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Patent code US9416154

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241872
PNG
(US9416154, 15)
Show SMILES CC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H20FN4O12P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(19)13(2,14)12(27-8)18-4-3-7-10(15)16-5-17-11(7)18/h3-6,8-9,12,19H,1-2H3,(H,23,24)(H,25,26)(H2,15,16,17)(H2,20,21,22)/t6?,8-,9-,12-,13-/m1/s1
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n/an/a>2.00E+4n/an/an/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241899
PNG
(US9416154, 37)
Show SMILES C[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H21N4O13P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(18)13(2,19)12(27-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-19H,1-2H3,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t6-,8+,9+,12+,13+/m0/s1
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n/an/a 4.00E+4n/an/an/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241898
PNG
(US9416154, 36)
Show SMILES C[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H21N4O13P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(18)13(2,19)12(27-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-19H,1-2H3,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t6-,8-,9-,12-,13-/m1/s1
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n/an/a 6.50E+4n/an/an/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241879
PNG
(US9416154, 22)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccccc1Cl |r|
Show InChI InChI=1S/C24H30ClFN5O7P/c1-5-35-22(33)13(2)30-39(34,38-17-9-7-6-8-16(17)25)37-14(3)18-19(32)24(4,26)23(36-18)31-11-10-15-20(27)28-12-29-21(15)31/h6-14,18-19,23,32H,5H2,1-4H3,(H,30,34)(H2,27,28,29)/t13-,14?,18+,19+,23+,24+,39?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241901
PNG
(US9416154, 27)
Show SMILES C[C@@H](O)C1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H18N4O4/c1-6(18)8-9(19)13(2,20)12(21-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-20H,1-2H3,(H2,14,15,16)/t6-,8?,9-,12-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241882
PNG
(US9416154, 33)
Show SMILES CC(O)[C@H]1O[C@@H](n2cc(-c3cc[nH]n3)c3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241887
PNG
(US9416154, 35)
Show SMILES COC(=O)[C@H](C)NP(=O)(O[C@@H](C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C23H30N5O8P/c1-13(21(30)33-4)27-37(32,36-15-8-6-5-7-9-15)35-14(2)17-18(29)23(3,31)22(34-17)28-11-10-16-19(24)25-12-26-20(16)28/h5-14,17-18,22,29,31H,1-4H3,(H,27,32)(H2,24,25,26)/t13-,14-,17+,18+,22+,23+,37?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241894
PNG
(US9416154, 44 | US9416154, 45)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C30H38N5O8P/c1-5-6-16-40-28(37)18(2)34-44(39,43-23-13-9-11-20-10-7-8-12-21(20)23)42-19(3)24-25(36)30(4,38)29(41-24)35-15-14-22-26(31)32-17-33-27(22)35/h7-15,17-19,24-25,29,36,38H,5-6,16H2,1-4H3,(H,34,39)(H2,31,32,33)/t18-,19?,24+,25+,29+,30+,44?/m0/s1
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n/an/an/an/a 2.00E+3n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241865
PNG
(US9416154, 6)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(O[C@H](CC)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C31H39FN5O8P/c1-5-7-15-42-29(39)18(3)36-46(41,45-23-14-10-12-19-11-8-9-13-20(19)23)44-22(6-2)25-26(38)31(4,40)30(43-25)37-16-21(32)24-27(33)34-17-35-28(24)37/h8-14,16-18,22,25-26,30,38,40H,5-7,15H2,1-4H3,(H,36,41)(H2,33,34,35)/t18-,22+,25+,26+,30+,31+,46?/m0/s1
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n/an/an/an/a 9.30E+3n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241877
PNG
(US9416154, 20)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H30ClFN5O7P/c1-5-35-22(33)13(2)30-39(34,38-16-8-6-15(25)7-9-16)37-14(3)18-19(32)24(4,26)23(36-18)31-11-10-17-20(27)28-12-29-21(17)31/h6-14,18-19,23,32H,5H2,1-4H3,(H,30,34)(H2,27,28,29)/t13-,14?,18+,19+,23+,24+,39?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241902
PNG
(US9416154, 25)
Show SMILES C[C@H](O)C1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H16F2N4O3/c1-5(20)8-9(21)13(2,15)12(22-8)19-3-6(14)7-10(16)17-4-18-11(7)19/h3-5,8-9,12,20-21H,1-2H3,(H2,16,17,18)/t5-,8?,9+,12+,13+/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241881
PNG
(US9416154, 32)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(Oc1cccc2ccccc12)OC(C)(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C30H37FN5O7P/c1-17(2)40-27(38)18(3)35-44(39,42-22-13-9-11-19-10-7-8-12-20(19)22)43-29(4,5)24-23(37)30(6,31)28(41-24)36-15-14-21-25(32)33-16-34-26(21)36/h7-18,23-24,28,37H,1-6H3,(H,35,39)(H2,32,33,34)/t18-,23+,24-,28+,30+,44?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241886
PNG
(US9416154, 34)
Show SMILES COC(=O)[C@H](C)NP(=O)(O[C@H](C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C23H30N5O8P/c1-13(21(30)33-4)27-37(32,36-15-8-6-5-7-9-15)35-14(2)17-18(29)23(3,31)22(34-17)28-11-10-16-19(24)25-12-26-20(16)28/h5-14,17-18,22,29,31H,1-4H3,(H,27,32)(H2,24,25,26)/t13-,14+,17+,18+,22+,23+,37?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241891
PNG
(US9416154, 41)
Show SMILES C[C@H](NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1)C(=O)OCC(C)(C)C |r|
Show InChI InChI=1S/C27H38N5O8P/c1-16(24(34)37-14-26(3,4)5)31-41(36,40-18-10-8-7-9-11-18)39-17(2)20-21(33)27(6,35)25(38-20)32-13-12-19-22(28)29-15-30-23(19)32/h7-13,15-17,20-21,25,33,35H,14H2,1-6H3,(H,31,36)(H2,28,29,30)/t16-,17?,20+,21+,25+,27+,41?/m0/s1
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n/an/an/an/a 1.80E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241889
PNG
(US9416154, 39)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(O[C@@H](C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C24H32N5O8P/c1-5-34-22(31)14(2)28-38(33,37-16-9-7-6-8-10-16)36-15(3)18-19(30)24(4,32)23(35-18)29-12-11-17-20(25)26-13-27-21(17)29/h6-15,18-19,23,30,32H,5H2,1-4H3,(H,28,33)(H2,25,26,27)/t14-,15-,18+,19+,23+,24+,38?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241860
PNG
(US9416154, 3)
Show SMILES C[C@@H](O)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H17FN4O4/c1-5(19)8-9(20)13(2,21)12(22-8)18-3-6(14)7-10(15)16-4-17-11(7)18/h3-5,8-9,12,19-21H,1-2H3,(H2,15,16,17)/t5-,8-,9-,12-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241861
PNG
(US9416154, 5)
Show SMILES CC[C@@H](O)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C14H19FN4O4/c1-3-7(20)9-10(21)14(2,22)13(23-9)19-4-6(15)8-11(16)17-5-18-12(8)19/h4-5,7,9-10,13,20-22H,3H2,1-2H3,(H2,16,17,18)/t7-,9-,10-,13-,14-/m1/s1
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n/an/an/an/a 2.30E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241900
PNG
(US9416154, 9)
Show SMILES C[C@H](O)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H17FN4O4/c1-5(19)8-9(20)13(2,21)12(22-8)18-3-6(14)7-10(15)16-4-17-11(7)18/h3-5,8-9,12,19-21H,1-2H3,(H2,15,16,17)/t5-,8+,9+,12+,13+/m0/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241867
PNG
(US9416154, 10)
Show SMILES CC[C@@H](OP(=O)(N[C@@H](C)C(=O)OC)Oc1ccccc1)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C24H31FN5O8P/c1-5-16(38-39(34,29-13(2)22(32)35-4)37-14-9-7-6-8-10-14)18-19(31)24(3,33)23(36-18)30-11-15(25)17-20(26)27-12-28-21(17)30/h6-13,16,18-19,23,31,33H,5H2,1-4H3,(H,29,34)(H2,26,27,28)/t13-,16+,18+,19+,23+,24+,39?/m0/s1
PDB

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n/an/an/an/a 1.50E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241892
PNG
(US9416154, 42)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C27H32N5O8P/c1-15(25(34)37-4)31-41(36,40-20-11-7-9-17-8-5-6-10-18(17)20)39-16(2)21-22(33)27(3,35)26(38-21)32-13-12-19-23(28)29-14-30-24(19)32/h5-16,21-22,26,33,35H,1-4H3,(H,31,36)(H2,28,29,30)/t15-,16?,21+,22+,26+,27+,41?/m0/s1
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n/an/an/an/a 4.80E+3n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241894
PNG
(US9416154, 44 | US9416154, 45)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C30H38N5O8P/c1-5-6-16-40-28(37)18(2)34-44(39,43-23-13-9-11-20-10-7-8-12-21(20)23)42-19(3)24-25(36)30(4,38)29(41-24)35-15-14-22-26(31)32-17-33-27(22)35/h7-15,17-19,24-25,29,36,38H,5-6,16H2,1-4H3,(H,34,39)(H2,31,32,33)/t18-,19?,24+,25+,29+,30+,44?/m0/s1
PDB

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n/an/an/an/a 2.20E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241863
PNG
(US9416154, 2)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(O[C@H](C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C30H38N5O8P/c1-5-6-16-40-28(37)18(2)34-44(39,43-23-13-9-11-20-10-7-8-12-21(20)23)42-19(3)24-25(36)30(4,38)29(41-24)35-15-14-22-26(31)32-17-33-27(22)35/h7-15,17-19,24-25,29,36,38H,5-6,16H2,1-4H3,(H,34,39)(H2,31,32,33)/t18-,19+,24+,25+,29+,30+,44?/m0/s1
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n/an/an/an/a 3.30E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241868
PNG
(US9416154, 11)
Show SMILES COC(=O)[C@H](C)NP(=O)(O[C@H](C)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C23H29FN5O8P/c1-12(21(31)34-4)28-38(33,37-14-8-6-5-7-9-14)36-13(2)17-18(30)23(3,32)22(35-17)29-10-15(24)16-19(25)26-11-27-20(16)29/h5-13,17-18,22,30,32H,1-4H3,(H,28,33)(H2,25,26,27)/t12-,13+,17+,18+,22+,23+,38?/m0/s1
PDB

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n/an/an/an/a 3.70E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241869
PNG
(US9416154, 12)
Show SMILES COC(=O)[C@H](C)NP(=O)(O[C@@H](C)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C23H29FN5O8P/c1-12(21(31)34-4)28-38(33,37-14-8-6-5-7-9-14)36-13(2)17-18(30)23(3,32)22(35-17)29-10-15(24)16-19(25)26-11-27-20(16)29/h5-13,17-18,22,30,32H,1-4H3,(H,28,33)(H2,25,26,27)/t12-,13-,17+,18+,22+,23+,38?/m0/s1
PDB

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n/an/an/an/a 3.90E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241870
PNG
(US9416154, 13)
Show SMILES CC(O)[C@H]1O[C@@H](n2cc(I)c3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H16FIN4O3/c1-5(20)8-9(21)13(2,14)12(22-8)19-3-6(15)7-10(16)17-4-18-11(7)19/h3-5,8-9,12,20-21H,1-2H3,(H2,16,17,18)/t5?,8-,9-,12-,13-/m1/s1
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n/an/an/an/a 5.80E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241874
PNG
(US9416154, 17)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C25H33FN5O7P/c1-14(2)35-23(33)15(3)30-39(34,38-17-9-7-6-8-10-17)37-16(4)19-20(32)25(5,26)24(36-19)31-12-11-18-21(27)28-13-29-22(18)31/h6-16,19-20,24,32H,1-5H3,(H,30,34)(H2,27,28,29)/t15-,16?,19+,20+,24+,25+,39?/m0/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241876
PNG
(US9416154, 19)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C29H35FN5O7P/c1-16(2)39-27(37)17(3)34-43(38,42-22-12-8-10-19-9-6-7-11-20(19)22)41-18(4)23-24(36)29(5,30)28(40-23)35-14-13-21-25(31)32-15-33-26(21)35/h6-18,23-24,28,36H,1-5H3,(H,34,38)(H2,31,32,33)/t17-,18?,23+,24+,28+,29+,43?/m0/s1
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n/an/an/an/a>2.00E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241903
PNG
(US9416154, 24)
Show SMILES CC(O)C1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H16F2N4O3/c1-5(20)8-9(21)13(2,15)12(22-8)19-3-6(14)7-10(16)17-4-18-11(7)19/h3-5,8-9,12,20-21H,1-2H3,(H2,16,17,18)/t5?,8?,9-,12-,13-/m1/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241883
PNG
(US9416154, 26)
Show SMILES C[C@@H](O)C1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H16F2N4O3/c1-5(20)8-9(21)13(2,15)12(22-8)19-3-6(14)7-10(16)17-4-18-11(7)19/h3-5,8-9,12,20-21H,1-2H3,(H2,16,17,18)/t5-,8?,9-,12-,13-/m1/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241896
PNG
(US9416154, 30)
Show SMILES CC(C)(O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C14H19FN4O3/c1-13(2,21)9-8(20)14(3,15)12(22-9)19-5-4-7-10(16)17-6-18-11(7)19/h4-6,8-9,12,20-21H,1-3H3,(H2,16,17,18)/t8-,9+,12-,14-/m1/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241866
PNG
(US9416154, 8)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(O[C@H](CC)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C31H40N5O8P/c1-5-7-17-41-29(38)19(3)35-45(40,44-24-14-10-12-20-11-8-9-13-21(20)24)43-23(6-2)25-26(37)31(4,39)30(42-25)36-16-15-22-27(32)33-18-34-28(22)36/h8-16,18-19,23,25-26,30,37,39H,5-7,17H2,1-4H3,(H,35,40)(H2,32,33,34)/t19-,23+,25+,26+,30+,31+,45?/m0/s1
PDB

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n/an/an/an/a 1.30E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241880
PNG
(US9416154, 23)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccccc1Cl |r|
Show InChI InChI=1S/C25H32ClFN5O7P/c1-13(2)36-23(34)14(3)31-40(35,39-18-9-7-6-8-17(18)26)38-15(4)19-20(33)25(5,27)24(37-19)32-11-10-16-21(28)29-12-30-22(16)32/h6-15,19-20,24,33H,1-5H3,(H,31,35)(H2,28,29,30)/t14-,15?,19+,20+,24+,25+,40?/m0/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241897
PNG
(US9416154, 31)
Show SMILES CC(C)(O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C14H20N4O4/c1-13(2,20)9-8(19)14(3,21)12(22-9)18-5-4-7-10(15)16-6-17-11(7)18/h4-6,8-9,12,19-21H,1-3H3,(H2,15,16,17)/t8-,9+,12-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241893
PNG
(US9416154, 43)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C25H34N5O8P/c1-14(2)35-23(32)15(3)29-39(34,38-17-9-7-6-8-10-17)37-16(4)19-20(31)25(5,33)24(36-19)30-12-11-18-21(26)27-13-28-22(18)30/h6-16,19-20,24,31,33H,1-5H3,(H,29,34)(H2,26,27,28)/t15-,16?,19+,20+,24+,25+,39?/m0/s1
PDB

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n/an/an/an/a 1.40E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241873
PNG
(US9416154, 16)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C24H31FN5O7P/c1-5-34-22(32)14(2)29-38(33,37-16-9-7-6-8-10-16)36-15(3)18-19(31)24(4,25)23(35-18)30-12-11-17-20(26)27-13-28-21(17)30/h6-15,18-19,23,31H,5H2,1-4H3,(H,29,33)(H2,26,27,28)/t14-,15?,18+,19+,23+,24+,38?/m0/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241871
PNG
(US9416154, 14)
Show SMILES CC(O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r|
Show InChI InChI=1S/C13H17FN4O3/c1-6(19)8-9(20)13(2,14)12(21-8)18-4-3-7-10(15)16-5-17-11(7)18/h3-6,8-9,12,19-20H,1-2H3,(H2,15,16,17)/t6?,8-,9-,12-,13-/m1/s1
PDB

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241875
PNG
(US9416154, 18)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C28H33FN5O7P/c1-5-38-26(36)16(2)33-42(37,41-21-12-8-10-18-9-6-7-11-19(18)21)40-17(3)22-23(35)28(4,29)27(39-22)34-14-13-20-24(30)31-15-32-25(20)34/h6-17,22-23,27,35H,5H2,1-4H3,(H,33,37)(H2,30,31,32)/t16-,17?,22+,23+,27+,28+,42?/m0/s1
PDB

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241878
PNG
(US9416154, 21)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C25H32ClFN5O7P/c1-13(2)36-23(34)14(3)31-40(35,39-17-8-6-16(26)7-9-17)38-15(4)19-20(33)25(5,27)24(37-19)32-11-10-18-21(28)29-12-30-22(18)32/h6-15,19-20,24,33H,1-5H3,(H,31,35)(H2,28,29,30)/t14-,15?,19+,20+,24+,25+,40?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241884
PNG
(US9416154, 28)
Show SMILES C[C@H](O)C1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H18N4O4/c1-6(18)8-9(19)13(2,20)12(21-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-20H,1-2H3,(H2,14,15,16)/t6-,8?,9+,12+,13+/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241885
PNG
(US9416154, 29)
Show SMILES CC(OP(=O)(N[C@@H](C)C(O)=O)Oc1ccccc1)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C22H28N5O8P/c1-12(20(29)30)26-36(32,35-14-7-5-4-6-8-14)34-13(2)16-17(28)22(3,31)21(33-16)27-10-9-15-18(23)24-11-25-19(15)27/h4-13,16-17,21,28,31H,1-3H3,(H,26,32)(H,29,30)(H2,23,24,25)/t12-,13?,16+,17+,21+,22+,36?/m0/s1
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n/an/an/an/a 4.55E+3n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241888
PNG
(US9416154, 38)
Show SMILES CCOC(=O)[C@H](C)NP(=O)(O[C@H](C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C24H32N5O8P/c1-5-34-22(31)14(2)28-38(33,37-16-9-7-6-8-10-16)36-15(3)18-19(30)24(4,32)23(35-18)29-12-11-17-20(25)26-13-27-21(17)29/h6-15,18-19,23,30,32H,5H2,1-4H3,(H,28,33)(H2,25,26,27)/t14-,15+,18+,19+,23+,24+,38?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241862
PNG
(US9416154, 7)
Show SMILES CC[C@@H](O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C14H20N4O4/c1-3-8(19)9-10(20)14(2,21)13(22-9)18-5-4-7-11(15)16-6-17-12(7)18/h4-6,8-10,13,19-21H,3H2,1-2H3,(H2,15,16,17)/t8-,9-,10-,13-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241890
PNG
(US9416154, 40)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1ccccc1 |r|
Show InChI InChI=1S/C23H30N5O8P/c1-13(21(30)33-4)27-37(32,36-15-8-6-5-7-9-15)35-14(2)17-18(29)23(3,31)22(34-17)28-11-10-16-19(24)25-12-26-20(16)28/h5-14,17-18,22,29,31H,1-4H3,(H,27,32)(H2,24,25,26)/t13-,14?,17+,18+,22+,23+,37?/m0/s1
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n/an/an/an/a 2.10E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241859
PNG
(US9416154, 1)
Show SMILES C[C@@H](O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r|
Show InChI InChI=1S/C13H18N4O4/c1-6(18)8-9(19)13(2,20)12(21-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-20H,1-2H3,(H2,14,15,16)/t6-,8-,9-,12-,13-/m1/s1
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n/an/an/an/a 6.10E+4n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241864
PNG
(US9416154, 4)
Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(O[C@H](C)[C@H]1O[C@@H](n2cc(F)c3c(N)ncnc23)[C@](C)(O)[C@@H]1O)Oc1cccc2ccccc12 |r|
Show InChI InChI=1S/C30H37FN5O8P/c1-5-6-14-41-28(38)17(2)35-45(40,44-22-13-9-11-19-10-7-8-12-20(19)22)43-18(3)24-25(37)30(4,39)29(42-24)36-15-21(31)23-26(32)33-16-34-27(23)36/h7-13,15-18,24-25,29,37,39H,5-6,14H2,1-4H3,(H,35,40)(H2,32,33,34)/t17-,18+,24+,25+,29+,30+,45?/m0/s1
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n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%