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Patent code US8937068

Compile Data Set for Download or QSAR

Found 220 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142655
PNG
(US8937068, 43)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 6n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47103
PNG
(US8937068, 124 | US8937068, 193)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C17H17N5O3/c1-3-18-17(24)22-15-7-5-11-16(21-15)20-12(9-19-11)10-4-6-13(23)14(8-10)25-2/h4-9,23H,3H2,1-2H3,(H2,18,20,21,22,24)
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n/an/a 62n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142653
PNG
(US8937068, 25)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5O2/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142681
PNG
(US8937068, 171)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC
Show InChI InChI=1S/C17H16ClN5O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)11-5-4-10(18)8-14(11)25-2/h4-9H,3H2,1-2H3,(H2,19,21,22,23,24)
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n/an/a 84n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142674
PNG
(US8937068, 163)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)c(OC)c3)nc2n1
Show InChI InChI=1S/C18H20N6O2/c1-4-19-18(25)24-15-8-7-13-17(22-15)23-16(10-20-13)21-12-6-5-11(2)14(9-12)26-3/h5-10H,4H2,1-3H3,(H3,19,21,22,23,24,25)
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n/an/a 96n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142680
PNG
(US8937068, 170)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1Cl
Show InChI InChI=1S/C16H14ClN5O2/c1-2-18-16(24)22-14-6-5-12-15(21-14)20-13(8-19-12)10-4-3-9(23)7-11(10)17/h3-8,23H,2H2,1H3,(H2,18,20,21,22,24)
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n/an/a 103n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 104n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 104n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142683
PNG
(US8937068, 173)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C14H15N7O/c1-3-15-14(22)20-12-5-4-10-13(19-12)18-11(7-16-10)9-6-17-21(2)8-9/h4-8H,3H2,1-2H3,(H2,15,18,19,20,22)
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n/an/a 107n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47095
PNG
(US8937068, 150)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(C)cc3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142691
PNG
(US8937068, 184)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccnc(Cl)c3)nc2n1
Show InChI InChI=1S/C15H14ClN7O/c1-2-17-15(24)23-12-4-3-10-14(21-12)22-13(8-19-10)20-9-5-6-18-11(16)7-9/h3-8H,2H2,1H3,(H3,17,18,20,21,22,23,24)
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n/an/a 133n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47100
PNG
(US8937068, 156 | US8937068, 175)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cc(Cl)c(O)c(OC)c1
Show InChI InChI=1S/C17H16ClN5O3/c1-3-19-17(25)23-14-5-4-11-16(22-14)21-12(8-20-11)9-6-10(18)15(24)13(7-9)26-2/h4-8,24H,3H2,1-2H3,(H2,19,21,22,23,25)
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n/an/a 138n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142671
PNG
(US8937068, 159)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(Cl)cc3)nc2n1
Show InChI InChI=1S/C16H15ClN6O/c1-2-18-16(24)23-13-8-7-12-15(21-13)22-14(9-19-12)20-11-5-3-10(17)4-6-11/h3-9H,2H2,1H3,(H3,18,20,21,22,23,24)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142679
PNG
(US8937068, 168)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NCCCCO)nc2n1
Show InChI InChI=1S/C19H21N5O4/c1-28-16-10-12(4-6-15(16)26)14-11-21-13-5-7-17(23-18(13)22-14)24-19(27)20-8-2-3-9-25/h4-7,10-11,25-26H,2-3,8-9H2,1H3,(H2,20,22,23,24,27)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142692
PNG
(US8937068, 185)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cc(Cl)c(O)c(Cl)c3)nc2n1
Show InChI InChI=1S/C16H14Cl2N6O2/c1-2-19-16(26)24-12-4-3-11-15(22-12)23-13(7-20-11)21-8-5-9(17)14(25)10(18)6-8/h3-7,25H,2H2,1H3,(H3,19,21,22,23,24,26)
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n/an/a 154n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142660
PNG
(US8937068, 146)
Show SMILES OCCCCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N5O2/c24-11-5-4-10-19-18(25)23-16-9-8-14-17(22-16)21-15(12-20-14)13-6-2-1-3-7-13/h1-3,6-9,12,24H,4-5,10-11H2,(H2,19,21,22,23,25)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47102
PNG
(US8937068, 178)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc4ccccc4c3)nc2n1
Show InChI InChI=1S/C20H18N6O/c1-2-21-20(27)26-17-10-9-16-19(24-17)25-18(12-22-16)23-15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3,(H3,21,23,24,25,26,27)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142670
PNG
(US8937068, 158)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(OC)cc3)nc2n1
Show InChI InChI=1S/C17H18N6O2/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-11-4-6-12(25-2)7-5-11/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142673
PNG
(US8937068, 162)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(CC)cc3)nc2n1
Show InChI InChI=1S/C18H20N6O/c1-3-12-5-7-13(8-6-12)21-16-11-20-14-9-10-15(22-17(14)23-16)24-18(25)19-4-2/h5-11H,3-4H2,1-2H3,(H3,19,21,22,23,24,25)
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n/an/a 190n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47100
PNG
(US8937068, 156 | US8937068, 175)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cc(Cl)c(O)c(OC)c1
Show InChI InChI=1S/C17H16ClN5O3/c1-3-19-17(25)23-14-5-4-11-16(22-14)21-12(8-20-11)9-6-10(18)15(24)13(7-9)26-2/h4-8,24H,3H2,1-2H3,(H2,19,21,22,23,25)
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n/an/a 191n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142686
PNG
(US8937068, 179)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cnc4ccccc4c3)nc2n1
Show InChI InChI=1S/C19H17N7O/c1-2-20-19(27)26-16-8-7-15-18(24-16)25-17(11-22-15)23-13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,2H2,1H3,(H3,20,23,24,25,26,27)
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n/an/a 202n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142690
PNG
(US8937068, 183)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1
Show InChI InChI=1S/C24H23N5O5S/c1-4-25-24(30)29-22-12-10-18-23(28-22)27-19(14-26-18)16-7-11-20(21(13-16)33-3)34-35(31,32)17-8-5-15(2)6-9-17/h5-14H,4H2,1-3H3,(H2,25,27,28,29,30)
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n/an/a 203n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47103
PNG
(US8937068, 124 | US8937068, 193)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C17H17N5O3/c1-3-18-17(24)22-15-7-5-11-16(21-15)20-12(9-19-11)10-4-6-13(23)14(8-10)25-2/h4-9,23H,3H2,1-2H3,(H2,18,20,21,22,24)
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n/an/a 212n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142693
PNG
(US8937068, 186)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cc(Cl)c(O)c(Cl)c1
Show InChI InChI=1S/C16H13Cl2N5O2/c1-2-19-16(25)23-13-4-3-11-15(22-13)21-12(7-20-11)8-5-9(17)14(24)10(18)6-8/h3-7,24H,2H2,1H3,(H2,19,21,22,23,25)
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n/an/a 223n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142696
PNG
(US8937068, 189)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cc(cc(c3)C(F)(F)F)C(O)=O)nc2n1
Show InChI InChI=1S/C18H15F3N6O3/c1-2-22-17(30)27-13-4-3-12-15(25-13)26-14(8-23-12)24-11-6-9(16(28)29)5-10(7-11)18(19,20)21/h3-8H,2H2,1H3,(H,28,29)(H3,22,24,25,26,27,30)
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n/an/a 237n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142697
PNG
(US8937068, 190)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(OC)nc3)nc2n1
Show InChI InChI=1S/C16H17N7O2/c1-3-17-16(24)23-12-6-5-11-15(21-12)22-13(9-18-11)20-10-4-7-14(25-2)19-8-10/h4-9H,3H2,1-2H3,(H3,17,20,21,22,23,24)
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n/an/a 271n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142685
PNG
(US8937068, 177)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(OC)c(Cl)c3)nc2n1
Show InChI InChI=1S/C17H17ClN6O2/c1-3-19-17(25)24-14-7-5-12-16(22-14)23-15(9-20-12)21-10-4-6-13(26-2)11(18)8-10/h4-9H,3H2,1-2H3,(H3,19,21,22,23,24,25)
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n/an/a 295n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47097
PNG
(US8937068, 157)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cccc(C)c3)nc2n1
Show InChI InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-8-7-13-16(21-14)22-15(10-19-13)20-12-6-4-5-11(2)9-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)
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n/an/a 348n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142654
PNG
(US8937068, 30)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=S)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5OS/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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n/an/a 370n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142654
PNG
(US8937068, 30)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=S)NCC=C)nc2n1
Show InChI InChI=1S/C17H15N5OS/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
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n/an/a 392n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142682
PNG
(US8937068, 172)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C15H17N7O/c1-4-16-15(23)20-12-6-5-10-14(19-12)18-11(7-17-10)13-8(2)21-22-9(13)3/h5-7H,4H2,1-3H3,(H,21,22)(H2,16,18,19,20,23)
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n/an/a 410n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142698
PNG
(US8937068, 192)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(cc3)C#N)nc2n1
Show InChI InChI=1S/C17H15N7O/c1-2-19-17(25)24-14-8-7-13-16(22-14)23-15(10-20-13)21-12-5-3-11(9-18)4-6-12/h3-8,10H,2H2,1H3,(H3,19,21,22,23,24,25)
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n/an/a 422n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47100
PNG
(US8937068, 156 | US8937068, 175)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cc(Cl)c(O)c(OC)c1
Show InChI InChI=1S/C17H16ClN5O3/c1-3-19-17(25)23-14-5-4-11-16(22-14)21-12(8-20-11)9-6-10(18)15(24)13(7-9)26-2/h4-8,24H,3H2,1-2H3,(H2,19,21,22,23,25)
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n/an/a 425n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142675
PNG
(US8937068, 164)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(O)cc3)nc2n1
Show InChI InChI=1S/C16H16N6O2/c1-2-17-16(24)22-13-8-7-12-15(20-13)21-14(9-18-12)19-10-3-5-11(23)6-4-10/h3-9,23H,2H2,1H3,(H3,17,19,20,21,22,24)
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n/an/a 444n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47100
PNG
(US8937068, 156 | US8937068, 175)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cc(Cl)c(O)c(OC)c1
Show InChI InChI=1S/C17H16ClN5O3/c1-3-19-17(25)23-14-5-4-11-16(22-14)21-12(8-20-11)9-6-10(18)15(24)13(7-9)26-2/h4-8,24H,3H2,1-2H3,(H2,19,21,22,23,25)
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n/an/a 458n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47103
PNG
(US8937068, 124 | US8937068, 193)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C17H17N5O3/c1-3-18-17(24)22-15-7-5-11-16(21-15)20-12(9-19-11)10-4-6-13(23)14(8-10)25-2/h4-9,23H,3H2,1-2H3,(H2,18,20,21,22,24)
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n/an/a 490n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM142657
PNG
(US8937068, 46)
Show SMILES CCN(C(C)=O)C(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H17N5O2/c1-3-23(12(2)24)18(25)22-16-10-9-14-17(21-16)20-15(11-19-14)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3,(H,20,21,22,25)
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n/an/a 495n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142667
PNG
(US8937068, 154)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)c(OC)c1
Show InChI InChI=1S/C17H18N6O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)10-4-5-11(18)14(8-10)25-2/h4-9H,3,18H2,1-2H3,(H2,19,21,22,23,24)
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n/an/a 592n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142666
PNG
(US8937068, 153)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C18H19N5O3/c1-4-19-18(24)23-16-8-6-12-17(22-16)21-13(10-20-12)11-5-7-14(25-2)15(9-11)26-3/h5-10H,4H2,1-3H3,(H2,19,21,22,23,24)
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n/an/a 612n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142679
PNG
(US8937068, 168)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NCCCCO)nc2n1
Show InChI InChI=1S/C19H21N5O4/c1-28-16-10-12(4-6-15(16)26)14-11-21-13-5-7-17(23-18(13)22-14)24-19(27)20-8-2-3-9-25/h4-7,10-11,25-26H,2-3,8-9H2,1H3,(H2,20,22,23,24,27)
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n/an/a 612n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142661
PNG
(US8937068, 147)
Show SMILES OCCCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O2/c23-10-4-9-18-17(24)22-15-8-7-13-16(21-15)20-14(11-19-13)12-5-2-1-3-6-12/h1-3,5-8,11,23H,4,9-10H2,(H2,18,20,21,22,24)
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n/an/a 711n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142694
PNG
(US8937068, 187)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3ccc(OC)c(OC)c3)nc2n1
Show InChI InChI=1S/C18H20N6O3/c1-4-19-18(25)24-15-8-6-12-17(22-15)23-16(10-20-12)21-11-5-7-13(26-2)14(9-11)27-3/h5-10H,4H2,1-3H3,(H3,19,21,22,23,24,25)
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n/an/a 712n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142688
PNG
(US8937068, 181)
Show SMILES CCNC(=O)Nc1ccc2ncc(Nc3cnccn3)nc2n1
Show InChI InChI=1S/C14H14N8O/c1-2-16-14(23)22-10-4-3-9-13(20-10)21-12(8-18-9)19-11-7-15-5-6-17-11/h3-8H,2H2,1H3,(H3,16,17,19,20,21,22,23)
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n/an/a 739n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142666
PNG
(US8937068, 153)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C18H19N5O3/c1-4-19-18(24)23-16-8-6-12-17(22-16)21-13(10-20-12)11-5-7-14(25-2)15(9-11)26-3/h5-10H,4H2,1-3H3,(H2,19,21,22,23,24)
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n/an/a 939n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142658
PNG
(US8937068, 82)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)cc1
Show InChI InChI=1S/C16H16N6O/c1-2-18-16(23)22-14-8-7-12-15(21-14)20-13(9-19-12)10-3-5-11(17)6-4-10/h3-9H,2,17H2,1H3,(H2,18,20,21,22,23)
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n/an/a 944n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM142663
PNG
(US8937068, 149)
Show SMILES CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C16H15N5OS/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 954n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM142667
PNG
(US8937068, 154)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(N)c(OC)c1
Show InChI InChI=1S/C17H18N6O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)10-4-5-11(18)14(8-10)25-2/h4-9H,3,18H2,1-2H3,(H2,19,21,22,23,24)
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n/an/a 984n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM47096
PNG
(US8937068, 1 | US8937068, 151)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C16H15N5O2/c1-2-17-16(23)21-14-7-6-12-15(20-14)19-13(9-18-12)10-4-3-5-11(22)8-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8/9


(Homo sapiens (Human))		BDBM47103
PNG
(US8937068, 124 | US8937068, 193)
Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(O)c(OC)c1
Show InChI InChI=1S/C17H17N5O3/c1-3-18-17(24)22-15-7-5-11-16(21-15)20-12(9-19-11)10-4-6-13(23)14(8-10)25-2/h4-9,23H,3H2,1-2H3,(H2,18,20,21,22,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...

US Patent US8937068 (2015)


BindingDB Entry DOI: 10.7270/Q2H993WP
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 220 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%