(34)30-26(2,15-33)18-10-8-17(13-32)9-11-18)31-12-4-7-22(24(31)29-16)35-14-19-20(27)5-3-6-21(19)28/h3-12,32-33H,13-15H2,1-2H3,(H,30,34)/t26-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
Using an sGCα 1 gene (NCBI accession No. BC028384.2) and an sGCβ1 gene (NCBI accession No. BC047620.1), an N-terminal FLAG tag-fused sGC&a...

US Patent US9278968 (2016)


BindingDB Entry DOI: 10.7270/Q2T43RXS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%