Found 45 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107023
(US8592579, 288)Show SMILES CC1(CC1)c1cc(Nc2nc(nn3cccc23)N2C[C@@H](O)C[C@H]2C(=O)Nc2ncns2)[nH]n1 |r| Show InChI InChI=1S/C20H22N10O2S/c1-20(4-5-20)14-8-15(27-26-14)23-16-12-3-2-6-30(12)28-18(24-16)29-9-11(31)7-13(29)17(32)25-19-21-10-22-33-19/h2-3,6,8,10-11,13,31H,4-5,7,9H2,1H3,(H,21,22,25,32)(H2,23,24,26,27,28)/t11-,13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107016
(US8592579, 219)Show SMILES CO[C@@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1 |r| Show InChI InChI=1S/C23H24FN9O2/c1-35-15-9-18(22(34)26-14-6-7-19(24)25-11-14)32(12-15)23-28-21(17-3-2-8-33(17)31-23)27-20-10-16(29-30-20)13-4-5-13/h2-3,6-8,10-11,13,15,18H,4-5,9,12H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t15-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107018
(US8592579, 254)Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1 |r| Show InChI InChI=1S/C23H24FN9O2/c1-35-15-9-18(22(34)26-14-6-7-19(24)25-11-14)32(12-15)23-28-21(17-3-2-8-33(17)31-23)27-20-10-16(29-30-20)13-4-5-13/h2-3,6-8,10-11,13,15,18H,4-5,9,12H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t15-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107013
(US8592579, 211)Show SMILES O[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1cccnc1 |r| Show InChI InChI=1S/C22H23N9O2/c32-15-9-18(21(33)24-14-3-1-7-23-11-14)30(12-15)22-26-20(17-4-2-8-31(17)29-22)25-19-10-16(27-28-19)13-5-6-13/h1-4,7-8,10-11,13,15,18,32H,5-6,9,12H2,(H,24,33)(H2,25,26,27,28,29)/t15-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107003
(CHEMBL575447 | US8592579, 110)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1cnccn1 |r| Show InChI InChI=1S/C22H24N10O/c1-22(20(33)26-18-13-23-8-9-24-18)7-3-10-31(22)21-27-19(16-4-2-11-32(16)30-21)25-17-12-15(28-29-17)14-5-6-14/h2,4,8-9,11-14H,3,5-7,10H2,1H3,(H,24,26,33)(H2,25,27,28,29,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107021
(US8592579, 259)Show SMILES CC1(CC1)c1cc(Nc2nc(nn3cccc23)N2C[C@@H](O)C[C@H]2C(=O)Nc2cnccn2)[nH]n1 |r| Show InChI InChI=1S/C22H24N10O2/c1-22(4-5-22)16-10-17(29-28-16)25-19-14-3-2-8-32(14)30-21(27-19)31-12-13(33)9-15(31)20(34)26-18-11-23-6-7-24-18/h2-3,6-8,10-11,13,15,33H,4-5,9,12H2,1H3,(H,24,26,34)(H2,25,27,28,29,30)/t13-,15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107020
(US8592579, 256)Show SMILES CO[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H22N10O2S/c1-32-12-7-15(18(31)25-20-21-10-22-33-20)29(9-12)19-24-17(14-3-2-6-30(14)28-19)23-16-8-13(26-27-16)11-4-5-11/h2-3,6,8,10-12,15H,4-5,7,9H2,1H3,(H,21,22,25,31)(H2,23,24,26,27,28)/t12-,15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107026
(US8592579, 301)Show SMILES Cc1nnn(n1)[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1 |r| Show InChI InChI=1S/C24H24FN13O/c1-13-30-35-38(33-13)16-9-19(23(39)27-15-6-7-20(25)26-11-15)36(12-16)24-29-22(18-3-2-8-37(18)34-24)28-21-10-17(31-32-21)14-4-5-14/h2-3,6-8,10-11,14,16,19H,4-5,9,12H2,1H3,(H,27,39)(H2,28,29,31,32,34)/t16-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107012
(US8592579, 209)Show SMILES O[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1cnccn1 |r| Show InChI InChI=1S/C21H22N10O2/c32-13-8-16(20(33)25-18-10-22-5-6-23-18)30(11-13)21-26-19(15-2-1-7-31(15)29-21)24-17-9-14(27-28-17)12-3-4-12/h1-2,5-7,9-10,12-13,16,32H,3-4,8,11H2,(H,23,25,33)(H2,24,26,27,28,29)/t13-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107000
(US8592579, 104)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1 |r| Show InChI InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107024
(US8592579, 293)Show SMILES F[C@@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ncns1 |r| Show InChI InChI=1S/C19H19FN10OS/c20-11-6-14(17(31)25-19-21-9-22-32-19)29(8-11)18-24-16(13-2-1-5-30(13)28-18)23-15-7-12(26-27-15)10-3-4-10/h1-2,5,7,9-11,14H,3-4,6,8H2,(H,21,22,25,31)(H2,23,24,26,27,28)/t11-,14+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107028
(US8592579, 318)Show SMILES F[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ncns1 |r| Show InChI InChI=1S/C19H19FN10OS/c20-11-6-14(17(31)25-19-21-9-22-32-19)29(8-11)18-24-16(13-2-1-5-30(13)28-18)23-15-7-12(26-27-15)10-3-4-10/h1-2,5,7,9-11,14H,3-4,6,8H2,(H,21,22,25,31)(H2,23,24,26,27,28)/t11-,14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107022
(US8592579, 287)Show SMILES O[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ncns1 |r| Show InChI InChI=1S/C19H20N10O2S/c30-11-6-14(17(31)24-19-20-9-21-32-19)28(8-11)18-23-16(13-2-1-5-29(13)27-18)22-15-7-12(25-26-15)10-3-4-10/h1-2,5,7,9-11,14,30H,3-4,6,8H2,(H,20,21,24,31)(H2,22,23,25,26,27)/t11-,14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107001
(US8592579, 105)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23N9OS/c1-21(18(31)25-20-22-8-11-32-20)7-3-9-29(21)19-24-17(15-4-2-10-30(15)28-19)23-16-12-14(26-27-16)13-5-6-13/h2,4,8,10-13H,3,5-7,9H2,1H3,(H,22,25,31)(H2,23,24,26,27,28)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107025
(US8592579, 294)Show SMILES CC1(CC1)c1cc(Nc2nc(nn3cccc23)N2C[C@H](F)C[C@H]2C(=O)Nc2ncns2)[nH]n1 |r| Show InChI InChI=1S/C20H21FN10OS/c1-20(4-5-20)14-8-15(28-27-14)24-16-12-3-2-6-31(12)29-18(25-16)30-9-11(21)7-13(30)17(32)26-19-22-10-23-33-19/h2-3,6,8,10-11,13H,4-5,7,9H2,1H3,(H,22,23,26,32)(H2,24,25,27,28,29)/t11-,13+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107015
(US8592579, 216)Show SMILES O[C@@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1nccs1 |r| Show InChI InChI=1S/C20H21N9O2S/c30-12-8-15(18(31)24-20-21-5-7-32-20)28(10-12)19-23-17(14-2-1-6-29(14)27-19)22-16-9-13(25-26-16)11-3-4-11/h1-2,5-7,9,11-12,15,30H,3-4,8,10H2,(H,21,24,31)(H2,22,23,25,26,27)/t12-,15+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107017
(US8592579, 243)Show SMILES CC(C)N1CCCC(C1)NC(=O)C1C[C@H](O)CN1c1nc(Nc2cn(cn2)C(C)C)c2cccn2n1 |r| Show InChI InChI=1S/C25H37N9O2/c1-16(2)31-9-5-7-18(12-31)27-24(36)21-11-19(35)13-33(21)25-29-23(20-8-6-10-34(20)30-25)28-22-14-32(15-26-22)17(3)4/h6,8,10,14-19,21,35H,5,7,9,11-13H2,1-4H3,(H,27,36)(H,28,29,30)/t18?,19-,21?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107004
(US8592579, 111)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1ccncn1 |r| Show InChI InChI=1S/C22H24N10O/c1-22(20(33)26-17-7-9-23-13-24-17)8-3-10-31(22)21-27-19(16-4-2-11-32(16)30-21)25-18-12-15(28-29-18)14-5-6-14/h2,4,7,9,11-14H,3,5-6,8,10H2,1H3,(H,23,24,26,33)(H2,25,27,28,29,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107027
(US8592579, 317)Show SMILES C[C@]1(CCCN1c1nc(Nc2ncc(s2)C(N)=O)c2cccn2n1)C(=O)Nc1ccc(F)nc1 |r| Show InChI InChI=1S/C21H20FN9O2S/c1-21(18(33)26-12-5-6-15(22)24-10-12)7-3-8-30(21)19-27-17(13-4-2-9-31(13)29-19)28-20-25-11-14(34-20)16(23)32/h2,4-6,9-11H,3,7-8H2,1H3,(H2,23,32)(H,26,33)(H,25,27,28,29)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107002
(US8592579, 107)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)Nc1ncc(Cl)s1 |r| Show InChI InChI=1S/C21H22ClN9OS/c1-21(18(32)26-20-23-11-15(22)33-20)7-3-8-30(21)19-25-17(14-4-2-9-31(14)29-19)24-16-10-13(27-28-16)12-5-6-12/h2,4,9-12H,3,5-8H2,1H3,(H,23,26,32)(H2,24,25,27,28,29)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107009
(US8592579, 154)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1ncccn1 |r| Show InChI InChI=1S/C22H24N10O/c1-22(19(33)27-20-23-9-4-10-24-20)8-3-11-31(22)21-26-18(16-5-2-12-32(16)30-21)25-17-13-15(28-29-17)14-6-7-14/h2,4-5,9-10,12-14H,3,6-8,11H2,1H3,(H,23,24,27,33)(H2,25,26,28,29,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107010
(US8592579, 188)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C(N)=O)c2cccn2n1)C(=O)Nc1ccc(N)nc1 |r| Show InChI InChI=1S/C21H23N11O2/c1-21(19(34)25-12-5-6-15(22)24-11-12)7-3-8-31(21)20-27-18(14-4-2-9-32(14)30-20)26-16-10-13(17(23)33)28-29-16/h2,4-6,9-11H,3,7-8H2,1H3,(H2,22,24)(H2,23,33)(H,25,34)(H2,26,27,28,29,30)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107007
(US8592579, 134)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1cc(n[nH]1)C1CC1 |r| Show InChI InChI=1S/C24H28N10O/c1-24(22(35)26-20-13-17(29-31-20)15-7-8-15)9-3-10-33(24)23-27-21(18-4-2-11-34(18)32-23)25-19-12-16(28-30-19)14-5-6-14/h2,4,11-15H,3,5-10H2,1H3,(H2,26,29,31,35)(H2,25,27,28,30,32)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50299139
((R)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)Show SMILES NC(=O)[C@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C17H20N8O/c18-15(26)12-3-1-7-24(12)17-20-16(13-4-2-8-25(13)23-17)19-14-9-11(21-22-14)10-5-6-10/h2,4,8-10,12H,1,3,5-7H2,(H2,18,26)(H2,19,20,21,22,23)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106999
(US8592579, 97)Show SMILES CC(C)(N)C(=O)N1CCCC(C1)NC(=O)[C@@H]1CCCN1c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C26H36N10O2/c1-26(2,27)24(38)34-11-3-6-17(15-34)28-23(37)20-8-4-12-35(20)25-30-22(19-7-5-13-36(19)33-25)29-21-14-18(31-32-21)16-9-10-16/h5,7,13-14,16-17,20H,3-4,6,8-12,15,27H2,1-2H3,(H,28,37)(H2,29,30,31,32,33)/t17?,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106990
(US8592579, 55)Show SMILES O=C(NC1CCCNC1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H29N9O/c32-21(24-15-4-1-9-23-13-15)18-6-2-10-30(18)22-26-20(17-5-3-11-31(17)29-22)25-19-12-16(27-28-19)14-7-8-14/h3,5,11-12,14-15,18,23H,1-2,4,6-10,13H2,(H,24,32)(H2,25,26,27,28,29)/t15?,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106988
(US8592579, 44)Show SMILES O=C(NC1CCNC1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C21H27N9O/c31-20(23-14-7-8-22-12-14)17-4-1-9-29(17)21-25-19(16-3-2-10-30(16)28-21)24-18-11-15(26-27-18)13-5-6-13/h2-3,10-11,13-14,17,22H,1,4-9,12H2,(H,23,31)(H2,24,25,26,27,28)/t14?,17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106987
(US8592579, 41)Show SMILES N[C@H]1CCN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C21H27N9O/c22-14-7-10-28(12-14)20(31)17-4-1-8-29(17)21-24-19(16-3-2-9-30(16)27-21)23-18-11-15(25-26-18)13-5-6-13/h2-3,9,11,13-14,17H,1,4-8,10,12,22H2,(H2,23,24,25,26,27)/t14-,17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106986
(US8592579, 42)Show SMILES N[C@@H]1CCC(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H28N8O/c23-15-8-7-14(11-15)20(31)17-3-1-9-29(17)22-25-21(18-4-2-10-30(18)28-22)24-19-12-16(26-27-19)13-5-6-13/h2,4,10,12-15,17H,1,3,5-9,11,23H2,(H2,24,25,26,27,28)/t14?,15-,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106993
(US8592579, 58)Show SMILES NC1CN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C20H25N9O/c21-13-10-27(11-13)19(30)16-4-1-7-28(16)20-23-18(15-3-2-8-29(15)26-20)22-17-9-14(24-25-17)12-5-6-12/h2-3,8-9,12-13,16H,1,4-7,10-11,21H2,(H2,22,23,24,25,26)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 174 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107011
(US8592579, 190)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C(N)=O)c2cccn2n1)C(=O)NC1CCCN(CC2CC2)C1 |r| Show InChI InChI=1S/C25H34N10O2/c1-25(23(37)27-17-5-2-10-33(15-17)14-16-7-8-16)9-4-11-34(25)24-29-22(19-6-3-12-35(19)32-24)28-20-13-18(21(26)36)30-31-20/h3,6,12-13,16-17H,2,4-5,7-11,14-15H2,1H3,(H2,26,36)(H,27,37)(H2,28,29,30,31,32)/t17?,25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 232 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106989
(US8592579, 47)Show SMILES N[C@@H]1CCCN(C1)C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H29N9O/c23-15-4-1-9-29(13-15)21(32)18-6-2-10-30(18)22-25-20(17-5-3-11-31(17)28-22)24-19-12-16(26-27-19)14-7-8-14/h3,5,11-12,14-15,18H,1-2,4,6-10,13,23H2,(H2,24,25,26,27,28)/t15-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 361 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107005
(US8592579, 126)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C20H22N10OS/c1-20(17(31)24-19-27-21-11-32-19)7-3-8-29(20)18-23-16(14-4-2-9-30(14)28-18)22-15-10-13(25-26-15)12-5-6-12/h2,4,9-12H,3,5-8H2,1H3,(H,24,27,31)(H2,22,23,25,26,28)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106997
(US8592579, 71)Show SMILES CC(C)(C)c1cc(Nc2nc(nn3cccc23)N2CCC[C@@]2(C)C(=O)NC2CCCNC2)[nH]n1 |r| Show InChI InChI=1S/C24H35N9O/c1-23(2,3)18-14-19(30-29-18)27-20-17-9-6-13-33(17)31-22(28-20)32-12-7-10-24(32,4)21(34)26-16-8-5-11-25-15-16/h6,9,13-14,16,25H,5,7-8,10-12,15H2,1-4H3,(H,26,34)(H2,27,28,29,30,31)/t16?,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 428 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106998
(US8592579, 75)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)NC1CCNC1 |r| Show InChI InChI=1S/C22H29N9O/c1-22(20(32)24-15-7-9-23-13-15)8-3-10-30(22)21-26-19(17-4-2-11-31(17)29-21)25-18-12-16(27-28-18)14-5-6-14/h2,4,11-12,14-15,23H,3,5-10,13H2,1H3,(H,24,32)(H2,25,26,27,28,29)/t15?,22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 462 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106994
(US8592579, 59)Show SMILES NC[C@H]1CCCN1C(=O)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H29N9O/c23-13-15-4-1-9-29(15)21(32)18-6-2-10-30(18)22-25-20(17-5-3-11-31(17)28-22)24-19-12-16(26-27-19)14-7-8-14/h3,5,11-12,14-15,18H,1-2,4,6-10,13,23H2,(H2,24,25,26,27,28)/t15-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107008
(US8592579, 149)Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N9O/c1-23(21(37)29-15-7-8-18(28-13-15)24(25,26)27)9-3-10-35(23)22-31-20(17-4-2-11-36(17)34-22)30-19-12-16(32-33-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,29,37)(H2,30,31,32,33,34)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 912 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106992
(US8592579, 57)Show SMILES O=C([C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)N1CCNCC1 |r| Show InChI InChI=1S/C21H27N9O/c31-20(28-11-7-22-8-12-28)17-4-1-9-29(17)21-24-19(16-3-2-10-30(16)27-21)23-18-13-15(25-26-18)14-5-6-14/h2-3,10,13-14,17,22H,1,4-9,11-12H2,(H2,23,24,25,26,27)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106985
(US8592579, 23)Show SMILES CCOC(=O)c1ccc(NC(=O)[C@@H]2CCCN2c2nc(Nc3cc([nH]n3)C3CC3)c3cccn3n2)cc1 |r| Show InChI InChI=1S/C26H28N8O3/c1-2-37-25(36)17-9-11-18(12-10-17)27-24(35)21-6-3-13-33(21)26-29-23(20-5-4-14-34(20)32-26)28-22-15-19(30-31-22)16-7-8-16/h4-5,9-12,14-16,21H,2-3,6-8,13H2,1H3,(H,27,35)(H2,28,29,30,31,32)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107014
(US8592579, 215)Show SMILES O[C@H]1C[C@H](N(C1)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1)C(=O)NS(=O)(=O)C1CC1 |r| Show InChI InChI=1S/C20H24N8O4S/c29-12-8-16(19(30)26-33(31,32)13-5-6-13)27(10-12)20-22-18(15-2-1-7-28(15)25-20)21-17-9-14(23-24-17)11-3-4-11/h1-2,7,9,11-13,16,29H,3-6,8,10H2,(H,26,30)(H2,21,22,23,24,25)/t12-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.07E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106996
(US8592579, 67)Show SMILES O=C(NC1CCCNC1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)-c2ccco2)c2cccn2n1 |r| Show InChI InChI=1S/C23H27N9O2/c33-22(25-15-5-1-9-24-14-15)18-7-2-10-31(18)23-27-21(17-6-3-11-32(17)30-23)26-20-13-16(28-29-20)19-8-4-12-34-19/h3-4,6,8,11-13,15,18,24H,1-2,5,7,9-10,14H2,(H,25,33)(H2,26,27,28,29,30)/t15?,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM107006
(US8592579, 133)Show SMILES Cn1nc(cc1NC(=O)[C@]1(C)CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C1CC1 |r| Show InChI InChI=1S/C25H30N10O/c1-25(23(36)27-21-14-18(16-8-9-16)31-33(21)2)10-4-11-34(25)24-28-22(19-5-3-12-35(19)32-24)26-20-13-17(29-30-20)15-6-7-15/h3,5,12-16H,4,6-11H2,1-2H3,(H,27,36)(H2,26,28,29,30,32)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106991
(US8592579, 56)Show SMILES O=C([C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)N1CCCNCC1 |r| Show InChI InChI=1S/C22H29N9O/c32-21(29-10-3-8-23-9-13-29)18-5-1-11-30(18)22-25-20(17-4-2-12-31(17)28-22)24-19-14-16(26-27-19)15-6-7-15/h2,4,12,14-15,18,23H,1,3,5-11,13H2,(H2,24,25,26,27,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.84E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106984
(US8592579, 10)Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C24H26N8O/c33-23(25-15-16-6-2-1-3-7-16)20-9-4-12-31(20)24-27-22(19-8-5-13-32(19)30-24)26-21-14-18(28-29-21)17-10-11-17/h1-3,5-8,13-14,17,20H,4,9-12,15H2,(H,25,33)(H2,26,27,28,29,30)/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.17E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM106995
(US8592579, 65)Show InChI InChI=1S/C13H9ClN6O/c14-13-16-12(9-3-1-5-20(9)19-13)15-11-7-8(17-18-11)10-4-2-6-21-10/h1-7H,(H2,15,16,17,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.77E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Kinase assay using IGF1-receptor. |
US Patent US8592579 (2013)
BindingDB Entry DOI: 10.7270/Q2SQ8Z12 |
More data for this
Ligand-Target Pair | |
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