Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM193115'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM193115 (US9193736, 31) Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccnn2c1-c1ccc(nc1)-c1nnn[nH]1)N1CCOCC1 Show InChI InChI=1S/C27H24N10O/c1-2-4-21-18(3-1)5-7-20(30-21)8-10-22-25(19-6-9-23(28-17-19)26-32-34-35-33-26)37-27(31-22)24(11-12-29-37)36-13-15-38-16-14-36/h1-7,9,11-12,17H,8,10,13-16H2,(H,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.8	n/a
Janssen Pharmaceutica, NV US Patent					Assay Description Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...				US Patent US9193736 (2015) BindingDB Entry DOI: 10.7270/Q2XK8DCS
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