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Patent code US8629167

Compile Data Set for Download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112830
PNG
(US8629167, 41)
Show SMILES C[C@@H](O)C(Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)c(O)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c1-9-13(6-7-14(22-3)16(9)20)23-17(10(2)26)19-25-24-18(28-19)11-4-5-12(21)15(27)8-11/h4-8,10,17,23,26-27H,1-2H3/t10-,17?/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112818
PNG
(US8629167, 29)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(O)c(F)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c1-9-13(5-6-14(22-3)16(9)20)23-17(10(2)26)19-25-24-18(28-19)11-4-7-15(27)12(21)8-11/h4-8,10,17,23,26-27H,1-2H3/t10-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112828
PNG
(US8629167, 39)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C19H15ClF2N4O2/c1-9-14(6-7-15(23-3)16(9)20)24-17(10(2)27)19-26-25-18(28-19)11-4-5-12(21)13(22)8-11/h4-8,10,17,24,27H,1-2H3/t10-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112829
PNG
(US8629167, 40)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)c(O)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c1-9-13(6-7-14(22-3)16(9)20)23-17(10(2)26)19-25-24-18(28-19)11-4-5-12(21)15(27)8-11/h4-8,10,17,23,26-27H,1-2H3/t10-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112824
PNG
(US8629167, 35)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1C)c1nnc(o1)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C19H15ClF2N4O2/c1-9-15(6-3-11(8-23)16(9)20)24-17(10(2)27)19-26-25-18(28-19)13-5-4-12(21)7-14(13)22/h3-7,10,17,24,27H,1-2H3/t10-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112826
PNG
(US8629167, 37)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(O)c(Cl)c1 |r|
Show InChI InChI=1S/C19H16Cl2N4O3/c1-9-13(5-6-14(22-3)16(9)21)23-17(10(2)26)19-25-24-18(28-19)11-4-7-15(27)12(20)8-11/h4-8,10,17,23,26-27H,1-2H3/t10-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112819
PNG
(US8629167, 30)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(O)c(Cl)c1 |r|
Show InChI InChI=1S/C19H16Cl2N4O3/c1-9-13(5-6-14(22-3)16(9)21)23-17(10(2)26)19-25-24-18(28-19)11-4-7-15(27)12(20)8-11/h4-8,10,17,23,26-27H,1-2H3/t10-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112797
PNG
(US8629167, 7)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1cccc(O)c1 |r|
Show InChI InChI=1S/C19H17ClN4O3/c1-10-14(7-8-15(21-3)16(10)20)22-17(11(2)25)19-24-23-18(27-19)12-5-4-6-13(26)9-12/h4-9,11,17,22,25-26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112805
PNG
(US8629167, 15)
Show SMILES Cc1c(N[C@@H](c2nnc(o2)-c2ccc(Cl)cc2)C(C)(C)O)ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C20H18Cl2N4O2/c1-11-14(9-10-15(23-4)16(11)22)24-17(20(2,3)27)19-26-25-18(28-19)12-5-7-13(21)8-6-12/h5-10,17,24,27H,1-3H3/t17-/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112812
PNG
(US8629167, 23)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C20H16ClN5O2/c1-11-15(8-9-16(23-3)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-6-4-13(10-22)5-7-14/h4-9,12,18,24,27H,1-2H3/t12-,18-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112852
PNG
(US8629167, 64)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H15FN4O2S/c1-11(26)17(20-25-24-19(27-20)12-3-5-13(21)6-4-12)23-15-7-8-16(22-2)18-14(15)9-10-28-18/h3-11,17,23,26H,1H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112867
PNG
(US8629167, 80)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C=C)c1nnc(o1)-c1ccc(cc1)[N+]#[C-] |r|
Show InChI InChI=1S/C21H16ClN5O2/c1-5-15-16(10-11-17(24-4)18(15)22)25-19(12(2)28)21-27-26-20(29-21)13-6-8-14(23-3)9-7-13/h5-12,19,25,28H,1H2,2H3/t12-,19+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112841
PNG
(US8629167, 53)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)-n1cccn1 |r|
Show InChI InChI=1S/C22H19ClN6O2/c1-13-17(9-10-18(24-3)19(13)23)26-20(14(2)30)22-28-27-21(31-22)15-5-7-16(8-6-15)29-12-4-11-25-29/h4-12,14,20,26,30H,1-2H3/t14-,20+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112842
PNG
(US8629167, 54)
Show SMILES CCc1c(N[C@H]([C@@H](C)O)c2nnc(o2)-c2ccc(cc2)[N+]#[C-])ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C21H18ClN5O2/c1-5-15-16(10-11-17(24-4)18(15)22)25-19(12(2)28)21-27-26-20(29-21)13-6-8-14(23-3)9-7-13/h6-12,19,25,28H,5H2,1-2H3/t12-,19-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112851
PNG
(US8629167, 63)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H16N4O2S/c1-12(25)17(20-24-23-19(26-20)13-6-4-3-5-7-13)22-15-8-9-16(21-2)18-14(15)10-11-27-18/h3-12,17,22,25H,1H3/t12-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112853
PNG
(US8629167, 65)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H16N4O2S/c1-12(25)17(20-24-23-19(26-20)13-6-4-3-5-7-13)22-15-8-9-16(21-2)18-14(15)10-11-27-18/h3-12,17,22,25H,1H3/t12-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112882
PNG
(US8629167, 95)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c2scc(Cl)c12)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H14ClN5O2S/c1-11(28)18(21-27-26-20(29-21)13-5-3-12(9-23)4-6-13)25-15-7-8-16(24-2)19-17(15)14(22)10-30-19/h3-8,10-11,18,25,28H,1H3/t11-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112836
PNG
(US8629167, 47)
Show SMILES CCc1c(N[C@H]([C@H](C)O)C2=NOC(O2)c2ccc(cc2)C#N)ccc(C#N)c1Cl |r,t:9|
Show InChI InChI=1S/C21H19ClN4O3/c1-3-16-17(9-8-15(11-24)18(16)22)25-19(12(2)27)20-26-29-21(28-20)14-6-4-13(10-23)5-7-14/h4-9,12,19,21,25,27H,3H2,1-2H3/t12-,19+,21?/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112849
PNG
(US8629167, 61)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H15N5O2S/c1-12(27)18(24-16-7-8-17(23-2)19-15(16)9-10-29-19)21-26-25-20(28-21)14-5-3-13(11-22)4-6-14/h3-10,12,18,24,27H,1H3/t12-,18-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112865
PNG
(US8629167, 78)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NC(C)=O)cc1 |r|
Show InChI InChI=1S/C21H20ClN5O3/c1-11-16(9-10-17(23-4)18(11)22)25-19(12(2)28)21-27-26-20(30-21)14-5-7-15(8-6-14)24-13(3)29/h5-10,12,19,25,28H,1-3H3,(H,24,29)/t12-,19+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112868
PNG
(US8629167, 81)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1cccc(F)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O2/c1-10-14(7-8-15(22-3)16(10)20)23-17(11(2)26)19-25-24-18(27-19)12-5-4-6-13(21)9-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112866
PNG
(US8629167, 79)
Show SMILES Cc1c(N[C@H](CCO)c2nnc(o2)-c2ccc(cc2)[N+]#[C-])ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C20H16ClN5O2/c1-12-15(8-9-16(23-3)18(12)21)24-17(10-11-27)20-26-25-19(28-20)13-4-6-14(22-2)7-5-13/h4-9,17,24,27H,10-11H2,1H3/t17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112821
PNG
(US8629167, 32)
Show SMILES C[C@@H](O)C(Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H15Cl3N4O2/c1-9-14(6-7-15(23-3)16(9)22)24-17(10(2)27)19-26-25-18(28-19)11-4-5-12(20)13(21)8-11/h4-8,10,17,24,27H,1-2H3/t10-,17?/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112811
PNG
(US8629167, 22)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C20H16ClN5O2/c1-11-15(8-9-16(23-3)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-6-4-13(10-22)5-7-14/h4-9,12,18,24,27H,1-2H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112885
PNG
(US8629167, 49)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(CO)cc1 |r|
Show InChI InChI=1S/C20H19ClN4O3/c1-11-15(8-9-16(22-3)17(11)21)23-18(12(2)27)20-25-24-19(28-20)14-6-4-13(10-26)5-7-14/h4-9,12,18,23,26-27H,10H2,1-2H3/t12-,18-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112791
PNG
(US8629167, 1)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c1-11-14(9-10-15(21-3)16(11)20)22-17(12(2)25)19-24-23-18(26-19)13-7-5-4-6-8-13/h4-10,12,17,22,25H,1-2H3/t12-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112810
PNG
(US8629167, 21)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-14(7-8-15(22-3)16(10)21)23-17(11(2)26)19-25-24-18(27-19)12-5-4-6-13(20)9-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112832
PNG
(US8629167, 43)
Show SMILES C[C@H](O)C(Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(C)o1 |r|
Show InChI InChI=1S/C14H15ClN4O2/c1-7-10(5-6-11(16-4)12(7)15)17-13(8(2)20)14-19-18-9(3)21-14/h5-6,8,13,17,20H,1-3H3/t8-,13?/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112823
PNG
(US8629167, 34)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1Cl)c1nnc(o1)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C18H13Cl3N4O2/c1-9(26)16(23-13-7-4-11(8-22)14(20)15(13)21)18-25-24-17(27-18)10-2-5-12(19)6-3-10/h2-7,9,16,23,26H,1H3/t9-,16+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112858
PNG
(US8629167, 70)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NC(C)=O)cc1 |r|
Show InChI InChI=1S/C21H20ClN5O3/c1-11-16(9-10-17(23-4)18(11)22)25-19(12(2)28)21-27-26-20(30-21)14-5-7-15(8-6-14)24-13(3)29/h5-10,12,19,25,28H,1-3H3,(H,24,29)/t12-,19-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112838
PNG
(US8629167, 50)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C19H14ClN5O2/c1-11(26)17(23-15-7-6-14(10-22)16(20)8-15)19-25-24-18(27-19)13-4-2-12(9-21)3-5-13/h2-8,11,17,23,26H,1H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112833
PNG
(US8629167, 44)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c(c1)C(F)(F)F)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C20H14F3N5O2/c1-11(29)17(26-15-7-6-14(10-25)16(8-15)20(21,22)23)19-28-27-18(30-19)13-4-2-12(9-24)3-5-13/h2-8,11,17,26,29H,1H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112803
PNG
(US8629167, 13)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c2ccccc12)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H18N4O2/c1-14(27)20(22-26-25-21(28-22)15-8-4-3-5-9-15)24-19-13-12-18(23-2)16-10-6-7-11-17(16)19/h3-14,20,24,27H,1H3/t14-,20+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112792
PNG
(US8629167, 2)
Show SMILES COc1ccc(cc1)-c1nnc(o1)[C@H](Nc1ccc([N+]#[C-])c(Cl)c1C)[C@H](C)O |r|
Show InChI InChI=1S/C20H19ClN4O3/c1-11-15(9-10-16(22-3)17(11)21)23-18(12(2)26)20-25-24-19(28-20)13-5-7-14(27-4)8-6-13/h5-10,12,18,23,26H,1-2,4H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112820
PNG
(US8629167, 31)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c(c1C)C(F)(F)F)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H16F3N5O2/c1-11-16(8-7-15(10-26)17(11)21(22,23)24)27-18(12(2)30)20-29-28-19(31-20)14-5-3-13(9-25)4-6-14/h3-8,12,18,27,30H,1-2H3/t12-,18-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112793
PNG
(US8629167, 3)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c1-11-14(9-10-15(21-3)16(11)20)22-17(12(2)25)19-24-23-18(26-19)13-7-5-4-6-8-13/h4-10,12,17,22,25H,1-2H3/t12-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112835
PNG
(US8629167, 46)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C19H14ClN5O2/c1-11(26)17(23-15-7-6-14(10-22)16(20)8-15)19-25-24-18(27-19)13-4-2-12(9-21)3-5-13/h2-8,11,17,23,26H,1H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112848
PNG
(US8629167, 60)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H15N5O2S/c1-12(27)18(24-16-7-8-17(23-2)19-15(16)9-10-29-19)21-26-25-20(28-21)14-5-3-13(11-22)4-6-14/h3-10,12,18,24,27H,1H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112831
PNG
(US8629167, 42)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(c1C)C(F)(F)F)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H16F3N5O2/c1-11-16(8-7-15(10-26)17(11)21(22,23)24)27-18(12(2)30)20-29-28-19(31-20)14-5-3-13(9-25)4-6-14/h3-8,12,18,27,30H,1-2H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112840
PNG
(US8629167, 52)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c2ccccc12)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H18N4O2/c1-14(27)20(22-26-25-21(28-22)15-8-4-3-5-9-15)24-19-13-12-18(23-2)16-10-6-7-11-17(16)19/h3-14,20,24,27H,1H3/t14-,20-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112799
PNG
(US8629167, 9)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1cccc(O)c1 |r|
Show InChI InChI=1S/C19H17ClN4O3/c1-10-14(7-8-15(21-3)16(10)20)22-17(11(2)25)19-24-23-18(27-19)12-5-4-6-13(26)9-12/h4-9,11,17,22,25-26H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112862
PNG
(US8629167, 74)
Show SMILES CCCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(OC(=O)CCC)cc1 |r|
Show InChI InChI=1S/C27H29ClN4O5/c1-6-8-22(33)35-17(4)25(30-20-14-15-21(29-5)24(28)16(20)3)27-32-31-26(37-27)18-10-12-19(13-11-18)36-23(34)9-7-2/h10-15,17,25,30H,6-9H2,1-4H3/t17-,25+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112807
PNG
(US8629167, 17)
Show SMILES Cc1c(N[C@H](CO)c2nnc(o2)-c2ccccc2)ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C18H15ClN4O2/c1-11-13(8-9-14(20-2)16(11)19)21-15(10-24)18-23-22-17(25-18)12-6-4-3-5-7-12/h3-9,15,21,24H,10H2,1H3/t15-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112846
PNG
(US8629167, 58)
Show SMILES Cc1c(N[C@H](CO)c2nnc(o2)-c2ccc(cc2)[N+]#[C-])ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C19H14ClN5O2/c1-11-14(8-9-15(22-3)17(11)20)23-16(10-26)19-25-24-18(27-19)12-4-6-13(21-2)7-5-12/h4-9,16,23,26H,10H2,1H3/t16-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112844
PNG
(US8629167, 56)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C19H16BrClN4O2/c1-10-14(8-9-15(22-3)16(10)21)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(20)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112816
PNG
(US8629167, 27)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(s1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H17ClN4OS/c1-11-14(9-10-15(21-3)16(11)20)22-17(12(2)25)19-24-23-18(26-19)13-7-5-4-6-8-13/h4-10,12,17,22,25H,1-2H3/t12-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112872
PNG
(US8629167, 85)
Show SMILES CCCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C24H22ClN5O3/c1-5-6-20(31)32-15(3)22(28-18-11-12-19(27-4)21(25)14(18)2)24-30-29-23(33-24)17-9-7-16(13-26)8-10-17/h7-12,15,22,28H,5-6H2,1-3H3/t15-,22+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112815
PNG
(US8629167, 26)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(s1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H17ClN4OS/c1-11-14(9-10-15(21-3)16(11)20)22-17(12(2)25)19-24-23-18(26-19)13-7-5-4-6-8-13/h4-10,12,17,22,25H,1-2H3/t12-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112794
PNG
(US8629167, 4)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-14(8-9-15(22-3)16(10)21)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(20)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112843
PNG
(US8629167, 55)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C19H15Cl3N4O2/c1-9-14(6-7-15(23-3)16(9)22)24-17(10(2)27)19-26-25-18(28-19)11-4-5-12(20)13(21)8-11/h4-8,10,17,24,27H,1-2H3/t10-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112845
PNG
(US8629167, 57)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(I)cc1 |r|
Show InChI InChI=1S/C19H16ClIN4O2/c1-10-14(8-9-15(22-3)16(10)20)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(21)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112825
PNG
(US8629167, 36)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1C)c1ncc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H18ClN3O2/c1-12-16(9-8-15(10-22)18(12)21)24-19(13(2)25)20-23-11-17(26-20)14-6-4-3-5-7-14/h3-9,11,13,19,24-25H,1-2H3/t13-,19+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112801
PNG
(US8629167, 11)
Show SMILES CCc1c(N[C@H]([C@H](C)O)c2nnc(o2)-c2ccccc2)ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C20H19ClN4O2/c1-4-14-15(10-11-16(22-3)17(14)21)23-18(12(2)26)20-25-24-19(27-20)13-8-6-5-7-9-13/h5-12,18,23,26H,4H2,1-2H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112856
PNG
(US8629167, 68)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H16ClF3N4O2/c1-10-14(8-9-15(25-3)16(10)21)26-17(11(2)29)19-28-27-18(30-19)12-4-6-13(7-5-12)20(22,23)24/h4-9,11,17,26,29H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112869
PNG
(US8629167, 82)
Show SMILES CCCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C23H23ClN4O3/c1-5-9-19(29)30-15(3)21(26-17-12-13-18(25-4)20(24)14(17)2)23-28-27-22(31-23)16-10-7-6-8-11-16/h6-8,10-13,15,21,26H,5,9H2,1-3H3/t15-,21+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112850
PNG
(US8629167, 62)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c2sccc12)c1nnc(o1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H15FN4O2S/c1-11(26)17(20-25-24-19(27-20)12-3-5-13(21)6-4-12)23-15-7-8-16(22-2)18-14(15)9-10-28-18/h3-11,17,23,26H,1H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112822
PNG
(US8629167, 33)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1Cl)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C18H14Cl2N4O2/c1-10(25)16(22-13-8-7-12(9-21)14(19)15(13)20)18-24-23-17(26-18)11-5-3-2-4-6-11/h2-8,10,16,22,25H,1H3/t10-,16+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112798
PNG
(US8629167, 8)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(O)cc1 |r|
Show InChI InChI=1S/C19H17ClN4O3/c1-10-14(8-9-15(21-3)16(10)20)22-17(11(2)25)19-24-23-18(27-19)12-4-6-13(26)7-5-12/h4-9,11,17,22,25-26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112800
PNG
(US8629167, 10)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(O)cc1 |r|
Show InChI InChI=1S/C19H17ClN4O3/c1-10-14(8-9-15(21-3)16(10)20)22-17(11(2)25)19-24-23-18(27-19)12-4-6-13(26)7-5-12/h4-9,11,17,22,25-26H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112809
PNG
(US8629167, 20)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-14(8-9-15(22-3)16(10)21)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(20)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112886
PNG
(US8629167, 76)
Show SMILES C[C@H](OC(C)=O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H19ClN4O3/c1-12-16(10-11-17(23-4)18(12)22)24-19(13(2)28-14(3)27)21-26-25-20(29-21)15-8-6-5-7-9-15/h5-11,13,19,24H,1-3H3/t13-,19+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112817
PNG
(US8629167, 28)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(s1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C19H16ClFN4OS/c1-10-14(8-9-15(22-3)16(10)20)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(21)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112796
PNG
(US8629167, 6)
Show SMILES COc1cccc(c1)-c1nnc(o1)[C@H](Nc1ccc([N+]#[C-])c(Cl)c1C)[C@H](C)O |r|
Show InChI InChI=1S/C20H19ClN4O3/c1-11-15(8-9-16(22-3)17(11)21)23-18(12(2)26)20-25-24-19(28-20)13-6-5-7-14(10-13)27-4/h5-10,12,18,23,26H,1-2,4H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112804
PNG
(US8629167, 14)
Show SMILES Cc1c(N[C@@H](c2nnc(o2)-c2ccccc2)C(C)(C)O)ccc([N+]#[C-])c1Cl |r|
Show InChI InChI=1S/C20H19ClN4O2/c1-12-14(10-11-15(22-4)16(12)21)23-17(20(2,3)26)19-25-24-18(27-19)13-8-6-5-7-9-13/h5-11,17,23,26H,1-3H3/t17-/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112808
PNG
(US8629167, 19)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C19H16ClFN4O2/c1-10-14(8-9-15(22-3)16(10)20)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(21)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112877
PNG
(US8629167, 90)
Show SMILES C[C@H](OS(N)(=O)=O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H18ClN5O4S/c1-11-14(9-10-15(22-3)16(11)20)23-17(12(2)29-30(21,26)27)19-25-24-18(28-19)13-7-5-4-6-8-13/h4-10,12,17,23H,1-2H3,(H2,21,26,27)/t12-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112870
PNG
(US8629167, 83)
Show SMILES C[C@H](OC(=O)c1ccccc1)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H21ClN4O3/c1-16-20(14-15-21(28-3)22(16)27)29-23(17(2)33-26(32)19-12-8-5-9-13-19)25-31-30-24(34-25)18-10-6-4-7-11-18/h4-15,17,23,29H,1-2H3/t17-,23+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112871
PNG
(US8629167, 84)
Show SMILES CCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H21ClN4O3/c1-5-18(28)29-14(3)20(25-16-11-12-17(24-4)19(23)13(16)2)22-27-26-21(30-22)15-9-7-6-8-10-15/h6-12,14,20,25H,5H2,1-3H3/t14-,20+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112880
PNG
(US8629167, 93)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NS(O)(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H18ClN5O5S/c1-10-14(8-9-15(21-3)16(10)20)22-17(11(2)26)19-24-23-18(30-19)12-4-6-13(7-5-12)25-31(27,28)29/h4-9,11,17,22,25-26H,1-2H3,(H,27,28,29)/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112861
PNG
(US8629167, 73)
Show SMILES C[C@H](OC(C)=O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(OC(C)=O)cc1 |r|
Show InChI InChI=1S/C23H21ClN4O5/c1-12-18(10-11-19(25-5)20(12)24)26-21(13(2)31-14(3)29)23-28-27-22(33-23)16-6-8-17(9-7-16)32-15(4)30/h6-11,13,21,26H,1-4H3/t13-,21+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112806
PNG
(US8629167, 16)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(c1)C(F)(F)F)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H15F3N4O2/c1-11(27)16(18-26-25-17(28-18)12-5-3-2-4-6-12)24-14-8-7-13(10-23)15(9-14)19(20,21)22/h2-9,11,16,24,27H,1H3/t11-,16+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112795
PNG
(US8629167, 5)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C19H16ClFN4O2/c1-10-14(8-9-15(22-3)16(10)20)23-17(11(2)26)19-25-24-18(27-19)12-4-6-13(21)7-5-12/h4-9,11,17,23,26H,1-2H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112827
PNG
(US8629167, 38)
Show SMILES Cc1c(NC(C(O)c2ccccc2)c2nnc(o2)-c2ccccc2)ccc([N+]#[C-])c1Cl
Show InChI InChI=1S/C24H19ClN4O2/c1-15-18(13-14-19(26-2)20(15)25)27-21(22(30)16-9-5-3-6-10-16)24-29-28-23(31-24)17-11-7-4-8-12-17/h3-14,21-22,27,30H,1H3
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112884
PNG
(US8629167, 18)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nc(no1)-c1ccccc1 |r|
Show InChI InChI=1S/C19H17ClN4O2/c1-11-14(9-10-15(21-3)16(11)20)22-17(12(2)25)19-23-18(24-26-19)13-7-5-4-6-8-13/h4-10,12,17,22,25H,1-2H3/t12-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112883
PNG
(US8629167, 98)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc2[nH]ccc2c1 |r|
Show InChI InChI=1S/C21H18ClN5O2/c1-11-15(6-7-17(23-3)18(11)22)25-19(12(2)28)21-27-26-20(29-21)14-4-5-16-13(10-14)8-9-24-16/h4-10,12,19,24-25,28H,1-2H3/t12-,19+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112875
PNG
(US8629167, 88)
Show SMILES C[C@H](OC(C)=O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C22H18ClN5O3/c1-12-17(9-10-18(25-4)19(12)23)26-20(13(2)30-14(3)29)22-28-27-21(31-22)16-7-5-15(11-24)6-8-16/h5-10,13,20,26H,1-3H3/t13-,20+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112873
PNG
(US8629167, 86)
Show SMILES CCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C23H20ClN5O3/c1-5-19(30)31-14(3)21(27-17-10-11-18(26-4)20(24)13(17)2)23-29-28-22(32-23)16-8-6-15(12-25)7-9-16/h6-11,14,21,27H,5H2,1-3H3/t14-,21+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112874
PNG
(US8629167, 87)
Show SMILES C[C@H](OC(=O)c1ccccc1)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C27H20ClN5O3/c1-16-21(13-14-22(30-3)23(16)28)31-24(17(2)35-27(34)20-7-5-4-6-8-20)26-33-32-25(36-26)19-11-9-18(15-29)10-12-19/h4-14,17,24,31H,1-2H3/t17-,24+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112813
PNG
(US8629167, 24)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)S(C)(=O)=O |r|
Show InChI InChI=1S/C20H19ClN4O4S/c1-11-15(9-10-16(22-3)17(11)21)23-18(12(2)26)20-25-24-19(29-20)13-5-7-14(8-6-13)30(4,27)28/h5-10,12,18,23,26H,1-2,4H3/t12-,18+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112855
PNG
(US8629167, 67)
Show SMILES CCCC(=O)O[C@@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(OC(=O)CCC)c(Cl)c1 |r|
Show InChI InChI=1S/C27H28Cl2N4O5/c1-6-8-22(34)36-16(4)25(31-19-11-12-20(30-5)24(29)15(19)3)27-33-32-26(38-27)17-10-13-21(18(28)14-17)37-23(35)9-7-2/h10-14,16,25,31H,6-9H2,1-4H3/t16-,25+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112814
PNG
(US8629167, 25)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(cc1)S(C)(=O)=O |r|
Show InChI InChI=1S/C20H19ClN4O4S/c1-11-15(9-10-16(22-3)17(11)21)23-18(12(2)26)20-25-24-19(29-20)13-5-7-14(8-6-13)30(4,27)28/h5-10,12,18,23,26H,1-2,4H3/t12-,18-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112859
PNG
(US8629167, 71)
Show SMILES CCCC(=O)Nc1ccc(cc1)-c1nnc(o1)[C@H](Nc1ccc([N+]#[C-])c(Cl)c1C)[C@@H](C)O |r|
Show InChI InChI=1S/C23H24ClN5O3/c1-5-6-19(31)26-16-9-7-15(8-10-16)22-28-29-23(32-22)21(14(3)30)27-17-11-12-18(25-4)20(24)13(17)2/h7-12,14,21,27,30H,5-6H2,1-3H3,(H,26,31)/t14-,21-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112802
PNG
(US8629167, 12)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1)c1nnc(o1)-c1ccccc1 |r|
Show InChI InChI=1S/C18H15ClN4O2/c1-11(24)16(21-13-8-9-15(20-2)14(19)10-13)18-23-22-17(25-18)12-6-4-3-5-7-12/h3-11,16,21,24H,1H3/t11-,16+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112854
PNG
(US8629167, 66)
Show SMILES CCCC(=O)O[C@H](C)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(F)c(OC(=O)CCC)c1 |r|
Show InChI InChI=1S/C27H28ClFN4O5/c1-6-8-22(34)36-16(4)25(31-19-12-13-20(30-5)24(28)15(19)3)27-33-32-26(38-27)17-10-11-18(29)21(14-17)37-23(35)9-7-2/h10-14,16,25,31H,6-9H2,1-4H3/t16-,25-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112834
PNG
(US8629167, 45)
Show SMILES C[C@H](O)[C@@H](Nc1ccc(C#N)c(c1)C(F)(F)F)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C20H14F3N5O2/c1-11(29)17(26-15-7-6-14(10-25)16(8-15)20(21,22)23)19-28-27-18(30-19)13-4-2-12(9-24)3-5-13/h2-8,11,17,26,29H,1H3/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112839
PNG
(US8629167, 51)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c2ccccc12)c1nnc(o1)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C23H17N5O2/c1-14(29)21(23-28-27-22(30-23)16-8-6-15(12-24)7-9-16)26-20-11-10-17(13-25)18-4-2-3-5-19(18)20/h2-11,14,21,26,29H,1H3/t14-,21-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112860
PNG
(US8629167, 72)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(OS([O-])(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H17ClN4O6S/c1-10-14(8-9-15(21-3)16(10)20)22-17(11(2)25)19-24-23-18(29-19)12-4-6-13(7-5-12)30-31(26,27)28/h4-9,11,17,22,25H,1-2H3,(H,26,27,28)/p-1/t11-,17+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112881
PNG
(US8629167, 94)
Show SMILES C[C@@H](OS(N)(=O)=O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NS(O)(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H19ClN6O7S2/c1-10-14(8-9-15(22-3)16(10)20)23-17(11(2)33-34(21,27)28)19-25-24-18(32-19)12-4-6-13(7-5-12)26-35(29,30)31/h4-9,11,17,23,26H,1-2H3,(H2,21,27,28)(H,29,30,31)/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112837
PNG
(US8629167, 48)
Show SMILES C[C@H](O)C(Nc1ccc(C#N)c(Cl)c1)c1nnc(o1)-c1ccc(cc1)S(C)(=O)=O |r|
Show InChI InChI=1S/C19H17ClN4O4S/c1-11(25)17(22-14-6-3-13(10-21)16(20)9-14)19-24-23-18(28-19)12-4-7-15(8-5-12)29(2,26)27/h3-9,11,17,22,25H,1-2H3/t11-,17?/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112857
PNG
(US8629167, 69)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NC(=O)c2ccccc2)cc1 |r|
Show InChI InChI=1S/C26H22ClN5O3/c1-15-20(13-14-21(28-3)22(15)27)30-23(16(2)33)26-32-31-25(35-26)18-9-11-19(12-10-18)29-24(34)17-7-5-4-6-8-17/h4-14,16,23,30,33H,1-2H3,(H,29,34)/t16-,23-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112863
PNG
(US8629167, 75)
Show SMILES C[C@H](OC(=O)c1ccccc1)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(OC(=O)c2ccccc2)cc1 |r|
Show InChI InChI=1S/C33H25ClN4O5/c1-20-26(18-19-27(35-3)28(20)34)36-29(21(2)41-32(39)23-10-6-4-7-11-23)31-38-37-30(43-31)22-14-16-25(17-15-22)42-33(40)24-12-8-5-9-13-24/h4-19,21,29,36H,1-2H3/t21-,29+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112864
PNG
(US8629167, 77)
Show SMILES C[C@H](O)[C@@H](Nc1ccc([N+]#[C-])c(Cl)c1C)c1nnc(o1)-c1ccc(NC(=O)c2ccccc2)cc1 |r|
Show InChI InChI=1S/C26H22ClN5O3/c1-15-20(13-14-21(28-3)22(15)27)30-23(16(2)33)26-32-31-25(35-26)18-9-11-19(12-10-18)29-24(34)17-7-5-4-6-8-17/h4-14,16,23,30,33H,1-2H3,(H,29,34)/t16-,23+/m0/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
Androgen receptor


(Rattus norvegicus (Rat))		BDBM112847
PNG
(US8629167, 59)
Show SMILES C[C@@H](O)[C@@H](Nc1ccc(C#N)c(c1)C(F)(F)F)c1nnc(o1)-c1ccc(cc1)S(C)(=O)=O |r|
Show InChI InChI=1S/C20H17F3N4O4S/c1-11(28)17(25-14-6-3-13(10-24)16(9-14)20(21,22)23)19-27-26-18(31-19)12-4-7-15(8-5-12)32(2,29)30/h3-9,11,17,25,28H,1-2H3/t11-,17-/m1/s1
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Radius Health, Inc.

US Patent


Assay Description
In order to demonstrate the utility of the compounds of this invention, an androgen receptor binding assay was performed wherein many of the compound...

US Patent US8629167 (2014)


BindingDB Entry DOI: 10.7270/Q2GT5KTX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%