Found 64 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97514
(Roche-Dataset for PDE10A, Compound 6 | US8470820, ...)Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1 Show InChI InChI=1S/C27H24N8O2/c36-12-11-35-25(13-24(34-35)22-8-7-17-3-1-2-4-20(17)31-22)33-27(37)26-23(30-19-14-28-16-29-15-19)10-9-21(32-26)18-5-6-18/h1-4,7-10,13-16,18,30,36H,5-6,11-12H2,(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97527
(Roche-Dataset for PDE10A, Compound 53 | US8470820,...)Show SMILES COCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C24H24N8O2/c1-34-11-10-32-22(12-21(31-32)19-4-2-3-9-27-19)30-24(33)23-20(28-17-13-25-15-26-14-17)8-7-18(29-23)16-5-6-16/h2-4,7-9,12-16,28H,5-6,10-11H2,1H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97521
(Roche-Dataset for PDE10A, Compound 7 | US8470820, ...)Show SMILES O=C(Nc1cc(nn1CC1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C28H30N8O/c37-28(27-24(32-21-15-29-18-30-16-21)12-11-22(33-27)20-9-10-20)34-26-14-25(23-8-4-5-13-31-23)35-36(26)17-19-6-2-1-3-7-19/h4-5,8,11-16,18-20,32H,1-3,6-7,9-10,17H2,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97501
(Roche-Dataset for PDE10A, Compound 33 | US8470820,...)Show SMILES CN(C)CCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C25H27N9O/c1-33(2)11-12-34-23(13-22(32-34)20-5-3-4-10-28-20)31-25(35)24-21(29-18-14-26-16-27-15-18)9-8-19(30-24)17-6-7-17/h3-5,8-10,13-17,29H,6-7,11-12H2,1-2H3,(H,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97523
(Roche-Dataset for PDE10A, Compound 107 | US8470820...)Show SMILES CCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1CCO)-c1ccccn1 Show InChI InChI=1S/C22H22N8O2/c1-2-15-6-7-18(26-16-12-23-14-24-13-16)21(27-15)22(32)28-20-11-19(29-30(20)9-10-31)17-5-3-4-8-25-17/h3-8,11-14,26,31H,2,9-10H2,1H3,(H,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97503
(BDBM97509 | Roche-Dataset for PDE10A, Compound 13 ...)Show SMILES O=C(Nc1cc(nn1C1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-19-15-28-17-29-16-19)12-11-21(32-26)18-9-10-18)33-25-14-24(22-8-4-5-13-30-22)34-35(25)20-6-2-1-3-7-20/h4-5,8,11-18,20,31H,1-3,6-7,9-10H2,(H,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97503
(BDBM97509 | Roche-Dataset for PDE10A, Compound 13 ...)Show SMILES O=C(Nc1cc(nn1C1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-19-15-28-17-29-16-19)12-11-21(32-26)18-9-10-18)33-25-14-24(22-8-4-5-13-30-22)34-35(25)20-6-2-1-3-7-20/h4-5,8,11-18,20,31H,1-3,6-7,9-10H2,(H,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97539
(Roche-Dataset for PDE10A, Compound 953 | US8470820...)Show SMILES O=C(Nc1ccc(s1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H18N6OS/c29-22(28-20-9-8-19(30-20)17-3-1-2-10-25-17)21-18(26-15-11-23-13-24-12-15)7-6-16(27-21)14-4-5-14/h1-3,6-14,26H,4-5H2,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97529
(Roche-Dataset for PDE10A, Compound 46 | US8470820,...)Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1 Show InChI InChI=1S/C26H22N8O/c1-34-24(12-23(33-34)21-9-8-16-4-2-3-5-19(16)30-21)32-26(35)25-22(29-18-13-27-15-28-14-18)11-10-20(31-25)17-6-7-17/h2-5,8-15,17,29H,6-7H2,1H3,(H,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97517
(Roche-Dataset for PDE10A, Compound 44 | US8470820,...)Show SMILES CC(C)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C25H26N8O/c1-16(2)14-33-23(11-22(32-33)20-5-3-4-10-28-20)31-25(34)24-21(29-18-12-26-15-27-13-18)9-8-19(30-24)17-6-7-17/h3-5,8-13,15-17,29H,6-7,14H2,1-2H3,(H,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97513
(Roche-Dataset for PDE10A, Compound 77 | US8470820,...)Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1cccc(Cl)n1 Show InChI InChI=1S/C23H21ClN8O2/c24-20-3-1-2-17(28-20)19-10-21(32(31-19)8-9-33)30-23(34)22-18(27-15-11-25-13-26-12-15)7-6-16(29-22)14-4-5-14/h1-3,6-7,10-14,27,33H,4-5,8-9H2,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97520
(Roche-Dataset for PDE10A, Compound 8 | US8470820, ...)Show SMILES O=C(Nc1cc(nn1CC1CCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-20-14-28-17-29-15-20)11-10-21(32-26)19-8-9-19)33-25-13-24(22-7-3-4-12-30-22)34-35(25)16-18-5-1-2-6-18/h3-4,7,10-15,17-19,31H,1-2,5-6,8-9,16H2,(H,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97512
(Roche-Dataset for PDE10A, Compound 58 | US8470820,...)Show SMILES CCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C24H24N8O/c1-2-11-32-22(12-21(31-32)19-5-3-4-10-27-19)30-24(33)23-20(28-17-13-25-15-26-14-17)9-8-18(29-23)16-6-7-16/h3-5,8-10,12-16,28H,2,6-7,11H2,1H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50397998
(CHEMBL2180800 | Roche-Dataset for PDE10A, Compound...)Show SMILES O=C(Nc1cnc(s1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H17N7OS/c29-20(28-18-11-25-21(30-18)17-3-1-2-8-24-17)19-16(26-14-9-22-12-23-10-14)7-6-15(27-19)13-4-5-13/h1-3,6-13,26H,4-5H2,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97518
(Roche-Dataset for PDE10A, Compound 5 | US8470820, ...)Show SMILES O=C(Nc1cc(nn1Cc1ccccc1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C28H24N8O/c37-28(27-24(32-21-15-29-18-30-16-21)12-11-22(33-27)20-9-10-20)34-26-14-25(23-8-4-5-13-31-23)35-36(26)17-19-6-2-1-3-7-19/h1-8,11-16,18,20,32H,9-10,17H2,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97515
(Roche-Dataset for PDE10A, Compound 69 | US8470820,...)Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc(Cl)cn1 Show InChI InChI=1S/C23H21ClN8O2/c24-15-3-4-18(27-10-15)20-9-21(32(31-20)7-8-33)30-23(34)22-19(28-16-11-25-13-26-12-16)6-5-17(29-22)14-1-2-14/h3-6,9-14,28,33H,1-2,7-8H2,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97505
(Roche-Dataset for PDE10A, Compound 16 | US8470820,...)Show SMILES O=C(Nc1cc(nn1CCN1CCOCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C27H29N9O2/c37-27(26-23(31-20-16-28-18-29-17-20)7-6-21(32-26)19-4-5-19)33-25-15-24(22-3-1-2-8-30-22)34-36(25)10-9-35-11-13-38-14-12-35/h1-3,6-8,15-19,31H,4-5,9-14H2,(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97499
(Roche-Dataset for PDE10A, Compound 103 | US8470820...)Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C23H22N8O2/c32-10-9-31-21(11-20(30-31)18-3-1-2-8-26-18)29-23(33)22-19(27-16-12-24-14-25-13-16)7-6-17(28-22)15-4-5-15/h1-3,6-8,11-15,27,32H,4-5,9-10H2,(H,29,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97511
(Roche-Dataset for PDE10A, Compound 88 | US8470820,...)Show SMILES FC(F)(F)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C23H19F3N8O/c24-23(25,26)12-34-20(9-19(33-34)17-3-1-2-8-29-17)32-22(35)21-18(30-15-10-27-13-28-11-15)7-6-16(31-21)14-4-5-14/h1-3,6-11,13-14,30H,4-5,12H2,(H,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97526
(Roche-Dataset for PDE10A, Compound 2 | US8470820, ...)Show SMILES Cn1cncc1Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C26H24N10O/c1-35-16-29-13-19(35)14-36-24(10-23(34-36)21-4-2-3-9-30-21)33-26(37)25-22(31-18-11-27-15-28-12-18)8-7-20(32-25)17-5-6-17/h2-4,7-13,15-17,31H,5-6,14H2,1H3,(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97508
(Roche-Dataset for PDE10A, Compound 295 | US8470820...)Show SMILES CCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C21H20N8O/c1-3-14-7-8-17(25-15-11-22-13-23-12-15)20(26-14)21(30)27-19-10-18(28-29(19)2)16-6-4-5-9-24-16/h4-13,25H,3H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97516
(Roche-Dataset for PDE10A, Compound 60 | US8470820,...)Show SMILES CC(C)n1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C24H24N8O/c1-15(2)32-22(11-21(31-32)19-5-3-4-10-27-19)30-24(33)23-20(28-17-12-25-14-26-13-17)9-8-18(29-23)16-6-7-16/h3-5,8-16,28H,6-7H2,1-2H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97530
(Roche-Dataset for PDE10A, Compound 159 | US8470820...)Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1cccc(Cl)n1 Show InChI InChI=1S/C22H19ClN8O/c1-31-20(9-18(30-31)16-3-2-4-19(23)27-16)29-22(32)21-17(26-14-10-24-12-25-11-14)8-7-15(28-21)13-5-6-13/h2-4,7-13,26H,5-6H2,1H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97528
(Roche-Dataset for PDE10A, Compound 124 | US8470820...)Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc(Cl)cn1 Show InChI InChI=1S/C22H19ClN8O/c1-31-20(8-19(30-31)17-5-4-14(23)9-26-17)29-22(32)21-18(27-15-10-24-12-25-11-15)7-6-16(28-21)13-2-3-13/h4-13,27H,2-3H2,1H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97540
(Roche-Dataset for PDE10A, Compound 737 | US8470820...)Show SMILES O=C(Nc1cc(no1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H17N7O2/c29-21(27-19-9-18(28-30-19)16-3-1-2-8-24-16)20-17(25-14-10-22-12-23-11-14)7-6-15(26-20)13-4-5-13/h1-3,6-13,25H,4-5H2,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97510
(US8470820, 21)Show SMILES Cn1nc(cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C21H19N9O/c1-30-18(8-16(29-30)15-4-2-3-7-24-15)28-21(31)19-20(26-14-9-22-12-23-10-14)25-11-17(27-19)13-5-6-13/h2-4,7-13H,5-6H2,1H3,(H,25,26)(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97544
(US8470820, 55)Show SMILES Cn1nc(cc1NC(=O)c1nc(ncc1Nc1cncnc1)C(C)(C)C)-c1ccccn1 Show InChI InChI=1S/C22H23N9O/c1-22(2,3)21-26-12-17(27-14-10-23-13-24-11-14)19(29-21)20(32)28-18-9-16(30-31(18)4)15-7-5-6-8-25-15/h5-13,27H,1-4H3,(H,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97525
(US8470820, 36)Show SMILES Cc1cnc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1CCO)-c1ccccn1 Show InChI InChI=1S/C20H19N9O2/c1-13-9-24-19(26-14-10-21-12-22-11-14)18(25-13)20(31)27-17-8-16(28-29(17)6-7-30)15-4-2-3-5-23-15/h2-5,8-12,30H,6-7H2,1H3,(H,24,26)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97532
(Roche-Dataset for PDE10A, Compound 12 | US8470820,...)Show SMILES CN1CCC(CC1)n1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C27H29N9O/c1-35-12-9-20(10-13-35)36-25(14-24(34-36)22-4-2-3-11-30-22)33-27(37)26-23(31-19-15-28-17-29-16-19)8-7-21(32-26)18-5-6-18/h2-4,7-8,11,14-18,20,31H,5-6,9-10,12-13H2,1H3,(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97504
(Roche-Dataset for PDE10A, Compound 41 | US8470820,...)Show SMILES CCOC(=O)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C25H24N8O3/c1-2-36-23(34)14-33-22(11-21(32-33)19-5-3-4-10-28-19)31-25(35)24-20(29-17-12-26-15-27-13-17)9-8-18(30-24)16-6-7-16/h3-5,8-13,15-16,29H,2,6-7,14H2,1H3,(H,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97506
(Roche-Dataset for PDE10A, Compound 18 | US8470820,...)Show SMILES O=C(Nc1cc(nn1CCc1ccccc1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C29H26N8O/c38-29(28-25(33-22-17-30-19-31-18-22)12-11-23(34-28)21-9-10-21)35-27-16-26(24-8-4-5-14-32-24)36-37(27)15-13-20-6-2-1-3-7-20/h1-8,11-12,14,16-19,21,33H,9-10,13,15H2,(H,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97500
(Roche-Dataset for PDE10A, Compound 91 | US8470820,...)Show SMILES COCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1CCO)-c1ccccn1 Show InChI InChI=1S/C22H22N8O3/c1-33-13-15-5-6-18(26-16-11-23-14-24-12-16)21(27-15)22(32)28-20-10-19(29-30(20)8-9-31)17-4-2-3-7-25-17/h2-7,10-12,14,26,31H,8-9,13H2,1H3,(H,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97497
(Roche-Dataset for PDE10A, Compound 113 | US8470820...)Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C22H20N8O/c1-30-20(10-19(29-30)17-4-2-3-9-25-17)28-22(31)21-18(26-15-11-23-13-24-12-15)8-7-16(27-21)14-5-6-14/h2-4,7-14,26H,5-6H2,1H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97519
(Roche-Dataset for PDE10A, Compound 90 | US8470820,...)Show SMILES CCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C23H22N8O/c1-2-31-21(11-20(30-31)18-5-3-4-10-26-18)29-23(32)22-19(27-16-12-24-14-25-13-16)9-8-17(28-22)15-6-7-15/h3-5,8-15,27H,2,6-7H2,1H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97549
(US8470820, 60)Show SMILES Cn1nc(cc1NC(=O)c1nc(ncc1Nc1cncnc1)C1CCCCC1)-c1ccccn1 Show InChI InChI=1S/C24H25N9O/c1-33-21(11-19(32-33)18-9-5-6-10-27-18)30-24(34)22-20(29-17-12-25-15-26-13-17)14-28-23(31-22)16-7-3-2-4-8-16/h5-6,9-16,29H,2-4,7-8H2,1H3,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97548
(Roche-Dataset for PDE10A, Compound 472 | US8470820...)Show SMILES COCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C21H20N8O2/c1-29-19(9-18(28-29)16-5-3-4-8-24-16)27-21(30)20-17(7-6-14(26-20)12-31-2)25-15-10-22-13-23-11-15/h3-11,13,25H,12H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97496
(Roche-Dataset for PDE10A, Compound 763 | US8470820...)Show SMILES O=C(Nc1ccn(n1)-c1ccncc1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H18N8O/c30-21(27-19-7-10-29(28-19)16-5-8-22-9-6-16)20-18(25-15-11-23-13-24-12-15)4-3-17(26-20)14-1-2-14/h3-14,25H,1-2H2,(H,27,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97507
(Roche-Dataset for PDE10A, Compound 104 | US8470820...)Show SMILES CC(C)(C)n1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C25H26N8O/c1-25(2,3)33-22(12-21(32-33)19-6-4-5-11-28-19)31-24(34)23-20(29-17-13-26-15-27-14-17)10-9-18(30-23)16-7-8-16/h4-6,9-16,29H,7-8H2,1-3H3,(H,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97542
(US8470820, 53)Show SMILES CC(C)c1ncc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C21H21N9O/c1-13(2)20-25-11-17(26-14-9-22-12-23-10-14)19(28-20)21(31)27-18-8-16(29-30(18)3)15-6-4-5-7-24-15/h4-13,26H,1-3H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97524
(US8470820, 35)Show SMILES Cc1cnc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C19H17N9O/c1-12-8-23-18(25-13-9-20-11-21-10-13)17(24-12)19(29)26-16-7-15(27-28(16)2)14-5-3-4-6-22-14/h3-11H,1-2H3,(H,23,25)(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97495
(Roche-Dataset for PDE10A, Compound 697 | US8470820...)Show SMILES Fc1ccc(cc1)-n1ccc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)n1 Show InChI InChI=1S/C22H18FN7O/c23-15-3-5-17(6-4-15)30-10-9-20(29-30)28-22(31)21-19(26-16-11-24-13-25-12-16)8-7-18(27-21)14-1-2-14/h3-14,26H,1-2H2,(H,28,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97531
(Roche-Dataset for PDE10A, Compound 35 | US8470820,...)Show SMILES CN(C)CCn1nc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)cc1-c1ccccn1 Show InChI InChI=1S/C25H27N9O/c1-33(2)11-12-34-22(20-5-3-4-10-28-20)13-23(32-34)31-25(35)24-21(29-18-14-26-16-27-15-18)9-8-19(30-24)17-6-7-17/h3-5,8-10,13-17,29H,6-7,11-12H2,1-2H3,(H,31,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97550
(US8470820, 61)Show SMILES CC(C)Cc1ncc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C22H23N9O/c1-14(2)8-19-26-12-18(27-15-10-23-13-24-11-15)21(28-19)22(32)29-20-9-17(30-31(20)3)16-6-4-5-7-25-16/h4-7,9-14,27H,8H2,1-3H3,(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97541
(Roche-Dataset for PDE10A, Compound 516 | US8470820...)Show SMILES O=C(Nc1cn(cn1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H18N8O/c30-21(28-18-11-29(13-25-18)19-3-1-2-8-24-19)20-17(26-15-9-22-12-23-10-15)7-6-16(27-20)14-4-5-14/h1-3,6-14,26H,4-5H2,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97494
(Roche-Dataset for PDE10A, Compound 843 | US8470820...)Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccncc1 Show InChI InChI=1S/C19H16N8O/c1-13-2-3-16(24-14-10-21-12-22-11-14)18(23-13)19(28)25-17-6-9-27(26-17)15-4-7-20-8-5-15/h2-12,24H,1H3,(H,25,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97553
(Roche-Dataset for PDE10A, Compound 1097 | US847082...)Show SMILES O=C(Nc1cnn(c1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H18N8O/c30-21(27-16-11-25-29(12-16)19-3-1-2-8-24-19)20-18(26-15-9-22-13-23-10-15)7-6-17(28-20)14-4-5-14/h1-3,6-14,26H,4-5H2,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97543
(US8470820, 54)Show SMILES Cn1nc(cc1NC(=O)c1nc(ncc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C21H19N9O/c1-30-18(8-16(29-30)15-4-2-3-7-24-15)27-21(31)19-17(26-14-9-22-12-23-10-14)11-25-20(28-19)13-5-6-13/h2-4,7-13,26H,5-6H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97492
(Roche-Dataset for PDE10A, Compound 872 | US8470820...)Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccccc1 Show InChI InChI=1S/C20H17N7O/c1-14-7-8-17(24-15-11-21-13-22-12-15)19(23-14)20(28)25-18-9-10-27(26-18)16-5-3-2-4-6-16/h2-13,24H,1H3,(H,25,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97498
(Roche-Dataset for PDE10A, Compound 284 | US8470820...)Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1 Show InChI InChI=1S/C24H23N7O2/c32-11-10-31-22(12-21(30-31)16-4-2-1-3-5-16)29-24(33)23-20(27-18-13-25-15-26-14-18)9-8-19(28-23)17-6-7-17/h1-5,8-9,12-15,17,27,32H,6-7,10-11H2,(H,29,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97522
(Roche-Dataset for PDE10A, Compound 56 | US8470820,...)Show SMILES O=C(Nc1cc(nn1CCC#N)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C24H21N9O/c25-9-3-11-33-22(12-21(32-33)19-4-1-2-10-28-19)31-24(34)23-20(29-17-13-26-15-27-14-17)8-7-18(30-23)16-5-6-16/h1-2,4,7-8,10,12-16,29H,3,5-6,11H2,(H,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97554
(US8470820, 66)Show SMILES O=C(Nc1cn(cn1)-c1ccccn1)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C20H17N9O/c30-20(28-16-10-29(12-25-16)17-3-1-2-6-23-17)18-19(26-14-7-21-11-22-8-14)24-9-15(27-18)13-4-5-13/h1-3,6-13H,4-5H2,(H,24,26)(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 187 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97502
(US8470820, 13)Show SMILES COCc1ncc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1 Show InChI InChI=1S/C20H19N9O2/c1-29-18(7-15(28-29)14-5-3-4-6-23-14)27-20(30)19-16(10-24-17(26-19)11-31-2)25-13-8-21-12-22-9-13/h3-10,12,25H,11H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 256 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97551
(Roche-Dataset for PDE10A, Compound 134 | US8470820...)Show SMILES Cn1nc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)cc1-c1ccccn1 Show InChI InChI=1S/C22H20N8O/c1-30-19(17-4-2-3-9-25-17)10-20(29-30)28-22(31)21-18(26-15-11-23-13-24-12-15)8-7-16(27-21)14-5-6-14/h2-4,7-14,26H,5-6H2,1H3,(H,28,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 327 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97493
(Roche-Dataset for PDE10A, Compound 903 | US8470820...)Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccccn1 Show InChI InChI=1S/C19H16N8O/c1-13-5-6-15(24-14-10-20-12-21-11-14)18(23-13)19(28)25-16-7-9-27(26-16)17-4-2-3-8-22-17/h2-12,24H,1H3,(H,25,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 368 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97537
(Roche-Dataset for PDE10A, Compound 670 | US8470820...)Show SMILES O=C(Nc1nnc(s1)-c1ccccc1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H17N7OS/c29-19(26-21-28-27-20(30-21)14-4-2-1-3-5-14)18-17(24-15-10-22-12-23-11-15)9-8-16(25-18)13-6-7-13/h1-5,8-13,24H,6-7H2,(H,26,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 435 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97535
(Roche-Dataset for PDE10A, Compound 488 | US8470820...)Show SMILES O=C(Nc1cc(no1)-c1ccccc1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H18N6O2/c29-22(27-20-10-19(28-30-20)14-4-2-1-3-5-14)21-18(25-16-11-23-13-24-12-16)9-8-17(26-21)15-6-7-15/h1-5,8-13,15,25H,6-7H2,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 612 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97538
(Roche-Dataset for PDE10A, Compound 555 | US8470820...)Show SMILES O=C(Nc1nnc(s1)-c1cnccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C19H15N9OS/c29-17(26-19-28-27-18(30-19)15-9-20-5-6-23-15)16-14(24-12-7-21-10-22-8-12)4-3-13(25-16)11-1-2-11/h3-11,24H,1-2H2,(H,26,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 744 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97546
(Roche-Dataset for PDE10A, Compound 534 | US8470820...)Show SMILES Brc1ccc(cc1)-c1cc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)on1 Show InChI InChI=1S/C22H17BrN6O2/c23-15-5-3-14(4-6-15)19-9-20(31-29-19)28-22(30)21-18(26-16-10-24-12-25-11-16)8-7-17(27-21)13-1-2-13/h3-13,26H,1-2H2,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 781 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97536
(Roche-Dataset for PDE10A, Compound 954 | US8470820...)Show SMILES O=C(Nc1cc(on1)-c1ccccc1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H18N6O2/c29-22(27-20-10-19(30-28-20)15-4-2-1-3-5-15)21-18(25-16-11-23-13-24-12-16)9-8-17(26-21)14-6-7-14/h1-5,8-14,25H,6-7H2,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97545
(Roche-Dataset for PDE10A, Compound 577 | US8470820...)Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)on1 Show InChI InChI=1S/C22H17ClN6O2/c23-15-5-3-14(4-6-15)19-9-20(31-29-19)28-22(30)21-18(26-16-10-24-12-25-11-16)8-7-17(27-21)13-1-2-13/h3-13,26H,1-2H2,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97533
(Roche-Dataset for PDE10A, Compound 459 | US8470820...)Show SMILES COc1ccc(cc1)-c1nnc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)s1 Show InChI InChI=1S/C22H19N7O2S/c1-31-16-6-4-14(5-7-16)21-28-29-22(32-21)27-20(30)19-18(25-15-10-23-12-24-11-15)9-8-17(26-19)13-2-3-13/h4-13,25H,2-3H2,1H3,(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97552
(Roche-Dataset for PDE10A, Compound 797 | US8470820...)Show SMILES O=C(Nc1nnc(o1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C20H16N8O2/c29-18(26-20-28-27-19(30-20)16-3-1-2-8-23-16)17-15(24-13-9-21-11-22-10-13)7-6-14(25-17)12-4-5-12/h1-3,6-12,24H,4-5H2,(H,26,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.04E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97547
(Roche-Dataset for PDE10A, Compound 509 | US8470820...)Show SMILES Fc1ccc(cc1)-c1cc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)on1 Show InChI InChI=1S/C22H17FN6O2/c23-15-5-3-14(4-6-15)19-9-20(31-29-19)28-22(30)21-18(26-16-10-24-12-25-11-16)8-7-17(27-21)13-1-2-13/h3-13,26H,1-2H2,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.45E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM97534
(Roche-Dataset for PDE10A, Compound 460 | US8470820...)Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)s1 Show InChI InChI=1S/C21H16FN7OS/c22-14-5-3-13(4-6-14)20-28-29-21(31-20)27-19(30)18-17(25-15-9-23-11-24-10-15)8-7-16(26-18)12-1-2-12/h3-12,25H,1-2H2,(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.38E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Hoffman-La Roche Inc.
US Patent
| Assay Description
Scintillation proximity assay using human PDE10A. |
US Patent US8470820 (2013)
BindingDB Entry DOI: 10.7270/Q2J96501 |
More data for this
Ligand-Target Pair | |
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