null

SMILES: Fc1ccc(F)c2c1OCC1[C@H](CCS(=O)(=O)c3ncccn3)OCC[C@@]21S(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=BUQADQXEEJVWLR-OUSZHMKWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200310   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM200310 (US9226927, 25e) Show SMILES Fc1ccc(F)c2c1OCC1[C@H](CCS(=O)(=O)c3ncccn3)OCC[C@@]21S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H21ClF2N2O6S2/c25-15-2-4-16(5-3-15)37(32,33)24-9-12-34-20(8-13-36(30,31)23-28-10-1-11-29-23)17(24)14-35-22-19(27)7-6-18(26)21(22)24/h1-7,10-11,17,20H,8-9,12-14H2/t17?,20-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.0	37
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9226927 (2016) BindingDB Entry DOI: 10.7270/Q24J0CX1
					More data for this Ligand-Target Pair