BDBM196774 US9212178, 3

SMILES: Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)n1

InChI Key: InChIKey=SUGDFLIUHAHCQF-INIZCTEOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196774   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM196774 (US9212178, 3) Show SMILES Cc1nn(cc1CN1C[C@H](O)CO1)-c1ccnc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)n1 |r| Show InChI InChI=1S/C23H22F3N7O3/c1-13-14(8-32-10-16(34)12-36-32)9-33(30-13)20-5-6-27-22(29-20)28-15-3-4-19-17(7-15)18(11-31(19)2)21(35)23(24,25)26/h3-7,9,11,16,34H,8,10,12H2,1-2H3,(H,27,28,29)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US9212178 (2015) BindingDB Entry DOI: 10.7270/Q2X9294C
					More data for this Ligand-Target Pair