Affinity Data by Patent

Patent code US9227959

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199988 (US9227959, 2) Show SMILES Clc1cccc(c1)C#Cc1ccc(nc1)C(=O)N1CCOCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199989 (US9227959, 3) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199990 (US9227959, 4) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	67	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199987 (US9227959, 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	72	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199985 (US9227959, Reference Compound 1, Ex. 35) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	201	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199986 (US9227959, Reference Compound 2, Ex. 46) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	315	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199985 (US9227959, Reference Compound 1, Ex. 35) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199986 (US9227959, Reference Compound 2, Ex. 46) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%