Affinity Data by Patent

Patent code US9090625

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172452 (US9090625, 4 \| US9260450, 4 \| US9938289, 4) Show SMILES CCc1cnn(c1-c1cc2cnccc2s1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.33	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172455 (US9090625, 7 \| US9260450, 7 \| US9938289, 7) Show SMILES Cc1cnn(c1-c1cc2cnccc2s1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.65	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172457 (US9090625, 12 \| US9260450, 12 \| US9938289, 12) Show SMILES Cc1cnn(c1-c1cc2ccncc2s1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172453 (US9090625, 5 \| US9260450, 5 \| US9938289, 5) Show SMILES Cc1cccc(n1)-n1nc2CCCc2c1-c1cc2cnccc2s1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172458 (US9090625, 13 \| US9260450, 13 \| US9938289, 13) Show SMILES Cc1cccc(n1)-n1nc2CCCc2c1-c1cc2ccncc2s1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.9	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172449 (US9090625, 1 \| US9260450, 1 \| US9938289, 1) Show SMILES Cc1cccc(n1)-n1nccc1-c1cc2cnccc2s1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23.4	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172454 (US9090625, 6 \| US9260450, 6 \| US9938289, 6) Show SMILES Cc1nn(c(c1C)-c1cc2cnccc2s1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35.2	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172450 (US9090625, 2 \| US9260450, 2 \| US9938289, 2) Show SMILES Cc1cc(-c2cc3cnccc3s2)n(n1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	94.1	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM172451 (US9090625, 3 \| US9260450, 3 \| US9938289, 3) Show SMILES CCc1cc(-c2cc3cnccc3s2)n(n1)-c1cccc(C)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
THESAN PHARMACEUTICALS, INC. US Patent					Assay Description Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...				US Patent US9090625 (2015) BindingDB Entry DOI: 10.7270/Q2BG2MRM
THESAN PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%