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SMILES: Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CCC(O)=O)s1

InChI Key: InChIKey=PXLXELCMOXDDSY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124636   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM124636
PNG
(US8759366, 3-[5-(3-methyl-5-{[4-(trifluoromethyl)p...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(CCC(O)=O)s1
Show InChI InChI=1S/C18H15F3N4O2S/c1-10-6-11(13-9-23-15(28-13)2-3-16(26)27)8-12(7-10)24-17-22-5-4-14(25-17)18(19,20)21/h4-9H,2-3H2,1H3,(H,26,27)(H,22,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi...

US Patent US8759366 (2014)


BindingDB Entry DOI: 10.7270/Q21N7ZS1
More data for this
Ligand-Target Pair