BindingDB logo
myBDB logout

Patent code US8759366

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124660
PNG
(US8759366, (1S,4R)-4-{5-[3-({4-[(1R)-1-fluoroethyl...)
Show SMILES C[C@@H](F)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)n1
Show InChI InChI=1S/C25H29FN4O3S/c1-14-9-16(11-17(10-14)29-23-27-8-6-19(30-23)15(2)26)20-12-28-22(34-20)25(33)7-5-18(21(31)32)24(3,4)13-25/h6,8-12,15,18,33H,5,7,13H2,1-4H3,(H,31,32)(H,27,29,30)/t15-,18-,25-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124640
PNG
(US8759366, (1S,4R)-4-hydroxy-2,2-dimethyl-4-[5-(3-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-14(10-15(9-13)30-21-28-7-5-18(31-21)24(25,26)27)17-11-29-20(35-17)23(34)6-4-16(19(32)33)22(2,3)12-23/h5,7-11,16,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t16-,23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124614
PNG
(US8759366, 4-{1-hydroxy-1-[5-(3-methyl-5-{[4-(trif...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H19F3N4O3S/c1-13-9-15(11-17(10-13)30-22-28-8-7-19(31-22)24(25,26)27)18-12-29-21(35-18)23(2,34)16-5-3-14(4-6-16)20(32)33/h3-12,34H,1-2H3,(H,32,33)(H,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124659
PNG
(US8759366, (1S,4R)-4-{5-[3-({4-[(1S)-1-fluoroethyl...)
Show SMILES C[C@H](F)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)n1
Show InChI InChI=1S/C25H29FN4O3S/c1-14-9-16(11-17(10-14)29-23-27-8-6-19(30-23)15(2)26)20-12-28-22(34-20)25(33)7-5-18(21(31)32)24(3,4)13-25/h6,8-12,15,18,33H,5,7,13H2,1-4H3,(H,31,32)(H,27,29,30)/t15-,18+,25+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124651
PNG
(US8759366, (1S,2R,4R)-4-hydroxy-2-methyl-4-[5-(3-m...)
Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C23H23F3N4O3S/c1-12-7-14(9-15(8-12)29-21-27-6-4-18(30-21)23(24,25)26)17-11-28-20(34-17)22(33)5-3-16(19(31)32)13(2)10-22/h4,6-9,11,13,16,33H,3,5,10H2,1-2H3,(H,31,32)(H,27,29,30)/t13-,16+,22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124625
PNG
(US8759366, (1S,4R)-4-hydroxy-2,2-dimethyl-4-(5-{3-...)
Show SMILES Cc1cc(Nc2nccc(C)n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H28N4O3S/c1-14-9-16(11-17(10-14)28-22-25-8-6-15(2)27-22)19-12-26-21(32-19)24(31)7-5-18(20(29)30)23(3,4)13-24/h6,8-12,18,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t18-,24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124635
PNG
(US8759366, cis-4-hydroxy-4-(5-{3-methyl-5-[(4-thio...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cccs2)cc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(.13,14.19,;1.47,13.42,;2.8,14.19,;4.13,13.42,;5.47,14.19,;5.47,15.73,;4.13,16.5,;4.13,18.04,;5.47,18.81,;6.8,18.04,;6.8,16.5,;8.13,18.81,;8.3,20.34,;9.8,20.66,;10.57,19.32,;9.54,18.18,;4.13,11.88,;2.8,11.11,;1.47,11.88,;2.8,9.57,;1.55,8.66,;2.03,7.2,;3.57,7.2,;4.05,8.66,;4.48,5.95,;5,7.4,;3.26,5,;3.48,3.48,;4.9,2.9,;6.12,3.85,;5.9,5.37,;5.12,1.38,;6.55,.8,;3.9,.43,)|
Show InChI InChI=1S/C25H24N4O3S2/c1-15-11-17(21-14-27-23(34-21)25(32)7-4-16(5-8-25)22(30)31)13-18(12-15)28-24-26-9-6-19(29-24)20-3-2-10-33-20/h2-3,6,9-14,16,32H,4-5,7-8H2,1H3,(H,30,31)(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124651
PNG
(US8759366, (1S,2R,4R)-4-hydroxy-2-methyl-4-[5-(3-m...)
Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C23H23F3N4O3S/c1-12-7-14(9-15(8-12)29-21-27-6-4-18(30-21)23(24,25)26)17-11-28-20(34-17)22(33)5-3-16(19(31)32)13(2)10-22/h4,6-9,11,13,16,33H,3,5,10H2,1-2H3,(H,31,32)(H,27,29,30)/t13-,16+,22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124615
PNG
(US8759366, (1S,4R)-4-[5-(3-cyclopropyl-5-{[4-(trif...)
Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)C1CC1
Show InChI InChI=1S/C26H27F3N4O3S/c1-24(2)13-25(36,7-5-18(24)21(34)35)22-31-12-19(37-22)16-9-15(14-3-4-14)10-17(11-16)32-23-30-8-6-20(33-23)26(27,28)29/h6,8-12,14,18,36H,3-5,7,13H2,1-2H3,(H,34,35)(H,30,32,33)/t18-,25-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124650
PNG
(US8759366, (1S,4R)-4-hydroxy-2,2-dimethyl-4-[5-(3-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(=O)NCCCN2CCCC2=O)C(C)(C)C1
Show InChI InChI=1S/C31H37F3N6O3S/c1-19-14-20(16-21(15-19)38-28-36-11-8-24(39-28)31(32,33)34)23-17-37-27(44-23)30(43)9-7-22(29(2,3)18-30)26(42)35-10-5-13-40-12-4-6-25(40)41/h8,11,14-17,22,43H,4-7,9-10,12-13,18H2,1-3H3,(H,35,42)(H,36,38,39)/t22-,30-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124633
PNG
(US8759366, (1S,4R)-4-[5-(3-chloro-5-{[4-(trifluoro...)
Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(Cl)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C23H22ClF3N4O3S/c1-21(2)11-22(34,5-3-15(21)18(32)33)19-29-10-16(35-19)12-7-13(24)9-14(8-12)30-20-28-6-4-17(31-20)23(25,26)27/h4,6-10,15,34H,3,5,11H2,1-2H3,(H,32,33)(H,28,30,31)/t15-,22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124628
PNG
(US8759366, (1S,4R)-N-(cyanomethyl)-4-hydroxy-2,2-d...)
Show SMILES Cc1cc(Nc2nccc(C)n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(=O)NCC#N)C(C)(C)C1
Show InChI InChI=1S/C26H30N6O2S/c1-16-11-18(13-19(12-16)32-24-29-9-6-17(2)31-24)21-14-30-23(35-21)26(34)7-5-20(25(3,4)15-26)22(33)28-10-8-27/h6,9,11-14,20,34H,5,7,10,15H2,1-4H3,(H,28,33)(H,29,31,32)/t20-,26-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124653
PNG
(US8759366, (1R,4S)-4-hydroxy-2,2-dimethyl-4-[5-(3-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-14(10-15(9-13)30-21-28-7-5-18(31-21)24(25,26)27)17-11-29-20(35-17)23(34)6-4-16(19(32)33)22(2,3)12-23/h5,7-11,16,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t16-,23-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124652
PNG
(US8759366, (1S,4R)-4-methoxy-2,2-dimethyl-4-[5-(3-...)
Show SMILES CO[C@@]1(CC[C@H](C(O)=O)C(C)(C)C1)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C25H27F3N4O3S/c1-14-9-15(11-16(10-14)31-22-29-8-6-19(32-22)25(26,27)28)18-12-30-21(36-18)24(35-4)7-5-17(20(33)34)23(2,3)13-24/h6,8-12,17H,5,7,13H2,1-4H3,(H,33,34)(H,29,31,32)/t17-,24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124649
PNG
(US8759366, cis-4-[(hydroxyacetyl)amino]-1-[5-(3-me...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(CCC(CC1)NC(=O)CO)C(N)=O |(1.66,13.57,;3,12.8,;4.33,13.57,;5.66,12.8,;7,13.57,;7,15.11,;5.66,15.88,;5.66,17.42,;7,18.19,;8.33,17.42,;8.33,15.88,;9.66,18.19,;11,18.96,;8.89,19.53,;10.43,16.86,;5.66,11.26,;4.33,10.49,;3,11.26,;4.33,8.95,;5.58,8.05,;5.1,6.58,;3.56,6.58,;3.08,8.05,;2.65,5.34,;1.23,4.76,;1.01,3.23,;2.23,2.29,;3.65,2.86,;3.87,4.39,;2.01,.76,;.58,.18,;-.63,1.13,;.37,-1.34,;-1.06,-1.92,;2.13,6.78,;2.24,8.32,;.61,7.05,)|
Show InChI InChI=1S/C24H25F3N6O3S/c1-13-8-14(10-16(9-13)32-22-29-7-4-18(33-22)24(25,26)27)17-11-30-21(37-17)23(20(28)36)5-2-15(3-6-23)31-19(35)12-34/h4,7-11,15,34H,2-3,5-6,12H2,1H3,(H2,28,36)(H,31,35)(H,29,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124644
PNG
(US8759366, cis-4-hydroxy-1-methyl-4-[5-(3-{[4-(tri...)
Show SMILES CC1(CCC(O)(CC1)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1)C(O)=O |(8.18,-2.89,;7.28,-1.64,;5.85,-1.06,;5.64,.46,;6.85,1.41,;7.38,2.86,;8.28,.83,;8.49,-.69,;5.95,2.65,;4.41,2.65,;3.93,4.12,;5.18,5.02,;6.42,4.12,;5.18,6.56,;6.51,7.33,;6.51,8.87,;5.18,9.64,;3.84,8.87,;2.51,9.64,;1.17,8.87,;1.17,7.33,;-.16,6.56,;-1.49,7.33,;-1.49,8.87,;-.16,9.64,;-2.83,9.64,;-4.16,10.41,;-2.06,10.98,;-3.6,8.31,;3.84,7.33,;6.75,-3.09,;5.24,-3.36,;7.74,-4.27,)|
Show InChI InChI=1S/C22H21F3N4O3S/c1-20(18(30)31)6-8-21(32,9-7-20)17-27-12-15(33-17)13-3-2-4-14(11-13)28-19-26-10-5-16(29-19)22(23,24)25/h2-5,10-12,32H,6-9H2,1H3,(H,30,31)(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124636
PNG
(US8759366, 3-[5-(3-methyl-5-{[4-(trifluoromethyl)p...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CCC(O)=O)s1
Show InChI InChI=1S/C18H15F3N4O2S/c1-10-6-11(13-9-23-15(28-13)2-3-16(26)27)8-12(7-10)24-17-22-5-4-14(25-17)18(19,20)21/h4-9H,2-3H2,1H3,(H,26,27)(H,22,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124654
PNG
(US8759366, N-{3-[2-(1-aminocyclobutyl)-1,3-thiazol...)
Show SMILES Cc1cc(Nc2nccc(n2)C2CC2)cc(c1)-c1cnc(s1)C1(N)CCC1
Show InChI InChI=1S/C21H23N5S/c1-13-9-15(18-12-24-19(27-18)21(22)6-2-7-21)11-16(10-13)25-20-23-8-5-17(26-20)14-3-4-14/h5,8-12,14H,2-4,6-7,22H2,1H3,(H,23,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124629
PNG
(US8759366, (1S,4R)-4-hydroxy-4-[5-(3-{[4-(2-hydrox...)
Show SMILES Cc1cc(Nc2nccc(OCCO)n2)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(N)=O)C(C)(C)C1
Show InChI InChI=1S/C25H31N5O4S/c1-15-10-16(12-17(11-15)29-23-27-7-5-20(30-23)34-9-8-31)19-13-28-22(35-19)25(33)6-4-18(21(26)32)24(2,3)14-25/h5,7,10-13,18,31,33H,4,6,8-9,14H2,1-3H3,(H2,26,32)(H,27,29,30)/t18-,25-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124655
PNG
(US8759366, 1-{Cis-4-hydroxy-4-[5-(3-methyl-5-{[4-(...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CCC(CC1)N1CCCC1=O |(2.5,4.97,;3.71,4.02,;5.14,4.6,;6.35,3.65,;7.78,4.23,;7.99,5.75,;6.78,6.7,;6.99,8.23,;8.42,8.8,;9.64,7.86,;9.42,6.33,;11.06,8.43,;12.49,9.01,;11.64,7.01,;10.49,9.86,;6.14,2.13,;4.71,1.55,;3.5,2.5,;4.49,.03,;3.14,-.7,;3.4,-2.21,;4.93,-2.43,;5.6,-1.04,;5.65,-3.79,;6.37,-2.43,;4.32,-4.56,;4.32,-6.1,;5.65,-6.87,;6.98,-6.1,;6.98,-4.56,;5.65,-8.41,;4.4,-9.31,;4.88,-10.78,;6.42,-10.78,;6.9,-9.31,;8.36,-8.84,)|
Show InChI InChI=1S/C25H26F3N5O2S/c1-15-11-16(13-17(12-15)31-23-29-9-6-20(32-23)25(26,27)28)19-14-30-22(36-19)24(35)7-4-18(5-8-24)33-10-2-3-21(33)34/h6,9,11-14,18,35H,2-5,7-8,10H2,1H3,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124644
PNG
(US8759366, cis-4-hydroxy-1-methyl-4-[5-(3-{[4-(tri...)
Show SMILES CC1(CCC(O)(CC1)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1)C(O)=O |(8.18,-2.89,;7.28,-1.64,;5.85,-1.06,;5.64,.46,;6.85,1.41,;7.38,2.86,;8.28,.83,;8.49,-.69,;5.95,2.65,;4.41,2.65,;3.93,4.12,;5.18,5.02,;6.42,4.12,;5.18,6.56,;6.51,7.33,;6.51,8.87,;5.18,9.64,;3.84,8.87,;2.51,9.64,;1.17,8.87,;1.17,7.33,;-.16,6.56,;-1.49,7.33,;-1.49,8.87,;-.16,9.64,;-2.83,9.64,;-4.16,10.41,;-2.06,10.98,;-3.6,8.31,;3.84,7.33,;6.75,-3.09,;5.24,-3.36,;7.74,-4.27,)|
Show InChI InChI=1S/C22H21F3N4O3S/c1-20(18(30)31)6-8-21(32,9-7-20)17-27-12-15(33-17)13-3-2-4-14(11-13)28-19-26-10-5-16(29-19)22(23,24)25/h2-5,10-12,32H,6-9H2,1H3,(H,30,31)(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124642
PNG
(US8759366, 2-({[5-(3-methyl-5-{[4-(trifluoromethyl...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CNCCS(N)(=O)=O)s1
Show InChI InChI=1S/C18H19F3N6O2S2/c1-11-6-12(14-9-25-16(30-14)10-23-4-5-31(22,28)29)8-13(7-11)26-17-24-3-2-15(27-17)18(19,20)21/h2-3,6-9,23H,4-5,10H2,1H3,(H2,22,28,29)(H,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124630
PNG
(US8759366, (1S,4R)-4-[5-(3-[(acetylamino)methyl]-5...)
Show SMILES CC(=O)NCc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(N)=O)C(C)(C)C1
Show InChI InChI=1S/C26H29F3N6O3S/c1-14(36)32-11-15-8-16(10-17(9-15)34-23-31-7-5-20(35-23)26(27,28)29)19-12-33-22(39-19)25(38)6-4-18(21(30)37)24(2,3)13-25/h5,7-10,12,18,38H,4,6,11,13H2,1-3H3,(H2,30,37)(H,32,36)(H,31,34,35)/t18-,25-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124637
PNG
(US8759366, N-(3-methyl-5-{2-[2-methyl-2-(1,3,4-oxa...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CC(C)(C)c2nnco2)s1
Show InChI InChI=1S/C21H19F3N6OS/c1-12-6-13(8-14(7-12)28-19-25-5-4-16(29-19)21(22,23)24)15-10-26-17(32-15)9-20(2,3)18-30-27-11-31-18/h4-8,10-11H,9H2,1-3H3,(H,25,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124619
PNG
(US8759366, 3-hydroxy-3-[5-(3-{[4-(trifluoromethyl)...)
Show SMILES NC(=O)N1CCC(O)(C1)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C19H17F3N6O2S/c20-19(21,22)14-4-6-24-17(27-14)26-12-3-1-2-11(8-12)13-9-25-15(31-13)18(30)5-7-28(10-18)16(23)29/h1-4,6,8-9,30H,5,7,10H2,(H2,23,29)(H,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124643
PNG
(US8759366, 1-({[5-(3-methyl-5-{[4-(trifluoromethyl...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CNC2(CCC2)C(O)=O)s1
Show InChI InChI=1S/C21H20F3N5O2S/c1-12-7-13(9-14(8-12)28-19-25-6-3-16(29-19)21(22,23)24)15-10-26-17(32-15)11-27-20(18(30)31)4-2-5-20/h3,6-10,27H,2,4-5,11H2,1H3,(H,30,31)(H,25,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124648
PNG
(US8759366, 1-{5-[3-(morpholin-4-yl)-5-{[4-(trifluo...)
Show SMILES OC1(CCC1)c1ncc(s1)-c1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)N1CCOCC1
Show InChI InChI=1S/C22H22F3N5O2S/c23-22(24,25)18-2-5-26-20(29-18)28-15-10-14(11-16(12-15)30-6-8-32-9-7-30)17-13-27-19(33-17)21(31)3-1-4-21/h2,5,10-13,31H,1,3-4,6-9H2,(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 13n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124656
PNG
(US8759366, (1S,4R)-4-(hydroxymethyl)-3,3-dimethyl-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](CO)C(C)(C)C1
Show InChI InChI=1S/C24H27F3N4O2S/c1-14-8-15(10-17(9-14)30-21-28-7-5-19(31-21)24(25,26)27)18-11-29-20(34-18)23(33)6-4-16(12-32)22(2,3)13-23/h5,7-11,16,32-33H,4,6,12-13H2,1-3H3,(H,28,30,31)/t16-,23-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 13n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124647
PNG
(US8759366, 8-[2-(2,2-difluoro-1-hydroxyethyl)-1,3-...)
Show SMILES CC1(C)Oc2c(NC1=O)cc(Nc1nccc(n1)C(F)(F)F)cc2-c1cnc(s1)C(O)C(F)F
Show InChI InChI=1S/C20H16F5N5O3S/c1-19(2)17(32)29-10-6-8(28-18-26-4-3-12(30-18)20(23,24)25)5-9(14(10)33-19)11-7-27-16(34-11)13(31)15(21)22/h3-7,13,15,31H,1-2H3,(H,29,32)(H,26,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124624
PNG
(US8759366, (1S,4R)-4-hydroxy-4-[5-(3-{[4-methoxy-5...)
Show SMILES COc1nc(Nc2cc(C)cc(c2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O4S/c1-13-7-14(9-15(8-13)31-22-30-10-17(25(26,27)28)19(32-22)36-4)18-11-29-21(37-18)24(35)6-5-16(20(33)34)23(2,3)12-24/h7-11,16,35H,5-6,12H2,1-4H3,(H,33,34)(H,30,31,32)/t16-,24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124631
PNG
(US8759366, N-{3-methyl-5-[2-(1H-pyrazol-5-yl)-1,3-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)-c1cc[nH]n1
Show InChI InChI=1S/C18H13F3N6S/c1-10-6-11(14-9-23-16(28-14)13-2-5-24-27-13)8-12(7-10)25-17-22-4-3-15(26-17)18(19,20)21/h2-9H,1H3,(H,24,27)(H,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124622
PNG
(US8759366, 2-(5-{3-[(5-fluoro-4-methoxypyrimidin-2...)
Show SMILES COc1nc(Nc2cc(C)cc(c2)-c2cnc(s2)C(C)(O)CO)ncc1F
Show InChI InChI=1S/C18H19FN4O3S/c1-10-4-11(14-8-20-16(27-14)18(2,25)9-24)6-12(5-10)22-17-21-7-13(19)15(23-17)26-3/h4-8,24-25H,9H2,1-3H3,(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124646
PNG
(US8759366, 1-[5-(3-methyl-5-{[4-(methylsulfanyl)py...)
Show SMILES CSc1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)C2(O)CCC2)n1
Show InChI InChI=1S/C19H20N4OS2/c1-12-8-13(15-11-21-17(26-15)19(24)5-3-6-19)10-14(9-12)22-18-20-7-4-16(23-18)25-2/h4,7-11,24H,3,5-6H2,1-2H3,(H,20,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 24n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124626
PNG
(US8759366, 1-(5-{3-[(4-tert-butylpyrimidin-2-yl)am...)
Show SMILES Cc1cc(Nc2nccc(n2)C(C)(C)C)cc(c1)-c1cnc(s1)C1(O)CCC1
Show InChI InChI=1S/C22H26N4OS/c1-14-10-15(17-13-24-19(28-17)22(27)7-5-8-22)12-16(11-14)25-20-23-9-6-18(26-20)21(2,3)4/h6,9-13,27H,5,7-8H2,1-4H3,(H,23,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 25n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124620
PNG
(US8759366, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-5-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(=O)NC(CO)CO
Show InChI InChI=1S/C19H18F3N5O3S/c1-10-4-11(14-7-24-17(31-14)16(30)25-13(8-28)9-29)6-12(5-10)26-18-23-3-2-15(27-18)19(20,21)22/h2-7,13,28-29H,8-9H2,1H3,(H,25,30)(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 26n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124657
PNG
(US8759366, Ethyl (1R,4S)-4-hydroxy-2,2-dimethyl-4-...)
Show SMILES CCOC(=O)[C@@H]1CC[C@](O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C26H29F3N4O3S/c1-5-36-21(34)18-6-8-25(35,14-24(18,3)4)22-31-13-19(37-22)16-10-15(2)11-17(12-16)32-23-30-9-7-20(33-23)26(27,28)29/h7,9-13,18,35H,5-6,8,14H2,1-4H3,(H,30,32,33)/t18-,25-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 49n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124658
PNG
(US8759366, 5-(aminomethyl)-5-[5-(3-methyl-5-{[4-(t...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(CN)CCNC(=O)CC1
Show InChI InChI=1S/C22H23F3N6OS/c1-13-8-14(10-15(9-13)30-20-28-6-3-17(31-20)22(23,24)25)16-11-29-19(33-16)21(12-26)4-2-18(32)27-7-5-21/h3,6,8-11H,2,4-5,7,12,26H2,1H3,(H,27,32)(H,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 50n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124627
PNG
(US8759366, cis-4-hydroxy-4-[5-(3-methyl-5-{[4-(tri...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(=O)NCc1ccc(OCC(F)(F)F)nc1 |(-2.7,15.57,;-1.37,14.8,;-.03,15.57,;1.3,14.8,;2.63,15.57,;2.63,17.11,;1.3,17.88,;1.3,19.42,;2.63,20.19,;3.97,19.42,;3.97,17.88,;5.3,20.19,;6.63,20.96,;6.07,18.86,;4.53,21.53,;1.3,13.26,;-.03,12.49,;-1.37,13.26,;-.03,10.95,;-1.28,10.05,;-.8,8.58,;.74,8.58,;1.21,10.05,;1.64,7.34,;2.17,8.78,;.43,6.39,;.64,4.86,;2.07,4.29,;3.28,5.24,;3.07,6.76,;2.28,2.76,;1.07,1.81,;3.71,2.19,;3.93,.66,;5.35,.08,;6.57,1.03,;8,.46,;8.21,-1.07,;9.64,-1.65,;10.85,-.7,;12.28,-1.28,;13.71,-1.85,;12.86,.15,;11.7,-2.7,;7,-2.02,;5.57,-1.44,)|
Show InChI InChI=1S/C30H28F6N6O3S/c1-17-10-20(12-21(11-17)41-27-37-9-6-23(42-27)30(34,35)36)22-15-40-26(46-22)28(44)7-4-19(5-8-28)25(43)39-14-18-2-3-24(38-13-18)45-16-29(31,32)33/h2-3,6,9-13,15,19,44H,4-5,7-8,14,16H2,1H3,(H,39,43)(H,37,41,42)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 222n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124641
PNG
(US8759366, (1-methyl-1H-pyrazol-5-yl)[5-(3-{[4-(tr...)
Show SMILES Cn1nccc1C(O)c1ncc(s1)-c1cccc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N6OS/c1-28-13(5-8-25-28)16(29)17-24-10-14(30-17)11-3-2-4-12(9-11)26-18-23-7-6-15(27-18)19(20,21)22/h2-10,16,29H,1H3,(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 237n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124638
PNG
(US8759366, 4-{[5-(3-methyl-5-{[4-(trifluoromethyl)...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(=O)N1CCNC(=O)C1
Show InChI InChI=1S/C20H17F3N6O2S/c1-11-6-12(8-13(7-11)27-19-25-3-2-15(28-19)20(21,22)23)14-9-26-17(32-14)18(31)29-5-4-24-16(30)10-29/h2-3,6-9H,4-5,10H2,1H3,(H,24,30)(H,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 314n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124618
PNG
(US8759366, ethyl 4-hydroxy-4-(5-{3-methyl-5-[(4-me...)
Show SMILES CCOC(=O)C1CCC(O)(CC1c1ccccc1)c1ncc(s1)-c1cc(C)cc(Nc2nccc(C)n2)c1
Show InChI InChI=1S/C30H32N4O3S/c1-4-37-27(35)24-10-12-30(36,17-25(24)21-8-6-5-7-9-21)28-32-18-26(38-28)22-14-19(2)15-23(16-22)34-29-31-13-11-20(3)33-29/h5-9,11,13-16,18,24-25,36H,4,10,12,17H2,1-3H3,(H,31,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 596n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124616
PNG
(US8759366, tert-butyl 3-hydroxy-3-[5-(3-methyl-5-{...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H24F3N5O3S/c1-13-7-14(9-15(8-13)29-19-27-6-5-17(30-19)23(24,25)26)16-10-28-18(35-16)22(33)11-31(12-22)20(32)34-21(2,3)4/h5-10,33H,11-12H2,1-4H3,(H,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 628n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124639
PNG
(US8759366, N-(dicyclopropylmethyl)-N-methyl-5-(3-m...)
Show SMILES CN(C(C1CC1)C1CC1)C(=O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N5OS/c1-13-9-16(11-17(10-13)30-23-28-8-7-19(31-23)24(25,26)27)18-12-29-21(34-18)22(33)32(2)20(14-3-4-14)15-5-6-15/h7-12,14-15,20H,3-6H2,1-2H3,(H,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.25E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124634
PNG
(US8759366, Cis-tert-butyl cis-4-hydroxy-4-[5-(3-me...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(=O)OC(C)(C)C |(-.09,14.41,;1.25,13.64,;2.58,14.41,;3.91,13.64,;5.25,14.41,;5.25,15.95,;3.91,16.72,;3.91,18.26,;5.25,19.03,;6.58,18.26,;6.58,16.72,;7.92,19.03,;7.15,20.36,;8.69,17.7,;9.25,19.8,;10.58,20.57,;8.48,21.13,;10.02,18.47,;3.91,12.1,;2.58,11.33,;1.25,12.1,;2.58,9.79,;1.33,8.89,;1.81,7.42,;3.35,7.42,;3.83,8.89,;4.26,6.18,;4.78,7.62,;3.04,5.23,;3.26,3.7,;4.68,3.12,;5.9,4.07,;5.68,5.6,;4.9,1.6,;6.33,1.02,;3.68,.65,;3.9,-.87,;4.11,-2.4,;2.37,-1.09,;5.42,-.66,)|
Show InChI InChI=1S/C27H29F5N4O3S/c1-15-11-17(13-18(12-15)35-23-33-10-7-20(36-23)26(28,29)27(30,31)32)19-14-34-22(40-19)25(38)8-5-16(6-9-25)21(37)39-24(2,3)4/h7,10-14,16,38H,5-6,8-9H2,1-4H3,(H,33,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.43E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124617
PNG
(US8759366, methyl 4-(5-{3-[(5-chloropyrimidin-2-yl...)
Show SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2ncc(Cl)cn2)c1
Show InChI InChI=1S/C24H27ClN4O3S/c1-14-7-15(9-17(8-14)29-22-27-10-16(25)11-28-22)19-12-26-21(33-19)24(31)6-5-18(20(30)32-4)23(2,3)13-24/h7-12,18,31H,5-6,13H2,1-4H3,(H,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.29E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124623
PNG
(US8759366, tert-butyl cis-4-hydroxy-4-{5-[3-({4-[1...)
Show SMILES COc1ccc(Cn2cc(nn2)-c2ccnc(Nc3cc(C)cc(c3)-c3cnc(s3)C3(O)CCC(CC3)C(=O)OC(C)(C)C)n2)cc1 |(9.2,2.84,;8.29,4.09,;6.76,3.93,;5.85,5.17,;4.32,5.01,;3.7,3.61,;2.16,3.45,;1.54,2.04,;.03,1.72,;-.13,.19,;1.28,-.44,;2.31,.71,;-1.46,-.58,;-2.8,.19,;-4.13,-.58,;-4.13,-2.12,;-2.8,-2.89,;-2.8,-4.43,;-1.46,-5.2,;-.13,-4.43,;1.2,-5.2,;2.54,-4.43,;1.2,-6.74,;-.13,-7.51,;-1.46,-6.74,;-.13,-9.05,;-1.38,-9.96,;-.9,-11.42,;.64,-11.42,;1.12,-9.96,;1.55,-12.67,;2.07,-11.22,;.33,-13.62,;.55,-15.14,;1.97,-15.72,;3.19,-14.77,;2.97,-13.25,;2.19,-17.24,;3.62,-17.82,;.98,-18.19,;1.19,-19.72,;1.4,-21.24,;-.34,-19.93,;2.71,-19.5,;-1.46,-2.12,;4.6,2.36,;6.13,2.52,)|
Show InChI InChI=1S/C35H39N7O4S/c1-22-16-25(30-19-37-32(47-30)35(44)13-10-24(11-14-35)31(43)46-34(2,3)4)18-26(17-22)38-33-36-15-12-28(39-33)29-21-42(41-40-29)20-23-6-8-27(45-5)9-7-23/h6-9,12,15-19,21,24,44H,10-11,13-14,20H2,1-5H3,(H,36,38,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.91E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124632
PNG
(US8759366, methyl 4-{difluoro[5-(3-methyl-5-{[4-(t...)
Show SMILES COC(=O)c1ccc(cc1)C(F)(F)c1ncc(s1)-c1cc(C)cc(Nc2nccc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C24H17F5N4O2S/c1-13-9-15(11-17(10-13)32-22-30-8-7-19(33-22)24(27,28)29)18-12-31-21(36-18)23(25,26)16-5-3-14(4-6-16)20(34)35-2/h3-12H,1-2H3,(H,30,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.08E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124621
PNG
(US8759366, methyl (1S,4R)-4-(5-{3-[(4,6-dimethylpy...)
Show SMILES COC(=O)[C@H]1CC[C@@](O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2nc(C)cc(C)n2)c1
Show InChI InChI=1S/C26H32N4O3S/c1-15-9-18(12-19(10-15)30-24-28-16(2)11-17(3)29-24)21-13-27-23(34-21)26(32)8-7-20(22(31)33-6)25(4,5)14-26/h9-13,20,32H,7-8,14H2,1-6H3,(H,28,29,30)/t20-,26-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.89E+3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%