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Patent code US8933099

Compile Data Set for Download or QSAR
Found 139 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142338
PNG
(US8933099, 112)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC |r|
Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m0/s1
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n/an/a 3.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142348
PNG
(US8933099, 114)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C)CC2)c1)C(=O)NC
Show InChI InChI=1S/C32H37N5O5/c1-4-40-17-18-41-28-21-27-25(12-16-37(27)32(39)33-2)19-29(28)42-26-9-13-34-30(20-26)35-31(38)24-7-5-22(6-8-24)23-10-14-36(3)15-11-23/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38)
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n/an/a 3.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142347
PNG
(US8933099, 109)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC(C)(C)O)CC2)c1)C(=O)NC
Show InChI InChI=1S/C35H43N5O6/c1-5-44-18-19-45-30-22-29-27(13-17-40(29)34(42)36-4)20-31(30)46-28-10-14-37-32(21-28)38-33(41)26-8-6-24(7-9-26)25-11-15-39(16-12-25)23-35(2,3)43/h6-10,13-14,17,20-22,25,43H,5,11-12,15-16,18-19,23H2,1-4H3,(H,36,42)(H,37,38,41)
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n/an/a 3.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142339
PNG
(US8933099, 113)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC)CC2)c1)C(=O)NC
Show InChI InChI=1S/C33H39N5O5/c1-4-37-15-11-24(12-16-37)23-6-8-25(9-7-23)32(39)36-31-21-27(10-14-35-31)43-30-20-26-13-17-38(33(40)34-3)28(26)22-29(30)42-19-18-41-5-2/h6-10,13-14,17,20-22,24H,4-5,11-12,15-16,18-19H2,1-3H3,(H,34,40)(H,35,36,39)
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n/an/a 4.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142337
PNG
(US8933099, 111)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@@H](C)O)CC2)c1)C(=O)NC |r|
Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1
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n/an/a 4.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142258
PNG
(US8933099, 24)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCNCC2)c1)C(=O)NC
Show InChI InChI=1S/C31H35N5O5/c1-3-39-16-17-40-27-20-26-24(11-15-36(26)31(38)32-2)18-28(27)41-25-10-14-34-29(19-25)35-30(37)23-6-4-21(5-7-23)22-8-12-33-13-9-22/h4-7,10-11,14-15,18-20,22,33H,3,8-9,12-13,16-17H2,1-2H3,(H,32,38)(H,34,35,37)
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n/an/a 4.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor 2


(Homo sapiens (Human))		BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 4.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142325
PNG
(US8933099, 91)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C33H39N5O6/c1-22(39)21-37-13-9-24(10-14-37)23-4-6-25(7-5-23)32(40)36-31-19-27(8-12-35-31)44-30-18-26-11-15-38(33(41)34-2)28(26)20-29(30)43-17-16-42-3/h4-8,11-12,15,18-20,22,24,39H,9-10,13-14,16-17,21H2,1-3H3,(H,34,41)(H,35,36,40)/t22-/m0/s1
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n/an/a 5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142333
PNG
(US8933099, 103)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C2)C(C)C)c1)C(=O)NC
Show InChI InChI=1S/C32H37N5O5/c1-5-40-14-15-41-28-18-27-24(11-13-37(27)32(39)33-4)16-29(28)42-26-10-12-34-30(17-26)35-31(38)23-8-6-22(7-9-23)25-19-36(20-25)21(2)3/h6-13,16-18,21,25H,5,14-15,19-20H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142341
PNG
(US8933099, 99)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@H]3CO)s2)c1)C(=O)NC |r|
Show InChI InChI=1S/C30H35N5O6S/c1-3-39-13-14-40-25-17-24-20(9-12-35(24)30(38)31-2)15-26(25)41-22-8-10-32-28(16-22)33-29(37)27-7-6-23(42-27)18-34-11-4-5-21(34)19-36/h6-10,12,15-17,21,36H,3-5,11,13-14,18-19H2,1-2H3,(H,31,38)(H,32,33,37)/t21-/m0/s1
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n/an/a 5.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor 2


(Homo sapiens (Human))		BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 5.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142359
PNG
(US8933099, 125)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C34H41N5O6/c1-23(40)22-38-14-10-25(11-15-38)24-5-7-26(8-6-24)33(41)37-32-20-28(9-13-36-32)45-31-19-27-12-16-39(34(42)35-2)29(27)21-30(31)44-18-4-17-43-3/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1
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n/an/a 5.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142259
PNG
(US8933099, 25)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CCO)CC2)c1)C(=O)NC
Show InChI InChI=1S/C33H39N5O6/c1-3-42-18-19-43-29-22-28-26(11-15-38(28)33(41)34-2)20-30(29)44-27-8-12-35-31(21-27)36-32(40)25-6-4-23(5-7-25)24-9-13-37(14-10-24)16-17-39/h4-8,11-12,15,20-22,24,39H,3,9-10,13-14,16-19H2,1-2H3,(H,34,41)(H,35,36,40)
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n/an/a 5.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142257
PNG
(US8933099, 23)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CC4)C(C)C)c3)c(OCCOC)cc12
Show InChI InChI=1S/C33H39N5O5/c1-22(2)37-14-10-24(11-15-37)23-5-7-25(8-6-23)32(39)36-31-20-27(9-13-35-31)43-30-19-26-12-16-38(33(40)34-3)28(26)21-29(30)42-18-17-41-4/h5-9,12-13,16,19-22,24H,10-11,14-15,17-18H2,1-4H3,(H,34,40)(H,35,36,39)
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n/an/a 5.30n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142265
PNG
(US8933099, 100 | US8933099, 31)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@@H](O)C3)s2)c1)C(=O)NC |r|
Show InChI InChI=1S/C29H33N5O6S/c1-3-38-12-13-39-24-16-23-19(7-11-34(23)29(37)30-2)14-25(24)40-21-6-9-31-27(15-21)32-28(36)26-5-4-22(41-26)18-33-10-8-20(35)17-33/h4-7,9,11,14-16,20,35H,3,8,10,12-13,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t20-/m1/s1
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n/an/a 5.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 5.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR3 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142336
PNG
(US8933099, 110)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC2)C(C)C)c1)C(=O)NC
Show InChI InChI=1S/C34H41N5O5/c1-5-42-18-19-43-30-22-29-27(13-17-39(29)34(41)35-4)20-31(30)44-28-10-14-36-32(21-28)37-33(40)26-8-6-24(7-9-26)25-11-15-38(16-12-25)23(2)3/h6-10,13-14,17,20-23,25H,5,11-12,15-16,18-19H2,1-4H3,(H,35,41)(H,36,37,40)
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n/an/a 5.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142326
PNG
(US8933099, 92)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCOC)ccn1
Show InChI InChI=1S/C32H37N5O5/c1-4-36-14-10-23(11-15-36)22-5-7-24(8-6-22)31(38)35-30-20-26(9-13-34-30)42-29-19-25-12-16-37(32(39)33-2)27(25)21-28(29)41-18-17-40-3/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38)
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n/an/a 5.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142282
PNG
(US8933099, 54)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C31H35N5O5/c1-20(37)19-35-13-9-22(10-14-35)21-4-6-23(7-5-21)30(38)34-29-17-25(8-12-33-29)41-28-16-24-11-15-36(31(39)32-2)26(24)18-27(28)40-3/h4-8,11-12,15-18,20,22,37H,9-10,13-14,19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m1/s1
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n/an/a 5.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142343
PNG
(US8933099, 101)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC(O)CC3)s2)c1)C(=O)NC
Show InChI InChI=1S/C30H35N5O6S/c1-3-39-14-15-40-25-18-24-20(7-13-35(24)30(38)31-2)16-26(25)41-22-6-10-32-28(17-22)33-29(37)27-5-4-23(42-27)19-34-11-8-21(36)9-12-34/h4-7,10,13,16-18,21,36H,3,8-9,11-12,14-15,19H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 5.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142254
PNG
(US8933099, 20)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCNCC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C30H33N5O5/c1-31-30(37)35-14-10-23-17-27(26(19-25(23)35)39-16-15-38-2)40-24-9-13-33-28(18-24)34-29(36)22-5-3-20(4-6-22)21-7-11-32-12-8-21/h3-6,9-10,13-14,17-19,21,32H,7-8,11-12,15-16H2,1-2H3,(H,31,37)(H,33,34,36)
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n/an/a 5.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142329
PNG
(US8933099, 95)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(CC(C)(C)O)C2)c1)C(=O)NC
Show InChI InChI=1S/C33H39N5O6/c1-5-42-14-15-43-28-18-27-24(11-13-38(27)32(40)34-4)16-29(28)44-26-10-12-35-30(17-26)36-31(39)23-8-6-22(7-9-23)25-19-37(20-25)21-33(2,3)41/h6-13,16-18,25,41H,5,14-15,19-21H2,1-4H3,(H,34,40)(H,35,36,39)
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n/an/a 5.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 5.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142323
PNG
(US8933099, 89)
Show SMILES CCN1CC(C1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCOC)ccn1
Show InChI InChI=1S/C30H33N5O5/c1-4-34-18-23(19-34)20-5-7-21(8-6-20)29(36)33-28-16-24(9-11-32-28)40-27-15-22-10-12-35(30(37)31-2)25(22)17-26(27)39-14-13-38-3/h5-12,15-17,23H,4,13-14,18-19H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 5.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 5.80n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR3 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142362
PNG
(US8933099, 128)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCCOC)cc12
Show InChI InChI=1S/C33H39N5O6/c1-34-33(41)38-15-11-26-20-30(29(22-28(26)38)43-19-3-18-42-2)44-27-8-12-35-31(21-27)36-32(40)25-6-4-23(5-7-25)24-9-13-37(14-10-24)16-17-39/h4-8,11-12,15,20-22,24,39H,3,9-10,13-14,16-19H2,1-2H3,(H,34,41)(H,35,36,40)
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n/an/a 6.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142364
PNG
(US8933099, 130)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCCOC)cc12
Show InChI InChI=1S/C32H37N5O5/c1-33-32(39)37-16-12-25-19-29(28(21-27(25)37)41-18-4-17-40-3)42-26-9-13-34-30(20-26)35-31(38)24-7-5-22(6-8-24)23-10-14-36(2)15-11-23/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38)
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n/an/a 6.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142260
PNG
(US8933099, 26)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(CC)C2)c1)C(=O)NC
Show InChI InChI=1S/C31H35N5O5/c1-4-35-19-24(20-35)21-6-8-22(9-7-21)30(37)34-29-17-25(10-12-33-29)41-28-16-23-11-13-36(31(38)32-3)26(23)18-27(28)40-15-14-39-5-2/h6-13,16-18,24H,4-5,14-15,19-20H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 6.30n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor 2


(Homo sapiens (Human))		BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 6.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142316
PNG
(US8933099, 82)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@@H]5CO)s4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C29H33N5O6S/c1-30-29(37)34-11-8-19-14-25(24(16-23(19)34)39-13-12-38-2)40-21-7-9-31-27(15-21)32-28(36)26-6-5-22(41-26)17-33-10-3-4-20(33)18-35/h5-9,11,14-16,20,35H,3-4,10,12-13,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t20-/m1/s1
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n/an/a 6.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142360
PNG
(US8933099, 126)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C34H41N5O6/c1-23(40)22-38-14-10-25(11-15-38)24-5-7-26(8-6-24)33(41)37-32-20-28(9-13-36-32)45-31-19-27-12-16-39(34(42)35-2)29(27)21-30(31)44-18-4-17-43-3/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m0/s1
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n/an/a 6.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142266
PNG
(US8933099, 102 | US8933099, 32)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C)C2)c1)C(=O)NC
Show InChI InChI=1S/C30H33N5O5/c1-4-38-13-14-39-26-17-25-22(10-12-35(25)30(37)31-2)15-27(26)40-24-9-11-32-28(16-24)33-29(36)21-7-5-20(6-8-21)23-18-34(3)19-23/h5-12,15-17,23H,4,13-14,18-19H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 6.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142320
PNG
(US8933099, 86)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)s4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C29H33N5O6S/c1-30-29(37)34-12-6-19-15-25(24(17-23(19)34)39-14-13-38-2)40-21-5-9-31-27(16-21)32-28(36)26-4-3-22(41-26)18-33-10-7-20(35)8-11-33/h3-6,9,12,15-17,20,35H,7-8,10-11,13-14,18H2,1-2H3,(H,30,37)(H,31,32,36)
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n/an/a 6.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142265
PNG
(US8933099, 100 | US8933099, 31)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@@H](O)C3)s2)c1)C(=O)NC |r|
Show InChI InChI=1S/C29H33N5O6S/c1-3-38-12-13-39-24-16-23-19(7-11-34(23)29(37)30-2)14-25(24)40-21-6-9-31-27(15-21)32-28(36)26-5-4-22(41-26)18-33-10-8-20(35)17-33/h4-7,9,11,14-16,20,35H,3,8,10,12-13,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t20-/m1/s1
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n/an/a 6.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142340
PNG
(US8933099, 98)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@@H]3CO)s2)c1)C(=O)NC |r|
Show InChI InChI=1S/C30H35N5O6S/c1-3-39-13-14-40-25-17-24-20(9-12-35(24)30(38)31-2)15-26(25)41-22-8-10-32-28(16-22)33-29(37)27-7-6-23(42-27)18-34-11-4-5-21(34)19-36/h6-10,12,15-17,21,36H,3-5,11,13-14,18-19H2,1-2H3,(H,31,38)(H,32,33,37)/t21-/m1/s1
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n/an/a 6.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142322
PNG
(US8933099, 88)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C4)C(C)C)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-20(2)35-18-24(19-35)21-5-7-22(8-6-21)30(37)34-29-16-25(9-11-33-29)41-28-15-23-10-12-36(31(38)32-3)26(23)17-27(28)40-14-13-39-4/h5-12,15-17,20,24H,13-14,18-19H2,1-4H3,(H,32,38)(H,33,34,37)
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n/an/a 6.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142319
PNG
(US8933099, 85)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@@H](O)C5)s4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C28H31N5O6S/c1-29-28(36)33-10-6-18-13-24(23(15-22(18)33)38-12-11-37-2)39-20-5-8-30-26(14-20)31-27(35)25-4-3-21(40-25)17-32-9-7-19(34)16-32/h3-6,8,10,13-15,19,34H,7,9,11-12,16-17H2,1-2H3,(H,29,36)(H,30,31,35)/t19-/m1/s1
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n/an/a 6.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142352
PNG
(US8933099, 118)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C[C@@H](C)O)C4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C32H37N5O6/c1-21(38)18-36-19-25(20-36)22-5-7-23(8-6-22)31(39)35-30-16-26(9-11-34-30)43-29-15-24-10-12-37(32(40)33-2)27(24)17-28(29)42-14-4-13-41-3/h5-12,15-17,21,25,38H,4,13-14,18-20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m1/s1
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n/an/a 7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142315
PNG
(US8933099, 81)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C[C@H](C)O)C4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-20(37)17-35-18-24(19-35)21-4-6-22(7-5-21)30(38)34-29-15-25(8-10-33-29)42-28-14-23-9-11-36(31(39)32-2)26(23)16-27(28)41-13-12-40-3/h4-11,14-16,20,24,37H,12-13,17-19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m0/s1
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n/an/a 7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142363
PNG
(US8933099, 129)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCCOC)ccn1
Show InChI InChI=1S/C33H39N5O5/c1-4-37-15-11-24(12-16-37)23-6-8-25(9-7-23)32(39)36-31-21-27(10-14-35-31)43-30-20-26-13-17-38(33(40)34-2)28(26)22-29(30)42-19-5-18-41-3/h6-10,13-14,17,20-22,24H,4-5,11-12,15-16,18-19H2,1-3H3,(H,34,40)(H,35,36,39)
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n/an/a 7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142324
PNG
(US8933099, 90)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C33H39N5O6/c1-22(39)21-37-13-9-24(10-14-37)23-4-6-25(7-5-23)32(40)36-31-19-27(8-12-35-31)44-30-18-26-11-15-38(33(41)34-2)28(26)20-29(30)43-17-16-42-3/h4-8,11-12,15,18-20,22,24,39H,9-10,13-14,16-17,21H2,1-3H3,(H,34,41)(H,35,36,40)/t22-/m1/s1
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n/an/a 7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142321
PNG
(US8933099, 87)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C)C4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C29H31N5O5/c1-30-29(36)34-11-9-21-14-26(25(16-24(21)34)38-13-12-37-3)39-23-8-10-31-27(15-23)32-28(35)20-6-4-19(5-7-20)22-17-33(2)18-22/h4-11,14-16,22H,12-13,17-18H2,1-3H3,(H,30,36)(H,31,32,35)
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n/an/a 7.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142361
PNG
(US8933099, 127)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CC4)C(C)C)c3)c(OCCCOC)cc12
Show InChI InChI=1S/C34H41N5O5/c1-23(2)38-15-11-25(12-16-38)24-6-8-26(9-7-24)33(40)37-32-21-28(10-14-36-32)44-31-20-27-13-17-39(34(41)35-3)29(27)22-30(31)43-19-5-18-42-4/h6-10,13-14,17,20-23,25H,5,11-12,15-16,18-19H2,1-4H3,(H,35,41)(H,36,37,40)
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n/an/a 7.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142238
PNG
(US8933099, 4)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C31H35N5O5/c1-20(37)19-35-13-9-22(10-14-35)21-4-6-23(7-5-21)30(38)34-29-17-25(8-12-33-29)41-28-16-24-11-15-36(31(39)32-2)26(24)18-27(28)40-3/h4-8,11-12,15-18,20,22,37H,9-10,13-14,19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m0/s1
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n/an/a 7.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142331
PNG
(US8933099, 97)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C[C@H](C)O)C2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O6/c1-4-41-13-14-42-28-17-27-24(10-12-37(27)32(40)33-3)15-29(28)43-26-9-11-34-30(16-26)35-31(39)23-7-5-22(6-8-23)25-19-36(20-25)18-21(2)38/h5-12,15-17,21,25,38H,4,13-14,18-20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m0/s1
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n/an/a 7.20n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142283
PNG
(US8933099, 39)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CC(C)(C)O)CC4)c3)c(OC)cc12
Show InChI InChI=1S/C32H37N5O5/c1-32(2,40)20-36-14-10-22(11-15-36)21-5-7-23(8-6-21)30(38)35-29-18-25(9-13-34-29)42-28-17-24-12-16-37(31(39)33-3)26(24)19-27(28)41-4/h5-9,12-13,16-19,22,40H,10-11,14-15,20H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 7.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142237
PNG
(US8933099, 3)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OC)cc12
Show InChI InChI=1S/C30H33N5O5/c1-31-30(38)35-14-10-23-17-27(26(39-2)19-25(23)35)40-24-7-11-32-28(18-24)33-29(37)22-5-3-20(4-6-22)21-8-12-34(13-9-21)15-16-36/h3-7,10-11,14,17-19,21,36H,8-9,12-13,15-16H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 7.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 7.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR3 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142309
PNG
(US8933099, 75)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OCCCF)cc12 |r|
Show InChI InChI=1S/C33H38FN5O5/c1-22(40)21-38-14-9-24(10-15-38)23-4-6-25(7-5-23)32(41)37-31-19-27(8-13-36-31)44-30-18-26-11-16-39(33(42)35-2)28(26)20-29(30)43-17-3-12-34/h4-8,11,13,16,18-20,22,24,40H,3,9-10,12,14-15,17,21H2,1-2H3,(H,35,42)(H,36,37,41)/t22-/m0/s1
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n/an/a 8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142261
PNG
(US8933099, 27)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(CCO)C2)c1)C(=O)NC
Show InChI InChI=1S/C31H35N5O6/c1-3-40-14-15-41-27-18-26-23(9-11-36(26)31(39)32-2)16-28(27)42-25-8-10-33-29(17-25)34-30(38)22-6-4-21(5-7-22)24-19-35(20-24)12-13-37/h4-11,16-18,24,37H,3,12-15,19-20H2,1-2H3,(H,32,39)(H,33,34,38)
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US Patent
n/an/a 8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142313
PNG
(US8933099, 79)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(CC(C)(C)O)C4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-32(2,40)20-36-18-24(19-36)21-5-7-22(8-6-21)30(38)35-29-16-25(9-11-34-29)43-28-15-23-10-12-37(31(39)33-3)26(23)17-27(28)42-14-13-41-4/h5-12,15-17,24,40H,13-14,18-20H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 8.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142358
PNG
(US8933099, 124)
Show SMILES CCN1CC(C1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCCOC)ccn1
Show InChI InChI=1S/C31H35N5O5/c1-4-35-19-24(20-35)21-6-8-22(9-7-21)30(37)34-29-17-25(10-12-33-29)41-28-16-23-11-13-36(31(38)32-2)26(23)18-27(28)40-15-5-14-39-3/h6-13,16-18,24H,4-5,14-15,19-20H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 8.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142267
PNG
(US8933099, 33)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCCF)ccn1
Show InChI InChI=1S/C32H36FN5O4/c1-3-37-15-10-23(11-16-37)22-5-7-24(8-6-22)31(39)36-30-20-26(9-14-35-30)42-29-19-25-12-17-38(32(40)34-2)27(25)21-28(29)41-18-4-13-33/h5-9,12,14,17,19-21,23H,3-4,10-11,13,15-16,18H2,1-2H3,(H,34,40)(H,35,36,39)
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n/an/a 8.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142314
PNG
(US8933099, 80)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C[C@@H](C)O)C4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-20(37)17-35-18-24(19-35)21-4-6-22(7-5-21)30(38)34-29-15-25(8-10-33-29)42-28-14-23-9-11-36(31(39)32-2)26(23)16-27(28)41-13-12-40-3/h4-11,14-16,20,24,37H,12-13,17-19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m1/s1
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n/an/a 8.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142308
PNG
(US8933099, 74)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OCCCF)cc12 |r|
Show InChI InChI=1S/C33H38FN5O5/c1-22(40)21-38-14-9-24(10-15-38)23-4-6-25(7-5-23)32(41)37-31-19-27(8-13-36-31)44-30-18-26-11-16-39(33(42)35-2)28(26)20-29(30)43-17-3-12-34/h4-8,11,13,16,18-20,22,24,40H,3,9-10,12,14-15,17,21H2,1-2H3,(H,35,42)(H,36,37,41)/t22-/m1/s1
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n/an/a 8.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142335
PNG
(US8933099, 105)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@H](O)C3)cc2)c1)C(=O)NC |r|
Show InChI InChI=1S/C31H35N5O6/c1-3-40-14-15-41-27-18-26-23(9-13-36(26)31(39)32-2)16-28(27)42-25-8-11-33-29(17-25)34-30(38)22-6-4-21(5-7-22)19-35-12-10-24(37)20-35/h4-9,11,13,16-18,24,37H,3,10,12,14-15,19-20H2,1-2H3,(H,32,39)(H,33,34,38)/t24-/m0/s1
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n/an/a 8.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142318
PNG
(US8933099, 84)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@H](O)C5)s4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C28H31N5O6S/c1-29-28(36)33-10-6-18-13-24(23(15-22(18)33)38-12-11-37-2)39-20-5-8-30-26(14-20)31-27(35)25-4-3-21(40-25)17-32-9-7-19(34)16-32/h3-6,8,10,13-15,19,34H,7,9,11-12,16-17H2,1-2H3,(H,29,36)(H,30,31,35)/t19-/m0/s1
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n/an/a 8.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142293
PNG
(US8933099, 59)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC2)C(C)C)c1)C(=O)NC
Show InChI InChI=1S/C32H37N5O4/c1-5-40-28-20-27-25(13-17-37(27)32(39)33-4)18-29(28)41-26-10-14-34-30(19-26)35-31(38)24-8-6-22(7-9-24)23-11-15-36(16-12-23)21(2)3/h6-10,13-14,17-21,23H,5,11-12,15-16H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 8.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142357
PNG
(US8933099, 123)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C4)C(C)C)c3)c(OCCCOC)cc12
Show InChI InChI=1S/C32H37N5O5/c1-21(2)36-19-25(20-36)22-6-8-23(9-7-22)31(38)35-30-17-26(10-12-34-30)42-29-16-24-11-13-37(32(39)33-3)27(24)18-28(29)41-15-5-14-40-4/h6-13,16-18,21,25H,5,14-15,19-20H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 8.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142344
PNG
(US8933099, 106)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CC[C@@H](O)C3)cc2)c1)C(=O)NC |r|
Show InChI InChI=1S/C31H35N5O6/c1-3-40-14-15-41-27-18-26-23(9-13-36(26)31(39)32-2)16-28(27)42-25-8-11-33-29(17-25)34-30(38)22-6-4-21(5-7-22)19-35-12-10-24(37)20-35/h4-9,11,13,16-18,24,37H,3,10,12,14-15,19-20H2,1-2H3,(H,32,39)(H,33,34,38)/t24-/m1/s1
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n/an/a 8.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142284
PNG
(US8933099, 40)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CC4)C(C)C)c3)c(OC)cc12
Show InChI InChI=1S/C31H35N5O4/c1-20(2)35-14-10-22(11-15-35)21-5-7-23(8-6-21)30(37)34-29-18-25(9-13-33-29)40-28-17-24-12-16-36(31(38)32-3)26(24)19-27(28)39-4/h5-9,12-13,16-20,22H,10-11,14-15H2,1-4H3,(H,32,38)(H,33,34,37)
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n/an/a 8.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142295
PNG
(US8933099, 61)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O5/c1-4-41-28-19-27-25(12-16-37(27)32(40)33-3)17-29(28)42-26-9-13-34-30(18-26)35-31(39)24-7-5-22(6-8-24)23-10-14-36(15-11-23)20-21(2)38/h5-9,12-13,16-19,21,23,38H,4,10-11,14-15,20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m0/s1
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n/an/a 8.90n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142294
PNG
(US8933099, 60)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@@H](C)O)CC2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O5/c1-4-41-28-19-27-25(12-16-37(27)32(40)33-3)17-29(28)42-26-9-13-34-30(18-26)35-31(39)24-7-5-22(6-8-24)23-10-14-36(15-11-23)20-21(2)38/h5-9,12-13,16-19,21,23,38H,4,10-11,14-15,20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m1/s1
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n/an/a 9.60n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142292
PNG
(US8933099, 58)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC(C)(C)O)CC2)c1)C(=O)NC
Show InChI InChI=1S/C33H39N5O5/c1-5-42-28-20-27-25(13-17-38(27)32(40)34-4)18-29(28)43-26-10-14-35-30(19-26)36-31(39)24-8-6-22(7-9-24)23-11-15-37(16-12-23)21-33(2,3)41/h6-10,13-14,17-20,23,41H,5,11-12,15-16,21H2,1-4H3,(H,34,40)(H,35,36,39)
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n/an/a 9.80n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142234
PNG
(US8933098, 1 | US8933099, 1)
Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1
Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28)
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n/an/a 9.80n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142263
PNG
(US8933099, 29)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@H]3CO)cc2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O6/c1-3-41-15-16-42-28-19-27-24(11-14-37(27)32(40)33-2)17-29(28)43-26-10-12-34-30(18-26)35-31(39)23-8-6-22(7-9-23)20-36-13-4-5-25(36)21-38/h6-12,14,17-19,25,38H,3-5,13,15-16,20-21H2,1-2H3,(H,33,40)(H,34,35,39)/t25-/m0/s1
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n/an/a 10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142291
PNG
(US8933099, 57)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OC)cc12
Show InChI InChI=1S/C29H31N5O4/c1-30-29(36)34-15-11-22-16-26(25(37-3)18-24(22)34)38-23-8-12-31-27(17-23)32-28(35)21-6-4-19(5-7-21)20-9-13-33(2)14-10-20/h4-8,11-12,15-18,20H,9-10,13-14H2,1-3H3,(H,30,36)(H,31,32,35)
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n/an/a 10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142297
PNG
(US8933099, 63)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CCO)CC2)c1)C(=O)NC
Show InChI InChI=1S/C31H35N5O5/c1-3-40-27-20-26-24(11-15-36(26)31(39)32-2)18-28(27)41-25-8-12-33-29(19-25)34-30(38)23-6-4-21(5-7-23)22-9-13-35(14-10-22)16-17-37/h4-8,11-12,15,18-20,22,37H,3,9-10,13-14,16-17H2,1-2H3,(H,32,39)(H,33,34,38)
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n/an/a 10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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US Patent
n/an/a 10.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142317
PNG
(US8933099, 83)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@H]5CO)s4)c3)c(OCCOC)cc12 |r|
Show InChI InChI=1S/C29H33N5O6S/c1-30-29(37)34-11-8-19-14-25(24(16-23(19)34)39-13-12-38-2)40-21-7-9-31-27(15-21)32-28(36)26-6-5-22(41-26)17-33-10-3-4-20(33)18-35/h5-9,11,14-16,20,35H,3-4,10,12-13,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t20-/m0/s1
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US Patent
n/an/a 10.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142349
PNG
(US8933099, 115)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC(O)CC3)cc2)c1)C(=O)NC
Show InChI InChI=1S/C32H37N5O6/c1-3-41-16-17-42-28-20-27-24(9-15-37(27)32(40)33-2)18-29(28)43-26-8-12-34-30(19-26)35-31(39)23-6-4-22(5-7-23)21-36-13-10-25(38)11-14-36/h4-9,12,15,18-20,25,38H,3,10-11,13-14,16-17,21H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 10.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142300
PNG
(US8933099, 66)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OC(C)C)cc12 |r|
Show InChI InChI=1S/C33H39N5O5/c1-21(2)42-30-19-28-26(12-16-38(28)33(41)34-4)17-29(30)43-27-9-13-35-31(18-27)36-32(40)25-7-5-23(6-8-25)24-10-14-37(15-11-24)20-22(3)39/h5-9,12-13,16-19,21-22,24,39H,10-11,14-15,20H2,1-4H3,(H,34,41)(H,35,36,40)/t22-/m0/s1
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n/an/a 10.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142310
PNG
(US8933099, 76)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCCF)cc12
Show InChI InChI=1S/C31H34FN5O4/c1-33-31(39)37-16-11-24-18-28(27(20-26(24)37)40-17-3-12-32)41-25-8-13-34-29(19-25)35-30(38)23-6-4-21(5-7-23)22-9-14-36(2)15-10-22/h4-8,11,13,16,18-20,22H,3,9-10,12,14-15,17H2,1-2H3,(H,33,39)(H,34,35,38)
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n/an/a 10.4n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142272
PNG
(US8933099, 38)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)s4)c3)c(OC)cc12
Show InChI InChI=1S/C27H29N5O5S/c1-28-27(35)32-12-6-17-13-23(22(36-2)15-21(17)32)37-19-5-9-29-25(14-19)30-26(34)24-4-3-20(38-24)16-31-10-7-18(33)8-11-31/h3-6,9,12-15,18,33H,7-8,10-11,16H2,1-2H3,(H,28,35)(H,29,30,34)
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n/an/a 10.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142285
PNG
(US8933099, 41)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(OC5CCN(C[C@@H](C)O)CC5)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-20(37)19-35-13-10-24(11-14-35)41-23-6-4-21(5-7-23)30(38)34-29-17-25(8-12-33-29)42-28-16-22-9-15-36(31(39)32-2)26(22)18-27(28)40-3/h4-9,12,15-18,20,24,37H,10-11,13-14,19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m1/s1
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n/an/a 10.6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142328
PNG
(US8933099, 94)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(nc2)C2CCN(CC2)C(C)C)c1)C(=O)NC
Show InChI InChI=1S/C33H40N6O5/c1-5-42-16-17-43-29-20-28-24(11-15-39(28)33(41)34-4)18-30(29)44-26-8-12-35-31(19-26)37-32(40)25-6-7-27(36-21-25)23-9-13-38(14-10-23)22(2)3/h6-8,11-12,15,18-23H,5,9-10,13-14,16-17H2,1-4H3,(H,34,41)(H,35,37,40)
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n/an/a 10.6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142351
PNG
(US8933099, 117)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@H]5CO)cc4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-11-24-17-29(28(19-27(24)37)42-16-4-15-41-2)43-26-10-12-34-30(18-26)35-31(39)23-8-6-22(7-9-23)20-36-13-3-5-25(36)21-38/h6-12,14,17-19,25,38H,3-5,13,15-16,20-21H2,1-2H3,(H,33,40)(H,34,35,39)/t25-/m0/s1
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n/an/a 10.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142269
PNG
(US8933099, 35)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@H]5CO)s4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C27H29N5O5S/c1-28-27(35)32-11-8-17-12-23(22(36-2)14-21(17)32)37-19-7-9-29-25(13-19)30-26(34)24-6-5-20(38-24)15-31-10-3-4-18(31)16-33/h5-9,11-14,18,33H,3-4,10,15-16H2,1-2H3,(H,28,35)(H,29,30,34)/t18-/m0/s1
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n/an/a 10.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142248
PNG
(US8933099, 14)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(OC5CCN(CCO)CC5)cc4)c3)c(OC)cc12
Show InChI InChI=1S/C30H33N5O6/c1-31-30(38)35-14-8-21-17-27(26(39-2)19-25(21)35)41-24-7-11-32-28(18-24)33-29(37)20-3-5-22(6-4-20)40-23-9-12-34(13-10-23)15-16-36/h3-8,11,14,17-19,23,36H,9-10,12-13,15-16H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 10.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142271
PNG
(US8933099, 37)
Show SMILES CCN1CCN(Cc2ccc(s2)C(=O)Nc2cc(Oc3cc4ccn(C(=O)NC)c4cc3OC)ccn2)CC1
Show InChI InChI=1S/C28H32N6O4S/c1-4-32-11-13-33(14-12-32)18-21-5-6-25(39-21)27(35)31-26-16-20(7-9-30-26)38-24-15-19-8-10-34(28(36)29-2)22(19)17-23(24)37-3/h5-10,15-17H,4,11-14,18H2,1-3H3,(H,29,36)(H,30,31,35)
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n/an/a 10.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142266
PNG
(US8933099, 102 | US8933099, 32)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C)C2)c1)C(=O)NC
Show InChI InChI=1S/C30H33N5O5/c1-4-38-13-14-39-26-17-25-22(10-12-35(25)30(37)31-2)15-27(26)40-24-9-11-32-28(16-24)33-29(36)21-7-5-20(6-8-21)23-18-34(3)19-23/h5-12,15-17,23H,4,13-14,18-19H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 10.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142240
PNG
(US8933099, 6)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCNCC4F)c3)c(OC)cc12
Show InChI InChI=1S/C28H28FN5O4/c1-30-28(36)34-12-9-19-13-25(24(37-2)15-23(19)34)38-20-7-11-32-26(14-20)33-27(35)18-5-3-17(4-6-18)21-8-10-31-16-22(21)29/h3-7,9,11-15,21-22,31H,8,10,16H2,1-2H3,(H,30,36)(H,32,33,35)
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n/an/a 11n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142330
PNG
(US8933099, 96)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C[C@@H](C)O)C2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O6/c1-4-41-13-14-42-28-17-27-24(10-12-37(27)32(40)33-3)15-29(28)43-26-9-11-34-30(16-26)35-31(39)23-7-5-22(6-8-23)25-19-36(20-25)18-21(2)38/h5-12,15-17,21,25,38H,4,13-14,18-20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m1/s1
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n/an/a 11n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142301
PNG
(US8933099, 67)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OC(C)C)cc12
Show InChI InChI=1S/C32H37N5O5/c1-21(2)41-29-20-27-25(11-15-37(27)32(40)33-3)18-28(29)42-26-8-12-34-30(19-26)35-31(39)24-6-4-22(5-7-24)23-9-13-36(14-10-23)16-17-38/h4-8,11-12,15,18-21,23,38H,9-10,13-14,16-17H2,1-3H3,(H,33,40)(H,34,35,39)
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n/an/a 11.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142262
PNG
(US8933099, 28)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(nc2)C2CCN(CC)CC2)c1)C(=O)NC
Show InChI InChI=1S/C32H38N6O5/c1-4-37-13-9-22(10-14-37)26-7-6-24(21-35-26)31(39)36-30-19-25(8-12-34-30)43-29-18-23-11-15-38(32(40)33-3)27(23)20-28(29)42-17-16-41-5-2/h6-8,11-12,15,18-22H,4-5,9-10,13-14,16-17H2,1-3H3,(H,33,40)(H,34,36,39)
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n/an/a 11.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142270
PNG
(US8933099, 36)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5C[C@H](C)N[C@H](C)C5)s4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C28H32N6O4S/c1-17-14-33(15-18(2)31-17)16-21-5-6-25(39-21)27(35)32-26-12-20(7-9-30-26)38-24-11-19-8-10-34(28(36)29-3)22(19)13-23(24)37-4/h5-13,17-18,31H,14-16H2,1-4H3,(H,29,36)(H,30,32,35)/t17-,18+
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n/an/a 11.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142353
PNG
(US8933099, 119)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C[C@H](C)O)C4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C32H37N5O6/c1-21(38)18-36-19-25(20-36)22-5-7-23(8-6-22)31(39)35-30-16-26(9-11-34-30)43-29-15-24-10-12-37(32(40)33-2)27(24)17-28(29)42-14-4-13-41-3/h5-12,15-17,21,25,38H,4,13-14,18-20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m0/s1
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n/an/a 11.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142346
PNG
(US8933099, 108)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCN(CC)CC3)cc2)c1)C(=O)NC
Show InChI InChI=1S/C33H40N6O5/c1-4-37-14-16-38(17-15-37)23-24-6-8-25(9-7-24)32(40)36-31-21-27(10-12-35-31)44-30-20-26-11-13-39(33(41)34-3)28(26)22-29(30)43-19-18-42-5-2/h6-13,20-22H,4-5,14-19,23H2,1-3H3,(H,34,41)(H,35,36,40)
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n/an/a 11.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142250
PNG
(US8933099, 16)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC)CC2)c1)C(=O)NC
Show InChI InChI=1S/C31H35N5O4/c1-4-35-15-11-22(12-16-35)21-6-8-23(9-7-21)30(37)34-29-19-25(10-14-33-29)40-28-18-24-13-17-36(31(38)32-3)26(24)20-27(28)39-5-2/h6-10,13-14,17-20,22H,4-5,11-12,15-16H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 11.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142241
PNG
(US8933099, 7)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4(F)CCNCC4)c3)c(OC)cc12
Show InChI InChI=1S/C28H28FN5O4/c1-30-27(36)34-14-8-19-15-24(23(37-2)17-22(19)34)38-21-7-11-32-25(16-21)33-26(35)18-3-5-20(6-4-18)28(29)9-12-31-13-10-28/h3-8,11,14-17,31H,9-10,12-13H2,1-2H3,(H,30,36)(H,32,33,35)
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n/an/a 11.6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142288
PNG
(US8933099, 49)
Show SMILES CCN1CC(C1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C28H29N5O4/c1-4-32-16-21(17-32)18-5-7-19(8-6-18)27(34)31-26-14-22(9-11-30-26)37-25-13-20-10-12-33(28(35)29-2)23(20)15-24(25)36-3/h5-15,21H,4,16-17H2,1-3H3,(H,29,35)(H,30,31,34)
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n/an/a 11.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142302
PNG
(US8933099, 68)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC(C)C)ccn1
Show InChI InChI=1S/C32H37N5O4/c1-5-36-15-11-23(12-16-36)22-6-8-24(9-7-22)31(38)35-30-19-26(10-14-34-30)41-28-18-25-13-17-37(32(39)33-4)27(25)20-29(28)40-21(2)3/h6-10,13-14,17-21,23H,5,11-12,15-16H2,1-4H3,(H,33,39)(H,34,35,38)
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n/an/a 11.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142298
PNG
(US8933099, 64)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C)CC2)c1)C(=O)NC
Show InChI InChI=1S/C30H33N5O4/c1-4-38-26-19-25-23(12-16-35(25)30(37)31-2)17-27(26)39-24-9-13-32-28(18-24)33-29(36)22-7-5-20(6-8-22)21-10-14-34(3)15-11-21/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 11.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142239
PNG
(US8933099, 5)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCCF)CC4)c3)c(OC)cc12
Show InChI InChI=1S/C31H34FN5O4/c1-33-31(39)37-17-11-24-18-28(27(40-2)20-26(24)37)41-25-8-13-34-29(19-25)35-30(38)23-6-4-21(5-7-23)22-9-15-36(16-10-22)14-3-12-32/h4-8,11,13,17-20,22H,3,9-10,12,14-16H2,1-2H3,(H,33,39)(H,34,35,38)
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n/an/a 12n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142334
PNG
(US8933099, 104)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@@H]3CO)cc2)c1)C(=O)NC |r|
Show InChI InChI=1S/C32H37N5O6/c1-3-41-15-16-42-28-19-27-24(11-14-37(27)32(40)33-2)17-29(28)43-26-10-12-34-30(18-26)35-31(39)23-8-6-22(7-9-23)20-36-13-4-5-25(36)21-38/h6-12,14,17-19,25,38H,3-5,13,15-16,20-21H2,1-2H3,(H,33,40)(H,34,35,39)/t25-/m1/s1
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n/an/a 12.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142287
PNG
(US8933099, 48)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(CC(C)(C)O)C4)c3)c(OC)cc12
Show InChI InChI=1S/C30H33N5O5/c1-30(2,38)18-34-16-22(17-34)19-5-7-20(8-6-19)28(36)33-27-14-23(9-11-32-27)40-26-13-21-10-12-35(29(37)31-3)24(21)15-25(26)39-4/h5-15,22,38H,16-18H2,1-4H3,(H,31,37)(H,32,33,36)
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n/an/a 12.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142268
PNG
(US8933099, 34)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@@H]5CO)s4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C27H29N5O5S/c1-28-27(35)32-11-8-17-12-23(22(36-2)14-21(17)32)37-19-7-9-29-25(13-19)30-26(34)24-6-5-20(38-24)15-31-10-3-4-18(31)16-33/h5-9,11-14,18,33H,3-4,10,15-16H2,1-2H3,(H,28,35)(H,29,30,34)/t18-/m1/s1
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n/an/a 12.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142303
PNG
(US8933099, 69)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OC(C)C)cc12
Show InChI InChI=1S/C31H35N5O4/c1-20(2)39-28-19-26-24(12-16-36(26)31(38)32-3)17-27(28)40-25-9-13-33-29(18-25)34-30(37)23-7-5-21(6-8-23)22-10-14-35(4)15-11-22/h5-9,12-13,16-20,22H,10-11,14-15H2,1-4H3,(H,32,38)(H,33,34,37)
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n/an/a 12.4n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142249
PNG
(US8933099, 15)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCNCC2)c1)C(=O)NC
Show InChI InChI=1S/C29H31N5O4/c1-3-37-25-18-24-22(11-15-34(24)29(36)30-2)16-26(25)38-23-10-14-32-27(17-23)33-28(35)21-6-4-19(5-7-21)20-8-12-31-13-9-20/h4-7,10-11,14-18,20,31H,3,8-9,12-13H2,1-2H3,(H,30,36)(H,32,33,35)
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n/an/a 12.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142274
PNG
(US8933099, 43)
Show SMILES CCN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O5/c1-4-34-14-11-23(12-15-34)39-22-7-5-20(6-8-22)29(36)33-28-18-24(9-13-32-28)40-27-17-21-10-16-35(30(37)31-2)25(21)19-26(27)38-3/h5-10,13,16-19,23H,4,11-12,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 12.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142252
PNG
(US8933099, 18)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OC(C)C)cc12 |r|
Show InChI InChI=1S/C33H39N5O5/c1-21(2)42-30-19-28-26(12-16-38(28)33(41)34-4)17-29(30)43-27-9-13-35-31(18-27)36-32(40)25-7-5-23(6-8-25)24-10-14-37(15-11-24)20-22(3)39/h5-9,12-13,16-19,21-22,24,39H,10-11,14-15,20H2,1-4H3,(H,34,41)(H,35,36,40)/t22-/m1/s1
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n/an/a 12.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142286
PNG
(US8933099, 47)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CN(C4)C(C)C)c3)c(OC)cc12
Show InChI InChI=1S/C29H31N5O4/c1-18(2)33-16-22(17-33)19-5-7-20(8-6-19)28(35)32-27-14-23(9-11-31-27)38-26-13-21-10-12-34(29(36)30-3)24(21)15-25(26)37-4/h5-15,18,22H,16-17H2,1-4H3,(H,30,36)(H,31,32,35)
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n/an/a 12.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142273
PNG
(US8933099, 42)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(OC5CCN(C[C@H](C)O)CC5)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-20(37)19-35-13-10-24(11-14-35)41-23-6-4-21(5-7-23)30(38)34-29-17-25(8-12-33-29)42-28-16-22-9-15-36(31(39)32-2)26(22)18-27(28)40-3/h4-9,12,15-18,20,24,37H,10-11,13-14,19H2,1-3H3,(H,32,39)(H,33,34,38)/t20-/m0/s1
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n/an/a 13n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142242
PNG
(US8933099, 8)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)N4CCC(CC4)N4CCCC4)c3)c(OC)cc12
Show InChI InChI=1S/C32H36N6O4/c1-33-32(40)38-18-10-23-19-29(28(41-2)21-27(23)38)42-26-9-13-34-30(20-26)35-31(39)22-5-7-24(8-6-22)37-16-11-25(12-17-37)36-14-3-4-15-36/h5-10,13,18-21,25H,3-4,11-12,14-17H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 13.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142253
PNG
(US8933099, 19)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OC(F)F)cc12
Show InChI InChI=1S/C29H29F2N5O5/c1-32-29(39)36-13-7-20-14-24(25(16-23(20)36)41-28(30)31)40-22-6-10-33-26(15-22)34-27(38)19-4-2-18(3-5-19)17-35-11-8-21(37)9-12-35/h2-7,10,13-16,21,28,37H,8-9,11-12,17H2,1H3,(H,32,39)(H,33,34,38)
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n/an/a 13.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142264
PNG
(US8933099, 30)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)c1)C(=O)NC |r|
Show InChI InChI=1S/C33H40N6O5/c1-5-42-14-15-43-29-18-28-26(11-13-39(28)33(41)34-4)16-30(29)44-27-10-12-35-31(17-27)37-32(40)25-8-6-24(7-9-25)21-38-19-22(2)36-23(3)20-38/h6-13,16-18,22-23,36H,5,14-15,19-21H2,1-4H3,(H,34,41)(H,35,37,40)/t22-,23+
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n/an/a 14.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142251
PNG
(US8933099, 17)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCNCC4)c3)c(OC(C)C)cc12
Show InChI InChI=1S/C30H33N5O4/c1-19(2)38-27-18-25-23(11-15-35(25)30(37)31-3)16-26(27)39-24-10-14-33-28(17-24)34-29(36)22-6-4-20(5-7-22)21-8-12-32-13-9-21/h4-7,10-11,14-19,21,32H,8-9,12-13H2,1-3H3,(H,31,37)(H,33,34,36)
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n/an/a 14.6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142327
PNG
(US8933099, 93)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O6/c1-32-31(39)36-14-8-23-17-28(27(19-26(23)36)41-16-15-40-2)42-25-7-11-33-29(18-25)34-30(38)22-5-3-21(4-6-22)20-35-12-9-24(37)10-13-35/h3-8,11,14,17-19,24,37H,9-10,12-13,15-16,20H2,1-2H3,(H,32,39)(H,33,34,38)
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n/an/a 14.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142355
PNG
(US8933099, 121)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@@H](O)C5)cc4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-32-31(39)36-13-9-23-16-28(27(18-26(23)36)41-15-3-14-40-2)42-25-8-11-33-29(17-25)34-30(38)22-6-4-21(5-7-22)19-35-12-10-24(37)20-35/h4-9,11,13,16-18,24,37H,3,10,12,14-15,19-20H2,1-2H3,(H,32,39)(H,33,34,38)/t24-/m1/s1
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n/an/a 16.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142345
PNG
(US8933099, 107)
Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC(F)CC3)cc2)c1)C(=O)NC
Show InChI InChI=1S/C32H36FN5O5/c1-3-41-16-17-42-28-20-27-24(9-15-38(27)32(40)34-2)18-29(28)43-26-8-12-35-30(19-26)36-31(39)23-6-4-22(5-7-23)21-37-13-10-25(33)11-14-37/h4-9,12,15,18-20,25H,3,10-11,13-14,16-17,21H2,1-2H3,(H,34,40)(H,35,36,39)
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n/an/a 16.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142354
PNG
(US8933099, 120)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@H](O)C5)cc4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C31H35N5O6/c1-32-31(39)36-13-9-23-16-28(27(18-26(23)36)41-15-3-14-40-2)42-25-8-11-33-29(17-25)34-30(38)22-6-4-21(5-7-22)19-35-12-10-24(37)20-35/h4-9,11,13,16-18,24,37H,3,10,12,14-15,19-20H2,1-2H3,(H,32,39)(H,33,34,38)/t24-/m0/s1
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n/an/a 16.6n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142356
PNG
(US8933099, 122)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OCCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-15-9-24-18-29(28(20-27(24)37)42-17-3-16-41-2)43-26-8-12-34-30(19-26)35-31(39)23-6-4-22(5-7-23)21-36-13-10-25(38)11-14-36/h4-9,12,15,18-20,25,38H,3,10-11,13-14,16-17,21H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 17.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142245
PNG
(US8933099, 11)
Show SMILES CCN1CCN(CCc2ccc(cc2)C(=O)Nc2cc(Oc3cc4ccn(C(=O)NC)c4cc3OC)ccn2)CC1
Show InChI InChI=1S/C31H36N6O4/c1-4-35-15-17-36(18-16-35)13-10-22-5-7-23(8-6-22)30(38)34-29-20-25(9-12-33-29)41-28-19-24-11-14-37(31(39)32-2)26(24)21-27(28)40-3/h5-9,11-12,14,19-21H,4,10,13,15-18H2,1-3H3,(H,32,39)(H,33,34,38)
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n/an/a 18n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142279
PNG
(US8933099, 51)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@H]5CO)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C29H31N5O5/c1-30-29(37)34-13-10-21-14-26(25(38-2)16-24(21)34)39-23-9-11-31-27(15-23)32-28(36)20-7-5-19(6-8-20)17-33-12-3-4-22(33)18-35/h5-11,13-16,22,35H,3-4,12,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t22-/m0/s1
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n/an/a 18.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142305
PNG
(US8933099, 71)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@H](O)C5)cc4)c3)c(OCCCF)cc12 |r|
Show InChI InChI=1S/C30H32FN5O5/c1-32-30(39)36-13-8-22-15-27(26(17-25(22)36)40-14-2-10-31)41-24-7-11-33-28(16-24)34-29(38)21-5-3-20(4-6-21)18-35-12-9-23(37)19-35/h3-8,11,13,15-17,23,37H,2,9-10,12,14,18-19H2,1H3,(H,32,39)(H,33,34,38)/t23-/m0/s1
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n/an/a 18.4n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142296
PNG
(US8933099, 62)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)N2CCC(CC2)N2CCCC2)c1)C(=O)NC
Show InChI InChI=1S/C33H38N6O4/c1-3-42-29-22-28-24(11-19-39(28)33(41)34-2)20-30(29)43-27-10-14-35-31(21-27)36-32(40)23-6-8-25(9-7-23)38-17-12-26(13-18-38)37-15-4-5-16-37/h6-11,14,19-22,26H,3-5,12-13,15-18H2,1-2H3,(H,34,41)(H,35,36,40)
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n/an/a 18.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142311
PNG
(US8933099, 77)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(nc4)C4CCN(CC4)C(C)C)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H38N6O5/c1-21(2)37-12-8-22(9-13-37)26-6-5-24(20-35-26)31(39)36-30-18-25(7-11-34-30)43-29-17-23-10-14-38(32(40)33-3)27(23)19-28(29)42-16-15-41-4/h5-7,10-11,14,17-22H,8-9,12-13,15-16H2,1-4H3,(H,33,40)(H,34,36,39)
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n/an/a 19.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142246
PNG
(US8933099, 12)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(OCCN5CCC(O)CC5)cc4)c3)c(OC)cc12
Show InChI InChI=1S/C30H33N5O6/c1-31-30(38)35-14-8-21-17-27(26(39-2)19-25(21)35)41-24-7-11-32-28(18-24)33-29(37)20-3-5-23(6-4-20)40-16-15-34-12-9-22(36)10-13-34/h3-8,11,14,17-19,22,36H,9-10,12-13,15-16H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 19.9n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142312
PNG
(US8933099, 78)
Show SMILES CCN1CCC(CC1)c1ccc(cn1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OCCOC)ccn1
Show InChI InChI=1S/C31H36N6O5/c1-4-36-12-8-21(9-13-36)25-6-5-23(20-34-25)30(38)35-29-18-24(7-11-33-29)42-28-17-22-10-14-37(31(39)32-2)26(22)19-27(28)41-16-15-40-3/h5-7,10-11,14,17-21H,4,8-9,12-13,15-16H2,1-3H3,(H,32,39)(H,33,35,38)
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n/an/a 20.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142350
PNG
(US8933099, 116)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@@H]5CO)cc4)c3)c(OCCCOC)cc12 |r|
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-11-24-17-29(28(19-27(24)37)42-16-4-15-41-2)43-26-10-12-34-30(18-26)35-31(39)23-8-6-22(7-9-23)20-36-13-3-5-25(36)21-38/h6-12,14,17-19,25,38H,3-5,13,15-16,20-21H2,1-2H3,(H,33,40)(H,34,35,39)/t25-/m1/s1
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n/an/a 22.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142306
PNG
(US8933099, 72)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@@H](O)C5)cc4)c3)c(OCCCF)cc12 |r|
Show InChI InChI=1S/C30H32FN5O5/c1-32-30(39)36-13-8-22-15-27(26(17-25(22)36)40-14-2-10-31)41-24-7-11-33-28(16-24)34-29(38)21-5-3-20(4-6-21)18-35-12-9-23(37)19-35/h3-8,11,13,15-17,23,37H,2,9-10,12,14,18-19H2,1H3,(H,32,39)(H,33,34,38)/t23-/m1/s1
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n/an/a 22.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142275
PNG
(US8933099, 44)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4cnn(c4)C4CCN(C[C@@H](C)O)CC4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C28H33N7O5/c1-18(36)16-33-9-6-21(7-10-33)35-17-20(15-31-35)27(37)32-26-13-22(4-8-30-26)40-25-12-19-5-11-34(28(38)29-2)23(19)14-24(25)39-3/h4-5,8,11-15,17-18,21,36H,6-7,9-10,16H2,1-3H3,(H,29,38)(H,30,32,37)/t18-/m1/s1
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n/an/a 22.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142281
PNG
(US8933099, 53)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@@H](O)C5)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C28H29N5O5/c1-29-28(36)33-12-8-20-13-25(24(37-2)15-23(20)33)38-22-7-10-30-26(14-22)31-27(35)19-5-3-18(4-6-19)16-32-11-9-21(34)17-32/h3-8,10,12-15,21,34H,9,11,16-17H2,1-2H3,(H,29,36)(H,30,31,35)/t21-/m1/s1
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n/an/a 23.4n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142280
PNG
(US8933099, 52)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CC[C@H](O)C5)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C28H29N5O5/c1-29-28(36)33-12-8-20-13-25(24(37-2)15-23(20)33)38-22-7-10-30-26(14-22)31-27(35)19-5-3-18(4-6-19)16-32-11-9-21(34)17-32/h3-8,10,12-15,21,34H,9,11,16-17H2,1-2H3,(H,29,36)(H,30,31,35)/t21-/m0/s1
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n/an/a 23.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142277
PNG
(US8933099, 46)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4cnn(c4)C4CCN(CC4)C(C)C)c3)c(OC)cc12
Show InChI InChI=1S/C28H33N7O4/c1-18(2)33-10-7-21(8-11-33)35-17-20(16-31-35)27(36)32-26-14-22(5-9-30-26)39-25-13-19-6-12-34(28(37)29-3)23(19)15-24(25)38-4/h5-6,9,12-18,21H,7-8,10-11H2,1-4H3,(H,29,37)(H,30,32,36)
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n/an/a 24.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142307
PNG
(US8933099, 73)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OCCCF)cc12
Show InChI InChI=1S/C31H34FN5O5/c1-33-31(40)37-15-8-23-17-28(27(19-26(23)37)41-16-2-11-32)42-25-7-12-34-29(18-25)35-30(39)22-5-3-21(4-6-22)20-36-13-9-24(38)10-14-36/h3-8,12,15,17-19,24,38H,2,9-11,13-14,16,20H2,1H3,(H,33,40)(H,34,35,39)
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n/an/a 24.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142290
PNG
(US8933099, 56)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CCN5CCC(O)CC5)cc4)c3)c(OC)cc12
Show InChI InChI=1S/C30H33N5O5/c1-31-30(38)35-16-9-22-17-27(26(39-2)19-25(22)35)40-24-7-12-32-28(18-24)33-29(37)21-5-3-20(4-6-21)8-13-34-14-10-23(36)11-15-34/h3-7,9,12,16-19,23,36H,8,10-11,13-15H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 24.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142276
PNG
(US8933099, 45)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4cnn(c4)C4CCN(C[C@H](C)O)CC4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C28H33N7O5/c1-18(36)16-33-9-6-21(7-10-33)35-17-20(15-31-35)27(37)32-26-13-22(4-8-30-26)40-25-12-19-5-11-34(28(38)29-2)23(19)14-24(25)39-3/h4-5,8,11-15,17-18,21,36H,6-7,9-10,16H2,1-3H3,(H,29,38)(H,30,32,37)/t18-/m0/s1
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n/an/a 26.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142243
PNG
(US8933099, 9)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OC)cc12
Show InChI InChI=1S/C29H31N5O5/c1-30-29(37)34-14-8-21-15-26(25(38-2)17-24(21)34)39-23-7-11-31-27(16-23)32-28(36)20-5-3-19(4-6-20)18-33-12-9-22(35)10-13-33/h3-8,11,14-17,22,35H,9-10,12-13,18H2,1-2H3,(H,30,37)(H,31,32,36)
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n/an/a 30n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142247
PNG
(US8933099, 13)
Show SMILES CCN1CCC(CC1)n1cc(cn1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C27H31N7O4/c1-4-32-10-7-20(8-11-32)34-17-19(16-30-34)26(35)31-25-14-21(5-9-29-25)38-24-13-18-6-12-33(27(36)28-2)22(18)15-23(24)37-3/h5-6,9,12-17,20H,4,7-8,10-11H2,1-3H3,(H,28,36)(H,29,31,35)
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n/an/a 31.2n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142304
PNG
(US8933099, 70)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC(O)CC5)cc4)c3)c(OC(C)C)cc12
Show InChI InChI=1S/C31H35N5O5/c1-20(2)40-28-18-26-23(9-15-36(26)31(39)32-3)16-27(28)41-25-8-12-33-29(17-25)34-30(38)22-6-4-21(5-7-22)19-35-13-10-24(37)11-14-35/h4-9,12,15-18,20,24,37H,10-11,13-14,19H2,1-3H3,(H,32,39)(H,33,34,38)
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n/an/a 32n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142278
PNG
(US8933099, 50)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5CCC[C@@H]5CO)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C29H31N5O5/c1-30-29(37)34-13-10-21-14-26(25(38-2)16-24(21)34)39-23-9-11-31-27(15-23)32-28(36)20-7-5-19(6-8-20)17-33-12-3-4-22(33)18-35/h5-11,13-16,22,35H,3-4,12,17-18H2,1-2H3,(H,30,37)(H,31,32,36)/t22-/m1/s1
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n/an/a 32.3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142299
PNG
(US8933099, 65)
Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC(O)CC3)cc2)c1)C(=O)NC
Show InChI InChI=1S/C30H33N5O5/c1-3-39-26-18-25-22(9-15-35(25)30(38)31-2)16-27(26)40-24-8-12-32-28(17-24)33-29(37)21-6-4-20(5-7-21)19-34-13-10-23(36)11-14-34/h4-9,12,15-18,23,36H,3,10-11,13-14,19H2,1-2H3,(H,31,38)(H,32,33,37)
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n/an/a 33.8n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142289
PNG
(US8933099, 55)
Show SMILES CCN1CCN(CCOc2ccc(cc2)C(=O)Nc2cc(Oc3cc4ccn(C(=O)NC)c4cc3OC)ccn2)CC1
Show InChI InChI=1S/C31H36N6O5/c1-4-35-13-15-36(16-14-35)17-18-41-24-7-5-22(6-8-24)30(38)34-29-20-25(9-11-33-29)42-28-19-23-10-12-37(31(39)32-2)26(23)21-27(28)40-3/h5-12,19-21H,4,13-18H2,1-3H3,(H,32,39)(H,33,34,38)
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n/an/a 34.1n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM142244
PNG
(US8933099, 10)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(CN5C[C@H](O)[C@H](C5)OC)cc4)c3)c(OC)cc12 |r|
Show InChI InChI=1S/C29H31N5O6/c1-30-29(37)34-11-9-20-12-25(24(38-2)14-22(20)34)40-21-8-10-31-27(13-21)32-28(36)19-6-4-18(5-7-19)15-33-16-23(35)26(17-33)39-3/h4-14,23,26,35H,15-17H2,1-3H3,(H,30,37)(H,31,32,36)/t23-,26-/m0/s1
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n/an/a 37.7n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 645n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR4 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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n/an/a 651n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR4 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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n/an/a 683n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR4 protein is measured.To each well of a flat b...

US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%