BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM97499'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM97499 (Roche-Dataset for PDE10A, Compound 103 \| US8470820...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Scintillation proximity assay using human PDE10A.				US Patent US8470820 (2013) BindingDB Entry DOI: 10.7270/Q2J96501
Hoffman-La Roche Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM97499 (Roche-Dataset for PDE10A, Compound 103 \| US8470820...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)