| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 |
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| Ligand | BDBM156252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quench Assay |
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| pH | 4.4±n/a |
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| IC50 | 4.5±n/a nM |
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| Comments | extracted |
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| Citation |  Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Dorner-Ciossek, C; Gross, U; Heine, N; Sauer, A Inhibitors of beta-secretase US Patent US9018391 Publication Date 4/28/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 |
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| Name: | Beta-secretase 1 |
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| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
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| Type: | Protein |
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| Mol. Mass.: | 55755.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56817 |
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| Residue: | 501 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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| BDBM156252 |
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| n/a |
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| Name | BDBM156252 |
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| Synonyms: | US9018391, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F2N4O2 |
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| Mol. Mass. | 442.5015 |
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| SMILES | C[C@H]1C[C@]2(Cc3ccc(cc3[C@]22N=C(N)N(CC3CC(F)(F)C3)C2=O)C#N)C[C@@H](C)[C@@H]1O |r,t:14| |
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| Structure | 
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