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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166433 (US9073833, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166439 (US9073833, Sivelestat) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166436 (US9073833, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166434 (US9073833, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166435 (US9073833, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166437 (US9073833, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166438 (US9073833, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | 37 |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (6) was dissolved in 100% DMSO so as to obtain stock to compound solutions with concentrations of 0.01, 0.03, 0.1, 0.3, 1, 3... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166433 (US9073833, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.13E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166439 (US9073833, Sivelestat) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166440 (US9073833, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.59E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166433 (US9073833, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.22E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Chang Gung University US Patent | Assay Description Compound (1) was mixed with 50 uL of buffer C [containing 100 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES, pH 7.5), 500 mM NaCl, 10%... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166437 (US9073833, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.24E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166439 (US9073833, Sivelestat) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.38E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Chang Gung University US Patent | Assay Description Compound (1) was mixed with 50 uL of buffer C [containing 100 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES, pH 7.5), 500 mM NaCl, 10%... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166438 (US9073833, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.67E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166435 (US9073833, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.68E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166436 (US9073833, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.94E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neutrophil elastase (Homo sapiens (Human)) | BDBM166434 (US9073833, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.79E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Chang Gung University US Patent | Assay Description Each of Compounds (1) to (7) was added into 50 μL buffer A (containing 20 mM Tris-HCl (pH 7.4), 0.1% NaN3 and 5 mM CaCl2) to obtain compound sol... | US Patent US9073833 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PQJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
