Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156246 (US9018391, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156243 (US9018391, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156242 (US9018391, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156241 (US9018391, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156245 (US9018391, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156252 (US9018391, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156244 (US9018391, 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156250 (US9018391, 12) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156251 (US9018391, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156254 (US9018391, 16) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156253 (US9018391, 15) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156240 (US9018391, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156248 (US9018391, 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156247 (US9018391, 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156239 (US9018391, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156249 (US9018391, 11) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair |