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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Genome polyprotein [2420-3010]' and Ligand = 'BDBM241878'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM241878
PNG
(US9416154, 21)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC(C)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O)Oc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C25H32ClFN5O7P/c1-13(2)36-23(34)14(3)31-40(35,39-17-8-6-16(26)7-9-17)38-15(4)19-20(33)25(5,27)24(37-19)32-11-10-18-21(28)29-12-30-22(18)32/h6-15,19-20,24,33H,1-5H3,(H,31,35)(H2,28,29,30)/t14-,15?,19+,20+,24+,25+,40?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+5n/an/a7.325



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...

US Patent US9416154 (2016)


BindingDB Entry DOI: 10.7270/Q2KK99PV
More data for this
Ligand-Target Pair