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Patent code US9056843

Compile Data Set for Download or QSAR

Found 460 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162854
PNG
(US9056843, 145)
Show SMILES CCCN(CC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H23F3N4O2/c1-4-10-25(5-2)11-12(3)22-16(26)14-8-6-13(7-9-14)15-23-17(27-24-15)18(19,20)21/h6-9,12H,4-5,10-11H2,1-3H3,(H,22,26)/t12-/m1/s1
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US Patent
n/an/a 0.75n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162865
PNG
(US9056843, 156)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21F3N4O2/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24/h3-11,14H,12-13H2,1-2H3,(H,25,29)/t14-/m1/s1
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n/an/a 0.850n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162846
PNG
(US9056843, 137)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1
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n/an/a 0.970n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162848
PNG
(US9056843, 139)
Show SMILES CCCN(C)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H21F3N4O2/c1-4-9-24(3)10-11(2)21-15(25)13-7-5-12(6-8-13)14-22-16(26-23-14)17(18,19)20/h5-8,11H,4,9-10H2,1-3H3,(H,21,25)/t11-/m1/s1
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n/an/a 1n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162859
PNG
(US9056843, 150)
Show SMILES CCCCN(C)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H23F3N4O2/c1-4-5-10-25(3)11-12(2)22-16(26)14-8-6-13(7-9-14)15-23-17(27-24-15)18(19,20)21/h6-9,12H,4-5,10-11H2,1-3H3,(H,22,26)/t12-/m1/s1
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n/an/a 1.10n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162852
PNG
(US9056843, 143)
Show SMILES CCCN(C)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H20F4N4O2/c1-4-7-25(3)9-10(2)22-15(26)12-6-5-11(8-13(12)18)14-23-16(27-24-14)17(19,20)21/h5-6,8,10H,4,7,9H2,1-3H3,(H,22,26)/t10-/m1/s1
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n/an/a 1.20n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162850
PNG
(US9056843, 141)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C19H24F4N4O2/c1-4-8-27(9-5-2)11-12(3)24-17(28)14-7-6-13(10-15(14)20)16-25-18(29-26-16)19(21,22)23/h6-7,10,12H,4-5,8-9,11H2,1-3H3,(H,24,28)/t12-/m1/s1
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n/an/a 1.40n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162855
PNG
(US9056843, 146)
Show SMILES CCCN(CC)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H22F4N4O2/c1-4-8-26(5-2)10-11(3)23-16(27)13-7-6-12(9-14(13)19)15-24-17(28-25-15)18(20,21)22/h6-7,9,11H,4-5,8,10H2,1-3H3,(H,23,27)/t11-/m1/s1
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n/an/a 1.60n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162860
PNG
(US9056843, 151)
Show SMILES CCCCN(C)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H22F4N4O2/c1-4-5-8-26(3)10-11(2)23-16(27)13-7-6-12(9-14(13)19)15-24-17(28-25-15)18(20,21)22/h6-7,9,11H,4-5,8,10H2,1-3H3,(H,23,27)/t11-/m1/s1
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n/an/a 1.80n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162862
PNG
(US9056843, 153)
Show SMILES CN1CC[C@H](C1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C15H15F3N4O2/c1-22-7-6-11(8-22)19-13(23)10-4-2-9(3-5-10)12-20-14(24-21-12)15(16,17)18/h2-5,11H,6-8H2,1H3,(H,19,23)/t11-/m1/s1
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n/an/a 3.60n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162847
PNG
(US9056843, 138)
Show SMILES C[C@H](CN(C)C(C)C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H21F3N4O2/c1-10(2)24(4)9-11(3)21-15(25)13-7-5-12(6-8-13)14-22-16(26-23-14)17(18,19)20/h5-8,10-11H,9H2,1-4H3,(H,21,25)/t11-/m1/s1
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n/an/a 4.5n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162841
PNG
(US9056843, 132)
Show SMILES CCN(CC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H21F3N4O2/c1-4-24(5-2)10-11(3)21-15(25)13-8-6-12(7-9-13)14-22-16(26-23-14)17(18,19)20/h6-9,11H,4-5,10H2,1-3H3,(H,21,25)/t11-/m1/s1
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n/an/a 5n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162851
PNG
(US9056843, 142)
Show SMILES C[C@H](CN(C)C(C)C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H20F4N4O2/c1-9(2)25(4)8-10(3)22-15(26)12-6-5-11(7-13(12)18)14-23-16(27-24-14)17(19,20)21/h5-7,9-10H,8H2,1-4H3,(H,22,26)/t10-/m1/s1
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n/an/a 7.20n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162832
PNG
(US9056843, 123)
Show SMILES CCN(CC)CC(C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C17H21F3N4O2/c1-4-24(5-2)10-11(3)21-15(25)13-8-6-12(7-9-13)14-22-16(26-23-14)17(18,19)20/h6-9,11H,4-5,10H2,1-3H3,(H,21,25)
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n/an/a 7.60n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162861
PNG
(US9056843, 152)
Show SMILES CCN(C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F)C(C)C |r|
Show InChI InChI=1S/C18H22F4N4O2/c1-5-26(10(2)3)9-11(4)23-16(27)13-7-6-12(8-14(13)19)15-24-17(28-25-15)18(20,21)22/h6-8,10-11H,5,9H2,1-4H3,(H,23,27)/t11-/m1/s1
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n/an/a 8.40n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162845
PNG
(US9056843, 136)
Show SMILES CCN(C)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C16H19F3N4O2/c1-4-23(3)9-10(2)20-14(24)12-7-5-11(6-8-12)13-21-15(25-22-13)16(17,18)19/h5-8,10H,4,9H2,1-3H3,(H,20,24)/t10-/m1/s1
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n/an/a 8.90n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162835
PNG
(US9056843, 126)
Show SMILES CCN(CC)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H20F4N4O2/c1-4-25(5-2)9-10(3)22-15(26)12-7-6-11(8-13(12)18)14-23-16(27-24-14)17(19,20)21/h6-8,10H,4-5,9H2,1-3H3,(H,22,26)/t10-/m1/s1
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n/an/a 8.90n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162843
PNG
(US9056843, 134)
Show SMILES CCN(CC)C[C@H](NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F)C(C)C |r|
Show InChI InChI=1S/C19H25F3N4O2/c1-5-26(6-2)11-15(12(3)4)23-17(27)14-9-7-13(8-10-14)16-24-18(28-25-16)19(20,21)22/h7-10,12,15H,5-6,11H2,1-4H3,(H,23,27)/t15-/m0/s1
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n/an/a 9.80n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162844
PNG
(US9056843, 135)
Show SMILES CCN(CC)C[C@H](NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F)C(C)C |r|
Show InChI InChI=1S/C19H24F4N4O2/c1-5-27(6-2)10-15(11(3)4)24-17(28)13-8-7-12(9-14(13)20)16-25-18(29-26-16)19(21,22)23/h7-9,11,15H,5-6,10H2,1-4H3,(H,24,28)/t15-/m0/s1
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n/an/a 10n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162840
PNG
(US9056843, 131)
Show SMILES C[C@H](CN1CCCCC1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H21F3N4O2/c1-12(11-25-9-3-2-4-10-25)22-16(26)14-7-5-13(6-8-14)15-23-17(27-24-15)18(19,20)21/h5-8,12H,2-4,9-11H2,1H3,(H,22,26)/t12-/m1/s1
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n/an/a 10n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162839
PNG
(US9056843, 130)
Show SMILES C[C@H](CN1CCCC1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H19F3N4O2/c1-11(10-24-8-2-3-9-24)21-15(25)13-6-4-12(5-7-13)14-22-16(26-23-14)17(18,19)20/h4-7,11H,2-3,8-10H2,1H3,(H,21,25)/t11-/m1/s1
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n/an/a 11n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162797
PNG
(US9056843, 88)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C15H16F4N4O2/c1-8(7-23(2)3)20-13(24)10-5-4-9(6-11(10)16)12-21-14(25-22-12)15(17,18)19/h4-6,8H,7H2,1-3H3,(H,20,24)/t8-/m1/s1
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n/an/a 12n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162864
PNG
(US9056843, 155)
Show SMILES CCN(CC)CCNC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H19F3N4O2/c1-3-23(4-2)10-9-20-14(24)12-7-5-11(6-8-12)13-21-15(25-22-13)16(17,18)19/h5-8H,3-4,9-10H2,1-2H3,(H,20,24)
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n/an/a 12n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162838
PNG
(US9056843, 129)
Show SMILES C[C@H](CN1CCCCC1)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H20F4N4O2/c1-11(10-26-7-3-2-4-8-26)23-16(27)13-6-5-12(9-14(13)19)15-24-17(28-25-15)18(20,21)22/h5-6,9,11H,2-4,7-8,10H2,1H3,(H,23,27)/t11-/m1/s1
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n/an/a 13n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162830
PNG
(US9056843, 121)
Show SMILES CCN(CC)CC(C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C17H20F4N4O2/c1-4-25(5-2)9-10(3)22-15(26)12-7-6-11(8-13(12)18)14-23-16(27-24-14)17(19,20)21/h6-8,10H,4-5,9H2,1-3H3,(H,22,26)
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n/an/a 15n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162792
PNG
(US9056843, 83)
Show SMILES CC(C)[C@@H](CN(C)C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H21F3N4O2/c1-10(2)13(9-24(3)4)21-15(25)12-7-5-11(6-8-12)14-22-16(26-23-14)17(18,19)20/h5-8,10,13H,9H2,1-4H3,(H,21,25)/t13-/m1/s1
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n/an/a 15n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162762
PNG
(US9056843, 53)
Show SMILES CC(CN(C)C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N4O2/c1-9(8-22(2)3)19-13(23)11-6-4-10(5-7-11)12-20-14(24-21-12)15(16,17)18/h4-7,9H,8H2,1-3H3,(H,19,23)
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n/an/a 26n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162789
PNG
(US9056843, 80 | US9056843, 86 | US9056843, 87)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NC1CCNC1
Show InChI InChI=1S/C14H13F3N4O2/c15-14(16,17)13-20-11(21-23-13)8-1-3-9(4-2-8)12(22)19-10-5-6-18-7-10/h1-4,10,18H,5-7H2,(H,19,22)
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n/an/a 26n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162837
PNG
(US9056843, 128)
Show SMILES C[C@H](CN1CCCC1)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H18F4N4O2/c1-10(9-25-6-2-3-7-25)22-15(26)12-5-4-11(8-13(12)18)14-23-16(27-24-14)17(19,20)21/h4-5,8,10H,2-3,6-7,9H2,1H3,(H,22,26)/t10-/m1/s1
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n/an/a 26n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162787
PNG
(US9056843, 78)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)NCC1CCCCN1
Show InChI InChI=1S/C16H17F3N4O2/c17-16(18,19)15-22-13(23-25-15)10-4-6-11(7-5-10)14(24)21-9-12-3-1-2-8-20-12/h4-7,12,20H,1-3,8-9H2,(H,21,24)
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n/an/a 30n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162790
PNG
(US9056843, 81)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N4O2/c1-9(8-22(2)3)19-13(23)11-6-4-10(5-7-11)12-20-14(24-21-12)15(16,17)18/h4-7,9H,8H2,1-3H3,(H,19,23)/t9-/m1/s1
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n/an/a 34n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162828
PNG
(US9056843, 119)
Show SMILES CN(C)CC(C)(C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H19F3N4O2/c1-15(2,9-23(3)4)21-13(24)11-7-5-10(6-8-11)12-20-14(25-22-12)16(17,18)19/h5-8H,9H2,1-4H3,(H,21,24)
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n/an/a 36n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162866
PNG
(US9056843, 157)
Show SMILES CNCCNC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C13H13F3N4O2/c1-17-6-7-18-11(21)9-4-2-8(3-5-9)10-19-12(22-20-10)13(14,15)16/h2-5,17H,6-7H2,1H3,(H,18,21)
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n/an/a 40n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162836
PNG
(US9056843, 127)
Show SMILES CCN(CC)C[C@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H20F4N4O2/c1-4-25(5-2)9-10(3)22-15(26)12-7-6-11(8-13(12)18)14-23-16(27-24-14)17(19,20)21/h6-8,10H,4-5,9H2,1-3H3,(H,22,26)/t10-/m0/s1
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n/an/a 44n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162798
PNG
(US9056843, 89)
Show SMILES CC(C)[C@H](CN(C)C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H20F4N4O2/c1-9(2)13(8-25(3)4)22-15(26)11-6-5-10(7-12(11)18)14-23-16(27-24-14)17(19,20)21/h5-7,9,13H,8H2,1-4H3,(H,22,26)/t13-/m0/s1
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n/an/a 45n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162842
PNG
(US9056843, 133)
Show SMILES CCN(CC)C[C@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C17H21F3N4O2/c1-4-24(5-2)10-11(3)21-15(25)13-8-6-12(7-9-13)14-22-16(26-23-14)17(18,19)20/h6-9,11H,4-5,10H2,1-3H3,(H,21,25)/t11-/m0/s1
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n/an/a 48n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162794
PNG
(US9056843, 85)
Show SMILES CC(C)C[C@H](CN(C)C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C18H23F3N4O2/c1-11(2)9-14(10-25(3)4)22-16(26)13-7-5-12(6-8-13)15-23-17(27-24-15)18(19,20)21/h5-8,11,14H,9-10H2,1-4H3,(H,22,26)/t14-/m1/s1
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n/an/a 48n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162834
PNG
(US9056843, 125)
Show SMILES C[C@H](CN(C)C)NC(=O)c1ccc(cc1Cl)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C15H16ClF3N4O2/c1-8(7-23(2)3)20-13(24)10-5-4-9(6-11(10)16)12-21-14(25-22-12)15(17,18)19/h4-6,8H,7H2,1-3H3,(H,20,24)/t8-/m1/s1
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n/an/a 53n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162782
PNG
(US9056843, 73)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)Nc1ccnc(c1)C#N
Show InChI InChI=1S/C16H8F3N5O2/c17-16(18,19)15-23-13(24-26-15)9-1-3-10(4-2-9)14(25)22-11-5-6-21-12(7-11)8-20/h1-7H,(H,21,22,25)
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n/an/a 53n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162756
PNG
(US9056843, 47)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C15H9F3N4O2/c16-15(17,18)14-21-12(22-24-14)9-1-3-10(4-2-9)13(23)20-11-5-7-19-8-6-11/h1-8H,(H,19,20,23)
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n/an/a 54n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162809
PNG
(US9056843, 100)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C14H9F3N4O3S/c15-14(16,17)13-19-12(20-24-13)9-3-5-11(6-4-9)25(22,23)21-10-2-1-7-18-8-10/h1-8,21H
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n/an/a 70n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162849
PNG
(US9056843, 140)
Show SMILES CCN(C)C[C@@H](C)NC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C16H18F4N4O2/c1-4-24(3)8-9(2)21-14(25)11-6-5-10(7-12(11)17)13-22-15(26-23-13)16(18,19)20/h5-7,9H,4,8H2,1-3H3,(H,21,25)/t9-/m1/s1
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n/an/a 72n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162740
PNG
(US9056843, 31)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C14H15F3N4O2/c1-21(2)8-7-18-12(22)10-5-3-9(4-6-10)11-19-13(23-20-11)14(15,16)17/h3-6H,7-8H2,1-2H3,(H,18,22)
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n/an/a 80n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162812
PNG
(US9056843, 103)
Show SMILES Cc1ccccc1NS(=O)(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N3O3S/c1-10-4-2-3-5-13(10)22-26(23,24)12-8-6-11(7-9-12)14-20-15(25-21-14)16(17,18)19/h2-9,22H,1H3
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n/an/a 80n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162801
PNG
(US9056843, 92)
Show SMILES CN(C)C[C@@H](Cc1ccccc1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21F3N4O2/c1-28(2)13-17(12-14-6-4-3-5-7-14)25-19(29)16-10-8-15(9-11-16)18-26-20(30-27-18)21(22,23)24/h3-11,17H,12-13H2,1-2H3,(H,25,29)/t17-/m1/s1
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n/an/a 85n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162831
PNG
(US9056843, 122)
Show SMILES CC(CNC(=O)c1ccc(cc1F)-c1noc(n1)C(F)(F)F)N(C)C
Show InChI InChI=1S/C15H16F4N4O2/c1-8(23(2)3)7-20-13(24)10-5-4-9(6-11(10)16)12-21-14(25-22-12)15(17,18)19/h4-6,8H,7H2,1-3H3,(H,20,24)
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n/an/a 85n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162760
PNG
(US9056843, 51)
Show SMILES CC(CNC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F)N(C)C
Show InChI InChI=1S/C15H17F3N4O2/c1-9(22(2)3)8-19-13(23)11-6-4-10(5-7-11)12-20-14(24-21-12)15(16,17)18/h4-7,9H,8H2,1-3H3,(H,19,23)
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n/an/a 90n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162779
PNG
(US9056843, 70)
Show SMILES Cc1cc(NC(=O)c2ccc(cc2)-c2noc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C16H11F3N4O2/c1-9-8-12(6-7-20-9)21-14(24)11-4-2-10(3-5-11)13-22-15(25-23-13)16(17,18)19/h2-8H,1H3,(H,20,21,24)
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n/an/a 90n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162817
PNG
(US9056843, 108)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2noc(n2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H12F3N3O3S/c1-10-2-6-12(7-3-10)22-26(23,24)13-8-4-11(5-9-13)14-20-15(25-21-14)16(17,18)19/h2-9,22H,1H3
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n/an/a 93n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))		BDBM162805
PNG
(US9056843, 96)
Show SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C15H10F3N3O3S/c16-15(17,18)14-19-13(20-24-14)10-6-8-12(9-7-10)25(22,23)21-11-4-2-1-3-5-11/h1-9,21H
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n/an/a 96n/an/an/an/a8.025



NOVARTIS AG

US Patent


Assay Description
Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...

US Patent US9056843 (2015)


BindingDB Entry DOI: 10.7270/Q24F1PG8
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%