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Patent code US8609647

Compile Data Set for Download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 1n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 1.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109866
PNG
(US8609647, 26 | US8609647, 4)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H14F2N6O/c16-15(17)8-23(11(24)1-4-18)14(15)3-6-22(7-14)13-10-2-5-19-12(10)20-9-21-13/h2,5,9H,1,3,6-8H2,(H,19,20,21)
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n/an/a 1.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109867
PNG
(US8609647, 27 | US8609647, 37 | US8609647, 5)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)
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n/an/a 1.90n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
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n/an/a 2.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 2.20n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109867
PNG
(US8609647, 27 | US8609647, 37 | US8609647, 5)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)
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n/an/a 3.30n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 3.40n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109867
PNG
(US8609647, 27 | US8609647, 37 | US8609647, 5)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)
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n/an/a 4n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 4.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 4.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109866
PNG
(US8609647, 26 | US8609647, 4)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H14F2N6O/c16-15(17)8-23(11(24)1-4-18)14(15)3-6-22(7-14)13-10-2-5-19-12(10)20-9-21-13/h2,5,9H,1,3,6-8H2,(H,19,20,21)
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n/an/a 5.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 5.80n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109909
PNG
(US8609647, 54 | US8609647, 66)
Show SMILES CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)
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n/an/a 5.90n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109910
PNG
(US8609647, 55)
Show SMILES FC1(F)CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)4-8-24(12(25)1-5-19)15(16)3-7-23(9-15)14-11-2-6-20-13(11)21-10-22-14/h2,6,10H,1,3-4,7-9H2,(H,20,21,22)
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n/an/a 6.60n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109911
PNG
(US8609647, 56)
Show SMILES FC1(F)CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18F2N6O/c18-17(19)5-9-25(13(26)2-6-20)16(17)4-1-8-24(10-16)15-12-3-7-21-14(12)22-11-23-15/h3,7,11H,1-2,4-5,8-10H2,(H,21,22,23)
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n/an/a 6.80n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 7.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
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n/an/a 7.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109907
PNG
(US8609647, 52)
Show SMILES O=C(NCC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N7O/c18-6-8-20-16(25)24-10-2-5-17(24)4-1-9-23(11-17)15-13-3-7-19-14(13)21-12-22-15/h3,7,12H,1-2,4-5,8-11H2,(H,20,25)(H,19,21,22)
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n/an/a 10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109909
PNG
(US8609647, 54 | US8609647, 66)
Show SMILES CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)
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n/an/a 11n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109866
PNG
(US8609647, 26 | US8609647, 4)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H14F2N6O/c16-15(17)8-23(11(24)1-4-18)14(15)3-6-22(7-14)13-10-2-5-19-12(10)20-9-21-13/h2,5,9H,1,3,6-8H2,(H,19,20,21)
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n/an/a 12n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109935
PNG
(US8609647, 82)
Show SMILES O=C(CC#N)N1CCCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c19-8-4-15(25)24-11-2-1-6-18(24)7-3-10-23(12-18)17-14-5-9-20-16(14)21-13-22-17/h5,9,13H,1-4,6-7,10-12H2,(H,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109915
PNG
(US8609647, 60)
Show SMILES CC1CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c1-13-5-10-24(15(25)3-7-19)18(13)6-2-9-23(11-18)17-14-4-8-20-16(14)21-12-22-17/h4,8,12-13H,2-3,5-6,9-11H2,1H3,(H,20,21,22)
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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
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n/an/a 21n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109913
PNG
(US8609647, 58)
Show SMILES O=C(NCCC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H23N7O/c19-7-3-8-21-17(26)25-11-2-6-18(25)5-1-10-24(12-18)16-14-4-9-20-15(14)22-13-23-16/h4,9,13H,1-3,5-6,8,10-12H2,(H,21,26)(H,20,22,23)
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n/an/a 31n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109941
PNG
(US8609647, 88)
Show SMILES O=C(CC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-8-1-4-16(22)5-9-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 32n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109890
PNG
(US8609647, 34)
Show SMILES CC1N(CCC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-17(5-2-9-23(17)14(24)3-7-18)6-10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)
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n/an/a 36n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109912
PNG
(US8609647, 57)
Show SMILES O=C(CC#N)N1CCC11CCCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-6-17(23)5-1-2-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 37n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 38n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109899
PNG
(US8609647, 43)
Show SMILES C[C@H](O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12 |r|
Show InChI InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)/t12-,17?/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109871
PNG
(US8609647, 14 | US8609647, 20)
Show SMILES CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 41n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109887
PNG
(US8609647, 31)
Show SMILES FC1(F)CCN(CC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18F2N6O/c18-17(19)5-9-24(15-12-3-7-21-14(12)22-11-23-15)10-16(17)4-1-8-25(16)13(26)2-6-20/h3,7,11H,1-2,4-5,8-10H2,(H,21,22,23)
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n/an/a 46n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109885
PNG
(US8609647, 29)
Show SMILES C=CCOCCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H27N5O2/c1-2-12-27-13-6-17(26)25-11-4-8-20(25)7-3-10-24(14-20)19-16-5-9-21-18(16)22-15-23-19/h2,5,9,15H,1,3-4,6-8,10-14H2,(H,21,22,23)
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n/an/a 47n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109931
PNG
(US8609647, 77)
Show SMILES O=C(CC#N)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-9-2-1-5-17(23)6-10-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 48n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109908
PNG
(US8609647, 53)
Show SMILES N#CCCN1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H20N6/c17-6-2-9-22-8-1-4-16(22)5-10-21(11-16)15-13-3-7-18-14(13)19-12-20-15/h3,7,12H,1-2,4-5,8-11H2,(H,18,19,20)
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n/an/a 56n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109873
PNG
(US8609647, 16)
Show SMILES CC1CN(CC2(CCN2C(=O)CC#N)C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-8-17(4-7-23(17)14(24)2-5-18)10-22(9-12)16-13-3-6-19-15(13)20-11-21-16/h3,6,11-12H,2,4,7-10H2,1H3,(H,19,20,21)
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n/an/a 58n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109900
PNG
(US8609647, 44)
Show SMILES OCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H21N5O2/c22-9-13(23)21-8-2-5-16(21)4-1-7-20(10-16)15-12-3-6-17-14(12)18-11-19-15/h3,6,11,22H,1-2,4-5,7-10H2,(H,17,18,19)
PDB

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n/an/a 67n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109928
PNG
(US8609647, 73)
Show SMILES O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)C1(CC1)C#N
Show InChI InChI=1S/C18H20N6O/c19-10-17(4-5-17)16(25)24-8-1-3-18(24)6-9-23(11-18)15-13-2-7-20-14(13)21-12-22-15/h2,7,12H,1,3-6,8-9,11H2,(H,20,21,22)
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n/an/a 73n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109948
PNG
(US8609647, 95)
Show SMILES O=C(CC#N)N1CCCCC11CCN(C1)c1ncnc2nc[nH]c12
Show InChI InChI=1S/C16H19N7O/c17-6-3-12(24)23-7-2-1-4-16(23)5-8-22(9-16)15-13-14(19-10-18-13)20-11-21-15/h10-11H,1-5,7-9H2,(H,18,19,20,21)
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n/an/a 78n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109874
PNG
(US8609647, 17)
Show SMILES O=C(CC#N)N1CCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H16N6O/c16-5-1-12(22)21-8-4-15(21)3-7-20(9-15)14-11-2-6-17-13(11)18-10-19-14/h2,6,10H,1,3-4,7-9H2,(H,17,18,19)
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n/an/a 87n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109867
PNG
(US8609647, 27 | US8609647, 37 | US8609647, 5)
Show SMILES FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)
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n/an/a 88n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109897
PNG
(US8609647, 41)
Show SMILES CC1(C)CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c1-17(2)5-10-24(14(25)3-7-19)18(17)6-9-23(11-18)16-13-4-8-20-15(13)21-12-22-16/h4,8,12H,3,5-6,9-11H2,1-2H3,(H,20,21,22)
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n/an/a 90n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109905
PNG
(US8609647, 49)
Show SMILES CCNC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H24N6O/c1-2-18-16(24)23-10-4-7-17(23)6-3-9-22(11-17)15-13-5-8-19-14(13)20-12-21-15/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,18,24)(H,19,20,21)
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n/an/a 92n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109889
PNG
(US8609647, 33 | US8609647, 42)
Show SMILES CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 100n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109933
PNG
(US8609647, 80)
Show SMILES CC(C)(C)OC(=O)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H27N5O2/c1-18(2,3)26-17(25)24-10-5-4-7-19(24)8-11-23(12-19)16-14-6-9-20-15(14)21-13-22-16/h6,9,13H,4-5,7-8,10-12H2,1-3H3,(H,20,21,22)
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n/an/a 100n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109871
PNG
(US8609647, 14 | US8609647, 20)
Show SMILES CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 100n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109903
PNG
(US8609647, 47)
Show SMILES C[C@H](OC(C)=O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12 |r|
Show InChI InChI=1S/C19H25N5O3/c1-13(27-14(2)25)18(26)24-10-4-7-19(24)6-3-9-23(11-19)17-15-5-8-20-16(15)21-12-22-17/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,20,21,22)/t13-,19?/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109946
PNG
(US8609647, 93)
Show SMILES Clc1cnc2[nH]ncc2c1N1CCC2(C1)CCCCN2C(=O)CC#N
Show InChI InChI=1S/C17H19ClN6O/c18-13-10-20-16-12(9-21-22-16)15(13)23-8-5-17(11-23)4-1-2-7-24(17)14(25)3-6-19/h9-10H,1-5,7-8,11H2,(H,20,21,22)
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n/an/a 110n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109895
PNG
(US8609647, 39)
Show SMILES COCCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H25N5O2/c1-25-11-5-15(24)23-10-3-7-18(23)6-2-9-22(12-18)17-14-4-8-19-16(14)20-13-21-17/h4,8,13H,2-3,5-7,9-12H2,1H3,(H,19,20,21)
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n/an/a 120n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109917
PNG
(US8609647, 62)
Show SMILES O=C(NCC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H19N7O/c17-5-7-19-15(24)23-8-1-3-16(23)4-9-22(10-16)14-12-2-6-18-13(12)20-11-21-14/h2,6,11H,1,3-4,7-10H2,(H,19,24)(H,18,20,21)
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n/an/a 130n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109880
PNG
(US8609647, 24)
Show SMILES CC1N(CCC11CCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-16(5-9-22(16)13(23)2-6-17)4-8-21(11)15-12-3-7-18-14(12)19-10-20-15/h3,7,10-11H,2,4-5,8-9H2,1H3,(H,18,19,20)
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n/an/a 130n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109884
PNG
(US8609647, 28)
Show SMILES CC1(C)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c1-17(2)10-24(14(25)4-7-19)18(17)6-3-9-23(11-18)16-13-5-8-20-15(13)21-12-22-16/h5,8,12H,3-4,6,9-11H2,1-2H3,(H,20,21,22)
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n/an/a 130n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109896
PNG
(US8609647, 40)
Show SMILES CC1CCN(C(=O)CC#N)C11CN(CC1(F)F)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18F2N6O/c1-11-4-7-25(13(26)2-5-20)16(11)8-24(9-17(16,18)19)15-12-3-6-21-14(12)22-10-23-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,21,22,23)
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n/an/a 140n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109932
PNG
(US8609647, 78)
Show SMILES CC(=O)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H21N5O/c1-12(22)21-8-3-2-5-16(21)6-9-20(10-16)15-13-4-7-17-14(13)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)
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n/an/a 150n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109927
PNG
(US8609647, 72)
Show SMILES OCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O2/c21-8-12(22)20-6-1-3-15(20)4-7-19(9-15)14-11-2-5-16-13(11)17-10-18-14/h2,5,10,21H,1,3-4,6-9H2,(H,16,17,18)
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n/an/a 150n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109894
PNG
(US8609647, 38)
Show SMILES CC1(C)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-16(2)9-23(13(24)3-6-18)17(16)5-8-22(10-17)15-12-4-7-19-14(12)20-11-21-15/h4,7,11H,3,5,8-10H2,1-2H3,(H,19,20,21)
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n/an/a 150n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109886
PNG
(US8609647, 30 | US8609647, 35 | US8609647, 36)
Show SMILES CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)
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n/an/a 150n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109904
PNG
(US8609647, 48)
Show SMILES COCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-24-10-14(23)22-9-3-6-17(22)5-2-8-21(11-17)16-13-4-7-18-15(13)19-12-20-16/h4,7,12H,2-3,5-6,8-11H2,1H3,(H,18,19,20)
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n/an/a 170n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109929
PNG
(US8609647, 74)
Show SMILES O=C(CC#N)N1CCCCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H24N6O/c20-9-5-16(26)25-12-3-1-2-7-19(25)8-4-11-24(13-19)18-15-6-10-21-17(15)22-14-23-18/h6,10,14H,1-5,7-8,11-13H2,(H,21,22,23)
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n/an/a 180n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109919
PNG
(US8609647, 64)
Show SMILES O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1cccc(c1)C#N
Show InChI InChI=1S/C21H20N6O/c22-12-15-3-1-4-16(11-15)20(28)27-9-2-6-21(27)7-10-26(13-21)19-17-5-8-23-18(17)24-14-25-19/h1,3-5,8,11,14H,2,6-7,9-10,13H2,(H,23,24,25)
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n/an/a 180n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109920
PNG
(US8609647, 65)
Show SMILES O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H20N6O/c22-12-15-2-4-16(5-3-15)20(28)27-10-1-7-21(27)8-11-26(13-21)19-17-6-9-23-18(17)24-14-25-19/h2-6,9,14H,1,7-8,10-11,13H2,(H,23,24,25)
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n/an/a 190n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109906
PNG
(US8609647, 50)
Show SMILES CC(=O)OCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H23N5O3/c1-13(24)26-10-15(25)23-9-3-6-18(23)5-2-8-22(11-18)17-14-4-7-19-16(14)20-12-21-17/h4,7,12H,2-3,5-6,8-11H2,1H3,(H,19,20,21)
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n/an/a 230n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 230n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109918
PNG
(US8609647, 63)
Show SMILES CN(CC#N)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N7O/c1-22(10-6-18)16(25)24-8-2-4-17(24)5-9-23(11-17)15-13-3-7-19-14(13)20-12-21-15/h3,7,12H,2,4-5,8-11H2,1H3,(H,19,20,21)
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n/an/a 240n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109922
PNG
(US8609647, 67)
Show SMILES O=C(NCCC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N7O/c18-6-2-7-20-16(25)24-9-1-4-17(24)5-10-23(11-17)15-13-3-8-19-14(13)21-12-22-15/h3,8,12H,1-2,4-5,7,9-11H2,(H,20,25)(H,19,21,22)
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n/an/a 240n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109926
PNG
(US8609647, 71)
Show SMILES [O-][N+](=O)c1ccc(OC(=O)N2CCCC22CCN(C2)c2ncnc3[nH]ccc23)cc1
Show InChI InChI=1S/C20H20N6O4/c27-19(30-15-4-2-14(3-5-15)26(28)29)25-10-1-7-20(25)8-11-24(12-20)18-16-6-9-21-17(16)22-13-23-18/h2-6,9,13H,1,7-8,10-12H2,(H,21,22,23)
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n/an/a 250n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109936
PNG
(US8609647, 83)
Show SMILES CC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H21N5O/c1-12(22)21-9-3-6-16(21)5-2-8-20(10-16)15-13-4-7-17-14(13)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)
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n/an/a 250n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109902
PNG
(US8609647, 46)
Show SMILES CO[C@H](C)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12 |r|
Show InChI InChI=1S/C18H25N5O2/c1-13(25-2)17(24)23-10-4-7-18(23)6-3-9-22(11-18)16-14-5-8-19-15(14)20-12-21-16/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,19,20,21)/t13-,18?/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109901
PNG
(US8609647, 45)
Show SMILES CO[C@@H](C)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12 |r|
Show InChI InChI=1S/C18H25N5O2/c1-13(25-2)17(24)23-10-4-7-18(23)6-3-9-22(11-18)16-14-5-8-19-15(14)20-12-21-16/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,19,20,21)/t13-,18?/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109923
PNG
(US8609647, 68)
Show SMILES CCCNC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H24N6O/c1-2-7-19-16(24)23-9-3-5-17(23)6-10-22(11-17)15-13-4-8-18-14(13)20-12-21-15/h4,8,12H,2-3,5-7,9-11H2,1H3,(H,19,24)(H,18,20,21)
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n/an/a 280n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109924
PNG
(US8609647, 69 | US8609647, 70)
Show SMILES COC(=O)CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H23N5O3/c1-26-15(25)4-3-14(24)23-9-2-6-18(23)7-10-22(11-18)17-13-5-8-19-16(13)20-12-21-17/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,19,20,21)
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n/an/a 300n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109924
PNG
(US8609647, 69 | US8609647, 70)
Show SMILES COC(=O)CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H23N5O3/c1-26-15(25)4-3-14(24)23-9-2-6-18(23)7-10-22(11-18)17-13-5-8-19-16(13)20-12-21-17/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,19,20,21)
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n/an/a 320n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109945
PNG
(US8609647, 92)
Show SMILES Clc1cnc2[nH]ncc2c1N1CCC2(CCCN2C(=O)CC#N)C1
Show InChI InChI=1S/C16H17ClN6O/c17-12-9-19-15-11(8-20-21-15)14(12)22-7-4-16(10-22)3-1-6-23(16)13(24)2-5-18/h8-9H,1-4,6-7,10H2,(H,19,20,21)
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n/an/a 330n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109947
PNG
(US8609647, 94)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2nc[nH]c12
Show InChI InChI=1S/C16H19N7O/c17-6-3-12(24)23-8-2-5-16(23)4-1-7-22(9-16)15-13-14(19-10-18-13)20-11-21-15/h10-11H,1-5,7-9H2,(H,18,19,20,21)
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n/an/a 350n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
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n/an/a 400n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109875
PNG
(US8609647, 18)
Show SMILES CC1CCC2(CCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-2-5-17(6-9-23(17)14(24)3-7-18)10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)
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n/an/a 410n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109939
PNG
(US8609647, 86)
Show SMILES CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H21N5O/c1-2-13(22)21-8-3-5-16(21)6-9-20(10-16)15-12-4-7-17-14(12)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)
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n/an/a 450n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109934
PNG
(US8609647, 81)
Show SMILES CC(=O)N1CCCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O/c1-13(23)22-10-3-2-6-17(22)7-4-9-21(11-17)16-14-5-8-18-15(14)19-12-20-16/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,18,19,20)
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n/an/a 460n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109889
PNG
(US8609647, 33 | US8609647, 42)
Show SMILES CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 480n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109888
PNG
(US8609647, 32)
Show SMILES FC1(F)CN(CC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H16F2N6O/c17-16(18)9-23(14-11-3-6-20-13(11)21-10-22-14)8-15(16)4-1-7-24(15)12(25)2-5-19/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)
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n/an/a 490n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109886
PNG
(US8609647, 30 | US8609647, 35 | US8609647, 36)
Show SMILES CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)
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n/an/a 530n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109943
PNG
(US8609647, 90)
Show SMILES C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C20H23N5/c1-2-5-16(6-3-1)13-25-11-4-8-20(25)9-12-24(14-20)19-17-7-10-21-18(17)22-15-23-19/h1-3,5-7,10,15H,4,8-9,11-14H2,(H,21,22,23)
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n/an/a 550n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109938
PNG
(US8609647, 85)
Show SMILES CC(C)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O/c1-12(2)16(23)22-8-3-5-17(22)6-9-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12H,3,5-6,8-10H2,1-2H3,(H,18,19,20)
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n/an/a 570n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109886
PNG
(US8609647, 30 | US8609647, 35 | US8609647, 36)
Show SMILES CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)
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n/an/a 580n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109916
PNG
(US8609647, 61)
Show SMILES COC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O2/c1-22-14(21)20-7-2-4-15(20)5-8-19(9-15)13-11-3-6-16-12(11)17-10-18-13/h3,6,10H,2,4-5,7-9H2,1H3,(H,16,17,18)
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n/an/a 650n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109870
PNG
(US8609647, 8)
Show SMILES CN(CCC#N)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H23N7O/c1-23(9-3-7-19)17(26)25-10-2-5-18(25)6-11-24(12-18)16-14-4-8-20-15(14)21-13-22-16/h4,8,13H,2-3,5-6,9-12H2,1H3,(H,20,21,22)
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n/an/a 730n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109930
PNG
(US8609647, 76)
Show SMILES CC(C)(C)OC(=O)N1CCCCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H31N5O2/c1-20(2,3)28-19(27)26-13-6-4-5-9-21(26)10-7-12-25(14-21)18-16-8-11-22-17(16)23-15-24-18/h8,11,15H,4-7,9-10,12-14H2,1-3H3,(H,22,23,24)
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n/an/a 760n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM109942
PNG
(US8609647, 89)
Show SMILES C1CNC2(C1)CCN(C2)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C13H17N5/c1-3-13(17-5-1)4-7-18(8-13)12-10-2-6-14-11(10)15-9-16-12/h2,6,9,17H,1,3-5,7-8H2,(H,14,15,16)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...

US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%