Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200301 (US9226927, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200304 (US9226927, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200302 (US9226927, 8a) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200314 (US9226927, 27a) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200311 (US9226927, 25f) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200307 (US9226927, 25b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200308 (US9226927, 25c) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200305 (US9226927, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200310 (US9226927, 25e) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200303 (US9226927, 8b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200309 (US9226927, 25d) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200312 (US9226927, 25g) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.9 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200313 (US9226927, 25h) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200315 (US9226927, 27b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM200306 (US9226927, 25a) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18.7 | n/a | n/a | n/a | n/a | 7.0 | 37 |
MERCK SHARP & DOHME CORP. US Patent | Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT... | US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
