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Patent code US9212178

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196801
PNG
(US9212178, 30)
Show SMILES Cn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)cn3)ccc12 |r|
Show InChI InChI=1S/C24H25N7O3/c1-29-13-20(23(33)16-2-3-16)19-8-17(4-5-21(19)29)27-24-25-7-6-22(28-24)31-11-15(9-26-31)10-30-12-18(32)14-34-30/h4-9,11,13,16,18,32H,2-3,10,12,14H2,1H3,(H,25,27,28)/t18-/m0/s1
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US Patent
n/an/a 2.46n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196774
PNG
(US9212178, 3)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)n1 |r|
Show InChI InChI=1S/C23H22F3N7O3/c1-13-14(8-32-10-16(34)12-36-32)9-33(30-13)20-5-6-27-22(29-20)28-15-3-4-19-17(7-15)18(11-31(19)2)21(35)23(24,25)26/h3-7,9,11,16,34H,8,10,12H2,1-2H3,(H,27,28,29)/t16-/m0/s1
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n/an/a 2.82n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196786
PNG
(US9212178, 15)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CC(F)(F)F)cc(C(=O)C4CC4)c3c2)n1 |r|
Show InChI InChI=1S/C26H26F3N7O3/c1-15-17(9-35-11-19(37)13-39-35)10-36(33-15)23-6-7-30-25(32-23)31-18-4-5-22-20(8-18)21(24(38)16-2-3-16)12-34(22)14-26(27,28)29/h4-8,10,12,16,19,37H,2-3,9,11,13-14H2,1H3,(H,30,31,32)/t19-/m0/s1
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n/an/a 2.98n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196794
PNG
(US9212178, 23 | US9212178, 24)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CCF)cc(C(=O)C4CC4)c3c2)n1 |r|
Show InChI InChI=1S/C26H28FN7O3/c1-16-18(11-33-13-20(35)15-37-33)12-34(31-16)24-6-8-28-26(30-24)29-19-4-5-23-21(10-19)22(14-32(23)9-7-27)25(36)17-2-3-17/h4-6,8,10,12,14,17,20,35H,2-3,7,9,11,13,15H2,1H3,(H,28,29,30)/t20-/m0/s1
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n/an/a 3.10n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196803
PNG
(US9212178, 32)
Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CCF)cc(C(=O)C5CC5)c4c3)n2)C1 |r|
Show InChI InChI=1S/C25H26FN7O3/c26-6-8-31-14-21(24(35)17-1-2-17)20-9-18(3-4-22(20)31)29-25-27-7-5-23(30-25)33-12-16(10-28-33)11-32-13-19(34)15-36-32/h3-5,7,9-10,12,14,17,19,34H,1-2,6,8,11,13,15H2,(H,27,29,30)/t19-/m0/s1
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n/an/a 3.52n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196794
PNG
(US9212178, 23 | US9212178, 24)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(CCF)cc(C(=O)C4CC4)c3c2)n1 |r|
Show InChI InChI=1S/C26H28FN7O3/c1-16-18(11-33-13-20(35)15-37-33)12-34(31-16)24-6-8-28-26(30-24)29-19-4-5-23-21(10-19)22(14-32(23)9-7-27)25(36)17-2-3-17/h4-6,8,10,12,14,17,20,35H,2-3,7,9,11,13,15H2,1H3,(H,28,29,30)/t20-/m0/s1
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n/an/a 3.71n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196777
PNG
(US9212178, 29 | US9212178, 6)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m0/s1
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n/an/a 4.69n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196804
PNG
(US9212178, 33)
Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CC(F)F)cc(C(=O)C5CC5)c4c3)n2)C1 |r|
Show InChI InChI=1S/C25H25F2N7O3/c26-22(27)13-32-12-20(24(36)16-1-2-16)19-7-17(3-4-21(19)32)30-25-28-6-5-23(31-25)34-10-15(8-29-34)9-33-11-18(35)14-37-33/h3-8,10,12,16,18,22,35H,1-2,9,11,13-14H2,(H,28,30,31)/t18-/m0/s1
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n/an/a 5.34n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196805
PNG
(US9212178, 34)
Show SMILES O[C@@H]1CON(Cc2cnn(c2)-c2ccnc(Nc3ccc4n(CC(F)(F)F)cc(C(=O)C5CC5)c4c3)n2)C1 |r|
Show InChI InChI=1S/C25H24F3N7O3/c26-25(27,28)14-33-12-20(23(37)16-1-2-16)19-7-17(3-4-21(19)33)31-24-29-6-5-22(32-24)35-10-15(8-30-35)9-34-11-18(36)13-38-34/h3-8,10,12,16,18,36H,1-2,9,11,13-14H2,(H,29,31,32)/t18-/m0/s1
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n/an/a 5.80n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196796
PNG
(US9212178, 25)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(n3)C3CC3)ccc12 |r|
Show InChI InChI=1S/C28H31N7O3/c1-2-33-15-23(27(37)18-5-6-18)22-11-20(7-8-24(22)33)30-28-29-10-9-25(31-28)35-13-19(26(32-35)17-3-4-17)12-34-14-21(36)16-38-34/h7-11,13,15,17-18,21,36H,2-6,12,14,16H2,1H3,(H,29,30,31)/t21-/m0/s1
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n/an/a 5.85n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196798
PNG
(US9212178, 27)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(cc(C(=O)C4CC4)c3c2)S(C)(=O)=O)n1 |r|
Show InChI InChI=1S/C25H27N7O5S/c1-15-17(10-30-12-19(33)14-37-30)11-31(29-15)23-7-8-26-25(28-23)27-18-5-6-22-20(9-18)21(24(34)16-3-4-16)13-32(22)38(2,35)36/h5-9,11,13,16,19,33H,3-4,10,12,14H2,1-2H3,(H,26,27,28)/t19-/m0/s1
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n/an/a 5.89n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196772
PNG
(US9212178, 1)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1 |r|
Show InChI InChI=1S/C25H27N7O3/c1-15-17(10-31-12-19(33)14-35-31)11-32(29-15)23-7-8-26-25(28-23)27-18-5-6-22-20(9-18)21(13-30(22)2)24(34)16-3-4-16/h5-9,11,13,16,19,33H,3-4,10,12,14H2,1-2H3,(H,26,27,28)/t19-/m0/s1
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n/an/a 6.15n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196782
PNG
(US9212178, 11)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m1/s1
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n/an/a 6.28n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196779
PNG
(US9212178, 8)
Show SMILES CC(C)n1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C27H31N7O3/c1-16(2)33-14-23(26(36)18-4-5-18)22-10-20(6-7-24(22)33)29-27-28-9-8-25(30-27)34-12-19(17(3)31-34)11-32-13-21(35)15-37-32/h6-10,12,14,16,18,21,35H,4-5,11,13,15H2,1-3H3,(H,28,29,30)/t21-/m0/s1
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n/an/a 7.37n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196778
PNG
(US9212178, 7)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3[nH]cc(C(=O)C(F)(F)F)c3c2)n1 |r|
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n/an/a 8.28n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196773
PNG
(US9212178, 2)
Show SMILES CC(C)C(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)cc12 |r|
Show InChI InChI=1S/C25H29N7O3/c1-15(2)24(34)21-13-30(4)22-6-5-18(9-20(21)22)27-25-26-8-7-23(28-25)32-11-17(16(3)29-32)10-31-12-19(33)14-35-31/h5-9,11,13,15,19,33H,10,12,14H2,1-4H3,(H,26,27,28)/t19-/m0/s1
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n/an/a 8.63n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196775
PNG
(US9212178, 4)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)F)c3c2)n1 |r|
Show InChI InChI=1S/C23H23F2N7O3/c1-13-14(8-31-10-16(33)12-35-31)9-32(29-13)20-5-6-26-23(28-20)27-15-3-4-19-17(7-15)18(11-30(19)2)21(34)22(24)25/h3-7,9,11,16,22,33H,8,10,12H2,1-2H3,(H,26,27,28)/t16-/m0/s1
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n/an/a 9.42n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196780
PNG
(US9212178, 9)
Show SMILES CC(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)cc12 |r|
Show InChI InChI=1S/C23H25N7O3/c1-14-16(9-29-11-18(32)13-33-29)10-30(27-14)22-6-7-24-23(26-22)25-17-4-5-21-19(8-17)20(15(2)31)12-28(21)3/h4-8,10,12,18,32H,9,11,13H2,1-3H3,(H,24,25,26)/t18-/m0/s1
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n/an/a 13.3n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196783
PNG
(US9212178, 12)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3[nH]cc(C(=O)C4CC4)c3c2)n1 |r|
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n/an/a 13.5n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196787
PNG
(US9212178, 16)
Show SMILES Cc1nn(cc1CN1CC(C)(O)CO1)-c1ccnc(Nc2ccc3n(CC(F)(F)F)cc(C(=O)C4CC4)c3c2)n1
Show InChI InChI=1S/C27H28F3N7O3/c1-16-18(10-36-13-26(2,39)15-40-36)11-37(34-16)23-7-8-31-25(33-23)32-19-5-6-22-20(9-19)21(24(38)17-3-4-17)12-35(22)14-27(28,29)30/h5-9,11-12,17,39H,3-4,10,13-15H2,1-2H3,(H,31,32,33)
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n/an/a 14.2n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196784
PNG
(US9212178, 13)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4CC(C)(O)CO4)c(C)n3)ccc12
Show InChI InChI=1S/C27H31N7O3/c1-4-32-14-22(25(35)18-5-6-18)21-11-20(7-8-23(21)32)29-26-28-10-9-24(30-26)34-13-19(17(2)31-34)12-33-15-27(3,36)16-37-33/h7-11,13-14,18,36H,4-6,12,15-16H2,1-3H3,(H,28,29,30)
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n/an/a 17.3n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/a 23.6n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196781
PNG
(US9212178, 10)
Show SMILES Cc1nn(cc1CN1C[C@@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)F)c3c2)n1 |r|
Show InChI InChI=1S/C23H23F2N7O3/c1-13-14(8-31-10-16(33)12-35-31)9-32(29-13)20-5-6-26-23(28-20)27-15-3-4-19-17(7-15)18(11-30(19)2)21(34)22(24)25/h3-7,9,11,16,22,33H,8,10,12H2,1-2H3,(H,26,27,28)/t16-/m1/s1
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n/an/a 24.4n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196802
PNG
(US9212178, 31)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r|
Show InChI InChI=1S/C22H24ClN7O2/c1-13-15(9-29-11-17(31)12-32-29)10-30(27-13)20-6-7-24-22(26-20)25-16-4-5-19-18(8-16)21(23)14(2)28(19)3/h4-8,10,17,31H,9,11-12H2,1-3H3,(H,24,25,26)/t17-/m0/s1
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n/an/a 26.7n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196785
PNG
(US9212178, 14)
Show SMILES Cc1nn(cc1CN1CC(C)(O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1
Show InChI InChI=1S/C26H29N7O3/c1-16-18(11-32-14-26(2,35)15-36-32)12-33(30-16)23-8-9-27-25(29-23)28-19-6-7-22-20(10-19)21(13-31(22)3)24(34)17-4-5-17/h6-10,12-13,17,35H,4-5,11,14-15H2,1-3H3,(H,27,28,29)
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n/an/a 41.7n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196776
PNG
(US9212178, 5)
Show SMILES CCOC(=O)n1cc(C(C)=O)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C25H27N7O5/c1-4-36-25(35)31-13-21(16(3)33)20-9-18(5-6-22(20)31)27-24-26-8-7-23(28-24)32-11-17(15(2)29-32)10-30-12-19(34)14-37-30/h5-9,11,13,19,34H,4,10,12,14H2,1-3H3,(H,26,27,28)/t19-/m0/s1
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n/an/a 45.6n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196791
PNG
(US9212178, 20 | US9212178, 21)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3ncc(F)c(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C26H28FN7O3/c1-3-32-13-21(24(36)16-4-5-16)20-8-18(6-7-23(20)32)29-26-28-9-22(27)25(30-26)34-11-17(15(2)31-34)10-33-12-19(35)14-37-33/h6-9,11,13,16,19,35H,3-5,10,12,14H2,1-2H3,(H,28,29,30)/t19-/m0/s1
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n/an/a 66.2n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196777
PNG
(US9212178, 29 | US9212178, 6)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3nccc(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C26H29N7O3/c1-3-31-14-22(25(35)17-4-5-17)21-10-19(6-7-23(21)31)28-26-27-9-8-24(29-26)33-12-18(16(2)30-33)11-32-13-20(34)15-36-32/h6-10,12,14,17,20,34H,3-5,11,13,15H2,1-2H3,(H,27,28,29)/t20-/m0/s1
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n/an/a 69.5n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196793
PNG
(US9212178, 22)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3ncc(C)c(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C27H31N7O3/c1-4-32-14-23(25(36)18-5-6-18)22-9-20(7-8-24(22)32)29-27-28-10-16(2)26(30-27)34-12-19(17(3)31-34)11-33-13-21(35)15-37-33/h7-10,12,14,18,21,35H,4-6,11,13,15H2,1-3H3,(H,28,29,30)/t21-/m0/s1
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n/an/a 79.3n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196797
PNG
(US9212178, 26)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)nc(c3c2)S(C)(=O)=O)n1 |r|
Show InChI InChI=1S/C21H24N8O4S/c1-13-14(9-28-11-16(30)12-33-28)10-29(25-13)19-6-7-22-21(24-19)23-15-4-5-18-17(8-15)20(26-27(18)2)34(3,31)32/h4-8,10,16,30H,9,11-12H2,1-3H3,(H,22,23,24)/t16-/m0/s1
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n/an/a 87.1n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196799
PNG
(US9212178, 28)
Show SMILES Cc1nn(cc1CN1CC(C)(O)CCO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)n1
Show InChI InChI=1S/C27H31N7O3/c1-17-19(13-33-16-27(2,36)9-11-37-33)14-34(31-17)24-8-10-28-26(30-24)29-20-6-7-23-21(12-20)22(15-32(23)3)25(35)18-4-5-18/h6-8,10,12,14-15,18,36H,4-5,9,11,13,16H2,1-3H3,(H,28,29,30)
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n/an/a 106n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196788
PNG
(US9212178, 17)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1nc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)ncc1Cl |r|
Show InChI InChI=1S/C23H21ClF3N7O3/c1-12-13(7-33-9-15(35)11-37-33)8-34(31-12)21-18(24)6-28-22(30-21)29-14-3-4-19-16(5-14)17(10-32(19)2)20(36)23(25,26)27/h3-6,8,10,15,35H,7,9,11H2,1-2H3,(H,28,29,30)/t15-/m0/s1
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n/an/a 132n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196789
PNG
(US9212178, 18)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1nc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)ncc1C |r|
Show InChI InChI=1S/C24H24F3N7O3/c1-13-7-28-23(30-22(13)34-9-15(14(2)31-34)8-33-10-17(35)12-37-33)29-16-4-5-20-18(6-16)19(11-32(20)3)21(36)24(25,26)27/h4-7,9,11,17,35H,8,10,12H2,1-3H3,(H,28,29,30)/t17-/m0/s1
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n/an/a 159n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196791
PNG
(US9212178, 20 | US9212178, 21)
Show SMILES CCn1cc(C(=O)C2CC2)c2cc(Nc3ncc(F)c(n3)-n3cc(CN4C[C@H](O)CO4)c(C)n3)ccc12 |r|
Show InChI InChI=1S/C26H28FN7O3/c1-3-32-13-21(24(36)16-4-5-16)20-8-18(6-7-23(20)32)29-26-28-9-22(27)25(30-26)34-11-17(15(2)31-34)10-33-12-19(35)14-37-33/h6-9,11,13,16,19,35H,3-5,10,12,14H2,1-2H3,(H,28,29,30)/t19-/m0/s1
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n/an/a 230n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM196790
PNG
(US9212178, 19)
Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1nc(Nc2ccc3n(C)cc(C(=O)C4CC4)c3c2)ncc1C |r|
Show InChI InChI=1S/C26H29N7O3/c1-15-9-27-26(29-25(15)33-11-18(16(2)30-33)10-32-12-20(34)14-36-32)28-19-6-7-23-21(8-19)22(13-31(23)3)24(35)17-4-5-17/h6-9,11,13,17,20,34H,4-5,10,12,14H2,1-3H3,(H,27,28,29)/t20-/m0/s1
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n/an/a 271n/an/an/an/an/a25



Genosco; Oscotec, Inc.

US Patent


Assay Description
Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...

US Patent US9212178 (2015)


BindingDB Entry DOI: 10.7270/Q2X9294C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%