Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM124625 (US8759366, (1S,4R)-4-hydroxy-2,2-dimethyl-4-(5-{3-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent | Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human SYK activity. The recombinant human GST-SYK (Carna Bi... | US Patent US8759366 (2014) BindingDB Entry DOI: 10.7270/Q21N7ZS1 | |||||||||||
More data for this Ligand-Target Pair |