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Patent code US8748458

Compile Data Set for Download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124206
PNG
(US8748458, 14)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc2ccccc2cn1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-14-25(19-11-6-7-13-22-19)20-15-17-9-4-5-10-18(17)16-23-20/h4-7,9-11,13,15-16,27H,1-3,8,12,14H2,(H,24,26)
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n/an/a 2n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124207
PNG
(US8748458, 15)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(OCc2ccccc2)ccn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-15-25-22)23-18-21(14-16-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 3n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 9n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124205
PNG
(US8748458, 11)
Show SMILES COc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O3/c1-25-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 13n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 16n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124202
PNG
(US8748458, 8)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C23H26N4O2/c28-23(26-29)13-6-1-2-9-17-27(21-12-7-8-15-24-21)22-18-20(14-16-25-22)19-10-4-3-5-11-19/h3-5,7-8,10-12,14-16,18,29H,1-2,6,9,13,17H2,(H,26,28)
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n/an/a 19n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124201
PNG
(US8748458, 5)
Show SMILES [#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6](\c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C18H21N3O2/c22-18(21-23)12-4-2-1-3-9-15(16-10-5-7-13-19-16)17-11-6-8-14-20-17/h5-11,13-14,23H,1-4,12H2,(H,21,22)
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n/an/a 22n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124203
PNG
(US8748458, 9)
Show SMILES Cc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O2/c1-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 31n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124204
PNG
(US8748458, 10)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc(OCc2ccccc2)cn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-16-25-22)23-15-14-21(18-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 57n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 62n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124206
PNG
(US8748458, 14)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc2ccccc2cn1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-14-25(19-11-6-7-13-22-19)20-15-17-9-4-5-10-18(17)16-23-20/h4-7,9-11,13,15-16,27H,1-3,8,12,14H2,(H,24,26)
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n/an/a 64n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM124198
PNG
(US8748458, 1)
Show SMILES [#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#6]=[#6](\c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C17H19N3O2/c21-17(20-22)11-3-1-2-8-14(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-10,12-13,22H,1-3,11H2,(H,20,21)
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n/an/a 68n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 71n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 90n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 112n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124202
PNG
(US8748458, 8)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C23H26N4O2/c28-23(26-29)13-6-1-2-9-17-27(21-12-7-8-15-24-21)22-18-20(14-16-25-22)19-10-4-3-5-11-19/h3-5,7-8,10-12,14-16,18,29H,1-2,6,9,13,17H2,(H,26,28)
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n/an/a 116n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 123n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Polyamine deacetylase HDAC10


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 126n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM124206
PNG
(US8748458, 14)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc2ccccc2cn1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-14-25(19-11-6-7-13-22-19)20-15-17-9-4-5-10-18(17)16-23-20/h4-7,9-11,13,15-16,27H,1-3,8,12,14H2,(H,24,26)
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n/an/a 145n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124207
PNG
(US8748458, 15)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(OCc2ccccc2)ccn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-15-25-22)23-18-21(14-16-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 151n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 157n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124198
PNG
(US8748458, 1)
Show SMILES [#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#6]=[#6](\c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C17H19N3O2/c21-17(20-22)11-3-1-2-8-14(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-10,12-13,22H,1-3,11H2,(H,20,21)
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n/an/a 158n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124205
PNG
(US8748458, 11)
Show SMILES COc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O3/c1-25-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 182n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124204
PNG
(US8748458, 10)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc(OCc2ccccc2)cn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-16-25-22)23-15-14-21(18-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 182n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 212n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124206
PNG
(US8748458, 14)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc2ccccc2cn1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-14-25(19-11-6-7-13-22-19)20-15-17-9-4-5-10-18(17)16-23-20/h4-7,9-11,13,15-16,27H,1-3,8,12,14H2,(H,24,26)
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n/an/a 306n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 307n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 312n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM124207
PNG
(US8748458, 15)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(OCc2ccccc2)ccn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-15-25-22)23-18-21(14-16-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 423n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124203
PNG
(US8748458, 9)
Show SMILES Cc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O2/c1-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 453n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 458n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 458n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM124200
PNG
(US8748458, 4)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H24N4O2/c26-21(24-27)12-3-1-2-8-16-25(19-11-6-7-15-22-19)20-14-13-17-9-4-5-10-18(17)23-20/h4-7,9-11,13-15,27H,1-3,8,12,16H2,(H,24,26)
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n/an/a 545n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124207
PNG
(US8748458, 15)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1cc(OCc2ccccc2)ccn1
Show InChI InChI=1S/C24H28N4O3/c29-24(27-30)13-6-1-2-9-17-28(22-12-7-8-15-25-22)23-18-21(14-16-26-23)31-19-20-10-4-3-5-11-20/h3-5,7-8,10-12,14-16,18,30H,1-2,6,9,13,17,19H2,(H,27,29)
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n/an/a 612n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM124201
PNG
(US8748458, 5)
Show SMILES [#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6](\c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C18H21N3O2/c22-18(21-23)12-4-2-1-3-9-15(16-10-5-7-13-19-16)17-11-6-8-14-20-17/h5-11,13-14,23H,1-4,12H2,(H,21,22)
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n/an/a 642n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 710n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM124205
PNG
(US8748458, 11)
Show SMILES COc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O3/c1-25-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 759n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM124203
PNG
(US8748458, 9)
Show SMILES Cc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O2/c1-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 759n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124205
PNG
(US8748458, 11)
Show SMILES COc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O3/c1-25-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 883n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124203
PNG
(US8748458, 9)
Show SMILES Cc1ccc(nc1)N(CCCCCCC(=O)NO)c1ccccn1
Show InChI InChI=1S/C18H24N4O2/c1-15-10-11-17(20-14-15)22(16-8-5-6-12-19-16)13-7-3-2-4-9-18(23)21-24/h5-6,8,10-12,14,24H,2-4,7,9,13H2,1H3,(H,21,23)
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n/an/a 1.14E+3n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))		BDBM124199
PNG
(US8748458, 3)
Show SMILES ONC(=O)CCCCCCN(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H22N4O2/c22-17(20-23)11-3-1-2-8-14-21(15-9-4-6-12-18-15)16-10-5-7-13-19-16/h4-7,9-10,12-13,23H,1-3,8,11,14H2,(H,20,22)
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n/an/a 1.54E+3n/an/an/an/an/a37



Karus Therapeutics Limited

US Patent


Assay Description
In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...

US Patent US8748458 (2014)


BindingDB Entry DOI: 10.7270/Q22N50Z7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%