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Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)' and Ligand = 'BDBM193221'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))		BDBM193221
PNG
(US9193736, 143)
Show SMILES OC(=O)c1cc2ccccc2nc1\C=C\c1cn2nc(Cl)cc(N3CCOCC3)c2n1
Show InChI InChI=1S/C22H18ClN5O3/c23-20-12-19(27-7-9-31-10-8-27)21-24-15(13-28(21)26-20)5-6-18-16(22(29)30)11-14-3-1-2-4-17(14)25-18/h1-6,11-13H,7-10H2,(H,29,30)/b6-5+
PDB

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PC cid
PC sid
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Similars
US Patent
n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica, NV

US Patent


Assay Description
Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6ÿH...

US Patent US9193736 (2015)


BindingDB Entry DOI: 10.7270/Q2XK8DCS
More data for this
Ligand-Target Pair