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Patent code US9193736

Compile Data Set for Download or QSAR

Found 311 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193145
PNG
(US9193736, 61)
Show SMILES OC(=O)c1ccc(s1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H23N5O3S/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-6,9-12H,7-8,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193121
PNG
(US9193736, 37)
Show SMILES Oc1nc(no1)-c1ccc(cn1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C28H24N8O3/c37-28-33-26(34-39-28)23-9-6-19(17-29-23)25-22(10-8-20-7-5-18-3-1-2-4-21(18)31-20)32-27-24(11-12-30-36(25)27)35-13-15-38-16-14-35/h1-7,9,11-12,17H,8,10,13-16H2,(H,33,34,37)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193144
PNG
(US9193736, 60)
Show SMILES OC(=O)c1ccc(o1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H23N5O4/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-6,9-12H,7-8,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193246
PNG
(US9193736, 170)
Show SMILES OC(=O)[C@@H]1C[C@@H]1c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1 |wU:27.31,wD:3.2,29.36,5.6,(-1.64,-8.26,;-.49,-7.23,;.97,-7.71,;-.81,-5.72,;-1.84,-4.58,;-.34,-4.26,;.81,-3.23,;.49,-1.72,;1.63,-.69,;3.1,-1.17,;3.42,-2.67,;2.27,-3.7,;4.24,-.14,;4.08,1.39,;5.49,2.02,;6.52,.88,;8.06,.88,;8.83,-.46,;8.06,-1.79,;6.52,-1.79,;5.75,-.46,;8.83,2.21,;8.06,3.54,;8.83,4.88,;10.37,4.88,;11.14,3.54,;10.37,2.21,;2.75,2.16,;1.26,1.77,;.86,3.25,;2.35,3.65,;-.47,4.02,;-.47,5.56,;-1.81,6.33,;-3.14,5.56,;-4.47,6.33,;-5.81,5.56,;-5.81,4.02,;-4.47,3.25,;-3.14,4.02,;-1.81,3.25,)|
Show InChI InChI=1S/C33H31N5O3/c39-33(40)26-19-25(26)20-5-7-22(8-6-20)31-30(36-32-29(11-12-34-38(31)32)37-13-15-41-16-14-37)24-17-23(18-24)28-10-9-21-3-1-2-4-27(21)35-28/h1-12,23-26H,13-19H2,(H,39,40)/t23-,24-,25-,26-/m1/s1
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193144
PNG
(US9193736, 60)
Show SMILES OC(=O)c1ccc(o1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H23N5O4/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-6,9-12H,7-8,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193115
PNG
(US9193736, 31)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccnn2c1-c1ccc(nc1)-c1nnn[nH]1)N1CCOCC1
Show InChI InChI=1S/C27H24N10O/c1-2-4-21-18(3-1)5-7-20(30-21)8-10-22-25(19-6-9-23(28-17-19)26-32-34-35-33-26)37-27(31-22)24(11-12-29-37)36-13-15-38-16-14-36/h1-7,9,11-12,17H,8,10,13-16H2,(H,32,33,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193141
PNG
(US9193736, 57)
Show SMILES OC(=O)c1ccc(s1)-c1c(\C=C\c2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H21N5O3S/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-12H,13-16H2,(H,32,33)/b8-7+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193112
PNG
(US9193736, 28)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(cn1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H23N7O4S/c1-40(37,38)33-28(36)24-10-7-20(18-29-24)26-23(11-9-21-8-6-19-4-2-3-5-22(19)31-21)32-27-25(12-13-30-35(26)27)34-14-16-39-17-15-34/h2-8,10,12-13,18H,14-17H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193121
PNG
(US9193736, 37)
Show SMILES Oc1nc(no1)-c1ccc(cn1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C28H24N8O3/c37-28-33-26(34-39-28)23-9-6-19(17-29-23)25-22(10-8-20-7-5-18-3-1-2-4-21(18)31-20)32-27-24(11-12-30-36(25)27)35-13-15-38-16-14-35/h1-7,9,11-12,17H,8,10,13-16H2,(H,33,34,37)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193202
PNG
(US9193736, 121)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3nc4c(ccnn4c3-c3ccccc3)N3CCOCC3)ccc12
Show InChI InChI=1S/C28H23N5O3/c34-28(35)22-7-4-8-23-21(22)11-9-20(30-23)10-12-24-26(19-5-2-1-3-6-19)33-27(31-24)25(13-14-29-33)32-15-17-36-18-16-32/h1-14H,15-18H2,(H,34,35)/b12-10+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193108
PNG
(US9193736, 24)
Show SMILES OC(=O)CNc1ccc(cn1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H23N7O3/c36-26(37)18-30-25-10-6-20(17-29-25)27-23(9-8-21-7-5-19-3-1-2-4-22(19)32-21)33-28-24(11-12-31-35(27)28)34-13-15-38-16-14-34/h1-7,10-12,17H,13-16,18H2,(H,29,30)(H,36,37)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193225
PNG
(US9193736, 148)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3nc4c(ccnn4c3-c3ccc(cc3)C#N)N3CCOCC3)ccc12
Show InChI InChI=1S/C29H22N6O3/c30-18-19-4-6-20(7-5-19)27-25(33-28-26(12-13-31-35(27)28)34-14-16-38-17-15-34)11-9-21-8-10-22-23(29(36)37)2-1-3-24(22)32-21/h1-13H,14-17H2,(H,36,37)/b11-9+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193240
PNG
(US9193736, 164)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1 |wU:24.27,wD:26.32,(4.46,-12.1,;4.14,-10.59,;2.67,-10.12,;5.28,-9.56,;4.96,-8.06,;6.11,-7.03,;7.57,-7.5,;7.89,-9.01,;6.75,-10.04,;8.72,-6.47,;8.55,-4.94,;9.96,-4.31,;10.99,-5.46,;12.53,-5.46,;13.3,-6.79,;12.53,-8.12,;10.99,-8.12,;10.22,-6.79,;13.3,-4.12,;12.53,-2.79,;13.3,-1.46,;14.84,-1.46,;15.61,-2.79,;14.84,-4.12,;7.22,-4.17,;5.73,-4.57,;5.33,-3.08,;6.82,-2.68,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-1.33,-2.31,;,-3.08,;1.33,-2.31,;2.67,-3.08,)|
Show InChI InChI=1S/C30H27N5O3/c36-30(37)21-7-5-20(6-8-21)28-27(33-29-26(11-12-31-35(28)29)34-13-15-38-16-14-34)23-17-22(18-23)25-10-9-19-3-1-2-4-24(19)32-25/h1-12,22-23H,13-18H2,(H,36,37)/t22-,23-
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193171
PNG
(US9193736, 87)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1nc2ccccc2s1
Show InChI InChI=1S/C26H19N5O3S/c32-26(33)18-7-5-17(6-8-18)24-20(9-10-23-28-19-3-1-2-4-22(19)35-23)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-8,11-12H,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193249
PNG
(US9193736, 174)
Show SMILES OC(=O)CC1(COC1)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)[C@H]1C[C@@H](C1)c1ccc2ccccc2n1 |wU:29.33,wD:31.38,(.21,-7.42,;1.41,-6.45,;2.84,-7,;1.16,-4.93,;-.27,-4.37,;-1.54,-3.5,;-2.41,-4.77,;-1.15,-5.64,;.87,-3.34,;.55,-1.84,;1.7,-.81,;3.16,-1.28,;3.48,-2.79,;2.34,-3.82,;4.3,-.25,;4.14,1.28,;5.55,1.91,;6.58,.76,;8.12,.76,;8.89,-.57,;8.12,-1.91,;6.58,-1.91,;5.81,-.57,;8.89,2.09,;8.12,3.43,;8.89,4.76,;10.43,4.76,;11.2,3.43,;10.43,2.09,;2.81,2.05,;1.32,1.65,;.92,3.14,;2.41,3.54,;-.41,3.91,;-.41,5.45,;-1.74,6.22,;-3.08,5.45,;-4.41,6.22,;-5.74,5.45,;-5.74,3.91,;-4.41,3.14,;-3.08,3.91,;-1.74,3.14,)|
Show InChI InChI=1S/C34H33N5O4/c40-30(41)19-34(20-43-21-34)26-8-5-23(6-9-26)32-31(37-33-29(11-12-35-39(32)33)38-13-15-42-16-14-38)25-17-24(18-25)28-10-7-22-3-1-2-4-27(22)36-28/h1-12,24-25H,13-21H2,(H,40,41)/t24-,25-
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193125
PNG
(US9193736, 41)
Show SMILES OC(=O)c1ccc(cc1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C28H25N5O3/c34-28(35)21-7-5-20(6-8-21)26-24(12-11-22-10-9-19-3-1-2-4-23(19)30-22)31-27-25(13-14-29-33(26)27)32-15-17-36-18-16-32/h1-10,13-14H,11-12,15-18H2,(H,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193126
PNG
(US9193736, 42)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C29H28N6O4S/c1-20(36)33-40(37,38)24-11-7-22(8-12-24)28-26(13-10-23-9-6-21-4-2-3-5-25(21)31-23)32-29-27(14-15-30-35(28)29)34-16-18-39-19-17-34/h2-9,11-12,14-15H,10,13,16-19H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193127
PNG
(US9193736, 43)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(cc1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C29H28N6O4S/c1-40(37,38)33-29(36)22-8-6-21(7-9-22)27-25(13-12-23-11-10-20-4-2-3-5-24(20)31-23)32-28-26(14-15-30-35(27)28)34-16-18-39-19-17-34/h2-11,14-15H,12-13,16-19H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193128
PNG
(US9193736, 44)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)-c1c(\C=C\c2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C31H28N6O4/c38-28(39)14-15-32-31(40)23-7-5-22(6-8-23)29-26(12-11-24-10-9-21-3-1-2-4-25(21)34-24)35-30-27(13-16-33-37(29)30)36-17-19-41-20-18-36/h1-13,16H,14-15,17-20H2,(H,32,40)(H,38,39)/b12-11+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193141
PNG
(US9193736, 57)
Show SMILES OC(=O)c1ccc(s1)-c1c(\C=C\c2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H21N5O3S/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-12H,13-16H2,(H,32,33)/b8-7+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193161
PNG
(US9193736, 77)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H21N5O3/c34-28(35)21-7-5-20(6-8-21)26-24(12-11-22-10-9-19-3-1-2-4-23(19)30-22)31-27-25(13-14-29-33(26)27)32-15-17-36-18-16-32/h1-10,13-14H,15-18H2,(H,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193169
PNG
(US9193736, 85)
Show SMILES OC(=O)c1ccc(s1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C26H19N5O3S/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-6,9-12H,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193199
PNG
(US9193736, 118)
Show SMILES ONC(=O)c1cccc2nc(\C=C\c3cn4nccc(N5CCOCC5)c4n3)ccc12
Show InChI InChI=1S/C22H20N6O3/c29-22(26-30)18-2-1-3-19-17(18)7-6-15(24-19)4-5-16-14-28-21(25-16)20(8-9-23-28)27-10-12-31-13-11-27/h1-9,14,30H,10-13H2,(H,26,29)/b5-4+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193216
PNG
(US9193736, 137)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3nc4c(ccnn4c3-c3cccnc3)N3CCOCC3)ccc12
Show InChI InChI=1S/C27H22N6O3/c34-27(35)21-4-1-5-22-20(21)8-6-19(30-22)7-9-23-25(18-3-2-11-28-17-18)33-26(31-23)24(10-12-29-33)32-13-15-36-16-14-32/h1-12,17H,13-16H2,(H,34,35)/b9-7+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193225
PNG
(US9193736, 148)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3nc4c(ccnn4c3-c3ccc(cc3)C#N)N3CCOCC3)ccc12
Show InChI InChI=1S/C29H22N6O3/c30-18-19-4-6-20(7-5-19)27-25(33-28-26(12-13-31-35(27)28)34-14-16-38-17-15-34)11-9-21-8-10-22-23(29(36)37)2-1-3-24(22)32-21/h1-13H,14-17H2,(H,36,37)/b11-9+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193126
PNG
(US9193736, 42)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C29H28N6O4S/c1-20(36)33-40(37,38)24-11-7-22(8-12-24)28-26(13-10-23-9-6-21-4-2-3-5-25(21)31-23)32-29-27(14-15-30-35(28)29)34-16-18-39-19-17-34/h2-9,11-12,14-15H,10,13,16-19H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193207
PNG
(US9193736, 127)
Show SMILES CS(=O)(=O)NC(=O)c1cc(\C=C\c2cn3nc(Cl)cc(N4CCOCC4)c3n2)nc2ccccc12
Show InChI InChI=1S/C23H21ClN6O4S/c1-35(32,33)28-23(31)18-12-15(25-19-5-3-2-4-17(18)19)6-7-16-14-30-22(26-16)20(13-21(24)27-30)29-8-10-34-11-9-29/h2-7,12-14H,8-11H2,1H3,(H,28,31)/b7-6+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193222
PNG
(US9193736, 144)
Show SMILES OC(=O)c1cc2ccccc2nc1\C=C\c1cn2nccc(N3CCOCC3)c2n1
Show InChI InChI=1S/C22H19N5O3/c28-22(29)17-13-15-3-1-2-4-18(15)25-19(17)6-5-16-14-27-21(24-16)20(7-8-23-27)26-9-11-30-12-10-26/h1-8,13-14H,9-12H2,(H,28,29)/b6-5+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193116
PNG
(US9193736, 32)
Show SMILES C(Sc1ccc2ccccc2n1)c1nc2c(ccnn2c1-c1ccc(nc1)-c1nnn[nH]1)N1CCOCC1
Show InChI InChI=1S/C26H22N10OS/c1-2-4-19-17(3-1)6-8-23(29-19)38-16-21-24(18-5-7-20(27-15-18)25-31-33-34-32-25)36-26(30-21)22(9-10-28-36)35-11-13-37-14-12-35/h1-10,15H,11-14,16H2,(H,31,32,33,34)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193168
PNG
(US9193736, 84)
Show SMILES C1CN(CCO1)c1ccnn2cc(nc12)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C21H17N5O/c1-2-4-19-16(3-1)5-6-17(23-19)7-8-18-15-26-21(24-18)20(9-10-22-26)25-11-13-27-14-12-25/h1-6,9-10,15H,11-14H2
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193145
PNG
(US9193736, 61)
Show SMILES OC(=O)c1ccc(s1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C26H23N5O3S/c32-26(33)23-10-9-22(35-23)24-20(8-7-18-6-5-17-3-1-2-4-19(17)28-18)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-6,9-12H,7-8,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193175
PNG
(US9193736, 91)
Show SMILES COc1cc(ccc1C(O)=O)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C29H23N5O4/c1-37-26-18-20(7-10-22(26)29(35)36)27-24(11-9-21-8-6-19-4-2-3-5-23(19)31-21)32-28-25(12-13-30-34(27)28)33-14-16-38-17-15-33/h2-8,10,12-13,18H,14-17H2,1H3,(H,35,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193197
PNG
(US9193736, 115)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3cn4nccc(N5CCOCC5)c4n3)ccc12
Show InChI InChI=1S/C22H19N5O3/c28-22(29)18-2-1-3-19-17(18)7-6-15(24-19)4-5-16-14-27-21(25-16)20(8-9-23-27)26-10-12-30-13-11-26/h1-9,14H,10-13H2,(H,28,29)/b5-4+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193168
PNG
(US9193736, 84)
Show SMILES C1CN(CCO1)c1ccnn2cc(nc12)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C21H17N5O/c1-2-4-19-16(3-1)5-6-17(23-19)7-8-18-15-26-21(24-18)20(9-10-22-26)25-11-13-27-14-12-25/h1-6,9-10,15H,11-14H2
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193172
PNG
(US9193736, 88)
Show SMILES OC(=O)c1cccc(c1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H21N5O3/c34-28(35)21-6-3-5-20(18-21)26-24(11-10-22-9-8-19-4-1-2-7-23(19)30-22)31-27-25(12-13-29-33(26)27)32-14-16-36-17-15-32/h1-9,12-13,18H,14-17H2,(H,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193222
PNG
(US9193736, 144)
Show SMILES OC(=O)c1cc2ccccc2nc1\C=C\c1cn2nccc(N3CCOCC3)c2n1
Show InChI InChI=1S/C22H19N5O3/c28-22(29)17-13-15-3-1-2-4-18(15)25-19(17)6-5-16-14-27-21(24-16)20(7-8-23-27)26-9-11-30-12-10-26/h1-8,13-14H,9-12H2,(H,28,29)/b6-5+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193112
PNG
(US9193736, 28)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(cn1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H23N7O4S/c1-40(37,38)33-28(36)24-10-7-20(18-29-24)26-23(11-9-21-8-6-19-4-2-3-5-22(19)31-21)32-27-25(12-13-30-35(26)27)34-14-16-39-17-15-34/h2-8,10,12-13,18H,14-17H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193164
PNG
(US9193736, 80)
Show SMILES Oc1c(F)cc(cc1F)-c1c(\C=C\c2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C27H21F2N5O2/c28-20-15-18(16-21(29)26(20)35)25-23(8-7-19-6-5-17-3-1-2-4-22(17)31-19)32-27-24(9-10-30-34(25)27)33-11-13-36-14-12-33/h1-10,15-16,35H,11-14H2/b8-7+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193165
PNG
(US9193736, 81)
Show SMILES Oc1c(F)cc(cc1F)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1
Show InChI InChI=1S/C27H23F2N5O2/c28-20-15-18(16-21(29)26(20)35)25-23(8-7-19-6-5-17-3-1-2-4-22(17)31-19)32-27-24(9-10-30-34(25)27)33-11-13-36-14-12-33/h1-6,9-10,15-16,35H,7-8,11-14H2
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193193
PNG
(US9193736, 109)
Show SMILES COc1cccc(n1)C#Cc1nc2c(ccnn2c1-c1ccc(cc1)C(O)=O)N1CCOCC1
Show InChI InChI=1S/C25H21N5O4/c1-33-22-4-2-3-19(27-22)9-10-20-23(17-5-7-18(8-6-17)25(31)32)30-24(28-20)21(11-12-26-30)29-13-15-34-16-14-29/h2-8,11-12H,13-16H2,1H3,(H,31,32)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193221
PNG
(US9193736, 143)
Show SMILES OC(=O)c1cc2ccccc2nc1\C=C\c1cn2nc(Cl)cc(N3CCOCC3)c2n1
Show InChI InChI=1S/C22H18ClN5O3/c23-20-12-19(27-7-9-31-10-8-27)21-24-15(13-28(21)26-20)5-6-18-16(22(29)30)11-14-3-1-2-4-17(14)25-18/h1-6,11-13H,7-10H2,(H,29,30)/b6-5+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193161
PNG
(US9193736, 77)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C28H21N5O3/c34-28(35)21-7-5-20(6-8-21)26-24(12-11-22-10-9-19-3-1-2-4-23(19)30-22)31-27-25(13-14-29-33(26)27)32-15-17-36-18-16-32/h1-10,13-14H,15-18H2,(H,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193166
PNG
(US9193736, 82)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C31H26N6O4/c38-28(39)14-15-32-31(40)23-7-5-22(6-8-23)29-26(12-11-24-10-9-21-3-1-2-4-25(21)34-24)35-30-27(13-16-33-37(29)30)36-17-19-41-20-18-36/h1-10,13,16H,14-15,17-20H2,(H,32,40)(H,38,39)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193221
PNG
(US9193736, 143)
Show SMILES OC(=O)c1cc2ccccc2nc1\C=C\c1cn2nc(Cl)cc(N3CCOCC3)c2n1
Show InChI InChI=1S/C22H18ClN5O3/c23-20-12-19(27-7-9-31-10-8-27)21-24-15(13-28(21)26-20)5-6-18-16(22(29)30)11-14-3-1-2-4-17(14)25-18/h1-6,11-13H,7-10H2,(H,29,30)/b6-5+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193096
PNG
(US9193736, 12)
Show SMILES C1CN(CCN1)c1ccc(cn1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C30H28N8O/c1-2-4-25-22(3-1)5-7-24(34-25)8-9-26-29(23-6-10-28(32-21-23)37-15-13-31-14-16-37)38-30(35-26)27(11-12-33-38)36-17-19-39-20-18-36/h1-7,10-12,21,31H,13-20H2
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193115
PNG
(US9193736, 31)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccnn2c1-c1ccc(nc1)-c1nnn[nH]1)N1CCOCC1
Show InChI InChI=1S/C27H24N10O/c1-2-4-21-18(3-1)5-7-20(30-21)8-10-22-25(19-6-9-23(28-17-19)26-32-34-35-33-26)37-27(31-22)24(11-12-29-37)36-13-15-38-16-14-36/h1-7,9,11-12,17H,8,10,13-16H2,(H,32,33,34,35)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193167
PNG
(US9193736, 83)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C29H24N6O4S/c1-40(37,38)33-29(36)22-8-6-21(7-9-22)27-25(13-12-23-11-10-20-4-2-3-5-24(20)31-23)32-28-26(14-15-30-35(27)28)34-16-18-39-19-17-34/h2-11,14-15H,16-19H2,1H3,(H,33,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193171
PNG
(US9193736, 87)
Show SMILES OC(=O)c1ccc(cc1)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1nc2ccccc2s1
Show InChI InChI=1S/C26H19N5O3S/c32-26(33)18-7-5-17(6-8-18)24-20(9-10-23-28-19-3-1-2-4-22(19)35-23)29-25-21(11-12-27-31(24)25)30-13-15-34-16-14-30/h1-8,11-12H,13-16H2,(H,32,33)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193175
PNG
(US9193736, 91)
Show SMILES COc1cc(ccc1C(O)=O)-c1c(nc2c(ccnn12)N1CCOCC1)C#Cc1ccc2ccccc2n1
Show InChI InChI=1S/C29H23N5O4/c1-37-26-18-20(7-10-22(26)29(35)36)27-24(11-9-21-8-6-19-4-2-3-5-23(19)31-21)32-28-25(12-13-30-34(27)28)33-14-16-38-17-15-33/h2-8,10,12-13,18H,14-17H2,1H3,(H,35,36)
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM193197
PNG
(US9193736, 115)
Show SMILES OC(=O)c1cccc2nc(\C=C\c3cn4nccc(N5CCOCC5)c4n3)ccc12
Show InChI InChI=1S/C22H19N5O3/c28-22(29)18-2-1-3-19-17(18)7-6-15(24-19)4-5-16-14-27-21(25-16)20(8-9-23-27)26-10-12-30-13-11-26/h1-9,14H,10-13H2,(H,28,29)/b5-4+
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Janssen Pharmaceutica, NV

US Patent


Assay Description
Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%