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Patent code US9693992

Compile Data Set for Download or QSAR

Found 251 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160394
PNG
(US9040714, 62 | US9693992, 62)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1nc2ccc(O)c(C=O)c2[nH]1
Show InChI InChI=1S/C20H20N4O3/c1-23-8-10-24(11-9-23)20(27)14-4-2-13(3-5-14)19-21-16-6-7-17(26)15(12-25)18(16)22-19/h2-7,12,26H,8-11H2,1H3,(H,21,22)
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US Patent
n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM51439
PNG
(BDBM160336 | US9040714, 116 | US9693992, 116)
Show SMILES Cc1c(-c2ccc(cc2)C(=O)NCCN2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C24H24N2O6/c1-15-18-6-7-20(28)19(14-27)22(18)32-24(30)21(15)16-2-4-17(5-3-16)23(29)25-8-9-26-10-12-31-13-11-26/h2-7,14,28H,8-13H2,1H3,(H,25,29)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160419
PNG
(US9040714, 129 | US9693992, 129)
Show SMILES Cc1c(CC(=O)N2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C17H17NO6/c1-10-11-2-3-14(20)13(9-19)16(11)24-17(22)12(10)8-15(21)18-4-6-23-7-5-18/h2-3,9,20H,4-8H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160434
PNG
(US9040714, 148 | US9693992, 148)
Show SMILES COc1cc2c(C)c(CC(=O)NCCO)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C16H17NO7/c1-8-9-5-12(23-2)14(21)11(7-19)15(9)24-16(22)10(8)6-13(20)17-3-4-18/h5,7,18,21H,3-4,6H2,1-2H3,(H,17,20)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160446
PNG
(US9040714, 168 | US9693992, 168)
Show SMILES COc1cc2c(C)c(CC(=O)N3CCN(C)CC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C19H22N2O6/c1-11-12-8-15(26-3)17(24)14(10-22)18(12)27-19(25)13(11)9-16(23)21-6-4-20(2)5-7-21/h8,10,24H,4-7,9H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160455
PNG
(US9040714, 177 | US9693992, 177)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CC(=O)N3CCOCC3)c(C)c12
Show InChI InChI=1S/C18H19NO7/c1-10-11(7-15(22)19-3-5-25-6-4-19)18(23)26-17-12(9-20)13(21)8-14(24-2)16(10)17/h8-9,21H,3-7H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160465
PNG
(US9040714, 194 | US9693992, 194)
Show SMILES COCCNC(=O)CCc1c(C)c2c(OC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(22)19-6-7-24-2)18(23)26-17-12(9-20)13(21)8-14(25-3)16(10)17/h8-9,21H,4-7H2,1-3H3,(H,19,22)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160466
PNG
(US9040714, 196 | US9693992, 196)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)NCCN3CCOCC3)c(C)c12
Show InChI InChI=1S/C21H26N2O7/c1-13-14(3-4-18(26)22-5-6-23-7-9-29-10-8-23)21(27)30-20-15(12-24)16(25)11-17(28-2)19(13)20/h11-12,25H,3-10H2,1-2H3,(H,22,26)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160349
PNG
(US9040714, 17 | US9693992, 17)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1c(C)c2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C20H17NO5/c1-11-14-8-9-16(23)15(10-22)18(14)26-20(25)17(11)12-4-6-13(7-5-12)19(24)21(2)3/h4-10,23H,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160367
PNG
(US9040714, 35 | US9693992, 35)
Show SMILES Cc1nc(sc1C(=O)NC1CCNCC1)N1CCc2c(C1)ccc(O)c2C=O
Show InChI InChI=1S/C20H24N4O3S/c1-12-18(19(27)23-14-4-7-21-8-5-14)28-20(22-12)24-9-6-15-13(10-24)2-3-17(26)16(15)11-25/h2-3,11,14,21,26H,4-10H2,1H3,(H,23,27)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160371
PNG
(US9040714, 39 | US9693992, 39)
Show SMILES CCc1cc2c(occ(-c3nc(C)cs3)c2=O)c(C=O)c1O
Show InChI InChI=1S/C16H13NO4S/c1-3-9-4-10-14(20)12(16-17-8(2)7-22-16)6-21-15(10)11(5-18)13(9)19/h4-7,19H,3H2,1-2H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160400
PNG
(US9040714, 69 | US9693992, 69)
Show SMILES Cc1c(CCC(=O)N2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C18H19NO6/c1-11-12-2-4-15(21)14(10-20)17(12)25-18(23)13(11)3-5-16(22)19-6-8-24-9-7-19/h2,4,10,21H,3,5-9H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160413
PNG
(US9040714, 118 | US9693992, 118)
Show SMILES CCc1cc2c(C)c(-c3ccc(cc3)C(=O)NCCOC)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C23H23NO6/c1-4-14-11-17-13(2)19(23(28)30-21(17)18(12-25)20(14)26)15-5-7-16(8-6-15)22(27)24-9-10-29-3/h5-8,11-12,26H,4,9-10H2,1-3H3,(H,24,27)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160416
PNG
(US9040714, 121 | US9693992, 121)
Show SMILES COCCOc1cc(O)c(C=O)c2oc(=O)cc(C)c12
Show InChI InChI=1S/C14H14O6/c1-8-5-12(17)20-14-9(7-15)10(16)6-11(13(8)14)19-4-3-18-2/h5-7,16H,3-4H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160427
PNG
(US9040714, 139 | US9693992, 139)
Show SMILES COCc1c(CCC(=O)N2CCOCC2)c(=O)oc2c(C=O)c(O)c(OC)cc12
Show InChI InChI=1S/C20H23NO8/c1-26-11-15-12(3-4-17(23)21-5-7-28-8-6-21)20(25)29-19-13(15)9-16(27-2)18(24)14(19)10-22/h9-10,24H,3-8,11H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160459
PNG
(US9040714, 182 | US9693992, 182)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)N3CCN(C)CC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C22H28N2O7/c1-14-15(4-5-19(26)24-8-6-23(2)7-9-24)22(28)31-21-16(14)12-18(30-11-10-29-3)20(27)17(21)13-25/h12-13,27H,4-11H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160345
PNG
(US9040714, 12 | US9693992, 12)
Show SMILES Cc1c(-c2ccc(cc2)C(=O)N2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C22H19NO6/c1-13-16-6-7-18(25)17(12-24)20(16)29-22(27)19(13)14-2-4-15(5-3-14)21(26)23-8-10-28-11-9-23/h2-7,12,25H,8-11H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160346
PNG
(US9040714, 13 | US9693992, 13)
Show SMILES Cc1c(-c2cccc(c2)C(=O)N2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C22H19NO6/c1-13-16-5-6-18(25)17(12-24)20(16)29-22(27)19(13)14-3-2-4-15(11-14)21(26)23-7-9-28-10-8-23/h2-6,11-12,25H,7-10H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160356
PNG
(US9040714, 24 | US9693992, 24)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1c(C)c2cc(F)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C22H21FN2O4/c1-13-16-11-18(23)20(27)17(12-26)21(16)29-22(28)19(13)14-3-5-15(6-4-14)25-9-7-24(2)8-10-25/h3-6,11-12,27H,7-10H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160357
PNG
(US9040714, 25 | US9693992, 25)
Show SMILES COc1cc2c(C)c(-c3ccc(cc3)N3CCN(C)CC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C23H24N2O5/c1-14-17-12-19(29-3)21(27)18(13-26)22(17)30-23(28)20(14)15-4-6-16(7-5-15)25-10-8-24(2)9-11-25/h4-7,12-13,27H,8-11H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160370
PNG
(US9040714, 38 | US9693992, 38)
Show SMILES CN1CCN(CC1)c1ncc(s1)C(=O)N1CCc2c(C1)ccc(O)c2C=O
Show InChI InChI=1S/C19H22N4O3S/c1-21-6-8-22(9-7-21)19-20-10-17(27-19)18(26)23-5-4-14-13(11-23)2-3-16(25)15(14)12-24/h2-3,10,12,25H,4-9,11H2,1H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160384
PNG
(US9040714, 52 | US9693992, 52)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1nc2ccc(O)c(C=O)c2s1
Show InChI InChI=1S/C20H19N3O3S/c1-22-7-9-23(10-8-22)20(26)14-4-2-3-13(11-14)19-21-16-5-6-17(25)15(12-24)18(16)27-19/h2-6,11-12,25H,7-10H2,1H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160385
PNG
(US9040714, 53 | US9693992, 53)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1nc2ccc(O)c(C=O)c2s1
Show InChI InChI=1S/C20H19N3O3S/c1-22-8-10-23(11-9-22)20(26)14-4-2-13(3-5-14)19-21-16-6-7-17(25)15(12-24)18(16)27-19/h2-7,12,25H,8-11H2,1H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160402
PNG
(US9040714, 106 | US9693992, 106)
Show SMILES CCOC(=O)c1cnc(s1)-c1cc2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C16H11NO6S/c1-2-22-16(21)12-6-17-14(24-12)9-5-8-3-4-11(19)10(7-18)13(8)23-15(9)20/h3-7,19H,2H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160420
PNG
(US9040714, 130 | US9693992, 130)
Show SMILES CN1CCN(CC1)C(=O)Cc1c(C)c2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H20N2O5/c1-11-12-3-4-15(22)14(10-21)17(12)25-18(24)13(11)9-16(23)20-7-5-19(2)6-8-20/h3-4,10,22H,5-9H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160399
PNG
(US9040714, 68 | US9693992, 68)
Show SMILES CCOC(=O)c1sc(nc1C)-c1cc2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C17H13NO6S/c1-3-23-17(22)14-8(2)18-15(25-14)10-6-9-4-5-12(20)11(7-19)13(9)24-16(10)21/h4-7,20H,3H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160401
PNG
(US9040714, 70 | US9693992, 70)
Show SMILES Cc1c(CC(O)=O)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C13H10O6/c1-6-7-2-3-10(15)9(5-14)12(7)19-13(18)8(6)4-11(16)17/h2-3,5,15H,4H2,1H3,(H,16,17)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160403
PNG
(US9040714, 107 | US9693992, 107)
Show SMILES CN1CCN(CC1)C(=O)c1cnc(s1)-c1cc2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C19H17N3O5S/c1-21-4-6-22(7-5-21)18(25)15-9-20-17(28-15)12-8-11-2-3-14(24)13(10-23)16(11)27-19(12)26/h2-3,8-10,24H,4-7H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160408
PNG
(US9040714, 112 | US9693992, 112)
Show SMILES CN1CCN(CC1)C(=O)\C=C\c1c(C)c2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C19H20N2O5/c1-12-13-3-5-16(23)15(11-22)18(13)26-19(25)14(12)4-6-17(24)21-9-7-20(2)8-10-21/h3-6,11,23H,7-10H2,1-2H3/b6-4+
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160417
PNG
(US9040714, 127 | US9693992, 127)
Show SMILES COCCOCCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C17H20O7/c1-10-11(4-5-23-7-6-21-2)17(20)24-16-12(10)8-14(22-3)15(19)13(16)9-18/h8-9,19H,4-7H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160425
PNG
(US9040714, 137 | US9693992, 137)
Show SMILES COCc1c(C)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C13H12O5/c1-7-10(6-17-2)8-3-4-11(15)9(5-14)12(8)18-13(7)16/h3-5,15H,6H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160445
PNG
(US9040714, 167 | US9693992, 167)
Show SMILES COc1cc2c(C)c(CC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C18H19NO7/c1-10-11-7-14(24-2)16(22)13(9-20)17(11)26-18(23)12(10)8-15(21)19-3-5-25-6-4-19/h7,9,22H,3-6,8H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160449
PNG
(US9040714, 171 | US9693992, 171)
Show SMILES COCCNC(=O)CCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(21)19-6-7-24-2)18(23)26-17-12(10)8-14(25-3)16(22)13(17)9-20/h8-9,22H,4-7H2,1-3H3,(H,19,21)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160464
PNG
(US9040714, 193 | US9693992, 193)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C20H24N2O6/c1-12-13(4-5-17(25)22-8-6-21(2)7-9-22)20(26)28-19-14(11-23)15(24)10-16(27-3)18(12)19/h10-11,24H,4-9H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160433
PNG
(US9040714, 147 | US9693992, 147)
Show SMILES COc1cc2c(C)c(CCC(=O)NCCO)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C17H19NO7/c1-9-10(3-4-14(21)18-5-6-19)17(23)25-16-11(9)7-13(24-2)15(22)12(16)8-20/h7-8,19,22H,3-6H2,1-2H3,(H,18,21)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160471
PNG
(US9040714, 201 | US9693992, 201)
Show SMILES Cc1c(CCC(=O)NCCN2CCOCC2)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C20H24N2O6/c1-13-14-2-4-17(24)16(12-23)19(14)28-20(26)15(13)3-5-18(25)21-6-7-22-8-10-27-11-9-22/h2,4,12,24H,3,5-11H2,1H3,(H,21,25)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160340
PNG
(US9040714, 7 | US9693992, 7)
Show SMILES Oc1ccc2cc(-c3ccc(Br)cc3)c(=O)oc2c1C=O
Show InChI InChI=1S/C16H9BrO4/c17-11-4-1-9(2-5-11)12-7-10-3-6-14(19)13(8-18)15(10)21-16(12)20/h1-8,19H
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MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160347
PNG
(US9040714, 14 | US9693992, 14)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1c(C)c2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C21H21N3O4/c1-13-15-4-5-17(26)16(12-25)20(15)28-21(27)19(13)14-3-6-18(22-11-14)24-9-7-23(2)8-10-24/h3-6,11-12,26H,7-10H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160359
PNG
(US9040714, 27 | US9693992, 27)
Show SMILES Cc1nc(sc1C(=O)N1CCOCC1)-c1cc2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C19H16N2O6S/c1-10-16(18(24)21-4-6-26-7-5-21)28-17(20-10)12-8-11-2-3-14(23)13(9-22)15(11)27-19(12)25/h2-3,8-9,23H,4-7H2,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160387
PNG
(US9040714, 55 | US9693992, 55)
Show SMILES CC(C)N1CCN(CC1)c1nc2ccc(O)c(C=O)c2s1
Show InChI InChI=1S/C15H19N3O2S/c1-10(2)17-5-7-18(8-6-17)15-16-12-3-4-13(20)11(9-19)14(12)21-15/h3-4,9-10,20H,5-8H2,1-2H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160395
PNG
(US9040714, 63 | US9693992, 63)
Show SMILES OC(=O)CSc1nc2ccc(O)c(C=O)c2[nH]1
Show InChI InChI=1S/C10H8N2O4S/c13-3-5-7(14)2-1-6-9(5)12-10(11-6)17-4-8(15)16/h1-3,14H,4H2,(H,11,12)(H,15,16)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160405
PNG
(US9040714, 109 | US9693992, 109)
Show SMILES Cc1nc(sc1C(=O)NCCN1CCOCC1)-c1cc2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C21H21N3O6S/c1-12-18(19(27)22-4-5-24-6-8-29-9-7-24)31-20(23-12)14-10-13-2-3-16(26)15(11-25)17(13)30-21(14)28/h2-3,10-11,26H,4-9H2,1H3,(H,22,27)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160447
PNG
(US9040714, 169 | US9693992, 169)
Show SMILES CCNC(=O)Cc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C16H17NO6/c1-4-17-13(19)6-10-8(2)9-5-12(22-3)14(20)11(7-18)15(9)23-16(10)21/h5,7,20H,4,6H2,1-3H3,(H,17,19)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160452
PNG
(US9040714, 174 | US9693992, 174)
Show SMILES CCNC(=O)CCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C17H19NO6/c1-4-18-14(20)6-5-10-9(2)11-7-13(23-3)15(21)12(8-19)16(11)24-17(10)22/h7-8,21H,4-6H2,1-3H3,(H,18,20)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160454
PNG
(US9040714, 176 | US9693992, 176)
Show SMILES COCCNC(=O)Cc1c(C)c2c(OC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C17H19NO7/c1-9-10(6-14(21)18-4-5-23-2)17(22)25-16-11(8-19)12(20)7-13(24-3)15(9)16/h7-8,20H,4-6H2,1-3H3,(H,18,21)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160461
PNG
(US9040714, 185 | US9693992, 185)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)NCCN(C)C)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C21H28N2O7/c1-13-14(5-6-18(25)22-7-8-23(2)3)21(27)30-20-15(13)11-17(29-10-9-28-4)19(26)16(20)12-24/h11-12,26H,5-10H2,1-4H3,(H,22,25)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160470
PNG
(US9040714, 200 | US9693992, 200)
Show SMILES COc1cc2c(C)c(C(C)C)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C15H16O5/c1-7(2)12-8(3)9-5-11(19-4)13(17)10(6-16)14(9)20-15(12)18/h5-7,17H,1-4H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160334
PNG
(US9040714, 1 | US9693992, 1)
Show SMILES Cc1c(Br)c(=O)oc2c(C=O)c(O)ccc12
Show InChI InChI=1S/C11H7BrO4/c1-5-6-2-3-8(14)7(4-13)10(6)16-11(15)9(5)12/h2-4,14H,1H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160335
PNG
(US9040714, 2 | US9693992, 2)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1c(C)c2ccc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C23H22N2O5/c1-14-17-7-8-19(27)18(13-26)21(17)30-23(29)20(14)15-3-5-16(6-4-15)22(28)25-11-9-24(2)10-12-25/h3-8,13,27H,9-12H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1


(Homo sapiens (Human))		BDBM160348
PNG
(US9040714, 16 | US9693992, 16)
Show SMILES Cc1c(Cc2ccccc2)c(=O)oc2c(C=O)c(O)c(O)cc12
Show InChI InChI=1S/C18H14O5/c1-10-12-8-15(20)16(21)14(9-19)17(12)23-18(22)13(10)7-11-5-3-2-4-6-11/h2-6,8-9,20-21H,7H2,1H3
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...

US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 251 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%