Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM196788 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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Temperature | 298.15±n/a K |
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IC50 | 131.7±n/a nM |
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Comments | extracted |
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Citation | Lee, J; Choi, J; Hwang, H; Song, H; Kim, J; Kim, S; Koh, JS; Lee, J; Lee, T; Choi, Y; Park, S; Lee, IY; Suh, B; Salgaonkar, PD; Jung, D Substituted pyrimidine compounds and their use as SYK inhibitors US Patent US9212178 Publication Date 12/15/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM196788 |
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n/a |
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Name | BDBM196788 |
Synonyms: | US9212178, 17 |
Type | Small organic molecule |
Emp. Form. | C23H21ClF3N7O3 |
Mol. Mass. | 535.906 |
SMILES | Cc1nn(cc1CN1C[C@H](O)CO1)-c1nc(Nc2ccc3n(C)cc(C(=O)C(F)(F)F)c3c2)ncc1Cl |r| |
Structure |
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