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Patent code US9169243

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187363
PNG
(US9169243, 11 | US9908875, 11)
Show SMILES CNC(=O)C1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C27H30N10O2S/c1-28-25(38)17-6-8-35(9-7-17)22-11-29-19(10-21(22)36-12-20(30-14-36)16-2-3-16)26(39)32-23-13-40-27(33-23)24-34-31-15-37(24)18-4-5-18/h10-18H,2-9H2,1H3,(H,28,38)(H,32,39)
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n/an/a 0.400n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187354
PNG
(US9169243, 2 | US9908875, 2)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC(C1)C#N)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H22N10OS/c25-6-14-8-32(9-14)20-7-26-17(5-19(20)33-10-18(27-12-33)15-1-2-15)23(35)29-21-11-36-24(30-21)22-31-28-13-34(22)16-3-4-16/h5,7,10-16H,1-4,8-9H2,(H,29,35)
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n/an/a 0.900n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187369
PNG
(US9169243, 17 | US9908875, 17)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC2CC2C1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H25N9OS/c35-24(29-22-11-36-25(30-22)23-31-28-13-34(23)17-3-4-17)18-6-20(33-10-19(27-12-33)14-1-2-14)21(7-26-18)32-8-15-5-16(15)9-32/h6-7,10-17H,1-5,8-9H2,(H,29,35)
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187385
PNG
(US9169243, 33 | US9908875, 33)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC(F)(F)F)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C26H26F6N10OS/c1-15(26(30,31)32)42-14-35-38-22(42)24-37-21(11-44-24)36-23(43)17-8-19(41-10-18(34-13-41)16-2-3-16)20(9-33-17)40-6-4-39(5-7-40)12-25(27,28)29/h8-11,13-16H,2-7,12H2,1H3,(H,36,43)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187376
PNG
(US9169243, 24 | US9908875, 24)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(C2)C#N)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C25H23F3N10OS/c1-14(25(26,27)28)38-13-32-35-21(38)23-34-20(8-40-23)33-22(39)16-5-18(36-7-17(31-12-36)15-3-4-15)19(6-30-16)37-10-24(2,9-29)11-37/h5-8,12-15H,3-4,10-11H2,1-2H3,(H,33,39)/t14-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187384
PNG
(US9169243, 32 | US9908875, 32)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(CC2)C(F)(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C26H25F6N9OS/c1-14(25(27,28)29)41-13-35-38-22(41)24-37-21(11-43-24)36-23(42)17-8-19(40-10-18(34-12-40)15-2-3-15)20(9-33-17)39-6-4-16(5-7-39)26(30,31)32/h8-16H,2-7H2,1H3,(H,36,42)/t14-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187381
PNG
(US9169243, 29 | US9908875, 29)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(CC2)C#N)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C26H25F3N10OS/c1-15(26(27,28)29)39-14-33-36-23(39)25-35-22(12-41-25)34-24(40)18-8-20(38-11-19(32-13-38)17-2-3-17)21(10-31-18)37-6-4-16(9-30)5-7-37/h8,10-17H,2-7H2,1H3,(H,34,40)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187378
PNG
(US9169243, 26 | US9908875, 26)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)C(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C24H22F5N9OS/c1-12(24(27,28)29)38-11-32-35-21(38)23-34-19(9-40-23)33-22(39)15-4-17(37-8-16(31-10-37)13-2-3-13)18(5-30-15)36-6-14(7-36)20(25)26/h4-5,8-14,20H,2-3,6-7H2,1H3,(H,33,39)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187386
PNG
(US9169243, 34 | US9908875, 34)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(F)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C25H25F4N9OS/c1-14(25(27,28)29)38-13-32-35-22(38)24-34-21(11-40-24)33-23(39)17-8-19(37-10-18(31-12-37)15-2-3-15)20(9-30-17)36-6-4-16(26)5-7-36/h8-16H,2-7H2,1H3,(H,33,39)/t14-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187389
PNG
(US9169243, 37)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN3CCCC3C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H29F3N10OS/c1-16(27(28,29)30)40-15-33-36-24(40)26-35-23(13-42-26)34-25(41)19-9-21(39-12-20(32-14-39)17-4-5-17)22(10-31-19)38-8-7-37-6-2-3-18(37)11-38/h9-10,12-18H,2-8,11H2,1H3,(H,34,41)/t16-,18?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187395
PNG
(US9169243, 43 | US9908875, 43)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC3CC3)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C28H31F3N10OS/c1-17(28(29,30)31)41-16-34-37-25(41)27-36-24(14-43-27)35-26(42)20-10-22(40-13-21(33-15-40)19-4-5-19)23(11-32-20)39-8-6-38(7-9-39)12-18-2-3-18/h10-11,13-19H,2-9,12H2,1H3,(H,35,42)/t17-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187394
PNG
(US9169243, 42 | US9908875, 42)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC2)C2CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H29F3N10OS/c1-16(27(28,29)30)40-15-33-36-24(40)26-35-23(13-42-26)34-25(41)19-10-21(39-12-20(32-14-39)17-2-3-17)22(11-31-19)38-8-6-37(7-9-38)18-4-5-18/h10-18H,2-9H2,1H3,(H,34,41)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187356
PNG
(US9169243, 4 | US9908875, 4)
Show SMILES COC1(C)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H27N9O2S/c1-25(36-2)11-33(12-25)20-8-26-17(7-19(20)32-9-18(27-13-32)15-3-4-15)23(35)29-21-10-37-24(30-21)22-31-28-14-34(22)16-5-6-16/h7-10,13-16H,3-6,11-12H2,1-2H3,(H,29,35)
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187373
PNG
(US9169243, 21 | US9908875, 21)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCC2(COC2)CC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H29N9O2S/c37-25(31-23-12-39-26(32-23)24-33-30-16-36(24)18-3-4-18)19-9-21(35-11-20(29-15-35)17-1-2-17)22(10-28-19)34-7-5-27(6-8-34)13-38-14-27/h9-12,15-18H,1-8,13-14H2,(H,31,37)
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187380
PNG
(US9169243, 28 | US9908875, 28)
Show SMILES COC1CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C25H26F3N9O2S/c1-14(25(26,27)28)37-13-31-34-22(37)24-33-21(11-40-24)32-23(38)17-7-19(36-10-18(30-12-36)15-3-4-15)20(8-29-17)35-6-5-16(9-35)39-2/h7-8,10-16H,3-6,9H2,1-2H3,(H,32,38)/t14-,16?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187388
PNG
(US9169243, 36 | US9908875, 36)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C25H26F3N9O2S/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-40-24)32-23(38)17-9-19(36-11-18(30-13-36)16-3-4-16)20(10-29-17)35-5-2-7-39-8-6-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187355
PNG
(US9169243, 3 | US9908875, 3)
Show SMILES CC1(CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1)C#N
Show InChI InChI=1S/C25H24N10OS/c1-25(10-26)11-34(12-25)20-7-27-17(6-19(20)33-8-18(28-13-33)15-2-3-15)23(36)30-21-9-37-24(31-21)22-32-29-14-35(22)16-4-5-16/h6-9,13-16H,2-5,11-12H2,1H3,(H,30,36)
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187393
PNG
(US9169243, 41 | US9908875, 41)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)N2CCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H29F3N10O2S/c1-16(27(28,29)30)40-15-33-36-24(40)26-35-23(13-43-26)34-25(41)19-8-21(39-12-20(32-14-39)17-2-3-17)22(9-31-19)38-10-18(11-38)37-4-6-42-7-5-37/h8-9,12-18H,2-7,10-11H2,1H3,(H,34,41)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187375
PNG
(US9169243, 23 | US9908875, 23)
Show SMILES COCC1CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C25H26F3N9O2S/c1-14(25(26,27)28)37-13-31-34-22(37)24-33-21(11-40-24)32-23(38)17-5-19(36-9-18(30-12-36)16-3-4-16)20(6-29-17)35-7-15(8-35)10-39-2/h5-6,9,11-16H,3-4,7-8,10H2,1-2H3,(H,32,38)/t14-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187377
PNG
(US9169243, 25 | US9908875, 25)
Show SMILES COC1(C)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C25H26F3N9O2S/c1-14(25(26,27)28)37-13-31-34-21(37)23-33-20(9-40-23)32-22(38)16-6-18(35-8-17(30-12-35)15-4-5-15)19(7-29-16)36-10-24(2,11-36)39-3/h6-9,12-15H,4-5,10-11H2,1-3H3,(H,32,38)/t14-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187396
PNG
(US9169243, 44 | US9908875, 44)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC3(COC3)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H28F3N9O2S/c1-16(27(28,29)30)39-15-33-36-23(39)25-35-22(11-42-25)34-24(40)18-8-20(38-10-19(32-14-38)17-2-3-17)21(9-31-18)37-6-4-26(5-7-37)12-41-13-26/h8-11,14-17H,2-7,12-13H2,1H3,(H,34,40)/t16-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187379
PNG
(US9169243, 27 | US9908875, 27)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(F)(F)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C24H22F5N9OS/c1-13(24(27,28)29)38-12-32-35-20(38)22-34-19(9-40-22)33-21(39)15-6-17(37-8-16(31-11-37)14-2-3-14)18(7-30-15)36-5-4-23(25,26)10-36/h6-9,11-14H,2-5,10H2,1H3,(H,33,39)/t13-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187392
PNG
(US9169243, 40 | US9908875, 40)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC3CC3C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C25H24F3N9OS/c1-13(25(26,27)28)37-12-31-34-22(37)24-33-21(10-39-24)32-23(38)17-5-19(36-9-18(30-11-36)14-2-3-14)20(6-29-17)35-7-15-4-16(15)8-35/h5-6,9-16H,2-4,7-8H2,1H3,(H,32,38)/t13-,15?,16?/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187361
PNG
(US9169243, 9 | US9908875, 9)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCC(CC1)C#N)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N10OS/c27-10-16-5-7-34(8-6-16)22-11-28-19(9-21(22)35-12-20(29-14-35)17-1-2-17)25(37)31-23-13-38-26(32-23)24-33-30-15-36(24)18-3-4-18/h9,11-18H,1-8H2,(H,31,37)
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n/an/a 2.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187353
PNG
(US9169243, 1 | US9908875, 1)
Show SMILES FC(F)C1CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H23F2N9OS/c25-21(26)14-7-33(8-14)19-6-27-16(5-18(19)34-9-17(28-11-34)13-1-2-13)23(36)30-20-10-37-24(31-20)22-32-29-12-35(22)15-3-4-15/h5-6,9-15,21H,1-4,7-8H2,(H,30,36)
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n/an/a 2.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187387
PNG
(US9169243, 35 | US9908875, 35)
Show SMILES COC1(C)CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C27H30F3N9O2S/c1-16(27(28,29)30)39-15-33-36-23(39)25-35-22(13-42-25)34-24(40)18-10-20(38-12-19(32-14-38)17-4-5-17)21(11-31-18)37-8-6-26(2,41-3)7-9-37/h10-17H,4-9H2,1-3H3,(H,34,40)/t16-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187383
PNG
(US9169243, 31 | US9908875, 31)
Show SMILES CNC(=O)C1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C27H29F3N10O2S/c1-15(27(28,29)30)40-14-34-37-23(40)26-36-22(12-43-26)35-25(42)18-9-20(39-11-19(33-13-39)16-3-4-16)21(10-32-18)38-7-5-17(6-8-38)24(41)31-2/h9-17H,3-8H2,1-2H3,(H,31,41)(H,35,42)/t15-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187370
PNG
(US9169243, 18 | US9908875, 18)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC(C1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H30N10O2S/c38-26(31-24-14-40-27(32-24)25-33-30-16-37(25)18-3-4-18)20-9-22(36-13-21(29-15-36)17-1-2-17)23(10-28-20)35-11-19(12-35)34-5-7-39-8-6-34/h9-10,13-19H,1-8,11-12H2,(H,31,38)
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n/an/a 2.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187391
PNG
(US9169243, 39 | US9908875, 39)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN3C(COC3=O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C26H25F3N10O3S/c1-14(26(27,28)29)39-13-32-35-22(39)24-34-21(11-43-24)33-23(40)17-6-19(37-9-18(31-12-37)15-2-3-15)20(7-30-17)36-4-5-38-16(8-36)10-42-25(38)41/h6-7,9,11-16H,2-5,8,10H2,1H3,(H,33,40)/t14-,16?/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187382
PNG
(US9169243, 30 | US9908875, 30)
Show SMILES COC1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F |r|
Show InChI InChI=1S/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-23(38)25-34-22(12-41-25)33-24(39)18-9-20(37-11-19(31-13-37)16-3-4-16)21(10-30-18)36-7-5-17(40-2)6-8-36/h9-17H,3-8H2,1-2H3,(H,33,39)/t15-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187390
PNG
(US9169243, 38 | US9908875, 38)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC3CN(C)CC3C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H29F3N10OS/c1-15(27(28,29)30)40-14-33-36-24(40)26-35-23(12-42-26)34-25(41)19-5-21(39-11-20(32-13-39)16-3-4-16)22(6-31-19)38-9-17-7-37(2)8-18(17)10-38/h5-6,11-18H,3-4,7-10H2,1-2H3,(H,34,41)/t15-,17?,18?/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187372
PNG
(US9169243, 20 | US9908875, 20)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCN(CC2CC2)CC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C28H32N10OS/c39-27(32-25-15-40-28(33-25)26-34-31-17-38(26)20-5-6-20)21-11-23(37-14-22(30-16-37)19-3-4-19)24(12-29-21)36-9-7-35(8-10-36)13-18-1-2-18/h11-12,14-20H,1-10,13H2,(H,32,39)
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n/an/a 2.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187360
PNG
(US9169243, 8 | US9908875, 8)
Show SMILES FC1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H26FN9OS/c26-16-5-7-33(8-6-16)21-10-27-18(9-20(21)34-11-19(28-13-34)15-1-2-15)24(36)30-22-12-37-25(31-22)23-32-29-14-35(23)17-3-4-17/h9-17H,1-8H2,(H,30,36)
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n/an/a 2.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187397
PNG
(US9169243, 45 | US9908875, 45)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC3(C2)CCOCC3)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r|
Show InChI InChI=1S/C27H28F3N9O2S/c1-16(27(28,29)30)39-15-33-36-23(39)25-35-22(11-42-25)34-24(40)18-8-20(37-10-19(32-14-37)17-2-3-17)21(9-31-18)38-12-26(13-38)4-6-41-7-5-26/h8-11,14-17H,2-7,12-13H2,1H3,(H,34,40)/t16-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187367
PNG
(US9169243, 15 | US9908875, 15)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCN2CCCC2C1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H30N10OS/c38-26(31-24-14-39-27(32-24)25-33-30-16-37(25)18-5-6-18)20-10-22(36-13-21(29-15-36)17-3-4-17)23(11-28-20)35-9-8-34-7-1-2-19(34)12-35/h10-11,13-19H,1-9,12H2,(H,31,38)
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n/an/a 2.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187368
PNG
(US9169243, 16 | US9908875, 16)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCN2C(COC2=O)C1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C26H26N10O3S/c37-24(30-22-12-40-25(31-22)23-32-29-14-36(23)16-3-4-16)18-7-20(34-10-19(28-13-34)15-1-2-15)21(8-27-18)33-5-6-35-17(9-33)11-39-26(35)38/h7-8,10,12-17H,1-6,9,11H2,(H,30,37)
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n/an/a 2.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187358
PNG
(US9169243, 6 | US9908875, 6)
Show SMILES COC1CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H27N9O2S/c1-36-17-6-7-32(10-17)21-9-26-18(8-20(21)33-11-19(27-13-33)15-2-3-15)24(35)29-22-12-37-25(30-22)23-31-28-14-34(23)16-4-5-16/h8-9,11-17H,2-7,10H2,1H3,(H,29,35)
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n/an/a 2.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187371
PNG
(US9169243, 19 | US9908875, 19)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCN(CC1)C1CC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H30N10OS/c38-26(31-24-14-39-27(32-24)25-33-30-16-37(25)19-5-6-19)20-11-22(36-13-21(29-15-36)17-1-2-17)23(12-28-20)35-9-7-34(8-10-35)18-3-4-18/h11-19H,1-10H2,(H,31,38)
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n/an/a 2.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187357
PNG
(US9169243, 5 | US9908875, 5)
Show SMILES FC1(F)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H21F2N9OS/c24-23(25)9-33(10-23)18-6-26-15(5-17(18)32-7-16(27-11-32)13-1-2-13)21(35)29-19-8-36-22(30-19)20-31-28-12-34(20)14-3-4-14/h5-8,11-14H,1-4,9-10H2,(H,29,35)
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n/an/a 2.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187365
PNG
(US9169243, 13 | US9908875, 13)
Show SMILES FC(F)(F)CN1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H27F3N10OS/c27-26(28,29)13-36-5-7-37(8-6-36)21-10-30-18(9-20(21)38-11-19(31-14-38)16-1-2-16)24(40)33-22-12-41-25(34-22)23-35-32-15-39(23)17-3-4-17/h9-12,14-17H,1-8,13H2,(H,33,40)
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n/an/a 2.90n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187362
PNG
(US9169243, 10 | US9908875, 10)
Show SMILES COC1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H29N9O2S/c1-37-18-6-8-33(9-7-18)22-11-27-19(10-21(22)34-12-20(28-14-34)16-2-3-16)25(36)30-23-13-38-26(31-23)24-32-29-15-35(24)17-4-5-17/h10-18H,2-9H2,1H3,(H,30,36)
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n/an/a 3.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187359
PNG
(US9169243, 7 | US9908875, 7)
Show SMILES FC(F)(F)C1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H26F3N9OS/c27-26(28,29)16-5-7-36(8-6-16)21-10-30-18(9-20(21)37-11-19(31-13-37)15-1-2-15)24(39)33-22-12-40-25(34-22)23-35-32-14-38(23)17-3-4-17/h9-17H,1-8H2,(H,33,39)
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n/an/a 3.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187366
PNG
(US9169243, 14 | US9908875, 14)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H27N9O2S/c35-24(29-22-13-37-25(30-22)23-31-28-15-34(23)17-4-5-17)18-10-20(33-12-19(27-14-33)16-2-3-16)21(11-26-18)32-6-1-8-36-9-7-32/h10-17H,1-9H2,(H,29,35)
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n/an/a 3.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187374
PNG
(US9169243, 22 | US9908875, 22)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC2(C1)CCOCC2)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H29N9O2S/c37-25(31-23-12-39-26(32-23)24-33-30-16-36(24)18-3-4-18)19-9-21(34-11-20(29-15-34)17-1-2-17)22(10-28-19)35-13-27(14-35)5-7-38-8-6-27/h9-12,15-18H,1-8,13-14H2,(H,31,37)
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n/an/a 4.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM187364
PNG
(US9169243, 12 | US9908875, 12)
Show SMILES COC1(C)CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C27H31N9O2S/c1-27(38-2)7-9-34(10-8-27)22-12-28-19(11-21(22)35-13-20(29-15-35)17-3-4-17)25(37)31-23-14-39-26(32-23)24-33-30-16-36(24)18-5-6-18/h11-18H,3-10H2,1-2H3,(H,31,37)
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n/an/a 14.2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...

US Patent US9169243 (2015)


BindingDB Entry DOI: 10.7270/Q2RF5ST3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%