BDBM187378 US9169243, 26::US9908875, 26

SMILES: C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)C(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F

InChI Key: InChIKey=KRYLADYSTZJSPE-LBPRGKRZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 187378   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM187378 (US9169243, 26 | US9908875, 26) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)C(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C24H22F5N9OS/c1-12(24(27,28)29)38-11-32-35-21(38)23-34-19(9-40-23)33-22(39)15-4-17(37-8-16(31-10-37)13-2-3-13)18(5-30-15)36-6-14(7-36)20(25)26/h4-5,8-14,20H,2-3,6-7H2,1H3,(H,33,39)/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q22F7QRX
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM187378 (US9169243, 26 | US9908875, 26) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)C(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C24H22F5N9OS/c1-12(24(27,28)29)38-11-32-35-21(38)23-34-19(9-40-23)33-22(39)15-4-17(37-8-16(31-10-37)13-2-3-13)18(5-30-15)36-6-14(7-36)20(25)26/h4-5,8-14,20H,2-3,6-7H2,1H3,(H,33,39)/t12-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				US Patent US9169243 (2015) BindingDB Entry DOI: 10.7270/Q2RF5ST3
					More data for this Ligand-Target Pair