BDBM142295 US8933099, 61

SMILES: CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC

InChI Key: InChIKey=NKBVMJLNCYTGJZ-NRFANRHFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 142295   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM142295 (US8933099, 61) Show SMILES CCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC |r| Show InChI InChI=1S/C32H37N5O5/c1-4-41-28-19-27-25(12-16-37(27)32(40)33-3)17-29(28)42-26-9-13-34-30(18-26)35-31(39)24-7-5-22(6-8-24)23-10-14-36(15-11-23)20-21(2)38/h5-9,12-13,16-19,21,23,38H,4,10-11,14-15,20H2,1-3H3,(H,33,40)(H,34,35,39)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...				US Patent US8933099 (2015) BindingDB Entry DOI: 10.7270/Q28S4NMG
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